CN112168717B - 基于水凝胶的缓释面膜及其制备方法和使用方法 - Google Patents
基于水凝胶的缓释面膜及其制备方法和使用方法 Download PDFInfo
- Publication number
- CN112168717B CN112168717B CN202011067465.0A CN202011067465A CN112168717B CN 112168717 B CN112168717 B CN 112168717B CN 202011067465 A CN202011067465 A CN 202011067465A CN 112168717 B CN112168717 B CN 112168717B
- Authority
- CN
- China
- Prior art keywords
- hydrogel
- woven fiber
- layer
- fiber layer
- mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 102
- 238000000034 method Methods 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title description 4
- 239000000835 fiber Substances 0.000 claims abstract description 61
- 239000000499 gel Substances 0.000 claims abstract description 15
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920001983 poloxamer Polymers 0.000 claims abstract description 13
- 229960000502 poloxamer Drugs 0.000 claims abstract description 13
- 230000007704 transition Effects 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920001400 block copolymer Polymers 0.000 claims abstract description 7
- 150000001413 amino acids Chemical class 0.000 claims abstract description 6
- 239000004615 ingredient Substances 0.000 claims abstract description 4
- 230000002441 reversible effect Effects 0.000 claims description 38
- 238000000576 coating method Methods 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 12
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 10
- 230000009466 transformation Effects 0.000 claims description 9
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 6
- 229940024606 amino acid Drugs 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 4
- 229920000570 polyether Polymers 0.000 claims description 4
- 238000005229 chemical vapour deposition Methods 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims description 3
- 125000004185 ester group Chemical group 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000007740 vapor deposition Methods 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960005305 adenosine Drugs 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 229960000271 arbutin Drugs 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 229930195712 glutamate Natural products 0.000 claims description 2
- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229960002446 octanoic acid Drugs 0.000 claims description 2
- 229940055577 oleyl alcohol Drugs 0.000 claims description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 238000005057 refrigeration Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000003111 delayed effect Effects 0.000 claims 4
- 229940009098 aspartate Drugs 0.000 claims 1
- 229960005188 collagen Drugs 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- -1 purslane extract Natural products 0.000 claims 1
- 229940064064 purslane extract Drugs 0.000 claims 1
- 238000012423 maintenance Methods 0.000 abstract description 14
- 230000001815 facial effect Effects 0.000 abstract description 8
- 230000032050 esterification Effects 0.000 abstract description 3
- 238000005886 esterification reaction Methods 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 description 20
- 230000000694 effects Effects 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
- B32B37/24—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer not being coherent before laminating, e.g. made up from granular material sprinkled onto a substrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/022—Non-woven fabric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
- B32B5/24—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer
- B32B5/26—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer another layer next to it also being fibrous or filamentary
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
- B32B37/24—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer not being coherent before laminating, e.g. made up from granular material sprinkled onto a substrate
- B32B2037/243—Coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
- B32B37/24—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer not being coherent before laminating, e.g. made up from granular material sprinkled onto a substrate
- B32B2037/246—Vapour deposition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/02—Coating on the layer surface on fibrous or filamentary layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/26—Polymeric coating
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
一种基于水凝胶的缓释面膜,所述基于水凝胶的缓释面膜包括依次排布的背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层。所述水凝胶层中的水凝胶包括(1)通式为R‑(EO)n‑(PO)m‑(EO)n‑R的水性嵌段共聚物,(2)通式为HO‑(EO)a‑(PO)b‑(EO)a‑H的泊洛沙姆,(3)辅助凝胶‑溶胶剂,(4)皮肤保养成分,(5)余量水。所使用的水性嵌段共聚物是基于泊洛沙姆的衍生物,利用氨基酸对结构通式为HO‑(EO)n‑(PO)m‑(EO)n‑H的泊洛沙姆进行酯化封端,然后再配合结构通式为HO‑(EO)a‑(PO)b‑(EO)a‑H的泊洛沙姆,可以将水凝胶的凝胶‑溶液转变温度控制在30‑35℃之间,同时使得水凝胶在0‑20℃之间呈现为透明凝胶形态。本发明的这种水凝胶在保养用面膜中具有特别的应用优势。
Description
技术领域
本发明涉及美容面膜领域,具体涉及一种基于水凝胶的缓释面膜及其制备方法和使用方法。
背景技术
面膜是女性常用的保养产品,通过将带有各种营养液、修复成分、美白成分、保湿成分等组分的面膜贴敷在面部,可以在保持面部肌肤水分充裕,增加皮肤角质层的湿度,软化角质,促使肌肤表面的毛孔扩张,促进新陈代谢,并将面膜中的各种保养成分吸收,以达到保养面部皮肤的作用。
传统的面膜产品中,有的面膜产品的吸附能力有限,所能携带的营养液等成分的较少,使得面膜的保养效果不足;有的面膜产品虽然能够携带大量的营养液等成分,但是,其无法将所携带的营养液等成分持续释放,或者释放营养液等成分的速度过慢,使得面膜的保养效果远低于预期;有的面膜产品既能够携带大量的营养液成分,也能够持续释放面膜内的营养液等成分,但是,其释放速度过快,远高于皮肤所能够吸收的速度,使得大量的营养液成分、水份挥发,面膜在较短的时间内变得干燥而失去保养效果。
水凝胶先在医用领域发挥作用,人们利用水凝胶的胶凝性质和凝胶状态,以及凝胶对药物活性成分的长时间缓释作用,将其用在人体的各种黏膜表面或皮肤表面的疾病治疗。随后,人们开始尝试将水凝胶用于非医用领域,如保养面膜中。然而,在这些尝试大都仅限于沿用水凝胶在医用领域的作用,并没有充分地实际结合到普通的保养面膜的实际情况中。
普通的保养面膜的使用时间一般在15-20分钟为宜,若延续水凝胶在医疗领域的用法,即利用水凝胶的胶凝状态,会使得普通的保养面膜的贴敷时间大幅增加至数小时,不太适用。因此,需要充分利用水凝胶的胶凝状态和溶液状态这两个状态,从而有效控制面膜中的营养液等成分的持续、合理释放。为此,本发明期望提出一种基于水凝胶的缓释面膜及其制备方法和使用方法。
发明内容
为了解决现有的保养面膜中所存在的上述不足,本发明提供了一种基于水凝胶的缓释面膜及其制备方法和使用方法。
本发明的第一方面包括一种基于水凝胶的缓释面膜。所述基于水凝胶的缓释面膜依次包括背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层,
其中,所述背衬层是以聚对二甲苯为原料,在室温附近的温度条件下,在非织造纤维层A表面气相沉积而成。
其中,所述非织造纤维层A和/或非织造纤维层B由多根随机排列的纤维经热粘合形成,所述纤维表面包括亲水性聚合物涂层。
其中,所述水凝胶层中的水凝胶为可逆透明水凝胶,所述可逆透明水凝胶在0-20℃之间呈现为透明凝胶形态,在30-35℃之间开始发生凝胶-溶液,即所述可逆透明水凝胶的凝胶-溶液转变温度介于30-35℃之间。
其中,所述可逆透明水凝胶包括:
(1)水性嵌段共聚物,所述水性嵌段共聚物具有如下通式,
R-(EO)n-(PO)m-(EO)n-R,
其中,R为氨基酸酯基,(EO)n是聚环氧乙烷嵌段,(PO)m是聚环氧丙烷嵌段,n是介于50-100的整数,m是介于30-50的整数,其含量约占可逆透明水凝胶总质量的10-20%,
(2)泊洛沙姆,所述泊洛沙姆具有如下通式,
HO-(EO)a-(PO)b-(EO)a-H,
其中,(EO)a是聚环氧乙烷嵌段,(PO)b是聚环氧丙烷嵌段,a是介于80-150的整数,b是介于40-80的整数,其含量约占可逆透明水凝胶总质量的1-10%,
(3)辅助凝胶-溶胶剂,选自月桂醇聚醚、油醇聚醚、脂肪醇聚醚、硬脂酸甘油酯、油酸甘油酯中的一种或多种,其含量约占可逆透明水凝胶总质量的1-5%,
(4)皮肤保养成分,皮肤保养成分可以是对皮肤具有改善皱纹、美白、保湿等功能的成分,如腺苷、熊果苷、透明质酸及其盐、甘油、胶原蛋白、马齿苋提取物、辛酸甘油酯等,其含量约占可逆透明水凝胶总质量的1-20%,
(5)余量水。
进一步地,所述氨基酸酯基选自丙氨酸酯基、谷氨酸酯基、甘氨酸酯基、天冬氨酸酯基、半胱氨酸酯基、赖氨酸酯基、亮氨酸酯基、异亮氨酸酯基、苯丙氨酸酯基中的一种或多种。
本发明的第二方面包括一种基于水凝胶的缓释面膜的制备方法,包括以下步骤:
(1)将聚合物材料挤出形成纤维丝,并在纤维丝表面涂覆亲水性聚合物涂层,然后将多跟涂覆有亲水性聚合物涂层的纤维丝随机平铺,并通过热粘合工艺进行粘合,得到非织造纤维层A和非织造纤维层B;
(2)以非织造纤维层A作为基底,以聚对二甲苯为原料,在基底温度为20-50℃的条件下进行化学气相沉积,在非织造纤维层的一侧沉积背衬层;
(3)将本发明的可逆透明水凝胶涂覆在非织造纤维层A的另一侧,并加热至40-60℃,使可逆透明水凝胶充分发生凝胶-溶液转变,然后将非织造纤维层B浸没并悬浮在可逆透明水凝胶的溶液中,然后将温度降至20℃以下,使其发生溶液-凝胶转变,转变完全后,即可得到依次包括背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层的基于水凝胶的缓释面膜。
由于本发明的可逆透明水凝胶的凝胶-溶液转变温度介于30-35℃之间,且在0-20℃之间呈现为透明凝胶形态,本发明所制得的基于水凝胶的缓释面膜需要在20℃以下冷藏为宜。
本发明的第三方面包括基于水凝胶的缓释面膜的使用方法,首先,将冷藏的基于水凝胶的缓释面膜取出,在自然环境中静置3-10min,使其温度接近于室内温度,然后在将其贴覆与皮肤表面,贴覆30-35min后,取下即可。
其中,所述皮肤表面可以是面部皮肤表面,也可以是手臂皮肤表面、腿部皮肤表面、腹部皮肤表面、背部皮肤表面。
进一步地,如果面膜中的初始水凝胶含量较高,在使用一次之后仍然还有较多的水凝胶,可以将使用后的面膜取下,然后降温至20℃以下使其再次发生溶液-凝胶转变,转变完全后,在20℃以下冷藏,可以再次使用。
本发明中,使用了可逆透明水凝胶作为面膜中的营养成分的载体。其中,所使用的水性嵌段共聚物是基于泊洛沙姆的衍生物,利用氨基酸对结构通式为HO-(EO)n-(PO)m-(EO)n-H的泊洛沙姆进行酯化封端,然后再配合结构通式为HO-(EO)a-(PO)b-(EO)a-H的泊洛沙姆,可以将水凝胶的凝胶-溶液转变温度控制在30-35℃之间,同时使得水凝胶在0-20℃之间呈现为透明凝胶形态。本发明的这种水凝胶在保养用面膜中具有特别的应用优势。
一方面,水凝胶对各种营养成分和水分的携带量充足,使得面膜保养效果得到保障。另一方面,面膜中使用的可逆透明水凝胶具有30-35℃的凝胶-溶液转变温度,将具有该凝胶-溶液转变温度的可逆透明水凝胶的面膜贴覆与人体皮肤表面后,人体皮肤表面的温度通常≥36.2℃,能够促使面膜中的可逆透明水凝胶逐步发生凝胶-溶液转变,实现面膜内的营养成分的缓释以及释放速度的控制。
通过面膜中的可逆透明水凝胶的凝胶-溶液转变而释放的营养成分和水分的速率比较适中,略高于皮肤的吸收速率,这使得皮肤能够充分利用面膜中的营养成分和水分,避免了大量溶液状态的营养成分和水分在空气中被挥发,造成营养液和水分的利用率不高的问题。
此外,在本发明的基于水凝胶的缓释面膜中,还包括设置在中间的非织造纤维层B,其表面具有亲水性聚合物涂层,能够有效地控制凝胶-溶液转变后的溶液,将溶液束缚在面膜区域内,避免了营养成分和水分的流失。
本发明的面膜采用化学气相沉积的聚对二甲苯作为背衬层,具有优异的阻隔效果,能够有效避免面膜中的营养成分和水分的挥发。
具体实施方式
以下的实例仅仅是以说明性的目的给出,不应将其理解为本发明的全部内容。
实施例
一种基于水凝胶的缓释面膜,包括依次排布的背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层,其中,所述背衬层是以聚对二甲苯为原料,在非织造纤维层A表面气相沉积而成;所述非织造纤维层A和/或非织造纤维层B由多根随机排列的纤维经热粘合形成,所述纤维表面包括亲水性聚合物涂层;
其特征在于:所述水凝胶层中的水凝胶为可逆透明水凝胶,所述可逆透明水凝胶在0-20℃之间呈现为透明凝胶形态,在30-35℃之间开始发生凝胶-溶液;
所述可逆透明水凝胶包括:
(1)水性嵌段共聚物,所述水性嵌段共聚物具有如下通式,
R-(EO)n-(PO)m-(EO)n-R,
其中,R为氨基酸酯基,(EO)n是聚环氧乙烷嵌段,(PO)m是聚环氧丙烷嵌段,n是介于50-100的整数,m是介于30-50的整数,其含量约占可逆透明水凝胶总质量的10-20%,
(2)泊洛沙姆,所述泊洛沙姆具有如下通式,
HO-(EO)a-(PO)b-(EO)a-H,
其中,(EO)a是聚环氧乙烷嵌段,(PO)b是聚环氧丙烷嵌段,a是介于80-150的整数,b是介于40-80的整数,其含量约占可逆透明水凝胶总质量的1-10%,
(3)辅助凝胶-溶胶剂,其含量约占可逆透明水凝胶总质量的1-5%。
(4)皮肤保养成分,其含量约占可逆透明水凝胶总质量的1-20%,
(5)余量水。
其中,所述水性嵌段共聚物是直接以结构式为HO-(EO)n-(PO)m-(EO)n-H的泊洛沙姆和氨基酸为原料,在催化剂的作用下,进行酯化封端反应而得到的。
所述基于水凝胶的缓释面膜按照如下方法进行制备:
(1)将聚合物材料挤出形成纤维丝,并在纤维丝表面涂覆亲水性聚合物涂层,然后将多跟涂覆有亲水性聚合物涂层的纤维丝随机平铺,并通过热粘合工艺进行粘合,得到非织造纤维层A和非织造纤维层B;
(2)以非织造纤维层A作为基底,以聚对二甲苯为原料,在基底温度为20-50℃的条件下进行化学气相沉积,在非织造纤维层的一侧沉积背衬层;
(3)将所述可逆透明水凝胶涂覆在非织造纤维层A的另一侧,并加热至40-60℃,使可逆透明水凝胶充分发生凝胶-溶液转变,然后将非织造纤维层B浸没并悬浮在可逆透明水凝胶的溶液中,然后将温度降至20℃以下,使其发生溶液-凝胶转变,转变完全后,即可得到依次包括背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层的基于水凝胶的缓释面膜。
表1中列出了三组具体的实例。
以实例1为例,将处于5℃的冰箱中冷藏的面膜的面膜从冰箱中取出,并在自然环境中放置10min后,待其温度与室温接近后,再将其贴敷在人体面部皮肤表面,约2min后,面膜内开始出现较多的溶液。随着时间的推移,溶液并为出现从面部溢流的情况,面膜内的溶液被有效地束缚在面膜的区域内。贴敷约30min后,面膜内的溶液量与贴敷约5min后的溶液量相当,表明本发明的基于水凝胶的缓释面膜能够有效地实现面膜内的营养成分和水分的持续释放,且释放速率适中,易于人体皮肤对营养成分和水分的充分吸收和利用。
Claims (5)
1.一种基于水凝胶的缓释面膜,所述基于水凝胶的缓释面膜包括依次排布的背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层,
其中,所述背衬层是以聚对二甲苯为原料,在非织造纤维层A表面气相沉积而成;所述非织造纤维层A和/或非织造纤维层B由多根随机排列的纤维经热粘合形成,所述纤维表面包括亲水性聚合物涂层;
其特征在于:所述水凝胶层中的水凝胶为可逆透明水凝胶,所述可逆透明水凝胶在0-20℃之间呈现为透明凝胶形态,在30-35℃之间开始发生凝胶-溶液转变,即所述可逆透明水凝胶的凝胶-溶液转变温度介于30-35℃之间;
所述可逆透明水凝胶包括:
(1)水性嵌段共聚物,所述水性嵌段共聚物具有如下通式,
R-(EO)n-(PO)m-(EO)n-R,
其中,R为氨基酸酯基,所述氨基酸酯基选自丙氨酸酯基、谷氨酸酯基、甘氨酸酯基、天冬氨酸酯基、半胱氨酸酯基、赖氨酸酯基、亮氨酸酯基、异亮氨酸酯基、苯丙氨酸酯基中的一种或多种,(EO)n是聚环氧乙烷嵌段,(PO)m是聚环氧丙烷嵌段,n是介于50-100的整数,m是介于30-50的整数,其含量约占可逆透明水凝胶总质量的10-20%,
(2)泊洛沙姆,所述泊洛沙姆具有如下通式,
HO-(EO)a-(PO)b-(EO)a-H,
其中,(EO)a是聚环氧乙烷嵌段,(PO)b是聚环氧丙烷嵌段,a是介于80-150的整数,b是介于40-80的整数,其含量约占可逆透明水凝胶总质量的1-10%,
(3)辅助凝胶-溶胶剂,其含量约占可逆透明水凝胶总质量的1-5%;所述辅助凝胶-溶胶剂选自月桂醇聚醚、油醇聚醚、脂肪醇聚醚、硬脂酸甘油酯、油酸甘油酯中的一种或多种。
(4)皮肤保养成分,其含量约占可逆透明水凝胶总质量的1-20%,
(5)余量水。
2.如权利要求1所述的一种基于水凝胶的缓释面膜,其特征在于,所述皮肤保养成分包括腺苷、熊果苷、透明质酸及其盐、甘油、胶原蛋白、马齿苋提取物、辛酸甘油酯中的一种或多种。
3.一种如权利要求1-2任一项所述的一种基于水凝胶的缓释面膜的制备方法,包括以下步骤:
(1)将聚合物材料挤出形成纤维丝,并在纤维丝表面涂覆亲水性聚合物涂层,然后将多跟涂覆有亲水性聚合物涂层的纤维丝随机平铺,并通过热粘合工艺进行粘合,得到非织造纤维层A和非织造纤维层B;
(2)以非织造纤维层A作为基底,以聚对二甲苯为原料,在基底温度为20-50℃的条件下进行化学气相沉积,在非织造纤维层的一侧沉积背衬层;
(3)将所述可逆透明水凝胶涂覆在非织造纤维层A的另一侧,并加热至40-60℃,使可逆透明水凝胶充分发生凝胶-溶液转变,然后将非织造纤维层B浸没并悬浮在可逆透明水凝胶的溶液中,然后将温度降至20℃以下,使其发生溶液-凝胶转变,转变完全后,即可得到依次包括背衬层、非织造纤维层A、水凝胶层、非织造纤维层B、水凝胶层的基于水凝胶的缓释面膜。
4.一种如权利要求1-2任一项所述的一种基于水凝胶的缓释面膜的使用方法,包括,未使用时,将基于水凝胶的缓释面膜放置在20℃以下的环境中冷藏,使用前,将冷藏的基于水凝胶的缓释面膜取出,在自然环境中静置3-10min,使其温度接近于室内温度,然后在将其贴覆与皮肤表面,贴覆30-35min后,取下即可。
5.一种如权利要求4所述的使用方法,包括将使用后的面膜取下,然后降温至20℃以下使其再次发生溶液-凝胶转变,转变完全后,在20℃以下冷藏,以备再次使用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011067465.0A CN112168717B (zh) | 2020-10-06 | 2020-10-06 | 基于水凝胶的缓释面膜及其制备方法和使用方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011067465.0A CN112168717B (zh) | 2020-10-06 | 2020-10-06 | 基于水凝胶的缓释面膜及其制备方法和使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112168717A CN112168717A (zh) | 2021-01-05 |
CN112168717B true CN112168717B (zh) | 2023-12-01 |
Family
ID=73947720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011067465.0A Active CN112168717B (zh) | 2020-10-06 | 2020-10-06 | 基于水凝胶的缓释面膜及其制备方法和使用方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112168717B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114948795B (zh) * | 2022-07-08 | 2023-09-08 | 上海信悉智能技术有限公司 | 一种温敏感凝胶面膜液及其制备方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101353475A (zh) * | 2008-09-09 | 2009-01-28 | 北京科技大学 | 一种具有热敏性和反应性水凝胶材料的制备方法 |
CN104887561A (zh) * | 2015-05-09 | 2015-09-09 | 青岛明药堂医疗股份有限公司 | 一种医用海洋生物成分的水凝胶护眼贴 |
CN106074217A (zh) * | 2016-06-01 | 2016-11-09 | 南京天朗制药有限公司 | 体温自塑成型皮肤护理材料及皮肤护理膜及制备方法 |
CN106511259A (zh) * | 2011-03-21 | 2017-03-22 | 博任达生化科技(上海)有限公司 | 逆向温敏可逆水凝胶组合物 |
CN107438420A (zh) * | 2015-04-02 | 2017-12-05 | 詹尼克公司 | 面膜用基底片材以及利用该面膜用基底片材的面膜 |
KR101977889B1 (ko) * | 2017-11-15 | 2019-05-13 | (주)이미인 | 하이드로 겔 마스크팩 및 이의 제조방법 |
CN110366377A (zh) * | 2017-02-28 | 2019-10-22 | 欧莱雅 | 适用于外部施用的非织造固体材料 |
CN110769945A (zh) * | 2017-06-22 | 2020-02-07 | 宝洁公司 | 包括水溶性层和气相沉积涂层的美容护理品膜 |
CN111603441A (zh) * | 2020-07-01 | 2020-09-01 | 瑞希(重庆)生物科技有限公司 | 一种两亲性聚氨基酸共聚物/泊洛沙姆温敏凝胶及其制备方法 |
-
2020
- 2020-10-06 CN CN202011067465.0A patent/CN112168717B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101353475A (zh) * | 2008-09-09 | 2009-01-28 | 北京科技大学 | 一种具有热敏性和反应性水凝胶材料的制备方法 |
CN106511259A (zh) * | 2011-03-21 | 2017-03-22 | 博任达生化科技(上海)有限公司 | 逆向温敏可逆水凝胶组合物 |
CN107438420A (zh) * | 2015-04-02 | 2017-12-05 | 詹尼克公司 | 面膜用基底片材以及利用该面膜用基底片材的面膜 |
CN104887561A (zh) * | 2015-05-09 | 2015-09-09 | 青岛明药堂医疗股份有限公司 | 一种医用海洋生物成分的水凝胶护眼贴 |
CN106074217A (zh) * | 2016-06-01 | 2016-11-09 | 南京天朗制药有限公司 | 体温自塑成型皮肤护理材料及皮肤护理膜及制备方法 |
CN110366377A (zh) * | 2017-02-28 | 2019-10-22 | 欧莱雅 | 适用于外部施用的非织造固体材料 |
CN110769945A (zh) * | 2017-06-22 | 2020-02-07 | 宝洁公司 | 包括水溶性层和气相沉积涂层的美容护理品膜 |
KR101977889B1 (ko) * | 2017-11-15 | 2019-05-13 | (주)이미인 | 하이드로 겔 마스크팩 및 이의 제조방법 |
CN111603441A (zh) * | 2020-07-01 | 2020-09-01 | 瑞希(重庆)生物科技有限公司 | 一种两亲性聚氨基酸共聚物/泊洛沙姆温敏凝胶及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN112168717A (zh) | 2021-01-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101092709B1 (ko) | 이산화탄소 외용제 및 이산화탄소 외용제 조제용 재료 | |
TWI327474B (en) | Kit for preparation of carbon dioxide agent for external use. | |
JP4838242B2 (ja) | アルギネートを含む多孔性成型品の製造方法 | |
CN105232354A (zh) | 生物透气美容用面膜及其制备方法 | |
KR101296105B1 (ko) | 하이드로겔화된 부직포, 이의 제조방법, 및 이를 이용한 마스크 팩 | |
CN112168717B (zh) | 基于水凝胶的缓释面膜及其制备方法和使用方法 | |
CN109437559B (zh) | 生物活性玻璃、生物活性玻璃凝胶及其制备方法和应用 | |
JPS6318566B2 (zh) | ||
CN106074217B (zh) | 体温自塑成型皮肤护理材料及皮肤护理膜及制备方法 | |
CN112472612A (zh) | 一种冻干面膜的制备工艺及其产品 | |
KR101782470B1 (ko) | 하이드로겔이 코팅된 미용팩용 베이스 시트 및 이의 제조 방법 | |
CN103739856B (zh) | 一种能自胶凝的水凝胶冻干粉的制备方法 | |
CN114557920A (zh) | 一种烘焙浮雕保湿粉饼及其制造方法 | |
CN109431858A (zh) | 一种医用皮肤屏障再生修复培植面膜 | |
CN111714415B (zh) | 一种高渗透性保湿面膜及其制备方法 | |
KR102060699B1 (ko) | 신축성 마스크팩용 하이드로겔 조성물 및 이를 함유하는 신축성 마스크팩 | |
CN105497964A (zh) | 一种岩藻多糖-海藻酸盐海绵及其制备方法 | |
EP1189587A1 (fr) | Article cosmetique ou dermatologique comprenant une composition d'hydrocollo de lyophilise | |
CN108210982A (zh) | 创面修复敷料及其制备方法和用途 | |
CN113730268A (zh) | 一种水凝胶及其应用 | |
CN211751166U (zh) | 一种用于补水保湿的微针导入型眼贴 | |
CN210583152U (zh) | 一种热敷蚕丝面膜 | |
CN111281646A (zh) | 一种医用冷敷贴生产工艺 | |
KR102517487B1 (ko) | 하이드로겔 조성물이 일측면에 코팅된 단면 하이드로겔 마스크팩 제조방법 및 이로부터 제조되는 단면 하이드로겔 마스크팩 | |
CN110464533A (zh) | 医用冷敷贴 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20231105 Address after: 526200 Industrial Agglomeration and Development Zone, Xiamao Town, Sihui City, Zhaoqing City, Guangdong Province, China, No. 15 (Factory Building 1-1) Applicant after: Guangdong Bisutong Biotechnology Co.,Ltd. Address before: Room 309, 3 / F, No.2 building, Qianwan bonded port area, Qingdao area, China (Shandong) pilot Free Trade Zone, Qingdao, Shandong Province Applicant before: Qingdao zizhiyan cosmetics technology Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant |