CN112121080A - A Chinese medicinal composition for moxibustion, and its preparation method - Google Patents

A Chinese medicinal composition for moxibustion, and its preparation method Download PDF

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CN112121080A
CN112121080A CN202011061011.2A CN202011061011A CN112121080A CN 112121080 A CN112121080 A CN 112121080A CN 202011061011 A CN202011061011 A CN 202011061011A CN 112121080 A CN112121080 A CN 112121080A
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folium artemisiae
artemisiae argyi
moxibustion
solution
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庞伟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/06—Devices for heating or cooling such points within cell-life limits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
    • A61H2201/0207—Characteristics of apparatus not provided for in the preceding codes heated or cooled heated
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a traditional Chinese medicine composition for moxibustion, which comprises the following raw materials: folium artemisiae argyi, radix angelicae, ligusticum wallichii, cinnamon, notopterygium root, perilla, modified loess and modified graphene, and also discloses a preparation method of the traditional Chinese medicine composition for moxibustion, by adding folium artemisiae argyi, radix angelicae, ligusticum wallichii, cinnamon and notopterygium root, the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, tonifying primordial qi, promoting metabolism, dredging channels and collaterals, regulating qi and blood, warming middle-jiao to dispel cold, resolving stagnation and dissipating stagnation, can improve human immunity, the purple perilla is added to fully exert and utilize the drug effect of the medicine, and the modified loess is added to have better fluidity, more uniform property and better viscosity and adsorptivity, thus being beneficial to keeping the effective components of the traditional Chinese medicines, by adding the modified graphene, the composite material has an ultra-large specific surface area, and the ultra-high adsorbability of the composite material can realize ultra-high drug loading, effective components can be effectively adsorbed in the processes of storage and moxibustion application, so as to prevent dissipation and ensure higher pharmacodynamic action.

Description

A Chinese medicinal composition for moxibustion, and its preparation method
Technical Field
The invention relates to the technical field of moxibustion, in particular to a traditional Chinese medicine composition for moxibustion and a preparation method thereof.
Background
Moxibustion, called moxibustion therapy or moxibustion method for short, is a treatment method which uses moxa sticks and moxa columns made of folium artemisiae argyi to generate moxa heat to stimulate acupuncture points or specific parts of a human body and regulate the physiological and biochemical functions of human body disorder by exciting the activity of meridian qi, thereby achieving the purpose of preventing and treating diseases. The moxibustion mechanism is similar to that of acupuncture and moxibustion, and has complementary therapeutic effects with acupuncture and moxibustion. Has the advantages of simple operation, low cost, obvious effect and the like.
Moxa sticks or moxa columns for moxibustion are generally made of folium artemisiae argyi by adding some traditional Chinese medicines, but the existing moxa sticks or moxa columns are low in medicine effect utilization rate, the effective ingredients of the traditional Chinese medicines are seriously lost, and the moxibustion effect is reduced.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for moxibustion and a preparation method thereof, and aims to solve the problems.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 300 parts of 200-fold artemisia leaves, 20-30 parts of angelica dahurica, 15-25 parts of ligusticum wallichii, 10-20 parts of cinnamon, 10-20 parts of notopterygium root, 5-15 parts of purple perilla, 1-5 parts of modified loess and 0.5-2.5 parts of modified graphene.
On the basis of the technical scheme, the invention also provides the following optional technical scheme:
in one alternative: the feed comprises the following raw materials in parts by weight: 280 parts of folium artemisiae argyi 220-.
In one alternative: the feed comprises the following raw materials in parts by weight: 250 parts of folium artemisiae argyi, 25 parts of radix angelicae, 20 parts of ligusticum wallichii, 15 parts of cinnamon, 15 parts of notopterygium root, 10 parts of perilla, 3 parts of modified loess and 1.5 parts of modified graphene.
In one alternative: the preparation method of the modified loess comprises the following steps: adding loess into water 3-5 times of the weight of loess, mixing, adjusting pH to 4-6 with acetic acid, adding aucubin 1-3% of loess, mixing, adjusting temperature to 50-70 deg.C, maintaining for 2-3 hr, adding hydroxyethyl methacrylate 2-4% of loess, stirring, and oven drying at 100-120 deg.C to constant weight to obtain modified loess.
In one alternative: the preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 9-10, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 20-40min under an ultraviolet lamp to obtain the modified graphene.
In one alternative: the mass ratio of the graphene oxide to the chitosan acid solution and the 3-amino-1, 2-propylene glycol is 2 (0.5-1) to 1, and the chitosan acid solution is preferably a chitosan hydrochloric acid solution with the mass concentration of 0.4%.
In one alternative: the alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
The preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning, drying and crushing folium artemisiae argyi, soaking the folium artemisiae argyi into red date vinegar which is 3-4 times of the weight of the folium artemisiae argyi, uniformly mixing and standing for 2-3 hours, baking the folium artemisiae argyi in a pot, uniformly spraying red date vinegar which is 1-2 times of the weight of the folium artemisiae argyi, baking the folium artemisiae argyi in the pot to obtain folium artemisiae argyi containing vinegar, then putting the folium artemisiae argyi in a carbonization kettle, carbonizing the folium artemisiae argyi at the temperature of 500-600 ℃ for 5-6 hours, and crushing the folium artemisiae argyi to obtain vinegar carbon folium artemisiae argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding ethanol 3-4 times of the mixed powder, and supercritical CO2Extracting for 2-3h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure is 40-50MPa, and the extraction temperature is 50-60 deg.C, desorption pressure of 6-8MPa, desorption temperature of 40-50 deg.C, and CO2The flow rate of the extracting solution A is 20-30L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 8-12 times of ethanol water solution to obtain percolate and percolate residue, adding the percolate residue into 4-6 times of ethanol water solution, soaking for 2-3 hr, ultrasonically extracting for 30-40min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding the ultrasonic extraction residue into 2-4 times of water, placing into a high pressure autoclave, decocting under high pressure for 20-30min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, the ultrasonic extractive solution and the high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In one alternative: in the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water with the weight 2-6 times of that of the red date powder, steaming for 1-2 hours to obtain red date juice, cooling to 30-40 ℃, adding yeast with the weight 1-3% of that of the red date juice and distiller's yeast with the weight 2-6% of that of the red date juice, mixing uniformly, adjusting the temperature to 15-20 ℃, performing primary fermentation for 8-12 hours, heating to 20-30 ℃, fermenting for 4-6 days, and filtering to obtain the red date vinegar.
The traditional Chinese medicines used in the invention have the following medicinal properties:
folium artemisiae argyi: pungent, bitter and warm, enter liver, spleen and kidney meridians, warm meridians to stop bleeding, dispel cold to stop pain; externally used for eliminating dampness and relieving itching;
radix angelicae: the medicine has pungent taste and warm nature, and can enter lung, spleen and stomach channels, relieve exterior syndrome, dispel cold, expel wind, relieve pain, relieve nasal obstruction, eliminate dampness, stop leucorrhea, relieve swelling, expel pus, dispel wind and relieve itching;
ligusticum wallichii: it is commonly used for promoting blood circulation and activating qi-flowing, dispelling pathogenic wind and relieving pain, rhizoma Ligustici Chuanxiong is pungent, warm, fragrant and dry, and can disperse and ascend to the vertex; it enters the blood system and goes down to reach the blood sea. Promoting blood circulation and removing blood stasis, and is suitable for various diseases caused by blood stasis; it has good effect in dispelling pathogenic wind and relieving pain, and can be used for treating headache, rheumatalgia, etc. Xiren is that Chuan Xiong is the qi-flowing medicine in blood, but it has the functions of dispersing acrid, relieving depression, dredging and relieving pain;
cinnamon: cortex Cinnamomi has effects in warming middle-jiao, invigorating kidney, dispelling cold, and relieving pain, and can be used for treating cold pain of waist and knee, deficiency cold gastralgia, chronic dyspepsia, abdominal pain, vomiting, diarrhea, and amenorrhea due to cold;
notopterygium root: it has warm nature, and has effects in relieving exterior syndrome, dispelling cold and eliminating cold dampness, and can be used for treating wind cold, headache, anhidrosis, arthralgia due to cold-dampness, and upper limb rheumatalgia;
purple perilla: sweating, relieving cough, aromatic stomach invigorating diuretic, analgesic, tranquilizing, and toxic materials clearing away effects, and can be used for treating common cold.
Compared with the prior art, the invention has the following beneficial effects:
through adding folium artemisiae argyi, radix angelicae, ligusticum wallichii, cinnamon and notopterygium root, activating blood circulation to dissipate blood stasis, reinforcing primordial qi, promoting metabolism, dredging channels and collaterals, regulating qi and blood, warming the middle-jiao to dispel cold, resolving stagnation and resolving hard mass, improving human immunity, through adding perilla frutescens, the contained volatile oil component and the pungent element can stimulate epidermal cells, increasing the permeability of cell membranes and facilitating medicine absorption, so that the medicine efficacy of the medicine can be fully exerted and utilized, meanwhile, the opening of skin glands on the epidermis is expanded due to pungent and warm stimulation, and some macromolecular and fat-soluble medicines can enter the body through gland openings, thereby being beneficial to exerting the medicine efficacy of the medicines, through modifying loess through aucubin and hydroxyethyl methacrylate, on one hand, loess treats sunstroke and diarrhea, dysentery, carbuncle-abscess and traumatic injury, and on the other hand, the flowability of the modified loess is better, the graphene is more uniform, has better viscosity and adsorbability, is beneficial to keeping effective components of various traditional Chinese medicines, modifies graphene through 3-amino-1, 2-propylene glycol and chitosan acid solution, changes the surface energy of graphene, increases the interlayer spacing, disperses the graphene into thinner single crystal chips, has an ultra-large specific surface area, can realize ultra-high drug loading due to the ultra-high adsorbability, can effectively adsorb the effective components in the storage and moxibustion application processes, prevents dissipation, and ensures higher pharmacodynamics.
Detailed Description
The present invention will be described in detail with reference to the following examples, which are provided for illustrative purposes only and are not intended to limit the scope of the present invention. Any obvious modifications or variations can be made to the present invention without departing from the spirit and scope of the invention.
Example 1
In the embodiment of the invention, the traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 200 parts of folium artemisiae argyi, 20 parts of radix angelicae, 15 parts of ligusticum wallichii, 10 parts of cinnamon, 10 parts of notopterygium root, 5 parts of perilla, 1 part of modified loess and 0.5 part of modified graphene.
Wherein the preparation method of the modified loess comprises the following steps: adding loess into water 3 times of the weight of loess, mixing, adjusting pH to 4 with acetic acid, adding aucubin 1% of the weight of loess, mixing, adjusting temperature to 50 deg.C, keeping the temperature for 2 hr, adding hydroxyethyl methacrylate 2% of the weight of loess, stirring, and oven drying at 100 deg.C to constant weight to obtain modified loess.
The preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 9, and drying; and (3) placing the dried graphene under tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 20min under an ultraviolet lamp to obtain the modified graphene.
The mass ratio of the graphene oxide to the chitosan acid solution to the 3-amino-1, 2-propylene glycol is 2:0.5: 1.
The alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
In this embodiment, the preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning folium Artemisiae Argyi, oven drying, pulverizing, soaking in red jujube vinegar 3 times the weight of folium Artemisiae Argyi, mixing, standing for 2h, baking in a pot, spraying red jujube vinegar 1 times the weight of folium Artemisiae Argyi, baking in a pot to obtain folium Artemisiae Argyi containing vinegar, carbonizing folium Artemisiae Argyi in a carbonization kettle at 500 deg.C for 5h, and pulverizing to obtain vinegar-carbon folium Artemisiae Argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding 3 times of ethanol, and supercritical CO2Extracting for 2h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure of the extraction is 40MPa, the extraction temperature is 50 ℃, the desorption pressure is 6MPa, the desorption temperature is 40 ℃, and CO is added2The flow rate of the extracting solution A is 20L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 8 times of ethanol water solution to obtain percolate and residue, adding the percolate residue into 4 times of ethanol water solution, soaking for 2 hr, ultrasonic extracting for 30min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding 2 times of water into the ultrasonic extraction residue, decocting in high pressure for 20min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, ultrasonic extractive solution and high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water 2 times of the weight of the red date powder, cooking for 1 hour to obtain red date juice, cooling to 30 ℃, adding yeast 1% and distiller's yeast 2% of the weight of the red date juice, mixing uniformly, adjusting the temperature to 15 ℃, performing primary fermentation for 8 hours, heating to 20 ℃, fermenting for 4 days, and filtering to obtain the red date vinegar.
Example 2
In the embodiment of the invention, the traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 220 parts of folium artemisiae argyi, 22 parts of radix angelicae, 18 parts of ligusticum wallichii, 13 parts of cinnamon, 12 parts of notopterygium root, 7 parts of perilla, 2 parts of modified loess and 1 part of modified graphene.
Wherein the preparation method of the modified loess comprises the following steps: adding loess into water 3 times of the weight of loess, mixing, adjusting pH to 4 with acetic acid, adding aucubin 1% of the weight of loess, mixing, adjusting temperature to 55 deg.C, keeping the temperature for 2 hr, adding hydroxyethyl methacrylate 2% of the weight of loess, stirring, and oven drying at 105 deg.C to constant weight to obtain modified loess.
The preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 9, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 25min under an ultraviolet lamp to obtain the modified graphene.
The mass ratio of the graphene oxide to the chitosan acid solution to the 3-amino-1, 2-propylene glycol is 2:0.5: 1.
The alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
In this embodiment, the preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning folium Artemisiae Argyi, oven drying, pulverizing, soaking in red jujube vinegar 3 times the weight of folium Artemisiae Argyi, mixing, standing for 2h, baking in a pot, spraying red jujube vinegar 1 times the weight of folium Artemisiae Argyi, baking in a pot to obtain folium Artemisiae Argyi containing vinegar, carbonizing folium Artemisiae Argyi in a carbonization kettle at 520 deg.C for 5h, and pulverizing to obtain vinegar-carbon folium Artemisiae Argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding 3 times of ethanol, and supercritical CO2Extracting for 2h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure of the extraction is 42MPa, and the extraction is carried outThe temperature is 52 ℃, the desorption pressure is 6MPa, the desorption temperature is 42 ℃, and CO is2The flow rate of the extracting solution A is 22L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 9 times of ethanol water solution to obtain percolate and percolate residue, adding the percolate residue into 4 times of ethanol water solution, soaking for 2 hr, ultrasonic extracting for 32min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding 2 times of water into the ultrasonic extraction residue, decocting in high pressure for 22min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, ultrasonic extractive solution and high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water with the weight 3 times that of the red date powder, cooking for 1 hour to obtain red date juice, cooling to 32 ℃, adding yeast with the weight 1% of that of the red date juice and distiller's yeast with the weight 3% of that of the red date juice, mixing uniformly, adjusting the temperature to 15 ℃, performing primary fermentation for 9 hours, heating to 22 ℃, fermenting for 4 days, and filtering to obtain the red date vinegar.
Example 3
In the embodiment of the invention, the traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 250 parts of folium artemisiae argyi, 25 parts of radix angelicae, 20 parts of ligusticum wallichii, 15 parts of cinnamon, 15 parts of notopterygium root, 10 parts of perilla, 3 parts of modified loess and 1.5 parts of modified graphene.
Wherein the preparation method of the modified loess comprises the following steps: adding loess into water 4 times of loess weight, mixing, adjusting pH to 5 with acetic acid, adding aucubin 2% of loess weight, mixing, adjusting temperature to 60 deg.C, keeping the temperature for 2.5 hr, adding hydroxyethyl methacrylate 3% of loess weight, stirring, and oven drying at 110 deg.C to constant weight to obtain modified loess.
The preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 9, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 30min under an ultraviolet lamp to obtain the modified graphene.
The mass ratio of the graphene oxide to the chitosan acid solution to the 3-amino-1, 2-propylene glycol is 2:0.8: 1.
The alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
In this embodiment, the preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning folium Artemisiae Argyi, oven drying, pulverizing, soaking in fructus Jujubae vinegar 3.5 times of folium Artemisiae Argyi, mixing, standing for 2.5 hr, baking in a pot, spraying fructus Jujubae vinegar 1.5 times of folium Artemisiae Argyi, baking in a pot to obtain folium Artemisiae Argyi containing vinegar, carbonizing folium Artemisiae Argyi in a carbonization kettle at 550 deg.C for 5.5 hr, and pulverizing to obtain vinegar-carbon folium Artemisiae Argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding ethanol 3.5 times of the mixed powder, and supercritical CO2Extracting for 2.5h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure of the extraction is 45MPa, the extraction temperature is 55 ℃, the desorption pressure is 7MPa, the desorption temperature is 45 ℃, and CO is added2The flow rate of the extracting solution A is 25L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 10 times of ethanol water solution to obtain percolate and residue, adding 5 times of ethanol water solution into the residue, soaking for 2.5 hr, ultrasonic extracting for 35min, filtering to obtain ultrasonic extractive solution and residue, adding 3 times of water into the residue, decocting in high pressure for 25min, filtering to obtain high pressure extractive solution and residue, mixing the percolate, the ultrasonic extractive solution and the high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water with the weight 4 times that of the red date powder, cooking for 1.5 hours to obtain red date juice, cooling to 35 ℃, adding yeast with the weight 2% of that of the red date juice and distiller's yeast with the weight 4% of that of the red date juice, mixing uniformly, adjusting the temperature to 18 ℃, performing primary fermentation for 10 hours, heating to 25 ℃, fermenting for 5 days, and filtering to obtain the red date vinegar.
Example 4
In the embodiment of the invention, the traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 280 parts of folium artemisiae argyi, 28 parts of radix angelicae, 22 parts of ligusticum wallichii, 17 parts of cinnamon, 17 parts of notopterygium root, 13 parts of perilla, 4 parts of modified loess and 2 parts of modified graphene.
Wherein the preparation method of the modified loess comprises the following steps: adding loess into water 5 times of loess weight, mixing, adjusting pH to 6 with acetic acid, adding aucubin 3% of loess weight, mixing, adjusting temperature to 65 deg.C, keeping the temperature for 2.5 hr, adding hydroxyethyl methacrylate 3% of loess weight, stirring, and oven drying at 110 deg.C to constant weight to obtain modified loess.
The preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 10, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 35min under an ultraviolet lamp to obtain the modified graphene.
The mass ratio of the graphene oxide to the chitosan acid solution to the 3-amino-1, 2-propylene glycol is 2:0.8: 1.
The alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
In this embodiment, the preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning folium Artemisiae Argyi, oven drying, pulverizing, soaking in fructus Jujubae vinegar 4 times of folium Artemisiae Argyi, mixing, standing for 3h, baking in a pot, spraying fructus Jujubae vinegar 2 times of folium Artemisiae Argyi, baking in a pot to obtain folium Artemisiae Argyi containing vinegar, carbonizing folium Artemisiae Argyi in a carbonization kettle at 580 deg.C for 6h, and pulverizing to obtain vinegar-carbon folium Artemisiae Argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding ethanol 4 times of the mixed powder, and supercritical CO2Extracting for 3h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure of the extraction is 48MPa, the extraction temperature is 57 ℃, the desorption pressure is 8MPa, the desorption temperature is 48 ℃, and CO is2The flow rate of the extracting solution A is 28L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 11 times of ethanol water solution to obtain percolate and percolate residue, adding 6 times of ethanol water solution into the percolate residue, soaking for 3 hr, ultrasonic extracting for 38min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding 4 times of water into the ultrasonic extraction residue, adding into a high pressure kettle, decocting at high pressure for 28min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, ultrasonic extractive solution and high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water 2 times the weight of the red date powder, cooking for 2 hours to obtain red date juice, cooling to 38 ℃, adding yeast 3% and distiller's yeast 5% of the weight of the red date juice, mixing uniformly, adjusting the temperature to 20 ℃, performing primary fermentation for 11 hours, heating to 28 ℃, fermenting for 6 days, and filtering to obtain the red date vinegar.
Example 5
In the embodiment of the invention, the traditional Chinese medicine composition for moxibustion comprises the following raw materials in parts by weight: 300 parts of folium artemisiae argyi, 30 parts of radix angelicae, 25 parts of ligusticum wallichii, 20 parts of cinnamon, 20 parts of notopterygium root, 15 parts of perilla, 5 parts of modified loess and 2.5 parts of modified graphene.
Wherein the preparation method of the modified loess comprises the following steps: adding loess into water 5 times of loess weight, mixing, adjusting pH to 6 with acetic acid, adding aucubin 3% of loess weight, mixing, adjusting temperature to 70 deg.C, keeping the temperature for 3 hr, adding hydroxyethyl methacrylate 4% of loess weight, stirring, and oven drying at 1120 deg.C to constant weight to obtain modified loess.
The preparation method of the modified graphene comprises the following steps: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 10, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 40min under an ultraviolet lamp to obtain the modified graphene.
The mass ratio of the graphene oxide to the chitosan acid solution to the 3-amino-1, 2-propylene glycol is 2:1: 1.
The alkali solution is sodium hydroxide aqueous solution with the concentration of 1.0mol/L, and the soaking time is not less than 2 h.
In this embodiment, the preparation method of the traditional Chinese medicine composition for moxibustion comprises the following steps:
1) weighing the raw materials according to the proportion;
2) cleaning folium Artemisiae Argyi, drying, pulverizing, soaking in fructus Jujubae vinegar 4 times of folium Artemisiae Argyi, mixing, standing for 3h, baking in a pot, spraying fructus Jujubae vinegar 2 times of folium Artemisiae Argyi, baking in a pot to obtain folium Artemisiae Argyi containing vinegar, carbonizing folium Artemisiae Argyi in a carbonization kettle at 600 deg.C for 6h, and pulverizing to obtain vinegar-carbon folium Artemisiae Argyi;
3) vacuum drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi, mixing, pulverizing, adding ethanol 4 times of the mixed powder, and supercritical CO2Extracting for 3h to obtain extractive solution with ethanol solution mass concentration of 90%, and supercritical CO2The extraction pressure of the extraction is 50MPa, the extraction temperature is 60 ℃, the desorption pressure is 8MPa, the desorption temperature is 50 ℃, and CO is added2The flow rate of the extracting solution A is 30L/h, and extracting solution A is obtained;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 12 times of ethanol water solution to obtain percolate and percolate residue, adding the percolate residue into 6 times of ethanol water solution, soaking for 3 hr, ultrasonic extracting for 40min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding 4 times of water into the ultrasonic extraction residue, decocting in high pressure for 30min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, ultrasonic extractive solution and high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
5) mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
In the step 2), the preparation method of the red date vinegar comprises the following steps: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water with the weight 6 times that of the red date powder, cooking for 2 hours to obtain red date juice, cooling to 40 ℃, adding yeast with the weight 3% of that of the red date juice and distiller's yeast with the weight 6% of that of the red date juice, mixing uniformly, adjusting the temperature to 20 ℃, performing primary fermentation for 12 hours, heating to 30 ℃, fermenting for 6 days, and filtering to obtain the red date vinegar.
Clinical trial
1. Case selection: randomly selecting 200 patients with chest distress, short breath and deficiency of qi and blood, wherein 100 male patients and 100 female patients are 18-65 years old, and the average age is 42.5 years old; patients were randomized into treatment, control 1, control 2 and control groups; 50 patients were present in each group, 25 males and 25 females, aged 18-65 years; the course and the severity of symptoms of the cases of the treatment group, the comparison group 1, the comparison group 2 and the comparison group are basically consistent, no obvious difference exists, and the treatment group, the comparison group 1, the comparison group 2 and the comparison group have comparability, 4-5 acupuncture points are selected for each time, each acupuncture point is subjected to moxibustion for 10-15min, the moxibustion is performed once a day, 7 days are a treatment course, and 4 treatment courses are implemented;
2. selecting the medicines: the treatment group was subjected to moxibustion using the moxa stick of example 3, the modified loess of example 3 was replaced with unmodified loess in comparative group 1, which was otherwise the same as example 3, and the modified graphene of example 3 was replaced with unmodified graphene in comparative group 2, which was otherwise the same as example 3, and the control group was treated using a conventional method.
3. And (3) judging the curative effect:
(1) and (3) curing: the symptoms are completely disappeared, the channels and collaterals are smooth, and the qi and blood are smooth;
(2) the effect is shown: elimination of major symptoms;
(3) the method has the following advantages: the main symptoms are basically eliminated and basically recovered;
(4) and (4) invalidation: the chief symptoms did not change significantly.
4. As a result:
group of Number of examples Cure of disease Show effect Is effective Invalidation Cure rate Total effective rate
Treatment group 50 42 4 3 1 84% 98%
Comparative group 1 50 28 9 8 5 56% 90%
Comparative group 2 50 27 8 9 6 54% 88%
Control group 50 15 10 12 13 30% 74%
The results show that the curative effect of the treatment group is obviously better than that of the comparison group 1, the comparison group 2 and the comparison group, and the modified loess and the modified graphene have a certain synergistic effect.
Through adding folium artemisiae argyi, radix angelicae, ligusticum wallichii, cinnamon and notopterygium root, activating blood circulation to dissipate blood stasis, reinforcing primordial qi, promoting metabolism, dredging channels and collaterals, regulating qi and blood, warming the middle-jiao to dispel cold, resolving stagnation and resolving hard mass, improving human immunity, through adding perilla frutescens, the contained volatile oil component and the pungent element can stimulate epidermal cells, increasing the permeability of cell membranes and facilitating medicine absorption, so that the medicine efficacy of the medicine can be fully exerted and utilized, meanwhile, the opening of skin glands on the epidermis is expanded due to pungent and warm stimulation, and some macromolecular and fat-soluble medicines can enter the body through gland openings, thereby being beneficial to exerting the medicine efficacy of the medicines, through modifying loess through aucubin and hydroxyethyl methacrylate, on one hand, loess treats sunstroke and diarrhea, dysentery, carbuncle-abscess and traumatic injury, and on the other hand, the flowability of the modified loess is better, the graphene is more uniform, has better viscosity and adsorbability, is beneficial to keeping effective components of various traditional Chinese medicines, modifies graphene through 3-amino-1, 2-propylene glycol and chitosan acid solution, changes the surface energy of graphene, increases the interlayer spacing, disperses the graphene into thinner single crystal chips, has an ultra-large specific surface area, can realize ultra-high drug loading due to the ultra-high adsorbability, can effectively adsorb the effective components in the storage and moxibustion application processes, prevents dissipation, and ensures higher pharmacodynamics.
The above description is only for the specific embodiments of the present disclosure, but the scope of the present disclosure is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present disclosure, and all the changes or substitutions should be covered within the scope of the present disclosure. Therefore, the protection scope of the present disclosure shall be subject to the protection scope of the claims.

Claims (9)

1. A traditional Chinese medicine composition for moxibustion is characterized by comprising the following raw materials in parts by weight: 300 parts of 200-fold artemisia leaves, 20-30 parts of angelica dahurica, 15-25 parts of ligusticum wallichii, 10-20 parts of cinnamon, 10-20 parts of notopterygium root, 5-15 parts of purple perilla, 1-5 parts of modified loess and 0.5-2.5 parts of modified graphene.
2. The traditional Chinese medicine composition for moxibustion as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 280 parts of folium artemisiae argyi 220-.
3. The traditional Chinese medicine composition for moxibustion as claimed in claim 2, which is characterized by comprising the following raw materials in parts by weight: 250 parts of folium artemisiae argyi, 25 parts of radix angelicae, 20 parts of ligusticum wallichii, 15 parts of cinnamon, 15 parts of notopterygium root, 10 parts of perilla, 3 parts of modified loess and 1.5 parts of modified graphene.
4. The traditional Chinese medicine composition for moxibustion according to claim 1, wherein the modified loess is prepared by the following method: adding loess into water 3-5 times of the weight of loess, mixing, adjusting pH to 4-6 with acetic acid, adding aucubin 1-3% of loess, mixing, adjusting temperature to 50-70 deg.C, maintaining for 2-3 hr, adding hydroxyethyl methacrylate 2-4% of loess, stirring, and oven drying at 100-120 deg.C to constant weight to obtain modified loess.
5. The traditional Chinese medicine composition for moxibustion as claimed in claim 1, wherein the preparation method of the modified graphene is as follows: carrying out alkali solution soaking treatment on graphene oxide under a heating condition, adjusting the pH value to 9-10, and drying; and (3) placing the dried graphene in tetramethyl tetravinylcyclotetrasiloxane steam, adding chitosan acid solution and 3-amino-1, 2-propylene glycol, mixing, and then exposing for 20-40min under an ultraviolet lamp to obtain the modified graphene.
6. The traditional Chinese medicine composition for moxibustion as claimed in claim 5, wherein the mass ratio of graphene oxide to the chitosan acid solution and 3-amino-1, 2-propanediol is 2 (0.5-1): 1.
7. The traditional Chinese medicine composition for moxibustion according to claim 5, wherein the alkali solution is an aqueous solution of sodium hydroxide with a concentration of 1.0mol/L, and the soaking time is not less than 2 hours.
8. The preparation method of a traditional Chinese medicine composition for moxibustion according to any one of claims 1-7, characterized by comprising the steps of:
1) weighing the raw materials according to the proportion;
2) cleaning, drying and crushing folium artemisiae argyi, soaking the folium artemisiae argyi into red date vinegar which is 3-4 times of the weight of the folium artemisiae argyi, uniformly mixing and standing for 2-3 hours, baking the folium artemisiae argyi in a pot, uniformly spraying red date vinegar which is 1-2 times of the weight of the folium artemisiae argyi, baking the folium artemisiae argyi in the pot to obtain folium artemisiae argyi containing vinegar, then putting the folium artemisiae argyi in a carbonization kettle, carbonizing the folium artemisiae argyi at the temperature of 500-600 ℃ for 5-6 hours, and crushing the folium artemisiae argyi to obtain vinegar carbon folium artemisiae argyi;
3) drying radix Angelicae Dahuricae, rhizoma Ligustici Chuanxiong, and cortex Cinnamomi under vacuum, mixing, pulverizing, adding 3-4 times of ethanol into the powder, and performing supercritical CO2 extraction for 2-3h to obtain extractive solution, wherein the mass concentration of ethanol solution is 90%, the extraction pressure of supercritical CO2 extraction is 40-50MPa, the extraction temperature is 50-60 deg.C, the analytic pressure is 6-8MPa, the analytic temperature is 40-50 deg.C, and the flow rate of CO2 is 20-30L/h to obtain extractive solution A;
4) vacuum drying Notopterygii rhizoma and Perillae herba, mixing, pulverizing, adding into a percolator, percolating with 8-12 times of ethanol water solution to obtain percolate and percolate residue, adding the percolate residue into 4-6 times of ethanol water solution, soaking for 2-3 hr, ultrasonically extracting for 30-40min, filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, adding the ultrasonic extraction residue into 2-4 times of water, placing into a high pressure autoclave, decocting under high pressure for 20-30min, filtering to obtain high pressure extractive solution and high pressure extraction residue, mixing the percolate, the ultrasonic extractive solution and the high pressure extractive solution, and concentrating under reduced pressure to 20% of original volume to obtain extractive solution B;
mixing and grinding the vinegar carbon moxa, the modified loess and the modified graphene, then uniformly mixing the vinegar carbon moxa, the modified loess and the modified graphene with the extracting solution A and the extracting solution B to obtain mixed paste, pressing the mixed paste into strips by using a machine, and airing to obtain the required traditional Chinese medicine composition for moxibustion.
9. The method for preparing a traditional Chinese medicine composition for moxibustion according to claim 8, wherein in step 2), the method for preparing the red date vinegar is as follows: cleaning red dates, removing cores, drying, crushing to obtain red date powder, adding water with the weight 2-6 times of that of the red date powder, steaming for 1-2 hours to obtain red date juice, cooling to 30-40 ℃, adding yeast with the weight 1-3% of that of the red date juice and distiller's yeast with the weight 2-6% of that of the red date juice, mixing uniformly, adjusting the temperature to 15-20 ℃, performing primary fermentation for 8-12 hours, heating to 20-30 ℃, fermenting for 4-6 days, and filtering to obtain the red date vinegar.
CN202011061011.2A 2020-09-30 2020-09-30 A Chinese medicinal composition for moxibustion, and its preparation method Pending CN112121080A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106822316A (en) * 2016-12-29 2017-06-13 河南忠澜艾瓷文化开发有限公司 A kind of invigorate blood circulation smokeless moxibustion bar and preparation method thereof
CN109090393A (en) * 2018-08-10 2018-12-28 伍超群 A kind of health drink and preparation method thereof can reduce blood lipid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106822316A (en) * 2016-12-29 2017-06-13 河南忠澜艾瓷文化开发有限公司 A kind of invigorate blood circulation smokeless moxibustion bar and preparation method thereof
CN109090393A (en) * 2018-08-10 2018-12-28 伍超群 A kind of health drink and preparation method thereof can reduce blood lipid

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Application publication date: 20201225