CN112075546A - Feed additive for improving oxygen-gaining capability of poultry and application thereof - Google Patents
Feed additive for improving oxygen-gaining capability of poultry and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a feed additive for improving the oxygen-gaining capacity of poultry, which comprises an active ingredient of 5-aminolevulinic acid. Or the additive can be added in a composite way according to the mass fraction: 2-10 wt% of 5-aminolevulinic acid, 10-45 wt% of feeding complex enzyme, 10-45 wt% of enterococcus faecalis and 0-75 wt% of carrier. The invention also discloses application of the feed additive in poultry breeding. The feed additive provided by the invention is applied to poultry, particularly high-density poultry breeding and poultry breeding in high-altitude areas, can obviously reduce the death and culling rate of the poultry and improve the production performance of the poultry, and the product has stronger economic application benefits and market popularization value.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive which is added in poultry feeding and can effectively improve oxygen supply capacity and improve the survival rate and the production performance of poultry and application thereof.
Background
In modern poultry farming, high-density farming is a ubiquitous phenomenon in pursuit of high economic benefits, and feeding density is an important factor affecting the performance of poultry production. Under the condition of raising in high-density or high-altitude areas with insufficient oxygen, the production performance of the poultry is reduced, and particularly in the process of raising in winter, the ventilation in a shed is not smooth, so that the problems of insufficient oxygen supply, increased death and culling rate and the like of the poultry are easily caused. Researches find that the 5-aminolevulinic acid can improve the hematopoietic function of organisms and the transportation efficiency of oxygen, thereby improving the anoxic state.
5-aminolevulinic acid (5-ALA), formula C5H9NO3Is a gamma-amino acid with amino and carboxyl groups on both sides. It is used as the important precursor for synthesizing tetrahydropyrrole in organism, and is used for synthesizing heme, cytochrome and vitamin B12And the like. 5-ALA is widely present in animal, plant and microbial cells, has the characteristics of no toxicity to human and livestock, easy degradation in environment, no residue and the like, and is gradually popularized and applied in the domestic feed industry at present. The 5-ALA is closely related to the synthesis regulation of Heme (Heme) in an organism, and the Heme is a main stable structure on hemoglobin molecules and participates in oxygen and carbon dioxide transportation, so that the 5-ALA added into the livestock and poultry feed can effectively improve the blood oxygen content of livestock and poultry, activate the cell function and accelerate the oxidation-reduction reaction in cells, thereby promoting the vigorous metabolism of the organism and improving the feed conversion rate; meanwhile, researches show that the 5-ALA can remarkably promote the hematopoietic function of the organism and increase the number of red blood cells in blood, thereby improving the transport capacity of the blood to nutrient substances and accelerating the turnover of nutrient substances of the feed; 5-ALA is added into livestock and poultry feed to adjust the feedThe immune system can increase the amount of immunoglobulin and leucocyte in organism and enhance the resistance to pathogenic microorganism.
The feed enzyme preparation and the enterococcus faecalis are novel biological preparation products, are non-toxic and non-residue, and have obvious application effects on adjusting the intestinal health of livestock and poultry, improving the production performance and the like. The feed enzyme preparation and the enterococcus faecalis can regulate the metabolic state in a body by reducing the anti-nutritional factors in the feed, reducing the chyme viscosity in the intestinal tract, improving the micro-ecological balance of flora in the intestinal tract, improving the disease resistance of livestock and poultry and the like, thereby improving the turnover efficiency of nutrient substances. Enterococcus faecalis is a facultative anaerobic gram-positive lactic acid bacteria, the shape of the bacteria is spherical or chain-shaped, the enterococcus faecalis can form a biological film in the intestinal tract of animals, attach to the intestinal mucosa of the animals, develop, grow and reproduce, and form a lactic acid bacteria barrier to resist the side effects of foreign bacteria, viruses, mycotoxin and the like.
At present, the commonly used feed additives, such as feeding complex enzyme and enterococcus faecalis, which are respectively and independently added into the feed, cannot obviously improve the oxygen supply capacity of livestock and poultry, and have very limited effects in the aspects of production performance and the like.
Disclosure of Invention
The invention aims to solve the problems of limited growth performance and high fatality rate of poultry caused by oxygen supply problem in the prior art, and provides a feed additive for improving the oxygen-gaining capability of poultry, wherein the effective component of the feed additive is 5-aminolevulinic acid, and the feed additive has obvious effect on improving the utilization efficiency of poultry organisms to oxygen. A large number of animal tests prove that the 5-ALA, the feeding complex enzyme and the enterococcus faecalis have a synergistic effect, and the combined use of the 5-ALA, the feeding complex enzyme and the enterococcus faecalis can obviously improve the blood oxygen supply condition of poultry and improve the survival rate and the production performance.
The invention provides a feed additive for improving the oxygen-gaining capacity of poultry, which comprises an active ingredient 5-aminolevulinic acid.
In one embodiment according to the invention, the 5-aminolevulinic acid active ingredient is selected from one or more of 5-aminolevulinic acid, a 5-aminolevulinic acid derivative or a 5-aminolevulinic acid salt.
In one embodiment according to the invention, the feed additive can be a compound additive which comprises 2-10% wt of 5-aminolevulinic acid active ingredient, 10-45% wt of complex enzyme for feed, 10-45% wt of enterococcus faecalis and 0-75% wt of carrier according to the following mass ratio.
In one embodiment according to the invention, the feeding additive comprises a beta-mannanase activity of 2000-6000U/g, a xylanase activity of 8000-20000U/g, a beta-glucanase activity of 400-1000U/g, a pectinase activity of 200-1000U/g and a cellulase activity of 300-600U/g.
In one embodiment according to the invention, the complex enzyme for feed comprises 5000U/g of beta-mannanase activity, 15000U/g of xylanase activity, 800U/g of beta-glucanase activity, 600U/g of pectinase activity and 600U/g of cellulase activity.
In one embodiment according to the invention, the viable count of enterococcus faecalis is 5 × 109—2×1010cfu/g。
In one embodiment according to the invention, the viable count of enterococcus faecalis is 1 × 1010cfu/g。
In one embodiment according to the invention, the carrier is selected from the group consisting of corn starch, wheat starch, tapioca starch, potato starch, beta-cyclodextrin, maltodextrin, modified starch.
In one embodiment according to the invention, 5-aminolevulinic acid is contained at 5% wt, complex enzyme for feed at 30% wt, enterococcus faecalis at 30% wt and corn starch at 35% wt.
The invention also provides the application of the feed additive in poultry breeding. Preferably, the poultry breeding is broiler breeding, and more preferably high-density cage-breeding broilers.
In one embodiment according to the invention, the amount added in the complete feed is 300-1000 g/ton.
The invention has the beneficial effects that:
the additive is applied to poultry, can obviously improve the blood oxygen supply capability of the poultry, reduce the death and culling rate of the poultry, provide the survival rate (particularly reduce the incidence rate of ascites disease of broiler chickens), and can improve the production performance of the poultry.
The specific implementation mode is as follows:
the following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention and to clearly define the scope of the invention.
Example 1
1. Test animal
1296 broiler chickens with the age of 1 day are selected, and are randomly divided into 4 treatments according to the male and female weights, each treatment has 12 times of repetition, each repetition has 27 chickens, each repetition is divided into 3 cages and 3 layers for feeding, and the bottom area of each cage is 0.54 m2The high-density feeding is carried out, the test period is 42 days, and the feeding is carried out in two stages.
2. Daily ration and test design
Before the test is started, the used feed raw materials are collected, the conventional nutrient content of the feed raw materials is analyzed, the feed formula is prepared according to the actual detection result, the content of other nutrient components of each raw material refers to 'Chinese feed components and nutrient value table 2017', and the nutrient requirement refers to the feeding standard of NRC (1994) broiler chickens. Feeding basal diet to control group; one group of experiments is that 25g/t 5-ALA is added into basic daily ration; the two experimental groups are that 150g/t of feeding enzyme preparation and 150g/t of enterococcus faecalis are added into basic daily ration; three groups of experiments are that 25g/t 5-ALA +150g/t feeding enzyme preparation +150g/t enterococcus faecalis are added into basic daily ration, and the experimental design is shown in the table 1:
in the test, the 5-ALA is an effective active ingredient which is more than or equal to 99 percent; the enzyme activity of the feed enzyme preparation is 5000U/g of beta-mannase activity, 15000U/g of xylanase activity, 800U/g of beta-glucanase activity, 600U/g of pectinase activity and 600U/g of cellulase activity; the number of the live enterococcus faecalis for feeding is 1 x 1010cfu/g。
TABLE 1 design of the experiments
3. Feeding management
The feeding test is carried out in a Beijing challenged group following an animal test base, the test process is conventional feeding, free food and water intake, and the immunization and medication are operated according to the immune program and the medication guide of chicken farms.
The raising test is carried out on an empty stomach in the morning respectively at the beginning and the end of the test, the daily feed intake is recorded in the test process, the average feed intake, the daily gain and the feed-meat ratio of the broilers in the whole stage are calculated after the test is finished, 6 broilers which are fasted for 12 hours are randomly extracted from each group at the age of 21d and 42d days in the raising test, the male and female halves are respectively filled with EDTA-K after the heart blood is collected2And detecting the red blood cell number RBC, the hemoglobin concentration HGB and the hematocrit PCV in the anticoagulation tube by using a full-automatic blood analyzer.
Data analysis was performed using SPSS17.0 software ANOVO module one-way analysis. The test results are shown in the following table.
4. Results and analysis
As can be seen from Table 2, the average daily gain and the average daily food consumption of the control group and the test group are not significantly different (P is more than 0.05), but the daily gain of the test group and the control group is significantly different (P is less than 0.05); the daily average food intake has no obvious difference, but the daily average food intake of two groups is obviously lower than that of other groups; the feed-meat ratio of each test group is obviously lower than that of a control group, the feed-meat ratio is reduced by adding 5-ALA, and the combined use effect of the 5-ALA, an enzyme preparation and enterococcus faecalis of the three test groups is better than the single use effect of the 5-ALA or the enzyme preparation and the enterococcus faecalis; the results of the death and culling rate of the broiler chickens show that different additive groups can obviously improve the death and culling rate of the broiler chickens (the incidence rate of ascites diseases is obviously reduced) (P is less than 0.05), and three groups of experiments are obviously superior to one group and two groups of experiments, which shows that the combined use effect of the 5-ALA, the enzyme preparation and the enterococcus faecalis is better.
TABLE 2 Effect of different additives on broiler productivity
Note: no letters in the same row or the same letter indicate no significant difference (P > 0.05), and different letters in the same row indicate significant difference (P < 0.05).
The results in the table 3 show that the addition of 5-ALA alone can obviously improve the red blood cell number RBC, the hemoglobin content HGB and the hematocrit PCV (P is less than 0.05) of the caged broiler chickens 21d and 42 d; the enterococcus faecalis and the enzyme preparation are added together, so that the red cell number RBC, hemoglobin content HGB and packed cell PCV of the broilers 21d and 42d tend to be improved (P is more than 0.05); the enzyme preparation and the enterococcus faecalis are supplemented on the basis of 5-ALA, the red blood cell number RBC, the hemoglobin content HGB and the hematocrit PCV (P is less than 0.05) of the broiler chickens 21d and 42d can be obviously improved, and the combined use effect is better than the single use effect of the 5-ALA, the enzyme preparation and the enterococcus faecalis, which shows that the 5-ALA, the feeding enzyme preparation and the enterococcus faecalis have a synergistic effect to improve the oxygen deficiency condition of the cage-reared broiler chickens.
TABLE 3 influence of different addition groups on blood index of broiler chickens
Note: no letters in the same row or the same letter indicate no significant difference (P > 0.05), and different letters in the same row indicate significant difference (P < 0.05).
Example 2
1. Test animal
1296 broiler chickens with the age of 1 day are selected, and are randomly divided into 4 treatments according to the male and female weights, each treatment has 12 times of repetition, each repetition has 27 chickens, each repetition is divided into 3 cages and 3 layers for feeding, and the bottom area of each cage is 0.54 m2The high-density feeding is carried out, the test period is 42 days, and the feeding is carried out in two stages.
2. Daily ration and test design
Before the test is started, the used feed raw materials are collected, the conventional nutrient content of the feed raw materials is analyzed, the feed formula is prepared according to the actual detection result, the content of other nutrient components of each raw material refers to 'Chinese feed components and nutrient value table 2017', and the nutrient requirement refers to the feeding standard of NRC (1994) broiler chickens. Feeding basal diet to control group; one group of experiments is that 15g/t 5-ALA +150g/t feeding enzyme preparation +150g/t enterococcus faecalis are added into basic daily ration; the test group is that 25g/t 5-ALA +150g/t feeding enzyme preparation +150g/t enterococcus faecalis are added into basic daily ration; three groups of experiments are that 35g/t 5-ALA +150g/t feeding enzyme preparation +150g/t enterococcus faecalis are added into basic daily ration, and the experimental design is shown in the table 1:
in the test, the 5-ALA is an effective active ingredient which is more than or equal to 99 percent; the enzyme activity of the feed enzyme preparation is 5000U/g of beta-mannase activity, 15000U/g of xylanase activity, 800U/g of beta-glucanase activity, 600U/g of pectinase activity and 600U/g of cellulase activity; the number of the live enterococcus faecalis for feeding is 1 x 1010cfu/g。
TABLE 1 design of the experiments
3. Feeding management
The feeding test is carried out in a Beijing challenged group following an animal test base, the test process is conventional feeding, free food and water intake, and the immunization and medication are operated according to the immune program and the medication guide of chicken farms.
The raising test is carried out on an empty stomach in the morning respectively at the beginning and the end of the test, the daily feed intake is recorded in the test process, the average feed intake, the daily gain and the feed-meat ratio of the broilers in the whole stage are calculated after the test is finished, 6 broilers which are fasted for 12 hours are randomly extracted from each group of the raising test at the age of 42d days, each half of a male parent and a female parent are respectively filled with EDTA-K for blood sampling of the heart2And detecting the red blood cell number RBC, the hemoglobin concentration HGB and the hematocrit PCV in the anticoagulation tube by using a full-automatic blood analyzer.
Data analysis was performed using SPSS17.0 software ANOVO module one-way analysis. The test results are shown in the following table.
4. Results and analysis
As can be seen from Table 2, the difference between the daily gain and the average daily feed intake of the control group and each experimental group was not significant (P > 0.05); each test group is obviously lower than the control group in the feed-meat ratio, and the feed-meat ratio of the test group and the control group is obviously different (P is less than 0.05) but the feed-meat ratio of the test group and the control group is not obviously different; the death and panning rate of each test group is obviously lower than that of the control group, and the test groups have obvious difference (P is less than 0.05) compared with the test groups and the control group, which indicates that the bottleneck effect exists in the use of the 5-ALA, and the effect is not more obvious when the adding amount of the 5-ALA is higher.
TABLE 25 influence of ALA in combination with fungal enzymes on broiler productivity
Note: no letters in the same row or the same letter indicate no significant difference (P > 0.05), and different letters in the same row indicate significant difference (P < 0.05).
As can be seen from the results in Table 3, the red blood cell number RBC (P is less than 0.05) of the broiler chicken 42d can be remarkably increased in each test group compared with the control group; two groups of experiments are carried out, and the three groups of experiments have obvious differences (P is less than 0.05) in the hemoglobin content HGB and the hematocrit PCV in the body of the broiler chicken 42d compared with a control group along with the increase of the 5-ALA content under the condition that the bacterial enzyme dosage is not changed; the combination of 5-ALA, feed enzyme preparation and enterococcus faecalis is shown to be capable of obviously improving the oxygen supply capacity of broiler chickens.
TABLE 3 influence of different addition groups on blood index of broiler chickens
Note: no letters in the same row or the same letter indicate no significant difference (P > 0.05), and different letters in the same row indicate significant difference (P < 0.05).
Example 3
1. Design of experiments
1380 healthy Korean quails with the age of 36 weeks are selected in the test and randomly divided into4 groups of 6 replicates (cages). The feeding amount of each quail in one group of test repeat (cage) is 60 per cage, the feeding amount of the quails in two groups of test, three groups of test, four groups of test, five groups of test, six groups of test and seven groups of test is 65 per cage, the quails in the first group and the two groups are fed with basic ration, the three groups of test are 25g/t 5-ALA in the basic ration, the four groups of test are 35g/t 5-ALA in the basic ration, the five groups of test are 150g/t feeding enzyme preparation +150g/t enterococcus faecalis added in the basic ration, and the six groups of test are 25g/t 5-ALA +150g/t feeding enzyme preparation +150g/t enterococcus faecalis added in the basic ration; the test quail is raised in a stacked cage, and the area of the quail cage is 0.7345 m2. Pre-run period 3d, positive run period 28 d.
In the test, the 5-ALA is an effective active ingredient which is more than or equal to 99 percent; the enzyme activity of the feed enzyme preparation is 5000U/g of beta-mannase activity, 15000U/g of xylanase activity, 800U/g of beta-glucanase activity, 600U/g of pectinase activity and 600U/g of cellulase activity; the number of the live enterococcus faecalis for feeding is 1 x 1010cfu/g。
2. Feeding management
The feeding test is carried out in Beijing challenged group following animal test base, and the test quail is fed with food and water freely according to the conventional feeding mode of the farm. The quails of all groups are fed with the same feed, and the feed is a conventional quail feed matched with the quails, so that the nutritional requirements of the quails in the test period can be met. Quail eggs were collected and weighed at 08:00 per day after the start of the trial, the total number of eggs per repeat of quail and the total egg weight were recorded, and the egg laying rate and average egg weight of each repeat of quail were calculated.
Data analysis was performed using SPSS17.0 software ANOVO module one-way analysis. The test results are shown in table 1.
4. Results and analysis
As can be seen from Table 1, the laying rate of quails can be remarkably reduced by high-density feeding (P is less than 0.05), and the addition of 5-ALA or a fungal enzyme combined preparation on the basis of the high-density feeding is beneficial to the improvement of the laying rate (P is less than 0.05); meanwhile, the laying rate of 35g/t 5-ALA supplemented by basic ration is slightly better than that of a 25g/t 5-ALA added group, but no obvious difference exists; the effect of the combined use of the 5-ALA and the bacterial enzyme preparation is obviously better than that of the single use of the 5-ALA (P is less than 0.05); however, the average total egg difference between each control group and the test group is not significant (P > 0.05).
TABLE 15 Effect of ALA in combination with fungal enzymes on quail egg laying Performance
Note: no letters in the same row or the same letter indicate no significant difference (P > 0.05), and different letters in the same row indicate significant difference (P < 0.05).
The above summary and the detailed description are intended to demonstrate the practical application of the technical solutions provided by the present invention, and should not be construed as limiting the scope of the present invention. Various modifications, equivalent substitutions, or improvements may be made by those skilled in the art within the spirit and principles of the invention. The scope of the invention is to be determined by the appended claims.
Claims (10)
1. A feed additive for improving the oxygen-gaining ability of poultry, characterized in that the feed additive comprises the active ingredient 5-aminolevulinic acid.
2. The feed additive of claim 1 wherein the 5-aminolevulinic acid active ingredient is selected from one or more of 5-aminolevulinic acid, a 5-aminolevulinic acid derivative, or a 5-aminolevulinic acid salt.
3. The feed additive of claim 1, wherein the feed additive comprises 2-10% wt of 5-aminolevulinic acid active ingredient, 10-45% wt of feed complex enzyme, 10-45% wt of enterococcus faecalis and 0-75% wt of carrier.
4. The feed additive as claimed in claim 3, wherein the feed additive comprises the beta-mannanase activity of 2000-6000U/g, the xylanase activity of 8000-20000U/g, the beta-glucanase activity of 400-1000U/g, the pectinase activity of 200-1000U/g and the cellulase activity of 300-600U/g.
5. The feed additive of claim 3 wherein the complex feed enzyme comprises a β -mannanase activity of 5000U/g, a xylanase activity of 15000U/g, a β -glucanase activity of 800U/g, a pectinase activity of 600U/g and a cellulase activity of 600U/g.
6. The feed additive of claim 3 wherein the viable count of enterococcus faecalis is 5 x 109—2*1010cfu/g。
7. The feed additive according to any one of claims 3 to 6 wherein the carrier is selected from the group consisting of corn starch, wheat starch, tapioca starch, potato starch, β -cyclodextrin, maltodextrin, modified starch.
8. The feed additive of claim 8 comprising 5% wt of 5-aminolevulinic acid, 30% wt of feeding complex enzyme, 30% wt of enterococcus faecalis and 35% wt of corn starch.
9. Use of a feed additive according to any one of claims 1-8 in poultry farming, preferably in high density poultry farming and poultry farming in high altitude areas.
10. The use as claimed in claim 9, wherein the amount added to the complete feed is 300-1000 g/t.
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| CN202011037608.3A CN112075546A (en) | 2020-09-28 | 2020-09-28 | Feed additive for improving oxygen-gaining capability of poultry and application thereof |
| PCT/CN2021/120945 WO2022063296A1 (en) | 2020-09-28 | 2021-09-27 | Feed additive for improving oxygen obtaining ability of poultry and use thereof |
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| CN112890006A (en) * | 2021-05-07 | 2021-06-04 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
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| CN114158657A (en) * | 2021-12-20 | 2022-03-11 | 北京挑战农业科技有限公司 | Functional amino acid for improving oxidation resistance and immunity of poultry and application thereof |
| WO2022063296A1 (en) * | 2020-09-28 | 2022-03-31 | 天津博菲德科技有限公司 | Feed additive for improving oxygen obtaining ability of poultry and use thereof |
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|---|---|---|---|---|
| WO2022063296A1 (en) * | 2020-09-28 | 2022-03-31 | 天津博菲德科技有限公司 | Feed additive for improving oxygen obtaining ability of poultry and use thereof |
| CN112931713A (en) * | 2021-03-23 | 2021-06-11 | 山东深海生物科技股份有限公司 | Promoter for improving iron nutrition status of piglets and application thereof |
| CN112890006A (en) * | 2021-05-07 | 2021-06-04 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
| CN112890006B (en) * | 2021-05-07 | 2021-08-13 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
| CN113170840A (en) * | 2021-05-20 | 2021-07-27 | 河南邑鸿善成生物技术有限公司 | Feed additive containing 5-aminolevulinic acid and ferrous glycinate as well as preparation method and application thereof |
| CN114158657A (en) * | 2021-12-20 | 2022-03-11 | 北京挑战农业科技有限公司 | Functional amino acid for improving oxidation resistance and immunity of poultry and application thereof |
| CN115024434A (en) * | 2022-08-11 | 2022-09-09 | 北京挑战生物技术有限公司 | Feed additive for prolonging egg laying period of laying hens and application thereof |
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| Publication number | Publication date |
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| WO2022063296A1 (en) | 2022-03-31 |
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