CN112074507A - 作为抗菌素的化合物 - Google Patents

作为抗菌素的化合物 Download PDF

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CN112074507A
CN112074507A CN201980012589.8A CN201980012589A CN112074507A CN 112074507 A CN112074507 A CN 112074507A CN 201980012589 A CN201980012589 A CN 201980012589A CN 112074507 A CN112074507 A CN 112074507A
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membered
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CN112074507B (zh
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黄振华
李丽
张敏
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KBP Biosciences Co Ltd
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

本发明提供一种下述通式(I)所示的新型抗菌剂化合物、其药学上可接受的盐、酯、其前体药物、其溶剂化物、氘代物或其立体异构体。本发明的化合物表现出优异的抗菌活性，特别是针对革兰氏菌表现出优异的抗菌活性。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980012589.8A 2018-02-10 2019-02-11 作为抗菌素的化合物 Active CN112074507B (zh)

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CN201810138645X 2018-02-10
CN201810138645 2018-02-10
CN2018103209801 2018-04-11
CN201810320980 2018-04-11
PCT/CN2019/074771 WO2019154412A1 (zh) 2018-02-10 2019-02-11 作为抗菌素的化合物

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
WO2021195258A1 (en) * 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor, formulations, and uses thereof
WO2023015236A2 (en) * 2021-08-04 2023-02-09 The Research Foundation For The State University Of New York Composition and method for treatment of gram negative bacterial infection
AU2022422562A1 (en) 2021-12-24 2024-06-13 Intervet International B.V. Process of the preparation of hydroxylamine derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101765585A (zh) * 2007-06-12 2010-06-30 尔察祯有限公司 抗菌剂
CN102267924A (zh) * 2003-01-08 2011-12-07 诺华疫苗和诊断公司 抗菌剂
WO2012031298A2 (en) * 2010-09-03 2012-03-08 Duke University Ethynylbenzene derivatives
CN103003233A (zh) * 2010-04-20 2013-03-27 大正制药株式会社 新型异羟肟酸衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529964A (ja) * 2008-08-04 2011-12-15 シェーリング コーポレイション 抗菌剤としての尿素誘導体
EP2512474B1 (en) * 2009-12-16 2014-11-05 Pfizer Inc N-linked hydroxamic acid derivatives useful as antibacterial agents
KR20140023869A (ko) * 2010-11-10 2014-02-27 아카오젠, 인코포레이티드 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용
WO2013170165A1 (en) * 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) * 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
CA2921427A1 (en) * 2013-08-16 2015-02-19 Duke University Substituted hydroxamic acid compounds
CN105777464B (zh) 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
EP3448375B1 (en) * 2016-04-25 2023-09-27 Duke University Benzoylglycine derivatives and methods of making and using same
MX2019007350A (es) * 2016-12-23 2019-11-05 Intervet Int Bv Compuestos para el tratamiento de enfermedad respiratoria bovina o porcina.
MX2019007468A (es) * 2016-12-23 2019-09-09 Intervet Int Bv Compuestos utiles para el tratamiento de una infeccion por mannheimia haemolytica o histophilus somni.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102267924A (zh) * 2003-01-08 2011-12-07 诺华疫苗和诊断公司 抗菌剂
CN101765585A (zh) * 2007-06-12 2010-06-30 尔察祯有限公司 抗菌剂
CN103003233A (zh) * 2010-04-20 2013-03-27 大正制药株式会社 新型异羟肟酸衍生物
WO2012031298A2 (en) * 2010-09-03 2012-03-08 Duke University Ethynylbenzene derivatives

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US20200392096A1 (en) 2020-12-17
CA3090833A1 (en) 2019-08-15
EP3750881A4 (en) 2021-11-17
KR20200120924A (ko) 2020-10-22
CN112074507B (zh) 2023-09-05
BR112020016270A2 (pt) 2020-12-15
JP7412004B2 (ja) 2024-01-12
SG11202007665RA (en) 2020-09-29
JP2021513543A (ja) 2021-05-27
EP3750881A1 (en) 2020-12-16
WO2019154412A1 (zh) 2019-08-15

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