CN112105634A - 新型白介素2及其用途 - Google Patents

新型白介素2及其用途 Download PDF

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CN112105634A
CN112105634A CN201980029372.8A CN201980029372A CN112105634A CN 112105634 A CN112105634 A CN 112105634A CN 201980029372 A CN201980029372 A CN 201980029372A CN 112105634 A CN112105634 A CN 112105634A
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mutein
cells
amino acid
sequence
wild
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CN112105634B (zh
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康立山
付凤根
周帅祥
史新震
刘军建
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Innovent Biologics Suzhou Co Ltd
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Abstract

本发明涉及新型白介素2(IL‑2)突变蛋白。本发明还提供包含该IL‑2突变蛋白的融合蛋白、免疫缀合物，以及编码该IL‑2突变蛋白的核酸、包含该核酸的载体和宿主细胞。本发明进一步提供制备该IL‑2突变蛋白的方法、包含该IL‑2突变蛋白的药物组合物和该突变蛋白的治疗用途。

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN201980029372.8A 2018-09-21 2019-09-20 新型白介素2及其用途 Active CN112105634B (zh)

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CN201811108663X 2018-09-21
CN201811108663 2018-09-21
PCT/CN2019/107054 WO2020057645A1 (zh) 2018-09-21 2019-09-20 新型白介素2及其用途

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EP (1) EP3854805A4 (zh)
JP (2) JP2022501009A (zh)
CN (1) CN112105634B (zh)
AU (1) AU2019344875B2 (zh)
CA (1) CA3098765A1 (zh)
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CN110642934A (zh) * 2019-09-10 2020-01-03 中国医学科学院北京协和医院 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用
CN114957441A (zh) * 2022-05-20 2022-08-30 南京涵台余生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用

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TWI790573B (zh) * 2020-03-19 2023-01-21 大陸商信達生物製藥（蘇州）有限公司 白介素２突變體及其用途
WO2021185362A1 (zh) * 2020-03-19 2021-09-23 信达生物制药(苏州)有限公司 白介素2突变体及其用途
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
CN115996946A (zh) 2020-04-30 2023-04-21 免疫靶向有限公司 可活化il2组合物和使用方法
CN113667003A (zh) * 2020-05-14 2021-11-19 上海盖浦生物科技有限公司 一种增殖调节性t细胞的突变体蛋白
BR112023000650A2 (pt) * 2020-07-14 2023-01-31 Pfizer Vírus vaccinia recombinante
EP4204439A1 (en) * 2020-08-28 2023-07-05 Ascendis Pharma Oncology Division A/S Glycosylated il-2 proteins and uses thereof
CN114380919B (zh) * 2020-10-18 2024-06-25 北京志道生物科技有限公司 经修饰的il-2分子及其用途
JP2024500232A (ja) * 2020-12-23 2024-01-05 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド インターロイキン２１変異体およびその使用
WO2023045977A1 (zh) * 2021-09-22 2023-03-30 信达生物制药(苏州)有限公司 白介素2突变体以及其融合蛋白
WO2023241653A1 (zh) * 2022-06-17 2023-12-21 舒泰神（北京）生物制药股份有限公司 白介素-2(il-2)突变体及其用途

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Publication number Priority date Publication date Assignee Title
CN110642934A (zh) * 2019-09-10 2020-01-03 中国医学科学院北京协和医院 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用
CN114957441A (zh) * 2022-05-20 2022-08-30 南京涵台余生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用
CN114957441B (zh) * 2022-05-20 2023-05-09 江苏康合生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用

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