CN111990407A - Compound polyhexamethylene biguanide hydrochloride disinfectant and preparation method thereof - Google Patents
Compound polyhexamethylene biguanide hydrochloride disinfectant and preparation method thereof Download PDFInfo
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- CN111990407A CN111990407A CN202011008377.3A CN202011008377A CN111990407A CN 111990407 A CN111990407 A CN 111990407A CN 202011008377 A CN202011008377 A CN 202011008377A CN 111990407 A CN111990407 A CN 111990407A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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Abstract
The invention discloses a compound polyhexamethylene biguanide hydrochloride disinfectant and a preparation method thereof, which comprises, by weight, 0.1-5% of polyhexamethylene biguanide, less than or equal to 0.1% of glutaraldehyde, 0.3-0.9% of a pH regulator, 0.1-0.5% of a chelating agent, 0.1-0.5% of a stabilizer, 0.1-0.9% of a humectant, 1% of a surfactant and the balance of water; the method comprises the following steps: firstly, adding polyhexamethylene biguanide into purified water according to a proportion, uniformly stirring, then adding glutaraldehyde and stirring; then adding a chelating agent, a surfactant and a stabilizer after adding the humectant, and fixing the volume; and finally, adding a pH regulator to regulate the pH to be between 5.0 and 6.5. The invention takes the polyhexamethylene biguanide as a main effective component, controls the mass ratio of the polyhexamethylene biguanide to other auxiliary additives in the disinfectant, can generate a synergistic interaction effect between the polyhexamethylene biguanide and the other auxiliary additives, achieves an effective disinfection effect under the condition of low biguanide content, meets the disinfection requirement of the surface of an object, and is suitable for disinfection and cleaning of the surface of articles such as medical instruments and the like.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a compound polyhexamethylene biguanide hydrochloride disinfectant and a preparation method thereof.
Background
Polyhexamethylene biguanide is a broad-spectrum antibacterial agent which is researched by Avecigo corporation in England and is generally recognized as the safest and efficient 21 st century, is colorless and tasteless, has low dosage, broad-spectrum and low toxicity, has high action speed and low foam quantity, can form a layer of cation on the surface of an article for a long time, does not generate antibacterial property, has the safety approved by FDA and EPA in the United states, and has the semi-lethal dose LD50 of more than 5000mg/kg for mice, which is practically nontoxic. The environment-friendly high-molecular polymer disinfectant, namely polyhexamethylene guanidine, has broad-spectrum sterilization; the effective concentration is low; the action speed is high; the property is stable; excellent performance of being easily dissolved in water; can be used at normal temperature; long-term bacteriostasis without side effect; no corrosion; colorless and odorless; is nontoxic; the material is non-combustible, non-explosive and safe to use; the polyhexamethylene biguanide (PHMB) has broad-spectrum, long-term and high-efficiency sterilization and disinfection capability, the toxicity of the PHMB is determined to be a non-toxic grade bactericide after detection, the PHMB has no irritation to skin mucous membrane and can be completely biodegraded, and the unique sterilization mechanism of the PHMB does not generate any drug resistance.
The polyhexamethylene biguanide serving as an environment-friendly degradable high-molecular polymer sterilization disinfectant has higher safety, mildness and sterilization performance compared with other salts, has no damage to various materials, is non-corrosive and degradable, has a good killing effect on bacterial propagules due to a guanidine disinfectant with small environmental influence, changes the killing effect on fungi and mycobacteria with strong resistance, certain hydrophilic viruses and the like, basically has no killing effect on bacterial spores, and only can inhibit germination and propagation of the bacterial spores. Therefore, the single-component aqueous solution of the compound is only suitable for washing disinfection or antibacterial application, and can achieve the purpose of comprehensive sterilization only after being compounded with other synergistic components.
Glutaraldehyde is effective in killing bacteria, spores, fungi and viruses. The glutaraldehyde disinfectant is a novel, efficient and low-toxicity neutral intensified disinfectant, and can kill pathogenic microorganisms such as bacterial propagules, bacterial spores, hepatitis viruses and the like. Since the notification of the release of the regulation of the limit value of the partial component in the skin mucosa disinfectant by the Ministry of health (Ministry of health and Law. [ 2003 ] 2014) specifies the limit concentration (W/V) of the partial component in the mucosa disinfectant for skin to be 0.10%. Therefore, the concentration of the glutaraldehyde is less than or equal to 0.10% (W/V)
The killing action to microbe depends mainly on aldehyde group, and these medicines mainly act on mercapto group, hydroxyl group, carboxyl group and amino group of mycoprotein to alkylate it and to cause protein coagulation and death of bacteria. The glutaraldehyde has the advantages of small irritation, low corrosivity, safety and no toxicity under the use concentration of 0.10%;
except for the polyhexamethylene biguanide and the glutaraldehyde, other disinfectants have common weaknesses such as bleaching and corrosion effects on clothes and the like, are easy to oxidize and difficult to store, have certain toxicity and irritation, and the oxygen-containing disinfectants are easy to generate secondary pollution to the environment.
Disclosure of Invention
In view of the above, the invention provides a compounded polyhexamethylene biguanide hydrochloride disinfectant and a preparation method thereof, which have the advantages of good disinfection effect, low production cost, irritation, safety and no toxicity.
In order to achieve the purpose, the invention provides the following technical scheme:
the compounded polyhexamethylene methyl biguanide hydrochloride disinfectant consists of polyhexamethylene methyl biguanide 0.1-5 wt%, glutaraldehyde not more than 0.1 wt%, pH regulator 0.3-0.9 wt%, chelating agent 0.1-0.5 wt%, stabilizer 0.1-0.5 wt%, humectant 0.1-0.9 wt%, surfactant 1 wt% and water for the rest.
Preferably, in the compound polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the pH value of the disinfectant is 5.0-6.5.
Preferably, in the above compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, polyhexamethylene biguanide is hydrochloride, and the molecular formula is:
preferably, in the compound polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the stabilizer is sodium nitrite to prevent products needing disinfection from rusting.
Preferably, in the compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the chelating agent is one or two of citric acid and tartaric acid.
Preferably, in the compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the humectant is one or more of glycerol, sodium hyaluronate, collagen or aloe gel.
Preferably, in the above compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the surfactant is benzethonium chloride.
Preferably, in the above compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the pH regulator is one of lactic acid, malic acid, sodium citrate or potassium citrate.
Preferably, in the above compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the method comprises the following steps: firstly, adding polyhexamethylene biguanide into purified water according to a proportion, uniformly stirring, then adding glutaraldehyde and stirring; then adding a chelating agent, a surfactant and a stabilizer after adding the humectant, and fixing the volume; and finally, adding a pH regulator to regulate the pH to be between 5.0 and 6.5.
Preferably, in the above compounded polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof, the method comprises the following steps: firstly, adding polyhexamethylene biguanide and aminoglycoside into purified water according to the weight ratio of 100:1, uniformly stirring, then adding glutaraldehyde and stirring; then adding a chelating agent, a surfactant and a stabilizer after adding the humectant, and fixing the volume; and finally, adding a pH regulator to regulate the pH to be between 5.0 and 6.5.
According to the technical scheme, compared with the prior art, the invention has the following characteristics:
the invention takes the poly-hexamethylene biguanide as the main effective component, controls the mass ratio of the poly-hexamethylene biguanide to other auxiliary additives in the disinfectant, can generate the synergistic interaction between the poly-hexamethylene biguanide and other auxiliary additives, achieves the effective disinfection effect under the condition of low biguanide content, meets the disinfection requirement of the surface of an object, and is suitable for the disinfection and cleaning of the surface of articles such as medical instruments and the like;
the compounded polyhexamethylene biguanide hydrochloride (PHMB) disinfectant is suitable for medical and personal care products and household disinfection, sterilization and corrosion prevention. The product has broad-spectrum antibacterial effect, and can kill gram-positive bacteria, gram-negative bacteria, fungi, yeast, etc. Can be widely applied to the fields of daily chemical industry, medical treatment and health, and the like.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Please refer to the compound polyhexamethylene biguanide hydrochloride disinfectant and the preparation method thereof disclosed by the invention, which specifically comprises the following steps:
comprises 0.1 to 5 percent of polyhexamethylene biguanide, less than or equal to 0.1 percent of glutaraldehyde, 0.3 to 0.9 percent of pH regulator, 0.1 to 0.5 percent of chelating agent, 0.1 to 0.5 percent of stabilizer, 0.1 to 0.9 percent of humectant, 1 percent of surfactant and the balance of water.
Example 1:
| polyhexamethylene biguanide hydrochloride | 0.36 |
| Glutaraldehyde | 0.1 |
| Other auxiliary additives | 2 |
| Purified water | Balance of |
The pH was adjusted to 5.5. Wherein, the pH regulator is 0.5 percent, the chelating agent is 0.2 percent, the stabilizing agent is 0.3 percent, the humectant is 0.1 to 0.9 percent, and the surfactant is 1 percent.
Example 2:
| polyhexamethylene biguanide hydrochloride | 0.25 |
| Glutaraldehyde | 0.05 |
| Other auxiliary additives | 2.5 |
| Purified water | Balance of |
The pH was adjusted to 6. Wherein, the pH regulator is 0.7 percent, the chelating agent is 0.3 percent, the stabilizing agent is 0.2 percent, the humectant is 0.3 percent, and the surfactant is 1 percent.
Example 3:
| polyhexamethylene biguanide hydrochloride | 2 |
| Glutaraldehyde | 0.1 |
| Other auxiliary additives | 1.6 |
| Purified water | Balance of |
The pH was adjusted to 6.5. Wherein, the pH regulator is 0.3 percent, the chelating agent is 0.1 percent, the stabilizing agent is 0.1 percent, the humectant is 0.1 percent, and the surfactant is 1 percent.
In example 1, the results of the quantitative sterilization test are as follows:
first, experimental basis
1. A neutralizer identification test and a bacteria quantitative sterilization test: ministry of health, Disinfection technical Specification (2002 edition) 2.1.1.5.5 and 2.1.1.7.4.
2. A neutralizer identification test and a bacteria quantitative sterilization test: ministry of health, Disinfection technical Specification (2002 edition) 2.1.1.5.5 and 2.1.1.9.
Second, check the conclusion
1. A neutralizer identification test and a bacteria quantitative sterilization test:
after 3 times of repeated tests, the results show that the TSB neutralizer containing 1.5% of soap base, 6.5% of Tween 80 and 4.5% of lecithin can neutralize the sterilization components in the antibacterial spray of the Longsha spray, and the neutralizer and the neutralized product have no obvious influence on the growth of the test bacteria and the culture medium. The result shows that the neutralizing agent is suitable for quantitative sterilization tests of the experimental sample on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa.
Repeated tests for 3 times show that the Longsha spray can act on Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in suspension for 3min, and the sterilization log value is greater than 5.00.
2. A neutralizer identification test and a bacteria quantitative sterilization test:
after 3 times of repeated tests, the results show that the TSB neutralizer containing 1.5% of soap base, 6.5% of Tween 80 and 4.5% of lecithin can neutralize the sterilization components in the antibacterial spray of the Longsha spray, and the neutralizer and the neutralized product have no obvious influence on the growth of the test bacteria and the culture medium. The neutralizing agent is indicated to be suitable for the quantitative sterilization test of the experimental sample on the candida albicans.
3 times of repeated tests show that the Longsha spray can be used for spraying the antibacterial spray to Candida albicans in suspension for 3min, and the sterilization log values are all more than 4.00.
As can be seen, the PHMB of the present invention has no surface activity and is stable and effective in a pH range of 1 to 11. Polyhexamethylene biguanide hydrochloride PHMB is compatible with nonionic surfactants, alcohols, glycol ethers, most strong acids and chelating agents (e.g. EDTA, NTA, IDS). Polyhexamethylene biguanide hydrochloride PHMB has limited compatibility with anionic surfactants, bases, complex phosphates and strong oxidizers. The effective components are stable to heat and are nonvolatile. It is generally stable down to 0 ℃ under storage conditions. If frozen, please thaw at room temperature and stir well before use. Directly diluting with purified water or mixing with other adjuvants. The reference dosage is 1: 125-1: 1000 (w/w).
The use method of the wet tissue industry comprises the following steps: 0.2% -0.4% effective content, specifically 0.2% effective concentration of non-woven fabric, and 0.3-0.4% effective concentration of towel.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The compounded polyhexamethylene methyl biguanide hydrochloride disinfectant consists of polyhexamethylene methyl biguanide 0.1-5 wt%, glutaraldehyde not more than 0.1 wt%, pH regulator 0.3-0.9 wt%, chelating agent 0.1-0.5 wt%, stabilizer 0.1-0.5 wt%, humectant 0.1-0.9 wt%, surfactant 1 wt% and water for the rest.
2. The compound polyhexamethylene biguanide hydrochloride disinfectant of claim 1 in which the pH of the disinfectant is 5.0-6.5.
3. The compound polyhexamethylene methyl biguanide hydrochloride disinfectant as claimed in claim 1, wherein polyhexamethylene methyl biguanide hydrochloride has a molecular formula of:
4. the compound polyhexamethylene methyl biguanide hydrochloride disinfectant of claim 1 wherein the stabilizer is sodium nitrite to prevent rusting of the product to be disinfected.
5. The compound polyhexamethylene methyl biguanide hydrochloride disinfectant of claim 1 wherein the chelating agent is one or both of citric acid and tartaric acid.
6. The compound polyhexamethylene methyl biguanide hydrochloride disinfectant of claim 1 wherein the humectant is one or more of glycerin, sodium hyaluronate, collagen or aloe vera gel.
7. The compounded polyhexamethylene methyl biguanide hydrochloride disinfectant of claim 1 wherein the surfactant is benzethonium chloride.
8. The compound polyhexamethylene methyl biguanide hydrochloride disinfectant of claim 1 wherein the pH adjusting agent is one of lactic acid, malic acid, sodium citrate or potassium citrate.
9. The preparation method of the compound polyhexamethylene biguanide hydrochloride disinfectant as claimed in any one of claims 1 to 8, which comprises the following steps: firstly, adding polyhexamethylene biguanide into purified water according to a proportion, uniformly stirring, then adding glutaraldehyde and stirring; then adding humectant and adding chelate.
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| CN202011008377.3A CN111990407A (en) | 2020-09-23 | 2020-09-23 | Compound polyhexamethylene biguanide hydrochloride disinfectant and preparation method thereof |
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| CN202011008377.3A CN111990407A (en) | 2020-09-23 | 2020-09-23 | Compound polyhexamethylene biguanide hydrochloride disinfectant and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114342950A (en) * | 2021-12-31 | 2022-04-15 | 上海明涌新材料有限公司 | Macromolecular guanidine salt disinfectant and preparation method and preparation thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751230A (en) * | 2016-08-16 | 2018-03-06 | 中国石油天然气股份有限公司 | A kind of water injection well bactericide and its preparation method and application |
| CN109381480A (en) * | 2018-11-15 | 2019-02-26 | 南京聚锦医药科技有限公司 | Compound poly hexamethylene biguanide thimerosal and preparation method thereof |
| CN111226929A (en) * | 2020-03-06 | 2020-06-05 | 吉林云飞医药有限公司 | Glutaraldehyde disinfectant, and preparation method and application thereof |
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2020
- 2020-09-23 CN CN202011008377.3A patent/CN111990407A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751230A (en) * | 2016-08-16 | 2018-03-06 | 中国石油天然气股份有限公司 | A kind of water injection well bactericide and its preparation method and application |
| CN109381480A (en) * | 2018-11-15 | 2019-02-26 | 南京聚锦医药科技有限公司 | Compound poly hexamethylene biguanide thimerosal and preparation method thereof |
| CN111226929A (en) * | 2020-03-06 | 2020-06-05 | 吉林云飞医药有限公司 | Glutaraldehyde disinfectant, and preparation method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114342950A (en) * | 2021-12-31 | 2022-04-15 | 上海明涌新材料有限公司 | Macromolecular guanidine salt disinfectant and preparation method and preparation thereof |
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