CN112021572A - 一种醒酒保肝保健食品及其制备方法 - Google Patents
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
本发明涉及食品的技术领域，具体涉及一种醒酒保肝保健食品及其制备方法，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素5％‑15％、番茄红素0.5％‑5％、水飞蓟素5％‑15％、维生素C 5％‑15％、玉米低聚肽10％‑30％、L‑半胱氨酸20％‑60％、玉米淀粉10％‑30％，各组份总量为100％。本发明经过无数次的动物试验，一方面验证各单独成分的解酒护肝效果，另一方面通过不同的组合来测试解酒护肝效果，最终证明本组方的解酒护肝效果最好，明显优于其它组方，且无任何不良反应和毒副作用。
Description
技术领域
本发明涉及食品的技术领域，具体涉及一种醒酒保肝保健食品及其制备方法。
背景技术
中国有着几千年的酒文化，饮酒特别是高度白酒成为中国人社交聚会的重要环节，高度白酒通常含有50％以上的酒精。酒精在体内先代谢为乙醇，经过乙醇脱氢酶脱氢而生成乙醛。由于酒精代谢产生的乙醛对人体肝脏、胰脏、肾脏功能的严重损伤，导致了众多因为酒精而引起的慢性疾病，特别是肝脏疾病，包括脂肪肝、肝炎、肝纤维化、肝硬化、肝癌等。此外，乙醛可对神经组织造成直接或间接的损害，导致记忆缺陷和认知障碍。在欧美国家，酒精性肝病是中青年死亡的主要原因，据报道，美国患有酒精性肝病的患者超过200万。我国也是酒精性肝病的发病大国，且有年轻化的趋势。目前还没有针对这些酒精性疾病的特效药物，但许多国家国有针对预防或缓解酒精性疾病的保健食品或药物。
我国传统的解酒药以中药材为主，根据前人的经验总结，这些中药材主要包括人参、茯苓、葛花、葛根、枳椇子、陈皮、灵芝、蜂蜜等。但是实际使用过程中，这些中药食材的解酒效果争议较大，且不能起到广谱的解酒功效。如果能开发出一种具有广谱解酒保肝的安全的保健食品，将会带来巨大的社会效益和经济效益。
发明内容
本发明的目的之一在于提供一种醒酒保肝保健食品，能够减少酒精对身体的毒害，并达到保护肝脏的效果。
本发明的目的之二在于提供一种醒酒保肝保健食品的制备方法，制备工艺简便，易于调节。
本发明实现目的之一所采用的方案是：一种醒酒保肝保健食品，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素5％-15％、番茄红素0.5％-5％、水飞蓟素5％-15％、维生素C 5％-15％、玉米低聚肽10％-30％、L-半胱氨酸20％-60％、玉米淀粉10％-30％。
优选地，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素6％-12％、番茄红素0.8％-4％、水飞蓟素6％-12％、维生素C 6％-12％、玉米低聚肽15％-25％、L-半胱氨酸30％-50％、和玉米淀粉15％-25％。
优选地，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素8％、番茄红素3％、水飞蓟素10％、维生素C12％、玉米低聚肽15％、L-半胱氨酸30％、和玉米淀粉22％。
本发明实现目的之二所采用的方案是：一种所述的醒酒保肝保健食品的制备方法，包括以下步骤：(1)根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉；
(2)将上述原料进行混合、干燥、制粒、整粒、灌注胶囊或压片包衣，制成固体制剂，或将上述原料混合溶解于一定的溶解介质中，灌装后制成口服液。
优选地，所述步骤(2)中，固体制剂为颗粒剂、片剂、胶囊剂、丸剂、粉剂中的至少一种；溶解介质为工艺用水、缓冲液、生理盐水、乳化剂、防腐剂中的任意一种。
本发明具有以下优点和有益效果：
本发明组方中，原花青素、番茄红素、水飞蓟素具有强力的抗氧化功能，可快速修复受损的肝脏细胞，并具有抗衰老、延缓皮肤老化的功效。玉米低聚肽具有抑制酒精的作用。维生素C能抗氧化、解毒，是最常用的膳食补充剂。L-半胱氨酸是一种氨基酸类解毒药，有保护肝细胞、促进肝脏功能恢复的功效。
本发明经过无数次的动物试验，一方面验证各单独成分的解酒护肝效果，另一方面通过不同的组合来测试解酒护肝效果，最终证明本组方的解酒护肝效果最好，明显优于其它组方，且无任何不良反应和毒副作用。
具体实施方式
为更好的理解本发明，下面的实施例是对本发明的进一步说明，但本发明的内容不仅仅局限于下面的实施例。
实施例1解酒保肝胶囊的制备
本实施例的醒酒保肝胶囊由以下重量百分比计的原料制成：原花青素8％、番茄红素3％、水飞蓟素10％、维生素C12％、玉米低聚肽15％、L-半胱氨酸30％、玉米淀粉22％，根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉，将上述原料进行混合、干燥、制粒、整粒、灌注胶囊，分装。为便于表述，将该醒酒保肝胶囊命名为XJBG-1胶囊。
实施例2解酒保肝胶囊的制备
本实施例的醒酒保肝片剂由以下重量百分比计的原料制成：原花青素15％、番茄红素5％、水飞蓟素15％、维生素C 5％、玉米低聚肽30％、L-半胱氨酸20％、玉米淀粉10％，根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉，将上述原料进行混合、干燥、压片包衣，分装，得到醒酒保肝片剂。
实施例3解酒保肝胶囊的制备
本实施例的醒酒保肝口服液由以下重量百分比计的原料制成：原花青素5％、番茄红素0.5％、水飞蓟素15％、维生素C 5％、玉米低聚肽10％、L-半胱氨酸34.5％、玉米淀粉30％，根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉，将上述原料进行混合、干燥后溶解于溶解介质中，分装，得到醒酒保肝口服液。
实施例4解酒保肝胶囊的制备
本实施例的醒酒保肝粉剂由以下重量百分比计的原料制成：原花青素5％、番茄红素5％、水飞蓟素5％、维生素C 5％、玉米低聚肽10％、L-半胱氨酸60％、玉米淀粉10％，根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉，将上述原料进行混合、干燥后研磨成粉，分装，得到醒酒保肝粉剂。
实施例5解酒保肝胶囊的制备
本实施例的醒酒保肝丸剂由以下重量百分比计的原料制成：原花青素15％、番茄红素2％、水飞蓟素13％、维生素C15％、玉米低聚肽10％、L-半胱氨酸25％、玉米淀粉20％，根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉，将上述原料进行混合、干燥后制丸包衣，分装，得到醒酒保肝丸剂。
实施例6XJBG-1胶囊对小鼠的解酒作用
实验方法：
翻正实验：30只实验小鼠(SPF级昆明鼠，雌雄各半，～20g)，按照雌雄各半随机分成3组，每组10只，分别为模型组、阳性药组、XJBG-1胶囊组，其中阳性药为某市售解酒产品。实验前禁食12小时。两组给药组分别灌胃给药0.25ml/10g(20倍人体剂量)，模型组给与等容积蒸馏水。给药30分钟后，各组均用56％(V/V)红星二锅头白酒按0.15mL/10g体重灌服。记录各小鼠醉酒耐受时间和消失持续时间。
醉酒睡眠实验：动物分组与处理方法同上。灌服白酒后，记录小鼠活动情况。以小鼠爬行不稳、后腹部拖地、闭眼懒动为醉酒睡眠指标，以行动自如、四肢灵活、精神恢复为醒酒指标，记录各小鼠入睡和苏醒时间，并计算睡眠耐受时间和持续时间。
实验结果：
表1、实验小鼠翻正反应和醉酒睡眠时间结果(x±s)
注：()中的数字为除去死亡小鼠或未醉酒小鼠后的小鼠数。与模型组比：***p<0.001。
上述实验结果表明，XJBG-1胶囊能显著延长实验小鼠的醉酒和睡眠潜伏时间，能显著加速醉酒小鼠的解酒和缩短醉酒睡眠持续时间。
实施例7XJBG-1胶囊对小鼠酒精性肝损伤的保护作用
实验方法：
40只雄性实验小鼠，体重20-22克，分成4组，分别为高剂量药物组，低剂量药物组，空白对照组，模型组，其中高剂量药物组为30倍人体摄入量的XJBG-1胶囊,低剂量组为10倍人体摄入量的XJBG-1胶囊，空白对照组和模型组给与生理盐水。每日经灌胃给与相应的受试物，空白对照组和模型组给与生理盐水，每天一次，连续给与受试物或生理盐水30天。然后受试物组和模型组一次灌胃给与50％乙醇，给与量为12ml/kg.BW，空白组给与生理盐水。禁食16小时后处死小鼠，然后检测肝组织中的丙二醛(MDA)，还原性谷胱甘肽(GSH)和甘油三酯(TG)。
实验结果：
表2、XJBG-1胶囊对酒精性肝损伤小鼠的保护结果(x±s)
| 组别 | TG(mmol/L) | MDA(nmol/mg蛋白) | GSH(mg/mg蛋白) |
| 模型组 | 16.26±3.92 | 4.25±1.08 | 22.38±3.72 |
| XJBG-1低剂量组 | 9.18±2.42** | 2.63±0.87** | 24.58±3.83 |
| XJBG-1高剂量组 | 7.09±1.67*** | 2.35±0.64*** | 25.14±3.91* |
| 空白对照组 | 6.73±1.51 | 1.89±0.38 | 26.23±3.34 |
注：与模型组比：*p<0.05，**p<0.01，***p<0.001。
上述实验结果表明，XJBG-1胶囊能显著降低实验小鼠的丙二醛和甘油三酯的升高，从而起到保护实验小鼠的酒精性肝损伤。
综上所述，本发明经过无数次的动物试验，一方面验证各单独成分的解酒护肝效果，另一方面通过不同的组合来测试解酒护肝效果，最终证明本组方的解酒护肝效果最好，明显优于其它组方，且无任何不良反应和毒副作用。
以上所述是本发明的优选实施方式而已，当然不能以此来限定本发明之权利范围，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和变动，这些改进和变动也视为本发明的保护范围。
Claims (5)
1.一种醒酒保肝保健食品，其特征在于，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素5％-15％、番茄红素0.5％-5％、水飞蓟素5％-15％、维生素C 5％-15％、玉米低聚肽10％-30％、L-半胱氨酸20％-60％、玉米淀粉10％-30％，各组份总量为100％。
2.根据权利要求1所述的醒酒保肝保健食品，其特征在于，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素6％-12％、番茄红素0.8％-4％、水飞蓟素6％-12％、维生素C 6％-12％、玉米低聚肽15％-25％、L-半胱氨酸30％-50％、和玉米淀粉15％-25％，各组份总量为100％。
3.根据权利要求1所述的醒酒保肝保健食品，其特征在于，该醒酒保肝保健食品由以下重量百分比计的原料制成：原花青素8％、番茄红素3％、水飞蓟素10％、维生素C12％、玉米低聚肽15％、L-半胱氨酸30％、和玉米淀粉22％。
4.一种如权利要求1-3中任一项所述的醒酒保肝保健食品的制备方法，其特征在于，包括以下步骤：(1)根据配方称取原花青素、番茄红素、水飞蓟素、维生素C、玉米低聚肽、L-半胱氨酸、和玉米淀粉；
(2)将上述原料进行混合、干燥、制粒、整粒、灌注胶囊或压片包衣，制成固体制剂，或将上述原料混合溶解于一定的溶解介质中，灌装后制成口服液。
5.根据权利要求4所述的醒酒保肝保健食品的制备方法，其特征在于：所述步骤(2)中，固体制剂为颗粒剂、片剂、胶囊剂、丸剂、粉剂中的至少一种；溶解介质为工艺用水、缓冲液、生理盐水、乳化剂、防腐剂中的任意一种。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113261635A (zh) * | 2021-01-22 | 2021-08-17 | 云南品斛堂酒业有限公司 | 一种具有醒酒、益胃、生津功效的饮料及其制备方法 |
| CN113693214A (zh) * | 2021-07-14 | 2021-11-26 | 西藏名承坤泰生物科技有限公司 | 一种番茄枸杞辣木粉及其制备方法 |
| CN114767826A (zh) * | 2022-04-01 | 2022-07-22 | 河北科技大学 | 一种醒酒护肝组合物、具有醒酒护肝功效的饮料及其制备方法 |
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| CN113261635A (zh) * | 2021-01-22 | 2021-08-17 | 云南品斛堂酒业有限公司 | 一种具有醒酒、益胃、生津功效的饮料及其制备方法 |
| CN113693214A (zh) * | 2021-07-14 | 2021-11-26 | 西藏名承坤泰生物科技有限公司 | 一种番茄枸杞辣木粉及其制备方法 |
| CN114767826A (zh) * | 2022-04-01 | 2022-07-22 | 河北科技大学 | 一种醒酒护肝组合物、具有醒酒护肝功效的饮料及其制备方法 |
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