CN112121118A - Traditional Chinese medicine composition for treating diabetes, preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating diabetes, preparation method and application thereof Download PDF

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CN112121118A
CN112121118A CN202011022964.8A CN202011022964A CN112121118A CN 112121118 A CN112121118 A CN 112121118A CN 202011022964 A CN202011022964 A CN 202011022964A CN 112121118 A CN112121118 A CN 112121118A
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parts
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chinese medicine
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medicine composition
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郭建大
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw materials: 10-30 parts of trichosanthes root, 3-6 parts of goldthread root, 10-15 parts of dried rehmannia root, 6-12 parts of dwarf lilyturf tuber, 10-15 parts of kudzu root, 10-15 parts of tuckahoe, 9-30 parts of astragalus root, 6-12 parts of dogwood fruit, 10-30 parts of yam, 6-12 parts of tree peony bark, 9-15 parts of sealwort, 9-30 parts of codonopsis pilosula and 20-30 parts of lotus root product. The traditional Chinese medicine composition prepared by the invention has the effects of clearing heat, moistening dryness, nourishing yin, promoting the secretion of saliva or body fluid, reinforcing kidney, replenishing vital essence, removing blood stasis, detoxifying and tonifying vital qi, can be used for fundamentally treating diabetes, and has high curative effect and no obvious adverse reaction.

Description

Traditional Chinese medicine composition for treating diabetes, preparation method and application thereof
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating diabetes, and further relates to a preparation method and application of the traditional Chinese medicine composition for treating diabetes.
Background
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia resulting from disorders of insulin secretion and/or utilization caused by multiple causes. The symptoms of diabetes patients are generally characterized by renal function weakening and qi and blood obstruction, thereby forming the blockage of the meridians of the whole body and the normal dysfunction of each viscera, and simultaneously, the diabetes patients have long-term thirst, heat burning and fluid loss, and yin essence loss to involve the insufficiency of yang qi generation.
Western medicine treatment is generally adopted at present, but the Western medicine mainly treats the diabetic patients by reducing blood sugar. The metformin hydrochloride tablets or the intramuscular insulin injection are selected by western medicine for reducing the blood sugar, even the serious patients can select the combination of the metformin hydrochloride tablets and the intramuscular insulin injection, but after the western medicine is taken soon, the diabetic patients quickly suffer from a series of side effects such as nausea, vomiting, abdominal pain, dysgeusia, liver and kidney function damage and the like, the symptoms are treated, the root causes are not treated, and the conditions of the patients are more serious.
In conclusion, a traditional Chinese medicine composition for treating diabetes is provided, and further relates to a preparation method and application of the traditional Chinese medicine composition for treating diabetes.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to overcome the defect that the traditional Chinese and western medicine treatment in the prior art does not treat the symptoms and root causes, thereby providing the traditional Chinese medicine composition for treating diabetes, which can be used for treating diabetes from the source.
Another technical problem to be solved by the present invention is to provide a corresponding preparation method according to the above-mentioned traditional Chinese medicine composition for treating diabetes.
Another technical problem to be solved by the present invention is to provide a corresponding use of the above-mentioned Chinese medicinal composition for treating diabetes.
A traditional Chinese medicine composition for treating diabetes mellitus is prepared from the following raw materials: 10-30 parts of trichosanthes root, 3-6 parts of goldthread root, 10-15 parts of dried rehmannia root, 6-12 parts of dwarf lilyturf tuber, 10-15 parts of kudzu root, 10-15 parts of tuckahoe, 9-30 parts of astragalus root, 6-12 parts of dogwood fruit, 10-30 parts of yam, 6-12 parts of tree peony bark, 9-15 parts of sealwort, 9-30 parts of codonopsis pilosula and 20-30 parts of lotus root product.
The raw materials for preparing the traditional Chinese medicine composition comprise: 30 parts of trichosanthes root, 4 parts of goldthread root, 15 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 15 parts of kudzuvine root, 15 parts of Indian buead, 30 parts of membranous milkvetch root, 12 parts of common macrocarpium fruit, 30 parts of common yam rhizome, 12 parts of tree peony bark, 15 parts of manyflower solomonseal rhizome, 30 parts of pilose asiabell root and 24 parts of lotus root product.
The raw materials for preparing the traditional Chinese medicine composition comprise: 20 parts of trichosanthes root, 6 parts of goldthread root, 12 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 12 parts of kudzuvine root, 12 parts of Indian buead, 30 parts of membranous milkvetch root, 10 parts of common macrocarpium fruit, 15 parts of common yam rhizome, 10 parts of tree peony bark, 10 parts of manyflower solomonseal rhizome, 20 parts of pilose asiabell root and 30 parts of lotus root product.
The lotus root product is lotus root starch, lotus root slices or fresh lotus root juice.
The Chinese medicinal composition can be prepared into pills, powder, decoction or capsules for oral administration.
The invention also claims a preparation method of the traditional Chinese medicine composition for treating diabetes, which comprises the following steps:
s1, grinding 10-30 parts of radix trichosanthis, 3-6 parts of rhizoma coptidis, 10-15 parts of radix rehmanniae, 6-12 parts of radix ophiopogonis, 10-15 parts of kudzu root, 10-15 parts of poria cocos, 9-30 parts of astragalus membranaceus, 6-12 parts of cornus officinalis, 10-30 parts of Chinese yam, 6-12 parts of cortex moutan, 9-15 parts of rhizoma polygonati and 9-30 parts of codonopsis pilosula into powder and sieving the powder with a 80-mesh sieve;
s2: and mixing 20-30 parts by weight of the lotus root product with the raw material treated by the S1, and uniformly stirring to obtain the traditional Chinese medicine composition.
In S1, the raw material is subjected to impurity removal, concentration, and baking before being ground.
In S2, the lotus root product is fresh lotus root juice, 20-30 parts by weight of the fresh lotus root juice is heated to 50 ℃ with soft fire, the raw materials processed with S1 are poured into the mixture while being heated and stirred, the mixture is heated with slow fire after being stirred and mixed to be in a semi-fluid state, the mixture is slowly stirred to be in a semi-solid state, and the mixture is placed in a disinfection container to be cooled to normal temperature, so that the traditional Chinese medicine composition is obtained.
In S2, when the mixture is cooled to 30 °, the mixture is kneaded into strips and cut into pieces, and the pieces are kneaded into pills to obtain the pill-form Chinese medicinal composition; wherein, the weight portion of each pill is 0.4 g.
Furthermore, the invention also claims application of the traditional Chinese medicine composition in preparation of a medicine for treating diabetes.
The technical scheme of the invention has the following advantages:
1. the trichosanthes root in the traditional Chinese medicine composition provided by the invention is sweet, slightly bitter and slightly cold, can clear heat and purge fire, promote the production of body fluid to quench thirst, reduce swelling and expel pus when entering lung and stomach channels, is a good medicine for clearing heat and stomach and quenching thirst due to fever , and has the curative effect of clearing heat and reducing pathogenic fire when being assisted by the coptis chinensis; the Chinese medicinal composition has bitter and cold taste, enters liver, stomach, heart and large intestine channels, has the effects of clearing heat, removing toxicity, drying dampness and purging pathogenic fire, is a good medicament for clearing heat, drying dampness, purging pathogenic fire and removing toxicity, and has the curative effect of supplementing each other when being used with the Mongolian snakegourd root; the kudzu root and the dwarf lilyturf tuber have the curative effects of nourishing yin and moistening lung, clearing heart fire and relieving restlessness, are mainly used for treating symptoms of lung dryness and dry cough, stomach yin deficiency, body fluid deficiency and thirst, internal heat and diabetes, can be used for treating dryness and lung stomach fluid deficiency together with the Mongolian snakegourd root, and have good curative effects on symptoms of dry throat, thirst, dry cough, little phlegm and the like; the Chinese yam, the tree peony bark and the dogwood fruit in the Chinese medicinal composition can strengthen the kidney and replenish vital essence, strengthen the spleen and dry dampness, and the radix rehmanniae can nourish yin and promote the production of body fluid, wherein the dogwood fruit has the curative effects of tonifying the liver and kidney, astringing and relieving depletion, and is mainly used for treating the symptoms of liver-kidney yin deficiency, internal heat and diabetes and the like; the lotus root product is added into the traditional Chinese medicine, and the prepared traditional Chinese medicine composition has the effects of clearing heat, moistening dryness, nourishing yin, promoting the production of body fluid, reinforcing kidney, benefiting essence, removing blood stasis, detoxifying and tonifying vital qi, can be used for fundamentally treating diabetes, and has high curative effect and no obvious adverse reaction.
2. The fresh lotus root juice has high nutrient content and has the curative effects of removing toxicity, dissipating heat and adjusting weakness of spleen and stomach.
3. The traditional Chinese medicine composition is prepared into pills, so that the medicine is convenient to carry, stable and long in effect, strong in medicine economy and more convenient to treat patients with diabetes.
4. The invention further provides a preparation method of the traditional Chinese medicine composition for treating diabetes, which adopts a processing method of grinding, sieving with a 80-mesh sieve, stirring and mixing, and all raw materials are subjected to impurity removal, selection and baking treatment before grinding, so that the processing process is simple and easy for quality control.
Detailed Description
Example 1
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw materials: 10-30 parts of trichosanthes root, 3-6 parts of goldthread root, 10-15 parts of dried rehmannia root, 6-12 parts of dwarf lilyturf tuber, 10-15 parts of kudzu root, 10-15 parts of tuckahoe, 9-30 parts of astragalus root, 6-12 parts of dogwood fruit, 10-30 parts of yam, 6-12 parts of tree peony bark, 9-15 parts of sealwort, 9-30 parts of codonopsis pilosula and 20-30 parts of lotus root product.
The trichosanthes root in the traditional Chinese medicine composition provided by the embodiment is sweet, slightly bitter and slightly cold, enters lung and stomach channels, can clear heat and purge fire, promote the production of body fluid to quench thirst, reduce swelling and expel pus, is good for fever thirst and clearing lung and stomach, and has the curative effect of clearing heat and reducing pathogenic fire when being assisted by the coptis chinensis; the Chinese medicinal composition has bitter and cold taste, enters liver, stomach, heart and large intestine channels, has the effects of clearing heat, removing toxicity, drying dampness and purging pathogenic fire, is a good medicament for clearing heat, drying dampness, purging pathogenic fire and removing toxicity, and has the curative effect of supplementing each other when being used with the Mongolian snakegourd root; the kudzu root and the dwarf lilyturf tuber have the curative effects of nourishing yin and moistening lung, clearing heart fire and relieving restlessness, are mainly used for treating symptoms of lung dryness and dry cough, stomach yin deficiency, body fluid deficiency and thirst, internal heat and diabetes, can be used for treating dryness and lung stomach fluid deficiency together with the Mongolian snakegourd root, and have good curative effects on symptoms of dry throat, thirst, dry cough, little phlegm and the like; the Chinese yam, the tree peony bark and the dogwood fruit in the Chinese medicinal composition can strengthen the kidney and replenish vital essence, strengthen the spleen and dry dampness, and the radix rehmanniae can nourish yin and promote the production of body fluid, wherein the dogwood fruit has the curative effects of tonifying the liver and kidney, astringing and relieving depletion, and is mainly used for treating the symptoms of liver-kidney yin deficiency, internal heat and diabetes and the like; the lotus root product is added into the traditional Chinese medicine, and the prepared traditional Chinese medicine composition has the effects of clearing heat, moistening dryness, nourishing yin, promoting the production of body fluid, reinforcing kidney, benefiting essence, removing blood stasis, detoxifying and tonifying vital qi, can be used for fundamentally treating diabetes, and has high curative effect and no obvious adverse reaction.
Among them, in a preferred embodiment, the lotus root product is fresh lotus root juice.
The fresh lotus root juice is the tender lotus root with high nutrient content and has the curative effects of removing toxicity, dissipating heat and adjusting weakness of spleen and stomach.
Further, in this embodiment, the Chinese medicinal composition can be prepared into pills for oral administration.
The traditional Chinese medicine composition is prepared into pills, so that the medicine is convenient to carry, stable and long in effect, strong in medicine economy and more convenient to treat patients with diabetes.
Certainly, the traditional Chinese medicine composition can also be prepared into capsules and powder which are convenient to carry, and the traditional Chinese medicine composition can be prepared into decoction which can quickly sweep away the internal organs of the human body and quickly reach the body surface, thereby having the curative effect of going out.
The preparation process of the traditional Chinese medicine composition of the embodiment is as follows:
s1, grinding 10-30 parts of radix trichosanthis, 3-6 parts of rhizoma coptidis, 10-15 parts of radix rehmanniae, 6-12 parts of radix ophiopogonis, 10-15 parts of kudzu root, 10-15 parts of poria cocos, 9-30 parts of astragalus membranaceus, 6-12 parts of cornus officinalis, 10-30 parts of Chinese yam, 6-12 parts of cortex moutan, 9-15 parts of rhizoma polygonati and 9-30 parts of codonopsis pilosula into powder and sieving the powder with a 80-mesh sieve;
s2: and mixing 20-30 parts by weight of the lotus root product with the raw material treated by the S1, and uniformly stirring to obtain the traditional Chinese medicine composition.
Further, in S1, the raw material is subjected to impurity removal, concentration, and baking before grinding.
Further, in S2, the lotus root product is fresh lotus root juice, 20-30 parts by weight of the fresh lotus root juice is heated to 50 ° with soft fire, the raw material processed with S1 is poured into the container while being heated, the mixture is stirred until the mixture is semi-fluid, then the mixture is heated with slow fire and is slowly stirred into semi-solid, and the mixture is placed in a disinfection container to be cooled to normal temperature, so that the traditional Chinese medicine composition is obtained.
Further, in S2, when the mixture is cooled to 30 °, the mixture is kneaded into strips and cut into pieces, and the pieces are kneaded into pills, to obtain a pill-form Chinese medicinal composition; wherein, the weight portion of each pill is 0.4 g.
In the preparation process of the traditional Chinese medicine composition: firstly, weighing the traditional Chinese medicine compositions according to the parts by weight, removing impurities from the weighed traditional Chinese medicine compositions, selecting, baking, then grinding the traditional Chinese medicine compositions into fine powder, sieving the fine powder by a 80-mesh sieve, and fully mixing the screened fine powder to prepare traditional Chinese medicine powder for later use; weighing fresh lotus root juice according to the parts by weight, pouring the weighed fresh lotus root juice into a clean pot, starting heating, pouring the traditional Chinese medicine powder when the temperature reaches 20 ℃, stirring while pouring, changing to slow fire for continuous heating after stirring to be in a semi-fluid state, then slowly stirring to be in a semi-solid state, pouring into a clean disinfection container, and cooling to 30 ℃ in the disinfection container to obtain the traditional Chinese medicine composition; thirdly, placing a small amount of sesame oil in the sterilized palm to rub the traditional Chinese medicine composition into strips, rubbing 20 strips in one treatment course, cutting each strip into 20 small blocks by a knife, and rubbing each block into pills, wherein the weight part of each pill is 0.4 g.
In the embodiment, the preparation method of the traditional Chinese medicine composition for treating diabetes is characterized in that a processing method of grinding, sieving with an 80-mesh sieve, stirring and mixing is adopted, all raw materials are subjected to impurity removal, selection and baking treatment before grinding, the processing process is simple, and the quality control is easy.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw materials: 30 parts of trichosanthes root, 4 parts of goldthread root, 15 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 15 parts of kudzuvine root, 15 parts of Indian buead, 30 parts of membranous milkvetch root, 12 parts of common macrocarpium fruit, 30 parts of common yam rhizome, 12 parts of tree peony bark, 15 parts of manyflower solomonseal rhizome, 30 parts of pilose asiabell root and 24 parts of lotus root product.
Among them, in a preferred embodiment, the lotus root product is fresh lotus root juice.
Further, in this embodiment, the Chinese medicinal composition can be prepared into pills for oral administration.
The preparation process of the traditional Chinese medicine composition of the embodiment is as follows:
s1, grinding 30 parts by weight of radix trichosanthis, 4 parts by weight of rhizoma coptidis, 15 parts by weight of radix rehmanniae, 12 parts by weight of radix ophiopogonis, 15 parts by weight of radix puerariae, 15 parts by weight of poria cocos, 30 parts by weight of radix astragali, 12 parts by weight of fructus corni, 30 parts by weight of Chinese yam, 12 parts by weight of cortex moutan, 15 parts by weight of rhizoma polygonati and 30 parts by weight of radix codonopsis into powder, and sieving the powder with a 80-mesh sieve;
s2: and mixing 24 parts by weight of the lotus root product with the raw materials processed by the S1, and uniformly stirring to obtain the traditional Chinese medicine composition.
Further, in S1, the raw material is subjected to impurity removal, concentration, and baking before grinding.
Further, in S2, preparing the lotus root product as fresh lotus root juice, heating 24 parts by weight of the fresh lotus root juice to 50 ° with slow fire, pouring the raw material treated in S1, heating while stirring, heating with slow fire after stirring and mixing to a semi-fluid state, slowly stirring to a semi-solid state, placing in a disinfection container, and cooling to normal temperature to obtain the traditional Chinese medicine composition.
Further, in S2, when the mixture is cooled to 30 °, the mixture is kneaded into strips and cut into pieces, and the pieces are kneaded into pills, to obtain a pill-form Chinese medicinal composition; wherein, the weight portion of each pill is 0.4 g.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw materials: 20 parts of trichosanthes root, 6 parts of goldthread root, 12 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 12 parts of kudzuvine root, 12 parts of Indian buead, 30 parts of membranous milkvetch root, 10 parts of common macrocarpium fruit, 15 parts of common yam rhizome, 10 parts of tree peony bark, 10 parts of manyflower solomonseal rhizome, 20 parts of pilose asiabell root and 30 parts of lotus root product.
Among them, in a preferred embodiment, the lotus root product is fresh lotus root juice.
Further, in this embodiment, the Chinese medicinal composition can be prepared into pills for oral administration.
The preparation process of the traditional Chinese medicine composition of the embodiment is as follows:
s1, grinding 20 parts by weight of radix trichosanthis, 6 parts by weight of rhizoma coptidis, 12 parts by weight of radix rehmanniae, 12 parts by weight of radix ophiopogonis, 12 parts by weight of radix puerariae, 12 parts by weight of poria cocos, 30 parts by weight of radix astragali, 10 parts by weight of fructus corni, 15 parts by weight of Chinese yam, 10 parts by weight of cortex moutan, 10 parts by weight of rhizoma polygonati and 20 parts by weight of radix codonopsis into powder and sieving the powder with a 80-mesh sieve;
s2: and mixing 30 parts by weight of the lotus root product with the raw materials treated by the S1, and uniformly stirring to obtain the traditional Chinese medicine composition.
Further, in S1, the raw material is subjected to impurity removal, concentration, and baking before grinding.
Further, in S2, preparing the lotus root product as fresh lotus root juice, heating 30 parts by weight of the fresh lotus root juice to 50 ° with slow fire, pouring the raw material treated in S1, heating while stirring, heating with slow fire after stirring and mixing to a semi-fluid state, slowly stirring to a semi-solid state, placing in a disinfection container, and cooling to normal temperature to obtain the traditional Chinese medicine composition.
Further, in S2, when the mixture is cooled to 30 °, the mixture is kneaded into strips and cut into pieces, and the pieces are kneaded into pills, to obtain a pill-form Chinese medicinal composition; wherein, the weight portion of each pill is 0.4 g.
Example 4:
the present embodiment further provides a use of the above-mentioned traditional Chinese medicine composition in preparing a medicament for treating diabetes.
The main components of the traditional Chinese medicine composition comprise: trichosanthis radix, Coptidis rhizoma, radix rehmanniae, radix Ophiopogonis, radix Puerariae, Poria, radix astragali, Corni fructus, rhizoma Dioscoreae, cortex moutan, rhizoma Polygonati, radix Codonopsis and rhizoma Nelumbinis product.
The traditional Chinese medicine composition has the main treatment effects that: clearing heat, moistening dryness, nourishing yin, promoting fluid production, invigorating kidney, replenishing vital essence, removing blood stasis, removing toxic substance, and invigorating vital qi, and can be used for treating polydipsia, polyphagia, diuresis, marasmus, tiredness, debilitation, diabetes with urine sugar and blood sugar increase (diabetes) of light and moderate adult type diabetes.
The Chinese medicinal composition can be prepared into other forms such as oral pills, powder, decoction or capsules for administration.
The usage and dosage are as follows: three times a day, 5 pills each time, and is taken with warm boiled water.
Note that: patients with liver and kidney insufficiency are forbidden to use, patients with diabetes complicated with acidosis or acute infection are forbidden to drink, and pregnant women are forbidden to use.
Example 5:
experiment of treatment
1. Selecting 1000 patients with mild, medium and heavy (without complications) diabetes, with age between 38-75 years and average age of 56 years (without severe impairment of liver and kidney functions); among them, 630 cases were male patients, 370 cases were female patients, 532 cases of mild symptoms, 268 cases of moderate symptoms, and 200 cases of severe symptoms (no complications).
2. Diagnostic criteria for the patient: the blood sugar and urine sugar are 5-10 mmol/L and the blood pressure is 80-140 mhg/L.
3. When the blood sugar value of a patient is within the controllable indexes, all western medicines are stopped to be taken, under the condition, all patients take the traditional Chinese medicine composition with warm water for 3 times every day, 5 pills are taken every time, 7 days are one treatment course, and 3 treatment courses are one experiment period.
4. The therapeutic effect judgment standard is as follows:
the effect is shown: the patient's symptoms completely disappeared; because the traditional Chinese medicine composition has the efficacies of clearing heat and moistening dryness, nourishing yin and promoting the production of body fluid, reinforcing kidney and replenishing vital essence, eliminating blood stasis and detoxifying and tonifying vital qi, the traditional Chinese medicine composition can radically treat patients, thereby completely eliminating related symptoms of the patients;
the method has the following advantages: symptoms disappear, and the blood sugar/urine sugar is tested to be slightly higher; because the traditional Chinese medicine composition has the efficacies of clearing heat and moistening dryness, nourishing yin and promoting the secretion of saliva or body fluid, reinforcing kidney and replenishing vital essence, eliminating blood stasis and detoxifying, and tonifying healthy qi, the traditional Chinese medicine composition can fundamentally treat patients, and although the symptoms of the patients are not completely disappeared in the experimental period, the symptoms of the patients are already improved or relieved;
and (4) invalidation: no improvement or worsening in the patient's symptoms;
5. the experimental results are as follows:
after 3 treatment courses, 1000 patients participating in the experimental treatment were counted according to the therapeutic effect judgment criteria, and as shown in table 1, the statistical results were as follows:
in 321 of 532 mild patients, symptoms completely disappear, 206 patients disappear, the blood sugar/urine sugar is slightly high, the symptoms of 5 patients are not improved, and the cure rate reaches 99%;
161 patients in 268 moderate patients have completely disappeared symptoms, 97 patients have disappeared symptoms, the blood sugar/urine sugar is slightly high, 10 patients have no improved symptoms, and the cure rate reaches 96.2%;
in 200 severe patients, 146 patients have completely disappeared symptoms, 27 patients have disappeared symptoms, the blood sugar/urine sugar is slightly high, the symptoms of the 27 patients are not improved, and the cure rate reaches 86.5%.
Figure BDA0002701259880000101
TABLE 1
In conclusion, after 1000 diabetics take the traditional Chinese medicine composition as required for 3 weeks, 628 cases of the traditional Chinese medicine composition are effective, 330 cases of the traditional Chinese medicine composition are effective, 42 cases of the traditional Chinese medicine composition are ineffective, and the total effective rate is 95.8%, so that the conclusion is that: the Chinese medicinal composition has remarkable curative effect on mild and moderate diabetes.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims (10)

1. A traditional Chinese medicine composition for treating diabetes is characterized in that raw materials for preparing the traditional Chinese medicine composition comprise: 10-30 parts of trichosanthes root, 3-6 parts of goldthread root, 10-15 parts of dried rehmannia root, 6-12 parts of dwarf lilyturf tuber, 10-15 parts of kudzu root, 10-15 parts of tuckahoe, 9-30 parts of astragalus root, 6-12 parts of dogwood fruit, 10-30 parts of yam, 6-12 parts of tree peony bark, 9-15 parts of sealwort, 9-30 parts of codonopsis pilosula and 20-30 parts of lotus root product.
2. The traditional Chinese medicine composition for treating diabetes according to claim 1, wherein raw materials for preparing the traditional Chinese medicine composition comprise: 30 parts of trichosanthes root, 4 parts of goldthread root, 15 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 15 parts of kudzuvine root, 15 parts of Indian buead, 30 parts of membranous milkvetch root, 12 parts of common macrocarpium fruit, 30 parts of common yam rhizome, 12 parts of tree peony bark, 15 parts of manyflower solomonseal rhizome, 30 parts of pilose asiabell root and 24 parts of lotus root product.
3. The traditional Chinese medicine composition for treating diabetes according to claim 1, wherein raw materials for preparing the traditional Chinese medicine composition comprise: 20 parts of trichosanthes root, 6 parts of goldthread root, 12 parts of dried rehmannia root, 12 parts of dwarf lilyturf tuber, 12 parts of kudzuvine root, 12 parts of Indian buead, 30 parts of membranous milkvetch root, 10 parts of common macrocarpium fruit, 15 parts of common yam rhizome, 10 parts of tree peony bark, 10 parts of manyflower solomonseal rhizome, 20 parts of pilose asiabell root and 30 parts of lotus root product.
4. The traditional Chinese medicine composition for treating diabetes according to claim 1, 2 or 3, wherein: the lotus root product is lotus root starch, lotus root slices or fresh lotus root juice.
5. The traditional Chinese medicine composition for treating diabetes according to claim 1, 2 or 3, wherein: the Chinese medicinal composition can be prepared into pills, powder, decoction or capsules for oral administration.
6. A preparation method of a traditional Chinese medicine composition for treating diabetes is characterized by comprising the following steps:
s1, grinding 10-30 parts of radix trichosanthis, 3-6 parts of rhizoma coptidis, 10-15 parts of radix rehmanniae, 6-12 parts of radix ophiopogonis, 10-15 parts of radix puerariae, 10-15 parts of poria cocos, 9-30 parts of radix astragali, 6-12 parts of cornus officinalis, 10-30 parts of Chinese yam, 6-12 parts of cortex moutan, 9-15 parts of rhizoma polygonati and 9-30 parts of codonopsis pilosula into powder and sieving the powder with a 80-mesh sieve;
s2: and mixing 20-30 parts by weight of the lotus root product with the raw material treated by the S1, and uniformly stirring to obtain the traditional Chinese medicine composition.
7. The preparation method of the traditional Chinese medicine composition for treating diabetes according to claim 6, characterized in that: in S1, the raw material is subjected to impurity removal, concentration, and baking before being ground.
8. The preparation method of the traditional Chinese medicine composition for treating diabetes according to claim 7, characterized in that: in S2, the lotus root product is fresh lotus root juice, 20-30 parts by weight of the fresh lotus root juice is heated to 50 ℃ with soft fire, the raw materials processed with S1 are poured into the mixture while being heated and stirred, the mixture is heated with slow fire after being stirred and mixed to be in a semi-fluid state, the mixture is slowly stirred to be in a semi-solid state, and the mixture is placed in a disinfection container to be cooled to normal temperature, so that the traditional Chinese medicine composition is obtained.
9. The preparation method of the traditional Chinese medicine composition for treating diabetes according to claim 8, characterized in that: in S2, when the mixture is cooled to 30 °, the mixture is kneaded into strips and cut into pieces, and the pieces are kneaded into pills to obtain the pill-form Chinese medicinal composition; wherein, the weight portion of each pill is 0.4 g.
10. Use of the Chinese medicinal composition according to any one of claims 1 to 9 in the preparation of a medicament for treating diabetes.
CN202011022964.8A 2020-09-25 2020-09-25 Traditional Chinese medicine composition for treating diabetes, preparation method and application thereof Pending CN112121118A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042710A (en) * 2018-02-06 2018-05-18 上海中医药大学附属曙光医院 A kind of Chinese medicine composition for treating deficiency of both qi and yin and retention of damp-heat in the interior type diabetes B and its application

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042710A (en) * 2018-02-06 2018-05-18 上海中医药大学附属曙光医院 A kind of Chinese medicine composition for treating deficiency of both qi and yin and retention of damp-heat in the interior type diabetes B and its application

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