CN112105634A - 新型白介素2及其用途 - Google Patents

新型白介素2及其用途 Download PDF

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CN112105634A
CN112105634A CN201980029372.8A CN201980029372A CN112105634A CN 112105634 A CN112105634 A CN 112105634A CN 201980029372 A CN201980029372 A CN 201980029372A CN 112105634 A CN112105634 A CN 112105634A
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mutein
cells
amino acid
sequence
wild
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CN112105634B (zh
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康立山
付凤根
周帅祥
史新震
刘军建
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Innovent Biologics Suzhou Co Ltd
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Abstract

本发明涉及新型白介素2(IL‑2)突变蛋白。本发明还提供包含该IL‑2突变蛋白的融合蛋白、免疫缀合物，以及编码该IL‑2突变蛋白的核酸、包含该核酸的载体和宿主细胞。本发明进一步提供制备该IL‑2突变蛋白的方法、包含该IL‑2突变蛋白的药物组合物和该突变蛋白的治疗用途。

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN201980029372.8A 2018-09-21 2019-09-20 新型白介素2及其用途 Active CN112105634B (zh)

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CN201811108663X 2018-09-21
CN201811108663 2018-09-21
PCT/CN2019/107054 WO2020057645A1 (zh) 2018-09-21 2019-09-20 新型白介素2及其用途

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US (1) US20210213102A1 (zh)
EP (1) EP3854805A4 (zh)
JP (2) JP2022501009A (zh)
CN (1) CN112105634B (zh)
AU (1) AU2019344875B2 (zh)
CA (1) CA3098765A1 (zh)
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CN110642934A (zh) * 2019-09-10 2020-01-03 中国医学科学院北京协和医院 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用
CN114957441A (zh) * 2022-05-20 2022-08-30 南京涵台余生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用

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AU2021237518A1 (en) * 2020-03-19 2022-10-13 Innovent Biologics (Singapore) Pte. Ltd. Interleukin-2 mutant and use thereof
CA3175717A1 (en) * 2020-03-19 2021-09-23 Innovent Biologics (Suzhou) Co., Ltd. Interleukin-2 mutant and use thereof
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
US11597753B2 (en) 2020-04-30 2023-03-07 Immune Targeting, Inc. Activatable IL2 composition and methods of use
CN113667003A (zh) * 2020-05-14 2021-11-19 上海盖浦生物科技有限公司 一种增殖调节性t细胞的突变体蛋白
CA3189291A1 (en) * 2020-07-14 2022-01-20 Pfizer Inc. Recombinant vaccinia virus
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CN114380919A (zh) * 2020-10-18 2022-04-22 北京志道生物科技有限公司 经修饰的il-2分子及其用途
EP4273158A1 (en) * 2020-12-23 2023-11-08 Innovent Biologics (Suzhou) Co., Ltd. Interleukin-21 mutant and use thereof
CA3233075A1 (en) * 2021-09-22 2023-03-30 Fortvita Biologics (Singapore) Pte. Ltd. Interleukin-2 mutant and fusion protein thereof
WO2023241653A1 (zh) * 2022-06-17 2023-12-21 舒泰神（北京）生物制药股份有限公司 白介素-2(il-2)突变体及其用途

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* Cited by examiner, † Cited by third party
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CN110642934A (zh) * 2019-09-10 2020-01-03 中国医学科学院北京协和医院 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用
CN114957441A (zh) * 2022-05-20 2022-08-30 南京涵台余生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用
CN114957441B (zh) * 2022-05-20 2023-05-09 江苏康合生物科技有限公司 转基因nk细胞及其在抗肿瘤药物中的应用

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EP3854805A1 (en) 2021-07-28
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JP2023174651A (ja) 2023-12-08
CA3098765A1 (en) 2020-03-26
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US20210213102A1 (en) 2021-07-15
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