CN112174965B - 氘修饰的碳青霉烯衍生物 - Google Patents
氘修饰的碳青霉烯衍生物 Download PDFInfo
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- CN112174965B CN112174965B CN201910592129.9A CN201910592129A CN112174965B CN 112174965 B CN112174965 B CN 112174965B CN 201910592129 A CN201910592129 A CN 201910592129A CN 112174965 B CN112174965 B CN 112174965B
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- Prior art keywords
- compound
- pharmaceutically acceptable
- deuterium
- acid
- independently selected
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910592129.9A CN112174965B (zh) | 2019-07-03 | 2019-07-03 | 氘修饰的碳青霉烯衍生物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910592129.9A CN112174965B (zh) | 2019-07-03 | 2019-07-03 | 氘修饰的碳青霉烯衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112174965A CN112174965A (zh) | 2021-01-05 |
CN112174965B true CN112174965B (zh) | 2022-02-08 |
Family
ID=73915822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201910592129.9A Active CN112174965B (zh) | 2019-07-03 | 2019-07-03 | 氘修饰的碳青霉烯衍生物 |
Country Status (1)
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CN (1) | CN112174965B (zh) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2177522B1 (en) * | 2007-06-28 | 2013-09-04 | XuanZhu Pharma Co., Ltd. | Novel carbapenem derivatives |
US8318716B2 (en) * | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
CN102250095A (zh) * | 2010-05-21 | 2011-11-23 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法 |
CN102267996A (zh) * | 2010-06-03 | 2011-12-07 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法 |
CN103298813B (zh) * | 2010-12-16 | 2016-09-14 | 珠海亿邦制药股份有限公司 | 碳青霉烯衍生物的无定形粉末和多晶型物及其制备方法和应用 |
CN102584827B (zh) * | 2010-12-21 | 2015-08-12 | 山东轩竹医药科技有限公司 | 含氨基磺酰基杂环甲胺基甲酰基吡咯烷的碳青霉烯化合物 |
-
2019
- 2019-07-03 CN CN201910592129.9A patent/CN112174965B/zh active Active
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Publication number | Publication date |
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CN112174965A (zh) | 2021-01-05 |
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CB02 | Change of applicant information |
Address after: 050000 Beijing Tianjin Hebei Collaborative Innovation Demonstration Park 203c507, 769 Taihang street, high tech Zone, Shijiazhuang City, Hebei Province Applicant after: Xuanzhu Biotechnology Co.,Ltd. Address before: 050000 Beijing Tianjin Hebei Collaborative Innovation Demonstration Park 203c507, 769 Taihang street, high tech Zone, Shijiazhuang City, Hebei Province Applicant before: Xuanzhu Biotechnology Co.,Ltd. |
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EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20210105 Assignee: SHANGHAI PHARMA XINYA PHARMACEUTICAL CO.,LTD. Assignor: Xuanzhu Biotechnology Co.,Ltd. Contract record no.: X2023980031338 Denomination of invention: Deuterium modified carbapenem derivatives Granted publication date: 20220208 License type: Exclusive License Record date: 20230113 |