CN111973488A

CN111973488A - Broad-spectrum antibacterial skin care product matrix for compatibility and preparation method thereof

Info

Publication number: CN111973488A
Application number: CN202010892214.XA
Authority: CN
Inventors: 葛顺英
Original assignee: Nanjing Yiwei'an Cosmetics Technology Co ltd
Current assignee: Nanjing Yiwei'an Cosmetics Technology Co ltd
Priority date: 2020-08-31
Filing date: 2020-08-31
Publication date: 2020-11-24

Abstract

The invention provides a broad-spectrum antibacterial skin care product matrix for compatibility and a preparation method thereof, wherein the matrix comprises the following components in parts by weight: the anti-acne skin care cream comprises, by weight, 6-8 parts of plant extract components, 10-15 parts of gel powder, 0.2-0.5 part of hydroxytyrosol, 0.3-0.6 part of hydroxypropyl methylcellulose, 60-80 parts of a solvent and 0-4 parts of dead sea black mud.

Description

Broad-spectrum antibacterial skin care product matrix for compatibility and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a broad-spectrum antibacterial compatible skin care product matrix and a preparation method thereof.

Background

Skin care has become a problem in modern times, and people are not blindly bought various skin care products in shops to try to do so due to skin problems, but are prescribed by dermatologists to provide targeted skin care suggestions. With the increasing pursuit of health and the rapid development of dermatology, medical skin care products with higher safety and effectiveness have become an irresistible trend. Along with more women paying attention to the quality and safety of skin care products, professionals can study and know the structure and physiological action of skin and accessories thereof more deeply, the study on the skin care products is more specialized, and the performance has pertinence, reliability and competitiveness.

In a word, the skin care product needs to be scientifically used to more effectively play the role of the skin care product. Generally, the skin of people needs to be maintained from multiple aspects, but if multiple skin care products are used at the same time, allergic reactions are easy to occur, the skin care products are more diverse in skin care varieties, multiple layers of skin care products are often needed to be overlapped for use, such as water, milk, cream, essence and the like, therefore, facial red swelling and allergy are easy to cause, even skin diseases such as acne and comedo are easy to occur, the skin diseases are caused by bacteria, the traditional skin care products do not have a good sterilization function, bacterial infection is easy to occur due to incomplete cleaning, and therefore, the antibacterial property, the sensitization property and the like of the skin care products need to be clearly detected.

In addition, normally, the skin care product not only contains functional components (which only occupies a small proportion), but also contains more auxiliary materials, so that in the production and preparation of the skin care product, the development and application of effective functional components are concerned, and the matrix composition is also important.

Disclosure of Invention

In view of the above, the invention aims to provide a broad-spectrum antibacterial compatible skin care product substrate and a preparation method thereof, the substrate prepared by reasonably selecting and matching raw materials and optimizing the matching ratio is safe and efficient, has no irritant component, has excellent antibacterial repairing effect, has remarkable repairing property on whelk, black spots, wrinkles, dryness, roughness and the like, is suitable for various skin care products such as milk, cream, ointment, facial mask and the like, and is worthy of popularization and application.

In order to achieve the purpose, the invention provides the following technical scheme:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 6-8 parts of plant extract component, 10-15 parts of gel powder, 0.2-0.5 part of hydroxytyrosol, 0.3-0.6 part of hydroxypropyl methylcellulose and 60-80 parts of solvent.

The invention further preferably comprises 0-4 parts of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushed and sieved by a 200-mesh and 250-mesh sieve for later use.

The invention further preferably selects the plant extract components as the gnetum montanum extract, the soapberry extract, the pine knot extract and the porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in the state of concentrated and purified extract, the pine knot and the porphyridium are applied in the state of crushing into powder after vacuum freeze drying of the extract, and the percentage of the four is 35-50 wt%, 15-25 wt% and 10-20 wt%.

In a further preferred embodiment of the present invention, the gel powder is gellan gum powder and seaweed gel powder in a mass ratio of 0.5: 1.

Further preferably, the solvent is glycerol and distilled water in a mass ratio of 1: 4-5.

As further optimization of the invention, the broad-spectrum antibacterial compatible skin care product matrix comprises the following preparation steps:

1) the solvent is divided into a large part and a small part independently, the large part and the small part are heated to 65-75 ℃ under the stirring condition respectively, then hydroxytyrosol and dead sea black mud are added into the small-volume solvent, gel powder is added into the large-volume solvent, and the stirring is continued until the uniform mixing is achieved, so that a first mixture and a second mixture are obtained respectively for later use;

2) shaking the plant extract in 40 deg.C water bath for 10-20min, adding into the first mixture, and stirring to obtain a third mixture;

3) slowly adding the mixture III into the mixture II under stirring at 30-35 ℃, adding hydroxypropyl cellulose after stirring uniformly, continuously stirring for 3-5min, discharging, standing, filling, packaging and spraying codes to obtain a matrix after the matrix is qualified to be detected, and warehousing for later use.

As a further preference of the present invention, the solvent in step 1) is divided into two portions in a volume of 1: 3.

As further preferred in the invention, the whole preparation process of the broad-spectrum antibacterial compatible skin care product substrate is in an aseptic environment.

The invention has the beneficial effects that: according to the invention, through reasonable selection and matching of raw materials and optimized matching, the prepared substrate is safe and efficient, has no irritation component, has an excellent antibacterial repairing effect, has remarkable repairing performance on whelks, black spots, wrinkles, dryness, roughness and the like, is suitable for various skin care products such as milk, cream, ointment, facial masks and the like, and is worthy of popularization and application.

The matrix has certain gel property, can lock nutrients by surface conjunctiva after being coated, has excellent interception effect on plant extraction components in the matrix, fully supplements nutrition required by skin under the carrier condition of seaweed gel and gellan gum, has good slow release and absorption promotion effects, has strong repairability on stratum corneum, can improve the water content of the stratum corneum by more than 5 percent, has excellent capturing performance on extracted active protein, amino acid and the like, and effectively improves the fatigue resistance, the aging resistance and the immunity of the skin.

Meanwhile, the abundant unsaturated fatty acid in the porphyridium provides guarantee for the permeability of skin cells, the exchange of cell active substances is obviously improved, the skin maintenance effect is quick and the lasting effect is long, compared with the conventional simple matrix, the functional performance is obviously stronger, the porphyridium can be used alone even, additional functional components (such as arbutin, tartaric acid, hyaluronic acid, nicotinamide and the like) are not required to be added, the cost performance is greatly improved, the preparation process is simpler and more convenient, the cost is obviously reduced on the basis of ensuring sufficient effects, and the porphyridium is worthy of popularization and application.

In addition, the plant extract has the functions of resisting oxidation, removing grease, inhibiting bacteria and diminishing inflammation, and the like, and is provided with dead sea black mud, so that mineral ions can be supplemented in an auxiliary mode, the comprehensive nutrition of the skin is further improved, the release of water-soluble ingredients in the gel is facilitated, the dissolution of a matrix carrier is improved, and the skin can be maintained more quickly and effectively.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.

Example 1:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 8 parts of plant extract component, 12 parts of gel powder, 0.3 part of hydroxytyrosol, 0.5 part of hydroxypropyl methylcellulose and 70 parts of solvent.

The method also comprises 2 parts of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushing and sieving with a 200-mesh and 250-mesh sieve for later use.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 50 wt%, 20 wt% and 10 wt%.

The gel powder is gellan gum powder and seaweed gel powder with the mass ratio of 0.5: 1.

The solvent is glycerol and distilled water in a mass ratio of 1: 5.

Based on the mixture ratio, the broad-spectrum antibacterial skin care product matrix for compatibility comprises the following preparation steps (the whole preparation process is in an aseptic environment, the same is true below):

1) dividing the solvent into a large part and a small part which are independent according to the volume ratio of 1:3, respectively heating to 65-75 ℃ under the stirring condition, then adding hydroxytyrosol and dead sea black mud into the small-volume solvent, adding gel powder into the large-volume solvent, and continuously stirring until the gel powder is uniformly mixed to respectively obtain a first mixture and a second mixture for later use;

Example 2:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 8 parts of plant extract component, 12 parts of gel powder, 0.3 part of hydroxytyrosol, 0.4 part of hydroxypropyl methylcellulose and 70 parts of solvent.

The method also comprises 4 parts of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushing and sieving with a 200-mesh and 250-mesh sieve for later use.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 40 wt%, 25 wt%, 15 wt% and 20 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 5.

Based on the mixture ratio, the preparation steps of the broad-spectrum antibacterial skin care product matrix for compatibility are the same as those of the example 1.

Example 3:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 6 parts of plant extract component, 15 parts of gel powder, 0.5 part of hydroxytyrosol, 0.5 part of hydroxypropyl methylcellulose and 75 parts of solvent.

The method also comprises 3 parts of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushing and sieving with a 200-mesh and 250-mesh sieve for later use.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the percentage of the four components is 35 wt%, 25 wt% and 15 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 4.

Example 4:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 6 parts of plant extract component, 10 parts of gel powder, 0.3 part of hydroxytyrosol, 0.5 part of hydroxypropyl methylcellulose and 60 parts of solvent.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 40 wt%, 25 wt%, 20 wt% and 15 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 4.

Example 5:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 6 parts of plant extract component, 15 parts of gel powder, 0.5 part of hydroxytyrosol, 0.3 part of hydroxypropyl methylcellulose and 70 parts of solvent.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 50 wt%, 15 wt%, 25 wt% and 10 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 4.

Example 6:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 8 parts of plant extract component, 10 parts of gel powder, 0.3 part of hydroxytyrosol, 0.6 part of hydroxypropyl methylcellulose and 80 parts of solvent.

The method also comprises 1 part of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushing and sieving with a 200-mesh and 250-mesh sieve for later use.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 40 wt%, 25 wt% and 10 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 4.

Example 7:

a broad-spectrum antibacterial skin care product matrix for compatibility comprises the following components in parts by weight: 6 parts of plant extract component, 15 parts of gel powder, 0.4 part of hydroxytyrosol, 0.5 part of hydroxypropyl methylcellulose and 80 parts of solvent.

Wherein, the plant extract components are a gnetum montanum extract, a soapberry extract, a pine knot extract and a porphyridium extract, which are prepared by water extraction and alcohol precipitation, the gnetum montanum and the soapberry are applied in a state of concentrated and purified extracting solution, the pine knot and the porphyridium are applied in a state of crushing the extracting solution into powder after vacuum freeze drying, and the four components account for 50 wt%, 15 wt% and 20 wt%.

The solvent is glycerol and distilled water in a mass ratio of 1: 5.

The skin care product matrix prepared in the embodiment is subjected to an allergy test by adopting a local closed coating method (allergic reaction), and the test result shows that the matrix has no obvious allergy phenomenon and the sensitization rate is lower than 0.5%.

Further, the substrate prepared in the above embodiment is used for preparing a skin care mask, and the specific components of the mask are as follows:

2.5 wt% of monostearic glyceric acid, 3 wt% of hexadecanol, 0.5 wt% of vitamin E, 3.5 wt% of glycerol, 7 wt% of matrix in the embodiment, 0.1 wt% of chamomile essential oil, 0.1 wt% of phenoxyethanol and the balance of deionized water.

The above prepared mask composition was also subjected to allergy test by the topical closed coating method.

At the same time, a comparative example was made, i.e. coating with the substrate of the present application alone.

The facial mask is subjected to a coating test, the test population is 35-55 years old female volunteers (90 people) and 18-30 years old acne muscle volunteers (male and female are unlimited, 150 people), the facial mask is coated by using the skin care product, the coating time is 21-23 points (meeting the requirements that half an hour before sleep is best, other conventional skin care products such as water, milk and cream are used under the same conditions, but not limited, conventional sensitive muscle products sold in the market can be purchased, Japanese skin moisturizing products are used here), the facial mask is coated once every two days, the facial mask is cleaned after 15min, the skin state is tested in a period of 5 times, after 2 periods, the skin state has an obvious youthful trend, and the skin state has the problems of red swelling, acne marks, black heads, acnes, color spots, fine wrinkles, coarse pores and the like, the moisturizing and water locking performances are good, the skin elasticity is better, and the data are as shown in the following table (the data are compared:

the table data show that the skin care product containing the matrix has excellent skin care repairing effects, including refining, wrinkle reduction, whitening, moisturizing, deep supply and stratum corneum repair, has strong antibacterial and antiallergic properties, is capable of relieving skin, has very excellent improving effects on facial injuries and large oil skin, and is wide in applicable age, wide in applicable skin, safe and efficient.

Meanwhile, the skin care product matrix has a very remarkable repairing effect, is safe and non-irritant, and is efficient and durable.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. The broad-spectrum antibacterial compatible skin care product matrix is characterized by comprising the following components in parts by weight: 6-8 parts of plant extract component, 10-15 parts of gel powder, 0.2-0.5 part of hydroxytyrosol, 0.3-0.6 part of hydroxypropyl methylcellulose and 60-80 parts of solvent.

2. The broad-spectrum antibacterial compatible skin care product substrate according to claim 1, characterized in that: also comprises 0-4 parts of dead sea black mud, wherein the dead sea black mud is subjected to vacuum freeze drying, crushing and sieving with a 200-mesh and 250-mesh sieve for later use.

3. The compatible skin care product base with broad spectrum antibacterial property of claim 2, wherein: the plant extract components are a gnetum vine extract, a soapberry extract, a pine knot extract and a porphyridium extract, and are prepared by water extraction and alcohol precipitation, wherein the gnetum vine and the soapberry are applied in a concentrated and purified extracting solution state, the pine knot and the porphyridium are applied in a powder form after the extracting solution is subjected to vacuum freeze drying, and the four components account for 35-50 wt%, 15-25 wt% and 10-20 wt%.

4. The compatible skin care product base with broad spectrum antibacterial property of claim 2, wherein: the gel powder is gellan gum powder and seaweed gel powder in a mass ratio of 0.5: 1.

5. The compatible skin care product base with broad spectrum antibacterial property of claim 2, wherein: the solvent is glycerol and distilled water in a mass ratio of 1: 4-5.

6. The compatible skin care product matrix of broad-spectrum antibacterial type according to any one of claims 2 to 5, which comprises the following preparation steps:

7. The broad-spectrum antibacterial compatible skin care product base according to claim 6, characterized in that: in the step 1), the solvent is divided into two parts according to the volume of 1: 3.

8. The broad-spectrum antibacterial compatible skin care product base according to claim 6, characterized in that: the whole preparation process is in a sterile environment.