CN111973670A - Wuzi mulberry chrysanthemum composition and preparation method and application thereof - Google Patents
Wuzi mulberry chrysanthemum composition and preparation method and application thereof Download PDFInfo
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- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
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Abstract
The invention relates to a Wuzi mulberry chrysanthemum composition and a preparation method and application thereof. The composition comprises parched semen Cassiae, parched Raphani semen, parched fructus Perillae, flos Chrysanthemi, folium Mori, fructus Gardeniae and semen Sesami Niger. The selection of the specific traditional Chinese medicine components of the wuzi mulberry chrysanthemum composition provided by the invention has an obvious effect on heat accumulation under the condition of greatly reducing the number of medicinal materials, and has the advantages of simple formula, no toxic or side effect, safety, reliability and convenience in taking.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a wuzi mulberry chrysanthemum composition as well as a preparation method and application thereof.
Background
With the development of society, the life style of people is gradually changed, and people suffering from constipation are gradually increased due to irregular diet, sedentary, lack of exercise, excessive living and working pressure and other factors. Constipation has become one of the important factors which troubles people's daily life, not only causes damage to the body of the patient, but also brings great influence to the psychology of the patient, and aggravates or induces various diseases, such as hemorrhoids, anal fissure, intestinal tumor, facial disfigurement disease, heart failure, sudden death, cerebral infarction and the like, and indirectly threatens the life of human beings. Epidemiology shows that the incidence rate of chronic constipation in China is rising year by year, the onset age is in a youthful trend, and constipation patients are more in the age range of less than 35 years old and 45-75 years old. The total incidence rate of constipation in China is 10-15%, wherein the incidence rate of patients over 60 years old accounts for 18-23%.
The causes of constipation are very complex and not clear at present, and factors such as bad living habits (dietary patterns, smoking, drinking, defecation habits, sleeping), psychopsychological factors and other factors such as age and sex are all related to the occurrence of constipation.
Constipation belongs to the categories of difficult defecation, splenic constipation, scrotum, yang and clothes changing in ancient medical books. The pathogenic heat is accumulated in the colon and the large intestine is disordered due to factors such as emotion and diet, and the dregs are not the basic etiology and pathogenesis of the disease. The division of spleen and stomach diseases in the Chinese traditional medicine society in 2017 divides constipation into six types of syndromes, namely heat accumulation, cold accumulation, qi stagnation, blood deficiency, yin deficiency and yang deficiency in the consensus opinion of Constipation Chinese traditional medicine diagnosis and treatment experts.
The data show that modern people like eating fat, sweet and thick food and pungent food can cause heat accumulation in stomach and intestine, heat transfer to large intestine, body fluid consumption, dryness and dryness of intestine, which results in the first rate of heat accumulation in the disease (47.70%).
At present, many researches focus on the constipation treatment effect of traditional Chinese medicines, but the traditional Chinese medicines have complex formula and different curative effects. For example, patent CN101513472 (kokai ri 20090826) discloses a Chinese medicinal preparation for mainly treating constipation, which is prepared from fourteen Chinese medicinal materials; patent CN104587401A (published japanese 20150506) discloses a medicine for treating functional constipation, which is prepared from twenty-four traditional Chinese medicinal materials and is mainly used for treating functional constipation. There is no traditional Chinese medicine formula aiming at heat accumulation, simple components and obvious effect.
Therefore, the development of a novel traditional Chinese medicine formula aiming at heat accumulation, simple components and remarkable effect has important research significance and popularization value.
Disclosure of Invention
The invention aims to overcome the defects or shortcomings of weak pertinence and complex components of a formula for treating constipation in the prior art, and provides a wuzi mulberry chrysanthemum composition. The Wuzi mulberry leaf chrysanthemum composition provided by the invention has an obvious effect on heat accumulation, has a relieving effect on some symptoms caused by excessive heat accumulation, such as eye acerbity, vigorous liver fire, easiness in growing pox, sore throat and the like, and is simple in formula, free of toxic and side effects, safe, reliable and convenient to take.
The invention also aims to provide a preparation method of the wuzi mulberry chrysanthemum composition.
The invention also aims to provide application of the wuzi mulberry chrysanthemum composition in preparing a medicine or food for preventing or treating heat accumulation.
In order to achieve the purpose, the invention adopts the following technical scheme:
the composition of wuzi mulberry chrysanthemum is characterized by comprising the following components in parts by weight:
10-40 parts of fried cassia seeds,
6-15 parts of fried radish seeds,
6-15 parts of fried perilla seeds,
10-30 parts of chrysanthemum flower,
10-30 parts of mulberry leaves,
4-10 parts of cape jasmine fruit,
1-5 parts of black sesame.
The large intestine belongs to one of the six fu-organs, and the physiological function of the six fu-organs is to receive and transform food, and the physiological characteristics are practical and not full, i.e. under the condition of normal physiological function, the food contained in the six fu-organs should keep continuously conducting and changing, and the internal state is replaced by deficiency and excess without being blocked. The large intestine is mainly used for transferring dregs, receiving food residues transferred by the small intestine, forming excrement after absorbing water, and discharging the excrement out of the body under the action of qi of the large intestine. If patients suffer from excessive yang heat, or are addicted to spicy and mellow wine, or feel heat evil, and stay in the interior, which causes heat accumulation in the stomach and intestine, and damages qi and fluid of the large intestine, causing dryness of the intestinal tract, disorder of large intestine conduction, and difficult defecation, heat accumulation is easy to form. Therefore, in the process of treating heat accumulation, the "clearing" method should be used throughout the treatment of the disease, and is not limited to purgative herbs, but is used to regulate qi and blood of internal organs, smooth qi and blood, calm yin and yang, and restore normal conduction function of large intestine, so that the disease is improved.
The components of the application consist of semen cassiae (fried), semen raphani (fried), fructus perillae (fried), chrysanthemum, mulberry leaf, gardenia and black sesame, wherein the semen cassiae in the formula is sweet and bitter in taste and cold in nature, enters liver and large intestine channels, has the effects of clearing liver and improving eyesight, and relaxing bowel, washes away stomach and intestine excess heat and stagnation, and eliminates pathogenic factors due to monarch drugs; for food stagnation in the intestines, the qi of the intestines cannot move, so Lai Fu Zi and Zi Su can regulate qi, relieve middle energizer, promote digestion and relieve distension. The two are mutually reinforced with the cassia seed, so as to promote digestion, remove distension and help the cassia seed to purge excess heat and accumulation stagnation in intestines, and are ministerial drugs; for pathogenic fire and heat accumulating in the intestines, yang excess causes yin disease, body fluids in the intestines are damaged and large intestine is not moistened and is obstructed for a long time, so black sesame is added to moisten intestines and relax bowels, and chrysanthemum, mulberry leaf and cape jasmine fruit are added to dispel wind and heat, purge fire and relieve restlessness, clear heat and remove toxicity, which are used as adjuvant drugs.
The invention has remarkable curative effect on constipation due to heat accumulation (dry stool, abdominal distension or abdominal pain) by selecting specific traditional Chinese medicine components under the condition of greatly reducing the quantity of medicinal materials. In addition, the formula of the invention selects components with homology of medicine and food as raw materials, has no toxic or side effect, is safe and reliable, and is convenient to take.
Meanwhile, the formula of the invention has the function of relieving some symptoms caused by excess heat stagnation, such as sour eyes, vigorous liver fire, easy pox growth, sore throat and the like.
Preferably, the wuzi mulberry chrysanthemum composition consists of the following components in parts by mass:
25-35 parts of fried cassia seeds,
8-10 parts of fried radish seeds,
8-10 parts of fried perilla seeds,
15-25 parts of chrysanthemum flower,
15-25 parts of mulberry leaves,
6-9 parts of cape jasmine fruit,
1-3 parts of black sesame.
More preferably, the wuzi mulberry chrysanthemum composition consists of the following components in parts by mass:
30 parts of fried cassia seed, namely,
9 parts of fried radish seeds, namely 9 parts of radish seeds,
9 parts of fried perilla seeds, namely, fried perilla seeds,
20 parts of chrysanthemum flower, wherein the weight portion of the chrysanthemum flower,
20 parts of mulberry leaves, namely, mulberry leaves,
8 parts of cape jasmine fruit, namely cape jasmine fruit,
and 1 part of black sesame.
Preferably, the wuzi mulberry chrysanthemum composition is a decoction, a wall-broken powder preparation or a wall-broken granule preparation.
More preferably, the wuzi mulberry chrysanthemum composition is a wall-broken granular preparation, and the particle size of the wall-broken granules is 20-60 meshes.
The preparation method of the wuzi mulberry chrysanthemum composition comprises the following steps:
s1: respectively coarsely pulverizing parched semen Cassiae, flos Chrysanthemi, folium Mori, and fructus Gardeniae, and mixing or coarsely pulverizing after mixing to obtain mixed fine powder; (ii) a The particle size of the mixed fine powder is not less than 70 meshes;
s2: mixing parched Raphani semen, parched fructus Perillae, semen Sesami Niger and the mixed fine powder, breaking cell wall at a temperature of not higher than 10 deg.C, and pulverizing to obtain cell wall-broken powder with particle diameter not more than 75 μm;
s3: and S2, performing wet granulation on the wall-broken powder to obtain the wuzisangju composition.
The method can obtain wall-broken granule preparation, which has better curative effect because each component in the formula is used as medicine.
Preferably, the S2 wall breaking and crushing method is vibration grinding and crushing, and the crushing time is 20-40 min.
Preferably, in S2, the mass ratio of the fried radish seed, the fried perilla seed, the black sesame and the mixed fine powder is 1: 1-2.5: 0.07-0.83: 2-18.
Preferably, the wet granulation process in S3 is: mixing the wall-broken powder and a wetting agent, adding into a swing granulator for granulation, and drying to obtain the Wuzi mulberry chrysanthemum composition.
More preferably, the wetting agent is 60% ethanol.
More preferably, the mass ratio of the wall-breaking powder to the wetting agent is 1: 0.6.
The application of the wuzi mulberry chrysanthemum composition in preparing the medicine or food for preventing or treating the heat accumulation is also within the protection scope of the invention.
Compared with the prior art, the invention has the following beneficial effects:
the wuzi mulberry chrysanthemum composition provided by the invention has an obvious effect on heat accumulation under the condition of greatly reducing the number of medicinal materials by selecting specific traditional Chinese medicine components, and has the advantages of simple formula, no toxic or side effect, safety, reliability and convenience in taking.
Detailed Description
The invention is further illustrated by the following examples. These examples are intended to illustrate the invention and are not intended to limit the scope of the invention. Experimental procedures without specific conditions noted in the examples below, generally according to conditions conventional in the art or as suggested by the manufacturer; the raw materials, reagents and the like used are, unless otherwise specified, those commercially available from the conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art based on the present invention are intended to be covered by the claims.
The parched cassia seeds, the parched perilla seeds and the parched radish seeds selected in the embodiments and the comparative examples of the invention are obtained by stir-frying the following steps:
(1) heating semen Cassiae with slow fire in a frying machine until the surface is slightly swelled and has fragrance, taking out, and cooling to obtain parched semen Cassiae.
(2) And (3) putting the cleaned perilla seeds into a medicine frying machine, heating and frying the cleaned perilla seeds by slow fire until the cleaned perilla seeds generate crackle sound and have burnt fragrance, taking out the cleaned perilla seeds, and cooling the cleaned perilla seeds to obtain the fried perilla seeds.
(3) Heating cleaned Raphani semen in a frying machine with slow fire, parching until the surface slightly swells and there is fragrance, taking out, and cooling to obtain Raphani semen.
Examples 1 to 6
This example provides a series of wuzisangju compositions, formulated as in table 1.
TABLE 1 formulation of the Wuzi Sangju compositions of examples 1 to 6 (parts/100 g)
The wuzi mulberry chrysanthemum composition of each example is prepared into a specific wall-broken granular preparation by the following method:
(1) coarse crushing: weighing semen Cassiae (parched), flos Chrysanthemi, folium Mori and fructus Gardeniae according to the prescription, mixing well, pulverizing into 120 mesh mixed fine powder by coarse pulverizer set.
(2) Breaking the wall and crushing: and (3) adding the mixed fine powder in the step (2), adding the mixed fine powder, radish seed (fried), perilla seed (fried) and black sesame, performing vibromill wall breaking and crushing system, starting strong refrigeration in advance to enable the refrigeration temperature in the vibromill process to be below 10 ℃, starting a vibromill crusher to perform vibromill crushing for 30min, and discharging to obtain mixed vibromill powder of about 300 meshes.
(3) And (3) granulating: and (3) throwing the mixed vibrating-grinding powder in the step (2) into a high-efficiency wet mixer, and starting the mixed dry mixing for 1-2 minutes to uniformly mix the materials. Taking 60% ethanol as a wetting agent, and adding the following mixed vibration grinding powder: granulating with 60% ethanol at a ratio of 1:0.6, placing the obtained wet granules into a hopper of a vertical fluidized drying bed, setting the air inlet temperature of the fluidized drying bed to be 80 ℃ and the air outlet temperature to be 52 ℃, starting to start only air inlet without heating for 5 minutes, starting a heating device after most ethanol is dissipated, stopping the heating device after the air outlet temperature exceeds 52 ℃, and continuing to feed air for about 10 minutes to obtain dry granules.
(4) Screening: sieving the dry granules by a vibration sieving machine preloaded with an upper 20-mesh sieve and a lower 60-mesh sieve to obtain Wuzi mulberry chrysanthemum composition wall-broken granules which are respectively marked as the wall-broken granule preparations of examples 1-6.
In addition, the formulation of example 1 was decocted to make a decoction (denoted as example 1-decoction) by the following procedure: according to the prescription of the example 1, according to the clinical traditional Chinese medicine decoction method, the traditional Chinese medicine is placed into a stainless steel pot, the stainless steel pot is spread, about 1000mL of water is added to the surface of myrrh 1-2 cm, the myrrh is soaked for 120min and decocted for 2 times, the decoction is poured out after 20min of boiling each time, the decoction is combined for 2 times, the decoction is decompressed and concentrated into extract containing 3g of crude drugs per milliliter, and the extract is stored at 4 ℃ for standby.
Meanwhile, the formula of example 1 is prepared into a wall-broken powder preparation (marked as example 1-wall-broken powder preparation) by a wall-breaking and crushing mode, and the process is as follows:
(1) coarse crushing: weighing semen Cassiae (parched), flos Chrysanthemi, folium Mori and fructus Gardeniae according to the prescription, mixing well, pulverizing into 120 mesh mixed fine powder by coarse pulverizer set.
(2) Breaking the wall and crushing: and (3) adding the mixed fine powder in the step (2), adding the mixed fine powder, radish seed (fried), perilla seed (fried) and black sesame, performing vibromill wall breaking and crushing system, starting strong refrigeration in advance to enable the refrigeration temperature in the vibromill process to be below 10 ℃, starting a vibromill crusher to perform vibromill crushing for 30min, and discharging to obtain mixed vibromill powder of about 300 meshes for later use as a wall breaking powder preparation.
Comparative example 1
The present comparative example provides a wuzi sangju composition, the formulation of which is identical to that of example 1 except that no cassia seed is selected. The preparation process is also consistent with that of example 1 and is marked as comparative example 1-wall-broken granule preparation.
Comparative example 2
This comparative example provides a wuzi sangju composition, the formulation of which is identical to that of example 1 except that radish seed is not selected. The preparation process is also consistent with that of example 1 and is marked as comparative example 2-wall-broken granule preparation.
Comparative example 3
This comparative example provides a wuzi sangju composition, the formulation of which is identical to that of example 1 except that perilla seed is not selected. The preparation process is also consistent with that of example 1 and is marked as comparative example 3-wall-broken granule preparation.
Performance testing
(1) Effect on Constipation model rats
1. Test article
Examples 1-6-wall-broken granule preparation, example 1-decoction, example 1-wall-broken powder preparation. Comparative examples 1-3-wall-broken granule preparation.
2. Laboratory animal
SD rats, male and female halves, body mass (20. + -.2) g.
3. Experimental methods
78 rats are randomly divided into 13 groups, 6 rats are taken out of each group, 6 rats are randomly taken out of the groups as blank control groups, and the rest rats are molded by a specific method that a gastric lavage method is adopted for molding according to 200mg/kg compound diphenoxylate tablets, equal volume of normal saline is applied to the blank control groups once a day, and molding is completed within 15 days. Feeding the rats with common feed in each group, and dividing the rats into a model group, an example 1-6 wall breaking granule group, an example 1-decoction group, an example 1-wall breaking powder preparation group and a comparative example 1-3 wall breaking granule group, wherein each group is subjected to gastric lavage for 4g (crude drugs)/kg of body weight according to measurement, and a blank control group and the model group are subjected to normal saline with the same volume for 1 time per day for 14 days continuously. Weighing the mass of the rat body before gastric lavage every day, replacing the padding of the rat after gastric lavage, picking up the feces of the rat after 24h, weighing the mass of the feces, recording the feces grain number, and observing the water content and the grain number of the feces.
4. Statistical treatment
All data were analyzed using SPSS18.0 statistical software. The data (x. + -.s) indicates that the difference is significant when the test is performed by t between groups, and P < 0.05.
5. Results of the experiment
Table 2 shows the effect on the water content and the number of feces grains in rat feces.
TABLE 2 Effect on Water content and stool particle count of rat feces
Note: in comparison to the set of models,①P<0.05; compared with the method after the mould is made,②P<0.05; compared with the group of wall-broken particles of example 1,③P<0.05。
the rats in the blank control group generally had good condition, soft feces and yellow color, such as wheat grains; after the model is made, the feces become small, the number of particles is reduced, the feces are dry and hard and are in the shape of sheep feces, which indicates that the model is successfully made. The experimental results of the invention prove that the wall-broken granular preparation groups of examples 1-6, the decoction groups of examples 1-and the wall-broken powder preparation groups are all increased in water content of 24h feces and the number of 24h feces grains (P <0.05) compared with the model group and the molded feces, and the results prove that the wall-broken granular preparation groups of examples 1-6, the decoction groups of examples 1-and the wall-broken powder preparation groups of examples 1-can improve the constipation symptom of rats. Meanwhile, the invention discovers that the moisture content of 24h excrement and the number of 24h excrement grains in the wall-broken granule group in the embodiment 1 are obviously higher than those in the decoction group in the embodiment 1 (P is less than 0.05), which indicates that the wall-broken preparation group administered by all components has better effect. The comparative difference between the wall-broken granule group of example 1 and the wall-broken powder preparation group of example 1 in the moisture content of 24h feces and the number of 24h feces grains is not statistically significant (P >0.05), but the invention finds that the wall-broken powder preparation group of example 1 is easy to absorb moisture and cake.
The result of the invention shows that the water content of the 24h excrement and the grain number of the 24h excrement in the groups of the comparative examples 1-3 have no statistical significance (P is more than 0.05) compared with the differences after modeling, which indicates that the groups of the comparative examples 1-3 have no remarkable effect on improving the constipation of rats.
(2) Volunteer experiment
1. Experimental methods
Selecting functional constipation patients according to the Roman III functional gastrointestinal disease diagnosis standard issued in 2006, and carrying out traditional Chinese medicine syndrome differentiation to obtain 30 patients with heat accumulation syndrome, wherein the standard is included: the Chinese medicine is in accordance with the Western diagnosis standard and the Chinese medicine dialectical typing standard; ② those aged 18-65 years old; and thirdly, other treatments or medicines which may influence the assessment of the curative effect of the method are stopped. Exclusion criteria: the enteroscope indicates that the relevant organic diseases such as colorectal tumor, intestinal obstruction, internal hemorrhoid and the like exist; ② patients with serious primary diseases and mental diseases such as heart, lung, blood vessel, liver, kidney, hemopoiesis system, etc.; ③ those caused by organic diseases; patients in gestation or lactation period; people with allergic constitution or people allergic to various medicines in the recipe; sixthly, the relevant examination and the scoring cannot be matched. 30 volunteers were randomly divided into a test group and a control group, and 30 volunteers were given the wall-broken granule preparation of example 1 (3 g/time, 3 times/day). All are taken for 2 weeks. Observing the improvement of clinical symptoms and signs and evaluating the treatment effect. According to the scoring standard of the clinical research guideline of new traditional Chinese medicine, the method comprises the following steps:
(1) the clinical cure is as follows: the excrement returns to normal, the main symptoms disappear, and the curative effect index is more than or equal to 95 percent;
(2) the effect is shown: the constipation symptom is obviously improved, and the curative effect index is more than or equal to 70 percent and less than 95 percent;
(3) the method has the following advantages: the constipation symptom is improved, and the curative effect index is more than or equal to 30 percent and less than 70 percent;
(4) and (4) invalidation: the constipation symptom is not obviously improved or aggravated, and the curative effect index is less than 30%.
Therapeutic index reference nimodipine method:
efficacy index (%) ═ 100% of total pre-treatment-total post-treatment symptoms/total pre-treatment symptoms; effective rate (cure + significant effect + effective)/total statistical number of cases 100
2. Clinical symptom scoring scale
The improvement was evaluated according to the clinical symptom score scale of table 3.
TABLE 3 clinical symptom score Scale
3. Results of the experiment
Tables 4 and 5 show the results of the experiments.
TABLE 4 results of the experiment
Note: compared with the method before the intervention, the method has the advantages that,①P<0.05。
TABLE 5 effectiveness results
| After treatment | Cure of disease | Show effect | Is effective | Invalidation | Always haveEffect of (1) |
| Number of cases (example) | 4 | 22 | 2 | 1 | 29 |
| Percent (%) | 13.33 | 73.33 | 6.67 | 3.33 | 96.67 |
。
From the results, the clinical main symptoms and physical signs of the heat accumulation secret volunteers can be obviously improved by taking the formula of the invention, the total effective rate of treatment is up to 96.67 percent, and the wall-broken granule preparation composition has good effect when being used for the heat accumulation secret volunteers.
The Wuzi mulberry leaf chrysanthemum composition provided by the invention has an obvious effect on heat accumulation, and has the advantages of simple formula, no toxic or side effect, safety, reliability and convenience in taking.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. The composition of wuzi mulberry chrysanthemum is characterized by comprising the following components in parts by weight:
10-40 parts of fried cassia seeds,
6-15 parts of fried radish seeds,
6-15 parts of fried perilla seeds,
10-30 parts of chrysanthemum flower,
10-30 parts of mulberry leaves,
4-10 parts of cape jasmine fruit,
1-5 parts of black sesame.
2. The wuzi mulberry chrysanthemum composition according to claim 1, which is characterized by comprising the following components in parts by mass:
25-35 parts of fried cassia seeds,
8-10 parts of fried radish seeds,
8-10 parts of fried perilla seeds,
15-25 parts of chrysanthemum flower,
15-25 parts of mulberry leaves,
6-9 parts of cape jasmine fruit,
1-3 parts of black sesame.
3. The wuzi mulberry chrysanthemum composition according to claim 1, which is characterized by comprising the following components in parts by mass:
30 parts of fried cassia seed, namely,
9 parts of fried radish seeds, namely 9 parts of radish seeds,
9 parts of fried perilla seeds, namely, fried perilla seeds,
20 parts of chrysanthemum flower, wherein the weight portion of the chrysanthemum flower,
20 parts of mulberry leaves, namely, mulberry leaves,
8 parts of cape jasmine fruit, namely cape jasmine fruit,
and 1 part of black sesame.
4. The wuzi mulberry chrysanthemum composition according to claim 1, which is a decoction, a wall-broken powder or a wall-broken granule.
5. The wuzisangju composition according to claim 4, wherein the wuzisangju composition is a wall-broken granule preparation; the particle size of the particles is 20-60 meshes.
6. A method for preparing the Wuzi Sangju composition as described in any one of claims 1 to 5, which comprises the following steps:
s1: respectively coarsely pulverizing parched semen Cassiae, flos Chrysanthemi, folium Mori, and fructus Gardeniae, and mixing or coarsely pulverizing after mixing to obtain mixed fine powder; the particle size of the mixed fine powder is not less than 70 meshes;
s2: mixing parched Raphani semen, parched fructus Perillae, semen Sesami Niger and the mixed fine powder, breaking cell wall at a temperature of not higher than 10 deg.C, and pulverizing to obtain cell wall-broken powder with particle diameter not more than 75 μm;
s3: and S2, performing wet granulation on the wall-broken powder to obtain the wuzisangju composition.
7. The preparation method according to claim 6, wherein the S2 wall breaking and crushing method is vibration milling and crushing, and the crushing time is 20-40 min; s2, the mass ratio of the fried radish seeds, the fried perilla seeds, the black sesame seeds and the mixed fine powder is 1: 1-2.5: 0.07-0.83: 2-18.
8. The preparation method of claim 7, wherein the mass ratio of the radish seed preparata, the perilla seed preparata, the black sesame seed and the mixed fine powder in the step S2 is 1:1:0.11: 10.8.
9. The method of claim 6, wherein the wet granulation process in S3 comprises: mixing the wall-broken powder and a wetting agent, adding into a swing granulator for granulation, and drying to obtain the Wuzi mulberry chrysanthemum composition.
10. Use of the wuzi mulberry chrysanthemum composition according to any one of claims 1 to 5 in the preparation of a medicament or food for preventing or treating heat accumulation.
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