CN112138024A - 治疗严重形式的肺动脉高压的方法 - Google Patents

治疗严重形式的肺动脉高压的方法 Download PDF

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Publication number
CN112138024A
CN112138024A CN201910964866.7A CN201910964866A CN112138024A CN 112138024 A CN112138024 A CN 112138024A CN 201910964866 A CN201910964866 A CN 201910964866A CN 112138024 A CN112138024 A CN 112138024A
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CN
China
Prior art keywords
copper
copper chelator
tetrathiomolybdate
group
ttm
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Pending
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CN201910964866.7A
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English (en)
Chinese (zh)
Inventor
诺伯特·F·弗尔克尔
查尔斯·马戈尔斯科
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Rivers Pah Co ltd
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Rivers Pah Co ltd
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Publication of CN112138024A publication Critical patent/CN112138024A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/02Ammonia; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/34Copper; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201910964866.7A 2019-06-26 2019-10-11 治疗严重形式的肺动脉高压的方法 Pending CN112138024A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962866781P 2019-06-26 2019-06-26
US62/866,781 2019-06-26

Publications (1)

Publication Number Publication Date
CN112138024A true CN112138024A (zh) 2020-12-29

Family

ID=73891720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910964866.7A Pending CN112138024A (zh) 2019-06-26 2019-10-11 治疗严重形式的肺动脉高压的方法

Country Status (4)

Country Link
US (1) US12268710B2 (https=)
JP (1) JP2023533485A (https=)
CN (1) CN112138024A (https=)
WO (1) WO2021263250A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737661A (zh) * 2022-10-24 2023-03-07 中国人民解放军海军军医大学第一附属医院 一种黄芩苷在制备抑制视网膜新生血管的药物中的应用
WO2023235267A3 (en) * 2022-05-28 2024-01-04 Avalyn Pharma Inc. Nintedanib and nintedanib combination dry powder compositions and uses
CN120789268A (zh) * 2025-09-16 2025-10-17 中南大学 Aldh1a2抑制剂和检测aldh1a2或ra的试剂的应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112138024A (zh) * 2019-06-26 2020-12-29 里弗斯Pah有限责任公司 治疗严重形式的肺动脉高压的方法
GB2612210B (en) * 2020-06-24 2025-08-27 Reverspah Llc Pharmaceutical composition comprising a tetrathiomolybdate salt and a diethylcarbamazine
CN118524835A (zh) * 2021-11-10 2024-08-20 瑞沃斯帕有限责任公司 用于治疗癌症的方法和组合物
WO2023086873A1 (en) * 2021-11-10 2023-05-19 Reverspah Llc Methods and compositions for treating cancer
CN115624562B (zh) * 2022-12-02 2023-05-09 首都医科大学附属北京友谊医院 黄芩苷在制备治疗对免疫检查点抑制剂无应答/超进展的肿瘤的药物中的应用
CN118078999B (zh) * 2024-02-23 2025-03-18 中山大学附属第一医院 铜离子螯合剂联合NF-κB抑制剂在制备肿瘤治疗药物中的应用

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CN1649577A (zh) 2002-03-08 2005-08-03 普罗特米克斯公司 预防和/或治疗心血管疾病和/或相关的心衰
CA2675230A1 (en) * 2006-01-10 2008-07-26 Pipex, Inc. Pharmaceutical compositions and methods to achieve and maintain a targeted and stable copper status and prevent and treat copper-related central nervous system diseases
US20110287110A1 (en) * 2010-04-23 2011-11-24 Mark Wesley Dewhirst Combination cancer treatment
WO2012122295A2 (en) * 2011-03-07 2012-09-13 Ned Biosystems, Inc. Treatment for pancreatic adenocarcinoma and other cancers of epithelial origin
US10195164B2 (en) * 2015-05-13 2019-02-05 Duke University Use of disulfiram for inflammatory breast cancer therapy
WO2017019892A1 (en) * 2015-07-28 2017-02-02 Insmed Incorporated Compositions comprising copper chelators and methods of use thereof for treating vasculopathies
CN106257609B (zh) 2016-08-22 2018-03-06 河南师范大学 一种制备单层1t相二硫化钼/石墨烯复合材料的方法
CN112138024A (zh) 2019-06-26 2020-12-29 里弗斯Pah有限责任公司 治疗严重形式的肺动脉高压的方法
WO2022035813A1 (en) * 2020-08-10 2022-02-17 Reverspah Llc Method and composition for treating corona virus, influenza, and acute respiratory distress syndrome
WO2023086873A1 (en) * 2021-11-10 2023-05-19 Reverspah Llc Methods and compositions for treating cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AYSAR AL-HUSSEINI等: "Increased Eicosanoid Levels in the Sugen/Chronic Hypoxia Model of Severe Pulmonary Hypertension", 《PLOS ONE》 *
HARM J. BOGAARD等: "Copper Dependence of Angioproliferation in Pulmonary Arterial Hypertension in Rats and Humans", 《AM J RESPIR CRIT CARE ED.》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023235267A3 (en) * 2022-05-28 2024-01-04 Avalyn Pharma Inc. Nintedanib and nintedanib combination dry powder compositions and uses
CN115737661A (zh) * 2022-10-24 2023-03-07 中国人民解放军海军军医大学第一附属医院 一种黄芩苷在制备抑制视网膜新生血管的药物中的应用
CN120789268A (zh) * 2025-09-16 2025-10-17 中南大学 Aldh1a2抑制剂和检测aldh1a2或ra的试剂的应用

Also Published As

Publication number Publication date
WO2021263250A2 (en) 2021-12-30
US12268710B2 (en) 2025-04-08
JP2023533485A (ja) 2023-08-03
WO2021263250A3 (en) 2022-02-24
US20200405748A1 (en) 2020-12-31

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