CN112126634A - 含用于纯化芳基硫酸酯酶a的方法 - Google Patents

含用于纯化芳基硫酸酯酶a的方法 Download PDF

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Publication number
CN112126634A
CN112126634A CN202011058581.6A CN202011058581A CN112126634A CN 112126634 A CN112126634 A CN 112126634A CN 202011058581 A CN202011058581 A CN 202011058581A CN 112126634 A CN112126634 A CN 112126634A
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China
Prior art keywords
chromatography
asa
protein
column
arylsulfatase
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CN202011058581.6A
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English (en)
Chinese (zh)
Inventor
D·尼科尔斯
I·基农尼斯·加西亚
B·L·郑
M·H·蒋
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Takeda Pharmaceutical Co Ltd
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Shire Human Genetics Therapies Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001—Arylsulfatase (3.1.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06008—Cerebroside-sulfatase (3.1.6.8)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202011058581.6A 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法 Pending CN112126634A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750693P 2013-01-09 2013-01-09
US61/750,693 2013-01-09
CN201480003307.5A CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Related Parent Applications (1)

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CN201480003307.5A Division CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Publications (1)

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CN112126634A true CN112126634A (zh) 2020-12-25

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN202011058581.6A Pending CN112126634A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202510351647.7A Pending CN119979504A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN201480003307.5A Pending CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202510851520.1A Pending CN120665836A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Family Applications After (3)

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CN202510351647.7A Pending CN119979504A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN201480003307.5A Pending CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202510851520.1A Pending CN120665836A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

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Country Link
US (3) US11407984B2 (https=)
EP (1) EP2943568B1 (https=)
JP (5) JP6427502B2 (https=)
CN (4) CN112126634A (https=)
AU (3) AU2014205441B2 (https=)
BR (1) BR112015015948B1 (https=)
CA (1) CA2896979C (https=)
EA (1) EA030551B1 (https=)
ES (1) ES2768261T3 (https=)
HK (1) HK1214622A1 (https=)
MX (2) MX372711B (https=)
WO (1) WO2014110246A1 (https=)

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US10336992B2 (en) 2011-07-08 2019-07-02 Shire Human Genetic Therapies, Inc. Methods for purification of arylsulfatase A
CN112126634A (zh) 2013-01-09 2020-12-25 夏尔人类遗传性治疗公司 含用于纯化芳基硫酸酯酶a的方法
EP3236772A4 (en) * 2014-12-22 2018-10-17 Alexion Pharmaceuticals, Inc. Methods of purifying recombinant proteins
KR20180048731A (ko) * 2015-08-20 2018-05-10 제넨테크, 인크. 재조합 폴리펩티드를 제조하기 위한 fkpa의 정제 및 그의 용도
MX2018011162A (es) * 2016-03-16 2018-11-22 Phoenix Tissue Repair Inc Metodos de purificacion de colageno 7.
EP3676375A4 (en) * 2017-08-31 2021-04-07 Green Cross Corporation PROCESS FOR PURIFYING A SULFATASE PROTEIN
CN111699249A (zh) * 2017-12-19 2020-09-22 夏尔人类遗传性治疗公司 纯化的芳基硫酸酯酶a及其组合物
WO2019150192A1 (en) * 2018-02-02 2019-08-08 Enzyvant Therapeutics Gmbh Methods for treating farber disease
MX2020010724A (es) * 2018-04-12 2020-11-06 Amgen Inc Metodos para preparar composiciones proteicas estables.
CN112082832B (zh) * 2019-06-12 2022-03-29 华南理工大学 一种保存城市污水中硫酸酯结合体和葡萄糖苷醛酸结合体的方法
KR102286892B1 (ko) * 2019-07-08 2021-08-06 삼천당제약주식회사 안과용 단백질 제제의 정제방법
CN110632052A (zh) * 2019-10-25 2019-12-31 山西师范大学 土壤芳基硫酸酯酶活性的荧光光谱检测法
AU2020401034B2 (en) * 2019-12-12 2024-08-29 Eli Lilly And Company Methods for viral inactivation by environmentally compatible detergents
CN112759643B (zh) * 2021-03-17 2023-05-30 华兰生物工程股份有限公司 一种血清白蛋白的脱脂方法
CN116693659B (zh) * 2023-07-11 2025-03-28 浙江大学 一种分离重组人血白蛋白的两步混合模式层析方法

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CN102272154A (zh) * 2008-10-29 2011-12-07 惠氏有限责任公司 单域抗原结合性分子的纯化方法
WO2011163650A2 (en) * 2010-06-25 2011-12-29 Shire Human Genetic Therapies, Inc. Methods and compositions for cns delivery of arylsulfatase a
WO2012013682A2 (en) * 2010-07-27 2012-02-02 Ucb Pharma, S.A. Protein purification
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Also Published As

Publication number Publication date
JP2020015750A (ja) 2020-01-30
MX2020003798A (es) 2020-08-03
EA201590826A1 (ru) 2015-11-30
JP6427502B2 (ja) 2018-11-21
US11884945B2 (en) 2024-01-30
WO2014110246A1 (en) 2014-07-17
AU2022221475B2 (en) 2025-05-22
US11407984B2 (en) 2022-08-09
AU2022221475A1 (en) 2022-09-22
US20150353904A1 (en) 2015-12-10
CA2896979A1 (en) 2014-07-17
CN119979504A (zh) 2025-05-13
HK1216429A1 (en) 2016-11-11
JP7407161B2 (ja) 2023-12-28
US20230235303A1 (en) 2023-07-27
HK1214622A1 (zh) 2016-07-29
EP2943568B1 (en) 2019-11-20
AU2020201079B2 (en) 2022-05-26
AU2014205441B2 (en) 2019-12-12
ES2768261T3 (es) 2020-06-22
JP2022023225A (ja) 2022-02-07
CN104903442A (zh) 2015-09-09
JP2016504040A (ja) 2016-02-12
JP7663649B2 (ja) 2025-04-16
EA030551B1 (ru) 2018-08-31
MX372711B (es) 2020-04-21
BR112015015948B1 (pt) 2022-05-17
JP2024001160A (ja) 2024-01-09
MX2015008875A (es) 2015-10-22
EP2943568A1 (en) 2015-11-18
US12319940B2 (en) 2025-06-03
BR112015015948A2 (https=) 2017-08-15
US20240392268A1 (en) 2024-11-28
JP2018171067A (ja) 2018-11-08
CN120665836A (zh) 2025-09-19
AU2014205441A1 (en) 2015-06-25
AU2020201079A1 (en) 2020-03-05
CA2896979C (en) 2023-05-02

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Effective date of registration: 20210720

Address after: Osaka, Japan

Applicant after: TAKEDA PHARMACEUTICAL Co.,Ltd.

Address before: Massachusetts, USA

Applicant before: SHIRE HUMAN GENETIC THERAPIES, Inc.