CN112175953B - 一种基因抑制剂在制备肺癌药物中的应用 - Google Patents
一种基因抑制剂在制备肺癌药物中的应用 Download PDFInfo
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- CN112175953B CN112175953B CN202011084618.2A CN202011084618A CN112175953B CN 112175953 B CN112175953 B CN 112175953B CN 202011084618 A CN202011084618 A CN 202011084618A CN 112175953 B CN112175953 B CN 112175953B
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract
Description
样本编号 | 肿瘤类型 | 诊断年龄 | 性别 | M分期 | N分期 |
1 | 肺腺癌 | 67 | 男 | M0 | N0 |
2 | 肺腺癌 | 78 | 女 | M0 | N1 |
3 | 肺腺癌 | 65 | 男 | M0 | N0 |
4 | 肺腺癌 | 70 | 男 | M0 | N2 |
5 | 肺腺癌 | 58 | 男 | M0 | N0 |
6 | 肺腺癌 | 75 | 女 | M0 | N2 |
7 | 肺腺癌 | 66 | 男 | M0 | N1 |
8 | 肺腺癌 | 76 | 女 | M0 | N0 |
9 | 肺腺癌 | 48 | 女 | M0 | N3 |
10 | 肺腺癌 | 74 | 女 | M0 | N0 |
11 | 肺腺癌 | 60 | 男 | M0 | N0 |
12 | 肺腺癌 | 51 | 女 | M0 | N0 |
13 | 肺腺癌 | 57 | 男 | M0 | N2 |
14 | 肺腺癌 | 68 | 男 | M0 | N2 |
15 | 肺腺癌 | 40 | 男 | M0 | N0 |
16 | 肺腺癌 | 43 | 男 | M0 | N0 |
17 | 肺腺癌 | 72 | 男 | M0 | N1 |
18 | 肺腺癌 | 59 | 女 | M0 | N0 |
19 | 肺腺癌 | 83 | 男 | M0 | N0 |
20 | 肺腺癌 | 50 | 男 | M0 | N2 |
时间 | si-NC | si-LINC01801 |
0h | 0.279±0.018 | 0.280±0.015 |
24h | 0.543±0.029 | 0.385±0.023 |
48h | 0.872±0.034 | 0.524±0.035 |
72h | 1.083±0.039 | 0.678±0.041 |
96h | 1.213±0.056 | 0.735±0.043 |
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CN202011084618.2A CN112175953B (zh) | 2020-03-13 | 2020-03-13 | 一种基因抑制剂在制备肺癌药物中的应用 |
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CN202010174971.3A CN111235275B (zh) | 2020-03-13 | 2020-03-13 | 一种肺癌的基因标志物及其应用 |
CN202011084618.2A CN112175953B (zh) | 2020-03-13 | 2020-03-13 | 一种基因抑制剂在制备肺癌药物中的应用 |
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CN202010174971.3A Division CN111235275B (zh) | 2020-03-13 | 2020-03-13 | 一种肺癌的基因标志物及其应用 |
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CN112175953A CN112175953A (zh) | 2021-01-05 |
CN112175953B true CN112175953B (zh) | 2022-05-24 |
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CN202011084618.2A Active CN112175953B (zh) | 2020-03-13 | 2020-03-13 | 一种基因抑制剂在制备肺癌药物中的应用 |
CN202010174971.3A Active CN111235275B (zh) | 2020-03-13 | 2020-03-13 | 一种肺癌的基因标志物及其应用 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113862349A (zh) * | 2021-10-26 | 2021-12-31 | 山东师范大学 | 一种肺纤维化诊断生物标志物 |
CN113925877B (zh) * | 2021-10-28 | 2022-06-07 | 青岛西凯生物技术有限公司 | 基因增强型免疫细胞在肺癌中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1307113A (zh) * | 2000-01-28 | 2001-08-08 | 上海博道基因技术有限公司 | 一种新的多肽——人3-beta羟甾醇脱氢酶/5-烯-4-烯异构酶57和编码这种多肽的多核苷酸 |
AU2001281939A1 (en) * | 2000-07-05 | 2002-01-14 | Bayer Aktiengesellschaft | Regulation of human alpha-hydroxysteroid dehydrogenase-like enzyme |
US8673873B1 (en) * | 2005-12-28 | 2014-03-18 | Alcon Research, Ltd. | RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders |
CN101698834B (zh) * | 2009-09-08 | 2012-05-23 | 北京利德曼生化股份有限公司 | 3α-羟基类固醇脱氢酶及其核苷酸序列、重组载体、重组宿主细胞和试剂盒 |
NZ603816A (en) * | 2010-05-27 | 2014-06-27 | Pharmazell Gmbh | Novel 7alpha-hydroxysteroid dehydrogenase knockout mutants and use thereof |
CN103316359B (zh) * | 2013-07-11 | 2014-10-15 | 南京医科大学第二附属医院 | 长链非编码rna在制备治疗非小细胞肺癌药物中的应用 |
CN105177005B (zh) * | 2015-10-13 | 2018-03-09 | 南京医科大学第二附属医院 | 一种长非编码rna及其应用 |
CN107365845A (zh) * | 2017-08-04 | 2017-11-21 | 上海易毕恩生物技术有限公司 | 用于检测肺癌的基因标志物、试剂盒及肺癌检测方法 |
CN109082419B (zh) * | 2018-09-07 | 2022-03-01 | 深圳上泰生物工程有限公司 | 一种3α-羟基类固醇脱氢酶突变体、编码核苷酸序列及试剂盒 |
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CN111235275A (zh) | 2020-06-05 |
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