CN111971302A - 制备稳定的蛋白质组合物的方法 - Google Patents

制备稳定的蛋白质组合物的方法 Download PDF

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Publication number
CN111971302A
CN111971302A CN201980025383.9A CN201980025383A CN111971302A CN 111971302 A CN111971302 A CN 111971302A CN 201980025383 A CN201980025383 A CN 201980025383A CN 111971302 A CN111971302 A CN 111971302A
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acid
buffer
protein
chromatography
ultrafiltration
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Pending
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CN201980025383.9A
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Chinese (zh)
Inventor
W·卡拉汉
L·德桑蒂亚戈
C·塔利
Y·维克斯勒-科亨
J·阿贝尔
R·考施克
N·M·雅各布
C·陈
N·鲍尔
M·戈斯
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Amgen Inc
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Amgen Inc
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    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CN201980025383.9A 2018-04-12 2019-03-28 制备稳定的蛋白质组合物的方法 Pending CN111971302A (zh)

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US201862656687P 2018-04-12 2018-04-12
US62/656687 2018-04-12
PCT/US2019/024683 WO2019199476A1 (en) 2018-04-12 2019-03-28 Methods for making stable protein compositions

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