CN112107514A - Anti-wrinkle skin care product composition and application thereof - Google Patents
Anti-wrinkle skin care product composition and application thereof Download PDFInfo
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- CN112107514A CN112107514A CN202010999329.9A CN202010999329A CN112107514A CN 112107514 A CN112107514 A CN 112107514A CN 202010999329 A CN202010999329 A CN 202010999329A CN 112107514 A CN112107514 A CN 112107514A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention relates to the field of cosmetics, in particular to a skin care product composition with anti-wrinkle effect and application thereof. The invention provides a safe and effective skin care product composition, which takes asiatic pennywort herb extract and amur corktree extract as active ingredients, can remarkably promote the biosynthesis of collagen, and has remarkable anti-wrinkle effect. The skin care product composition provided by the invention has good anti-wrinkle effect and is safe to use, the selection of anti-wrinkle people is increased, and the skin care product composition has a good application prospect.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a skin care product composition with anti-wrinkle effect and application thereof.
Background
Wrinkles are the initial sign of skin aging, and the wrinkles further develop and form folds, i.e. deeper folds in the skin. With the age, the activity of skin cells is reduced, the cell proliferation is weakened, the horny cells accumulated on the surface layer are not easy to fall off and are continuously thickened on the surface layer of the skin, and meanwhile, the horny layer is damaged by external environments such as continuous wind and rain, solar stimulation and the like, so that the skin becomes thinner, becomes hard, dry and has reduced tension and poorer softness, finally, the strength and the elasticity of the skin are reduced, and wrinkles appear.
With the improvement of the life quality of people, the anti-aging and wrinkle-removing topics become the concerns of consumers, and a plurality of wrinkle-removing products appear on the market. Along with the advocation of nature, environmental protection and mild concept, various natural active extracts with special characteristics are more and more favored by people. However, the effective components in the existing anti-wrinkle products are not easy to be absorbed by human bodies and have poor effects, so that the improvement space is still left.
Disclosure of Invention
The invention provides a safe and effective skin care product composition, which takes asiatic pennywort herb extract and amur corktree extract as active ingredients, can remarkably promote the biosynthesis of collagen, and has remarkable anti-wrinkle effect. The skin care product composition provided by the invention has good anti-wrinkle effect and is safe to use, the selection of anti-wrinkle people is increased, and the skin care product composition has a good application prospect.
One of the objects of the present invention is to provide a skin care composition, the active ingredients of which consist of centella asiatica extract and phellodendron amurense extract.
The anti-wrinkle skin care product composition takes the asiatic pennywort herb extract and the amur corktree extract as active ingredients.
Preferably, the weight ratio of the asiatic pennywort herb extract to the phellodendron amurense extract in the skin care product composition of the present invention is 1: (0.05-50), and more preferably, the weight ratio of the asiatic pennywort herb extract to the phellodendron amurense extract in the skin care product composition is 1: (0.1-20).
The anti-wrinkle composition contains centella asiatica extract and phellodendron amurense extract, wherein the content of asiatic centella total aglycone is not less than 50% and the content of asiatic acid is not less than 30% by liquid phase detection of the centella asiatica extract.
The extraction method of the centella extract comprises the following steps:
dissolving asiaticoside in ethanol, regulating acidity, heating for reaction, cooling to neutralize pH, adding water to regulate ethanol content, vacuum filtering, washing filter cake with water to neutrality, and drying to obtain herba Centellae extract.
Preferably, the asiaticoside is dissolved in 30-80% ethanol, the acidity is adjusted to 0.1-10%, the mixture is heated to 40-80 ℃ to react for 2-48h, the temperature is reduced to neutralize the pH value to 2-5, water is added to adjust the ethanol content to be below 10%, the mixture is filtered, a filter cake is washed to be neutral, and the asiaticoside is dried to obtain the asiatic centella extract.
The liquid phase detection conditions of the asiaticoside and asiatic acid are as follows:
liquid phase conditions: the instrument comprises the following steps: agilent 1260;
mobile phase: acetonitrile: 2mmol/L β -cyclodextrin 44: 56;
detection wavelength: 205 nm;
column temperature: 30 ℃;
flow rate: 1.0 ml/min.
The anti-wrinkle composition contains centella asiatica extract and phellodendron amurense extract, and the content of berberine in the phellodendron amurense extract is not less than 0.5%.
The extraction method of the phellodendron amurense extract comprises the following steps:
pulverizing cortex Phellodendri, soaking in lime water, filtering, adjusting pH, collecting precipitate, washing with water, precipitating with propylene glycol solvent, adjusting to neutrality to obtain cortex Phellodendri extractive solution, concentrating under reduced pressure, vacuum filtering, and drying to obtain cortex Phellodendri extract.
The liquid phase detection conditions of the berberine are as follows:
liquid phase conditions: octadecylsilane chemically bonded silica is used as a filler;
mobile phase: 0.01mol/L ammonium dihydrogen phosphate solution: acetonitrile 75: 25;
detection wavelength: 345 nm.
Example 1 of the present invention shows that the skin care composition of centella asiatica extract and phellodendron amurense extract according to the present invention can significantly promote collagen biosynthesis. The skin care product composition of the asiatic pennywort herb extract and the amur corktree extract has obviously better effect of promoting the collagen biosynthesis than the asiatic pennywort herb extract group and the amur corktree extract group.
Through a large number of experiments, the inventor finds that the centella asiatica extract and the phellodendron amurense extract in the skin care product composition can achieve the synergistic improvement effect of wrinkle resistance. The weight ratio of the asiatic pennywort herb extract to the phellodendron amurense extract in the skin care product composition of the present invention is preferably 1: (0.05-50), and more preferably, the weight ratio of the asiatic pennywort herb extract to the phellodendron amurense extract in the skin care product composition is 1: (0.1-20).
The anti-wrinkle effect of the skin care product composition is not only obviously superior to the effect of the two components when the two components are used independently, but also superior to the addition of the two effects.
The active substance component and the mass percentage of the skin care product composition are 0.1-10% of asiatic pennywort herb extract and 0.1-10% of amur corktree extract.
The skin care product composition also comprises the following components in percentage by mass: 7-12% of grease, 8-15% of humectant, 1-5% of emulsifier, 0.2-1.5% of thickener and the balance of water.
The third purpose of the invention is to provide the skin care effect of the skin care product composition, namely the application of the skin care product composition in preparing an anti-wrinkle skin care product.
The skin care product containing the skin care product composition is cream, emulsion, gel or water.
Further preferably, the skin care product is in the form of a skin care product: a toner, a lotion, a cream, a massage cream, an essence, a gel cream, a mask, a mascara, a concealer, a lipstick, a lip gloss, or a foundation.
The skin care product composition can be clinically used for resisting wrinkles and has a remarkable effect. Clinical trial shows that the anti-wrinkle composition is easy to absorb and has a good anti-wrinkle effect, fine lines on the face are obviously smoothed after the face cream is used, and wrinkles are effectively reduced or relieved. The subjects did not have skin allergy, red swelling, and other adverse conditions.
Compared with the prior art, the skin care product composition has the following outstanding advantages in the aspect of anti-wrinkle:
(1) compared with the single use of the asiatic pennywort herb extract or the amur corktree extract, the skin care product composition containing the asiatic pennywort herb extract and the amur corktree extract can obviously promote the synthesis of collagen, and the two components show good synergistic effect in the aspect of anti-wrinkle.
(2) The skin care product composition disclosed by the invention is a combination of traditional Chinese medicine extracts, is remarkable in curative effect and high in use safety, and increases the use options of anti-wrinkle crowds.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the scope of application of the present invention is not limited to the following examples. Alterations and/or combinations of features of the invention will be apparent to those skilled in the art from the disclosure, spirit and/or scope of the invention, and are intended to be encompassed by the invention.
The raw material sources are as follows:
the centella asiatica extract is prepared according to the invention.
Phellodendron amurense extract: quzhou City exhibition-macro Biotechnology Ltd.
Formulation example 1 cream
Formulation example 2 cream
| Composition (I) | Content (wt%) |
| Centella asiatica extract | 1.00 |
| Cortex Phellodendri extract | 2.00 |
| Glycerol | 9.10 |
| Triethanolamine | 0.35 |
| Tocopheryl acetate | 0.90 |
| Liquid paraffin | 4.50 |
| Squalane | 5.00 |
| Polysorbate 60 | 1.15 |
| Carboxylic acid polymers | 0.30 |
| Xanthan gum | 0.12 |
| Purified water | Other parts |
| Total up to | 100 |
Formulation example 3 emulsion
Formulation example 4 facial mask
| Composition (I) | Content (wt%) |
| Centella asiatica extract | 1.00 |
| Cortex Phellodendri extract | 10.0 |
| Polyvinyl alcohol | 10.00 |
| L-ascorbic acid-2-magnesium phosphate | 1.00 |
| Lauroyl hydroxyproline | 1.00 |
| Water-soluble collagen (1% aqueous solution) | 3.00 |
| Purified water | Other parts |
| Total up to | 100 |
Formulation example 5 facial mask
Example 1 measurement of collagen biosynthesis in skin Care compositions of the invention
Skin wrinkling is caused by a lack of collagen, and collagen is the main protein constituting the dermis of the skin and acts to maintain the structure and elasticity of the skin. With age, the production of collagen becomes less and its decomposition increases, thereby causing a depression of the dermal layer of the skin, thereby generating wrinkles in the skin. For anti-wrinkle efficacy, collagen biosynthesis was evaluated.
Measuring the amount of biosynthetic collagen
To evaluate the anti-wrinkle efficacy of the skin care product composition according to the present invention, collagen biosynthesis promotion test using fibroblast (Sircol) was performedTMSoluble collagen analysis kit (Sircol)TM Soluble Collagen Assay Kit))。
Cultured human fibroblasts were aliquoted into media containing 5% FBS to achieve 1X 10 in 12-well cell culture dishes5Individual cells/well and subsequently cultured for 24 hours. In addition, the centella asiatica extract, phellodendron amurense extract, and centella asiatica extract phellodendron amurense extract compositions were diluted to different concentrations in a medium containing 2% FBS, added to the cells, cultured for 48 hours, and then used for the following tests.
Wherein composition 1 group: centella asiatica extract: phellodendron amurense extract is 1: 0.1;
composition 2 group: centella asiatica extract: phellodendron amurense extract at a ratio of 1: 20;
composition 3 group: centella asiatica extract: phellodendron amurense extract is 1: 3;
composition 4 group: centella asiatica extract: phellodendron amurense extract at a ratio of 1: 0.05;
composition 5 group: centella asiatica extract: phellodendron amurense extract at a ratio of 1: 50.
To determine the actual increase in the amount of collagen synthesized in fibroblasts, a soluble collagen assay kit was purchased and the amount of collagen was measured by the test method mentioned in the product manual. The collagen assay kit is a quantitative method based on the coupling of a staining reagent to collagen, which is introduced into the culture medium during cell culture.
Specifically, 1ml of a staining reagent (a solution including picric acid and sirius red reagent) was added to 100 μ L of the culture supernatant, and reacted for 30 minutes (depending on the amount of collagen produced, the culture broth may be concentrated, or 200 μ L of the culture supernatant may be reacted with 1ml of the staining reagent). Sirius red is specifically conjugated to collagen as an anionic dye. After the reaction for 30 minutes, the reaction solution was centrifuged at a centrifugal force of 12000 Xg or more for 10 minutes to precipitate the collagen-dye complex. To the precipitate was added 1.0ml of an alkaline agent, and thereby it was dissolved at room temperature for 5 minutes. The absorbance of the above solution was measured at 540nm using an absorption spectrophotometer.
The results are shown in table 1 below, and the absorbances of the respective groups were compared to evaluate the collagen biosynthesis promoting efficacy.
TABLE 1 comparison of absorbance for each group
Compared with the centella asiatica extract group,&P<0.05，&&P<0.01，&&&P<0.001；
compared with the extract of phellodendron amurense,★P<0.05，★★P<0.01，★★★P<0.001；
compared with the group of composition 4,＊P<0.05，＊＊P<0.01，＊＊＊P<0.001；
compared with the group of composition 5,#P<0.05，##P<0.01，###P<0.001。
the experimental results show that the efficacy of each group of the composition for promoting the biosynthesis of collagen is obviously superior to that of the asiatic pennywort herb extract group and that of the amur corktree extract group.
The composition 1 group, composition 2 group and composition 3 group had better collagen biosynthesis promoting effects than the composition 4 group.
The composition 1 group, composition 2 group and composition 3 group had better collagen biosynthesis promoting effects than the composition 5 group.
Example 2 anti-wrinkle Effect of the anti-wrinkle skin Care article of the present invention
1. General data
60 people of 30-40 years old are selected to participate in the method voluntarily, and healthy women have no wound, no skin disease, no infectious disease and no long-term medicine taking history.
Sex: female, the female is provided with a drug.
Age: 30-40 years old.
2. Treatment course and application method
The course of treatment is as follows: four weeks is a course of treatment.
The using method comprises the following steps: the face cream prepared in the application formula example 2 is used for 1 time respectively after face cleaning in the morning and at night and is continuously used for eight weeks.
The forehead wrinkles before use were used as a control group, and the forehead wrinkles after eight weeks were used continuously as a sample group.
Anti-wrinkle effect determination criteria:
the effect is excellent: compared with the wrinkle before use, the wrinkle subsides more than 90%, and is obviously improved.
The effect is shown: compared with the wrinkle before use, the wrinkle is removed by 70-90 percent and obviously improved.
The method has the following advantages: wrinkles resolved 30-70% compared to before use, but still a few wrinkles were present, improving.
And (4) invalidation: wrinkles resolved by less than 30% without improvement compared to before use.
3. The anti-wrinkle results are shown in table 2.
The course of treatment is as follows: 14 patients with excellent treatment effect, 25 patients with obvious effect, 14 patients with effective effect and 7 patients with ineffective effect.
TABLE 2 anti-wrinkle Effect
| Function(s) | Number of examples | The effect is excellent | Show effect | Is effective | Invalidation | Total effective rate (%) |
| Anti-wrinkle | 60 | 14 | 25 | 14 | 7 | 88％ |
4. Conclusion
The cream in the example 2 has high acceptance, and trial volunteers all show that the cream is easy to absorb and has good wrinkle removing effect, fine lines on the face are obviously smoothed after the cream is used for 8 weeks, and wrinkles are effectively reduced or relieved. The subjects did not have skin allergy, red swelling, and other adverse conditions.
The skin care product composition provided by the invention can obviously promote the synthesis of collagen, keep the skin elastic, reduce wrinkles, and ensure that the skin is smooth, full, tight and fine. After the anti-wrinkle cosmetic is used, the skin can be moisturized, fine and soft.
Claims (9)
1. A composition characterized in that the active ingredients of said composition consist of centella asiatica extract and phellodendron amurense extract.
2. The composition of claim 1, wherein the weight ratio of centella asiatica extract to phellodendron amurense extract in the composition is 1: (0.05-50).
3. The composition of claim 2, wherein the weight ratio of centella asiatica extract to phellodendron amurense extract in the composition is 1: (0.1-20).
4. The composition of claim 1, wherein the centella asiatica extract has a total aglycone content of not less than 50% and a centella asiatica content of not less than 30%; the content of berberine extracted from cortex Phellodendri in the composition is not less than 0.5%.
5. A skin care composition containing the composition of claim 1, wherein the active substance component and the mass percentage of the active substance component in the skin care composition are 0.1-10% of centella asiatica extract and 0.1-10% of phellodendron amurense extract.
6. The skin care composition of claim 5, further comprising the following components in mass percent: 7-12% of grease, 8-15% of humectant, 1-5% of emulsifier, 0.2-1.5% of thickener and 46.5-83.6% of water.
7. Use of the skin care composition according to any one of claims 1 to 6 in the preparation of a cosmetic product in the form of a cream, emulsion, gel or lotion.
8. The use of claim 7, wherein the skin care product is in the form of a toner, lotion, cream, massage cream, essence, gel cream, mask, mascara, concealer, lipstick, lip gloss, or foundation.
9. Use according to claim 8, wherein the skin care product is in the form of a lotion, cream or mask.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010999329.9A CN112107514A (en) | 2020-09-22 | 2020-09-22 | Anti-wrinkle skin care product composition and application thereof |
| CN202111049229.0A CN113546021A (en) | 2020-09-22 | 2021-09-08 | Anti-wrinkle skin care product composition and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010999329.9A CN112107514A (en) | 2020-09-22 | 2020-09-22 | Anti-wrinkle skin care product composition and application thereof |
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| CN112107514A true CN112107514A (en) | 2020-12-22 |
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| CN202010999329.9A Pending CN112107514A (en) | 2020-09-22 | 2020-09-22 | Anti-wrinkle skin care product composition and application thereof |
| CN202111049229.0A Pending CN113546021A (en) | 2020-09-22 | 2021-09-08 | Anti-wrinkle skin care product composition and application thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001037799A1 (en) * | 1999-11-26 | 2001-05-31 | Lvmh Recherche | Ajuga turkestanica extract and its cosmetic uses |
| CN108272740A (en) * | 2018-03-28 | 2018-07-13 | 湖南御家化妆品制造有限公司 | Composition and acne containing the composition repair cosmetics |
| CN109925247A (en) * | 2019-04-09 | 2019-06-25 | 上海新高姿化妆品有限公司 | A kind of toner and preparation method thereof with full stage anti-acne effect |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011063563A (en) * | 2009-09-18 | 2011-03-31 | Fuji Chem Ind Co Ltd | Wrinkle-improving composition |
| CN104983624A (en) * | 2015-06-29 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Repairing skin-protecting nourishing mask impregnation liquid and preparation method thereof |
-
2020
- 2020-09-22 CN CN202010999329.9A patent/CN112107514A/en active Pending
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2021
- 2021-09-08 CN CN202111049229.0A patent/CN113546021A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001037799A1 (en) * | 1999-11-26 | 2001-05-31 | Lvmh Recherche | Ajuga turkestanica extract and its cosmetic uses |
| CN108272740A (en) * | 2018-03-28 | 2018-07-13 | 湖南御家化妆品制造有限公司 | Composition and acne containing the composition repair cosmetics |
| CN109925247A (en) * | 2019-04-09 | 2019-06-25 | 上海新高姿化妆品有限公司 | A kind of toner and preparation method thereof with full stage anti-acne effect |
Non-Patent Citations (2)
| Title |
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| 王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 盛夏，等著: "《美容大王和化学家》", 31 August 2015, 安徽美术出版社 * |
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Application publication date: 20201222 |