CN111978325B - 咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用 - Google Patents
咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用 Download PDFInfo
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- CN111978325B CN111978325B CN201910431113.XA CN201910431113A CN111978325B CN 111978325 B CN111978325 B CN 111978325B CN 201910431113 A CN201910431113 A CN 201910431113A CN 111978325 B CN111978325 B CN 111978325B
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- acid
- pharmaceutically acceptable
- pyridazin
- alkyl
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 125000003831 tetrazolyl group Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910431113.XA CN111978325B (zh) | 2019-05-22 | 2019-05-22 | 咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用 |
| PCT/CN2020/091893 WO2020233716A1 (fr) | 2019-05-22 | 2020-05-22 | Inhibiteurs de kinase imidazopyridazine mnk1/mnk2, procédé de préparation correspondant et utilisation associée |
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| CN201910431113.XA CN111978325B (zh) | 2019-05-22 | 2019-05-22 | 咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用 |
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| CN111978325A CN111978325A (zh) | 2020-11-24 |
| CN111978325B true CN111978325B (zh) | 2023-11-17 |
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Country Status (2)
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|---|---|
| CN (1) | CN111978325B (fr) |
| WO (1) | WO2020233716A1 (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009144395A1 (fr) * | 2008-03-21 | 2009-12-03 | Sanofi-Aventis | DÉRIVÉS POLYSUBSTITUES DE 2-HETEROARYL-6-PHENYL-IMIDAZO[1,2- α]PYRIDINES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE |
| WO2014138692A1 (fr) * | 2013-03-07 | 2014-09-12 | Califia Bio, Inc. | Inhibiteurs de kinases de lignée mixte et procédés thérapeutiques |
| CN104350055A (zh) * | 2012-03-30 | 2015-02-11 | 新加坡科技研究局 | 作为mnk1和mnk2调节剂的二环杂芳基衍生物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541243B (zh) * | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| CA2837630A1 (fr) * | 2011-06-01 | 2012-12-06 | Knut Eis | Aminoimidazopyridazines substituees |
| GB2518873A (en) * | 2013-10-03 | 2015-04-08 | Agency Science Tech & Res | Bicyclic alkyne derivatives and uses thereof |
| CN107108636A (zh) * | 2014-12-23 | 2017-08-29 | 拜耳医药股份公司 | 6‑羟基苯并呋喃基‑和6‑烷氧基苯并呋喃基‑取代的咪唑并哒嗪 |
-
2019
- 2019-05-22 CN CN201910431113.XA patent/CN111978325B/zh active Active
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2020
- 2020-05-22 WO PCT/CN2020/091893 patent/WO2020233716A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009144395A1 (fr) * | 2008-03-21 | 2009-12-03 | Sanofi-Aventis | DÉRIVÉS POLYSUBSTITUES DE 2-HETEROARYL-6-PHENYL-IMIDAZO[1,2- α]PYRIDINES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE |
| CN104350055A (zh) * | 2012-03-30 | 2015-02-11 | 新加坡科技研究局 | 作为mnk1和mnk2调节剂的二环杂芳基衍生物及其用途 |
| WO2014138692A1 (fr) * | 2013-03-07 | 2014-09-12 | Califia Bio, Inc. | Inhibiteurs de kinases de lignée mixte et procédés thérapeutiques |
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| Publication number | Publication date |
|---|---|
| WO2020233716A1 (fr) | 2020-11-26 |
| CN111978325A (zh) | 2020-11-24 |
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