CN112041422A - 具有灌注功能的生物反应器 - Google Patents

具有灌注功能的生物反应器 Download PDF

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Publication number
CN112041422A
CN112041422A CN201980023489.5A CN201980023489A CN112041422A CN 112041422 A CN112041422 A CN 112041422A CN 201980023489 A CN201980023489 A CN 201980023489A CN 112041422 A CN112041422 A CN 112041422A
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China
Prior art keywords
collection chamber
bioreactor
liquid
medium
media collection
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Pending
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CN201980023489.5A
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English (en)
Chinese (zh)
Inventor
华莱士·格雷戈里·索耶
萨曼莎·劳伦·马歇尔
埃里克·O·麦吉
亚历山大·麦吉
凯莉·范·米特
安吉拉·雅典娜·皮特尼斯
胡安·曼努埃尔·乌鲁埃尼亚
德里克·L·胡德
迈克尔·道格堤
克里斯蒂安·乔宾
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University of Florida Research Foundation Inc
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University of Florida Research Foundation Inc
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Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CN112041422A publication Critical patent/CN112041422A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201980023489.5A 2018-02-08 2019-02-08 具有灌注功能的生物反应器 Pending CN112041422A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862628011P 2018-02-08 2018-02-08
US62/628,011 2018-02-08
US201862756732P 2018-11-07 2018-11-07
US62/756,732 2018-11-07
PCT/US2019/017316 WO2019157356A1 (en) 2018-02-08 2019-02-08 Perfusion enabled bioreactors

Publications (1)

Publication Number Publication Date
CN112041422A true CN112041422A (zh) 2020-12-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980023489.5A Pending CN112041422A (zh) 2018-02-08 2019-02-08 具有灌注功能的生物反应器

Country Status (4)

Country Link
EP (1) EP3749335B1 (https=)
JP (1) JP7450269B2 (https=)
CN (1) CN112041422A (https=)
WO (1) WO2019157356A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118086053A (zh) * 2024-04-29 2024-05-28 四川迪亚生物科技集团有限公司 一种自灌流培养板及使用方法
PL443555A1 (pl) * 2023-01-23 2024-07-29 Politechnika Warszawska Urządzenie do automatycznego precyzyjnego powtarzalnego dozowania odczynników
CN119425839A (zh) * 2024-11-15 2025-02-14 广州洁特生物过滤股份有限公司 一种负压超滤离心管装置

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020074698A (ja) * 2018-11-06 2020-05-21 国立大学法人 東京大学 灌流培養システム及び培養方法
NL2025320B1 (en) * 2020-04-09 2021-10-25 Univ Twente Fluidic device, cell culturing system and method of testing a compound
US20230272327A1 (en) * 2020-07-02 2023-08-31 University Of Florida Research Foundation, Inc. Perfusion-enabled bioreactor
US20240368518A1 (en) * 2021-05-30 2024-11-07 University Of Florida Research Foundation, Inc. Devices, systems, and methods relating to pressurized perfusion-enabled bio-reactors
CN117625394B (zh) * 2023-12-01 2024-12-06 东莞合安机电有限公司 一种荔枝菌菌种培养液、制备方法及培养方法

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US20100009335A1 (en) * 2006-02-07 2010-01-14 Victor Joseph Temperature-regulated culture plates
CN203048951U (zh) * 2013-01-24 2013-07-10 中山大学 嵌入式多细胞共培养装置
CN103194390A (zh) * 2013-04-19 2013-07-10 南方医科大学南方医院 双环路振荡灌注式生物反应系统
CN103849567A (zh) * 2012-12-06 2014-06-11 中国科学院大连化学物理研究所 非接触共培养诱导干细胞体外三维定向分化的生物反应器
US20150125942A1 (en) * 2013-11-05 2015-05-07 Axion Biosystems, Inc. Devices, systems, and methods for targeted plating of materials in high-throughput culture plates
CN105518121A (zh) * 2013-07-12 2016-04-20 中南创发生物科技有限公司 肝脏感染
CN205188305U (zh) * 2015-10-22 2016-04-27 深圳爱生再生医学科技有限公司 细胞共培养的培养皿
WO2016182969A1 (en) * 2015-05-08 2016-11-17 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
WO2017049066A1 (en) * 2015-09-18 2017-03-23 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
CN206359535U (zh) * 2016-08-16 2017-07-28 天津市宝恒生物科技有限公司 一种细胞培养皿

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US20070207537A1 (en) * 2004-09-20 2007-09-06 Zhanfeng Cui Bioreactor
US20100009335A1 (en) * 2006-02-07 2010-01-14 Victor Joseph Temperature-regulated culture plates
CN103849567A (zh) * 2012-12-06 2014-06-11 中国科学院大连化学物理研究所 非接触共培养诱导干细胞体外三维定向分化的生物反应器
CN203048951U (zh) * 2013-01-24 2013-07-10 中山大学 嵌入式多细胞共培养装置
CN103194390A (zh) * 2013-04-19 2013-07-10 南方医科大学南方医院 双环路振荡灌注式生物反应系统
CN105518121A (zh) * 2013-07-12 2016-04-20 中南创发生物科技有限公司 肝脏感染
US20150125942A1 (en) * 2013-11-05 2015-05-07 Axion Biosystems, Inc. Devices, systems, and methods for targeted plating of materials in high-throughput culture plates
WO2016182969A1 (en) * 2015-05-08 2016-11-17 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
WO2017049066A1 (en) * 2015-09-18 2017-03-23 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
CN205188305U (zh) * 2015-10-22 2016-04-27 深圳爱生再生医学科技有限公司 细胞共培养的培养皿
CN206359535U (zh) * 2016-08-16 2017-07-28 天津市宝恒生物科技有限公司 一种细胞培养皿

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL443555A1 (pl) * 2023-01-23 2024-07-29 Politechnika Warszawska Urządzenie do automatycznego precyzyjnego powtarzalnego dozowania odczynników
PL249320B1 (pl) * 2023-01-23 2026-03-23 Politechnika Warszawska Urządzenie do automatycznego precyzyjnego powtarzalnego dozowania odczynników
CN118086053A (zh) * 2024-04-29 2024-05-28 四川迪亚生物科技集团有限公司 一种自灌流培养板及使用方法
CN119425839A (zh) * 2024-11-15 2025-02-14 广州洁特生物过滤股份有限公司 一种负压超滤离心管装置

Also Published As

Publication number Publication date
EP3749335A4 (en) 2021-11-03
EP3749335A1 (en) 2020-12-16
JP2021513363A (ja) 2021-05-27
EP3749335B1 (en) 2025-09-24
WO2019157356A1 (en) 2019-08-15
JP7450269B2 (ja) 2024-03-15

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