CN112147351A - Sample adding arm operation device and sample adding cleaning method thereof - Google Patents

Sample adding arm operation device and sample adding cleaning method thereof Download PDF

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Publication number
CN112147351A
CN112147351A CN202011074125.0A CN202011074125A CN112147351A CN 112147351 A CN112147351 A CN 112147351A CN 202011074125 A CN202011074125 A CN 202011074125A CN 112147351 A CN112147351 A CN 112147351A
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China
Prior art keywords
washing
sample
needle
cantilever
dyeing
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Pending
Application number
CN202011074125.0A
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Chinese (zh)
Inventor
聂垒
胡付余
朱海龟
汪钰青
王扩业
李一鸣
陈石磊
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Jiaxing Jingzhu Biotechnology Co ltd
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Jiaxing Jingzhu Biotechnology Co ltd
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Priority to CN202011074125.0A priority Critical patent/CN112147351A/en
Publication of CN112147351A publication Critical patent/CN112147351A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N2001/002—Devices for supplying or distributing samples to an analysing apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention provides a sample adding arm operation device which comprises a dyeing and washing cantilever, a washing needle, a reagent needle, a first motor, a second motor and a rotating shaft, wherein the reagent needle is arranged on the dyeing and washing cantilever; the cleaning needle and the reagent needle are arranged on the dyeing and washing cantilever, and the dyeing and washing cantilever is detachably connected with the rotating shaft; the first motor can drive the rotating shaft to move in the X-axis direction, and the dyeing and washing cantilever rotates to a position right above the settling bin; under the first working state of the sample adding arm, the second motor drives the dyeing and washing cantilever to move downwards, and the washing needle and the reagent needle move downwards to the corresponding sedimentation cup; and the sample adding arm is in a second working state, the second motor drives the dyeing and washing cantilever to move upwards, and the sedimentation disc synchronously rotates the sedimentation cup for sample adding operation of the reagent needle to a position right above the washing needle. The invention can realize simultaneous sample adding and cleaning, save a large amount of time of the inspection process and further improve the efficiency of the sheet discharging.

Description

Sample adding arm operation device and sample adding cleaning method thereof
Technical Field
The invention relates to the technical field of biological detection, in particular to a sample adding arm operation device and a sample adding and cleaning method thereof.
Background
Medical test technology devices play an important role in clinical diagnostics, and for assays after sample collection typically include a sample application step. In current application of sample equipment, use application of sample arm to carry out the application of sample to the reaction plate on the sample platform usually to only a reagent needle can carry out application of sample operation, and it is long, the assay is inefficient to consume.
Through retrieval, patent document CN210427602U discloses a full-automatic gas-liquid displacement sample injector, which comprises a base, wherein the top of the base is provided with a suction head assembly and a sample assembly which are fixedly connected with the base, a first motor on the base drives a sample injection arm device to slide along a first linear guide rail, a second motor in the sample injection arm device drives a sample injection channel device to slide along a second linear guide rail, and the sample injection channel device is provided with an automatic injector and an automatic needle removal device. The defects of the prior art are that the sample adding and cleaning can not be carried out simultaneously, the sheet discharging efficiency can not be improved, and the result can not be efficiently and timely discharged when a large number of samples to be tested exist.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a sample adding operation device and a sample adding cleaning method thereof.
The invention provides a sample adding running device, which comprises: the device comprises a dyeing and washing cantilever, a washing needle, a reagent needle, a first motor, a second motor and a rotating shaft; the cleaning needle and the reagent needle are arranged on the dyeing and washing cantilever, and the dyeing and washing cantilever is detachably connected with the rotating shaft; the first motor can drive the rotating shaft to move in the X-axis direction, and the dyeing and washing cantilever rotates to a position right above the settling bin;
under the first working state of the sample adding arm, the second motor drives the dyeing and washing cantilever to move downwards, and the washing needle and the reagent needle move downwards to the corresponding sedimentation cup;
and the sample adding arm is in a second working state, the second motor drives the dyeing and washing cantilever to move upwards, and the sedimentation disc synchronously rotates the sedimentation cup for sample adding operation of the reagent needle to a position right above the washing needle.
Preferably, the dyeing and washing cantilever is of a T-like structure, and one side of a cross arm of the dyeing and washing cantilever, which is far away from a vertical arm in the dyeing and washing cantilever, is in a circular arc shape.
Preferably, the rotating shaft comprises a coupler and a spline shaft, and the coupler is connected between the dyeing and washing cantilever and the spline shaft.
Preferably, the first motor is provided with a belt and a driven pulley, and the rotating shaft rotates in the X-axis direction by the transmission of the belt and the driven pulley.
Preferably, the second motor is provided with a belt wheel and a belt, the belt wheel and the belt are used for matching movement, and the rotating shaft performs lifting movement in the Z-axis direction.
Preferably, the device further comprises a guide shaft and a Z-axis moving plate, wherein the spline shafts on the guide shaft and the rotating shaft are fixed on the Z-axis moving plate, and the Z-axis moving plate moves on the guide shaft in the Y-axis direction.
Preferably, the positioning device further comprises a positioning sensor, wherein the positioning sensor is arranged on the Z-axis moving plate, and the position of the Z-axis moving plate is determined by the positioning sensor.
Preferably, the dyeing and washing machine further comprises a sloping plate, the sloping plate is connected to the extension part of the dyeing and washing cantilever, and the bottom of the sloping plate is vertically connected with a coupling of the rotating shaft.
Preferably, be provided with buffer on the washing needle, buffer includes buffer board and spring, and the one end and the washing needle of buffer board are connected, and the other end and the spring coupling of buffer board.
According to the sample adding and cleaning method provided by the invention, the sample adding arm operation device is adopted for sample adding and cleaning.
Compared with the prior art, the invention has the following beneficial effects:
1. the sample adding arm operation device can realize simultaneous sample adding and cleaning, so that time of a large number of inspection processes is saved, and the efficiency of sheet discharging is improved.
2. Thereby realize the application of sample arm and carry out application of sample and washing simultaneously in subsiding the storehouse through adopting first motor and second motor drive application of sample arm to control, rotate from top to bottom.
3. Through set up buffer on washing needle and reagent needle, can play the cushioning effect and utilize inertia can play the effect of resilience.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic view of the overall structure of the device for operating the sample-feeding arm.
In the figure:
Figure BDA0002716155970000031
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
The invention provides a sample adding arm operation device, which comprises: the dyeing and washing cantilever 31, the washing needle 3, the reagent needle 33, the rotating shaft, the first motor 36, the second motor 37, the in-place sensor 38, the Z-axis moving plate 39, the buffer device 310, the inclined plate and the guide shaft, wherein the washing needle 32 and the reagent needle 33 are arranged on the dyeing and washing cantilever 31, and the dyeing and washing cantilever 31 is detachably connected with the rotating shaft; wherein, the rotation axis includes shaft coupling 34 and integral key shaft 35, and shaft coupling 34 is connected between dyeing and washing cantilever 31 and integral key shaft 35. Coupling 34 is a device that couples two shafts or a shaft and a rotating member to rotate together during the process of transmitting motion and power without separating under normal conditions. Sometimes it is used as a safety device to prevent the coupled machine parts from bearing excessive load, and it plays the role of overload protection.
Further, the first motor 36 is provided with a belt and a driven pulley, and the rotating shaft rotates in the X-axis direction by the transmission of the belt and the driven pulley; the second motor 37 is provided with a belt wheel and a belt, the belt wheel and the belt are used for matching movement, and the rotating shaft carries out lifting movement in the Z-axis direction.
Further, a position sensor 38 is provided on the Z-axis moving plate 39, and the position of movement of the Z-axis moving plate 39 is determined using the position sensor 38; the guide shaft and the spline shaft 35 are fixed to a Z-axis moving plate, and the Z-axis moving plate 39 performs Y-axis movement on the guide shaft.
Still further, a sloping plate is connected to the extension of the dyeing and washing cantilever 31, the bottom of the sloping plate is vertically connected to a coupling (34) of the rotating shaft, and a small hole on the sloping plate is used for passing through a pipe for liquid inlet and outlet connecting the reagent needle 33 and the washing needle 32. Be provided with buffer 310 on washing needle 32, including buffer board and spring, the one end and the washing needle 32 of buffer board are connected, and the other end and the spring coupling of buffer board.
Still further, the dyeing and washing cantilever 31 is of a similar T-shaped structure, and one side of a cross arm of the dyeing and washing cantilever 31, which is far away from a vertical arm in the dyeing and washing cantilever, is in a circular arc shape.
The sample adding and cleaning method comprises the following steps:
step 1: pushing the slide into a settling bin fixed on a settling plate;
step 2: the sedimentation disc rotates the slide to a sample adding position, and the sample adding arm performs vertical movement by using a second motor to realize sample adding action;
and step 3: and the back large disc rotates to enter a cleaning needle position cleaning needle to spit the cleaning agent by utilizing three grooves below the second cleaning plate (the middle groove blows air to realize the rolling of liquid, and the grooves on two sides pump out the reagent), and the sedimentation cup is cleaned by utilizing the same spitting and sucking actions in the previous step through the three grooves below the first cleaning plate.
According to the inventionPreferred embodiment(s) of the inventionFor further explanation.
According to the basic embodiment, the side of the cross arm of the dyeing and washing cantilever 31, which is far away from the vertical arm in the dyeing and washing cantilever, is arc-shaped, and the radian of the cross arm is kept the same as that of the sedimentation plate, so that the operation and the matching of the sample adding arm are more accurate.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.

Claims (10)

1. A sample application arm operation device, comprising: a dye-washing cantilever (31), a washing needle (32), a reagent needle (33), a first motor (36), a second motor (37) and a rotating shaft;
the cleaning needle (32) and the reagent needle (33) are arranged on the dyeing and washing cantilever (31), and the dyeing and washing cantilever (31) is detachably connected with the rotating shaft;
the first motor (36) can drive the rotating shaft to move in the X-axis direction, and the dyeing and washing cantilever (31) rotates to a position right above the settling bin;
under a first working state of the sample adding arm, the second motor drives the staining and washing cantilever (31) to move downwards, and the washing needle (32) and the reagent needle (33) move downwards to corresponding sedimentation cups;
and under a second working state of the sample adding arm, the second motor drives the dyeing and washing cantilever (31) to move upwards, and the sedimentation disc synchronously rotates the sedimentation cup of the reagent needle (33) subjected to sample adding operation to a position right above the washing needle (32).
2. The sample adding arm operating device according to claim 1, wherein the dye washing cantilever (31) is of a T-like structure, and the side of the cross arm of the dye washing cantilever (31) far away from the vertical arm in the dye washing cantilever (31) is of a circular arc shape.
3. Sample application arm movement device according to claim 1, characterized in that the rotation axis comprises a coupling (34) and a splined shaft (35), the coupling (34) being connected between the dye washing cantilever (31) and the splined shaft (35).
4. The sample-adding arm operating device according to claim 1, wherein the first motor (36) is provided with a belt and a driven pulley, and the rotating shaft is rotated in the X-axis direction by the transmission of the belt and the driven pulley.
5. The sample-adding arm operating device according to claim 1, wherein the second motor (37) is provided with a belt wheel and a belt, the belt wheel and the belt are cooperatively moved, and the rotating shaft performs Z-axis lifting movement.
6. The sample-adding arm operating device according to claim 1, further comprising a guide shaft and a Z-axis moving plate (39), wherein the spline shaft (35) on the guide shaft and the spline shaft on the rotation shaft are fixed on the Z-axis moving plate (39), and the Z-axis moving plate (39) performs a movement in the Y-axis direction on the guide shaft.
7. The sample arm operating device according to claim 6, further comprising a position sensor (38), wherein the position sensor (38) is disposed on the Z-axis moving plate (39), and the position of the movement of the Z-axis moving plate (39) is determined by the position sensor (38).
8. The sample loading arm operating device according to claim 1, further comprising an inclined plate connected to the extension part of the dyeing and washing cantilever (31), wherein the bottom of the inclined plate is vertically connected with the coupling (34) of the rotating shaft.
9. A sample arm operating device according to claim 1, wherein a buffer device (310) is disposed on the cleaning pin (32), the buffer device (310) comprises a buffer plate and a spring, one end of the buffer plate is connected to the cleaning pin (32), and the other end of the buffer plate is connected to the spring.
10. A sample application and cleaning method, characterized in that the sample application and cleaning is carried out by using the sample application arm operating device according to any one of claims 1 to 9.
CN202011074125.0A 2020-10-09 2020-10-09 Sample adding arm operation device and sample adding cleaning method thereof Pending CN112147351A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011074125.0A CN112147351A (en) 2020-10-09 2020-10-09 Sample adding arm operation device and sample adding cleaning method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011074125.0A CN112147351A (en) 2020-10-09 2020-10-09 Sample adding arm operation device and sample adding cleaning method thereof

Publications (1)

Publication Number Publication Date
CN112147351A true CN112147351A (en) 2020-12-29

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Country Status (1)

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CN (1) CN112147351A (en)

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