CN111971301B - 抗ms4a4a抗体及其使用方法 - Google Patents

抗ms4a4a抗体及其使用方法 Download PDF

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Publication number
CN111971301B
CN111971301B CN201980023444.8A CN201980023444A CN111971301B CN 111971301 B CN111971301 B CN 111971301B CN 201980023444 A CN201980023444 A CN 201980023444A CN 111971301 B CN111971301 B CN 111971301B
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amino acid
seq
acid sequence
antibody
hvr
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CN111971301A (zh
Inventor
P·空
H·莱茵
T·施瓦伯
A·易
I·塔斯
M·A·奥哈瓦格力
A·罗森斯奥
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Alexite Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980023444.8A 2018-01-31 2019-01-31 抗ms4a4a抗体及其使用方法 Active CN111971301B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862624600P 2018-01-31 2018-01-31
US62/624,600 2018-01-31
US201862783096P 2018-12-20 2018-12-20
US62/783,096 2018-12-20
PCT/US2019/016156 WO2019152715A1 (en) 2018-01-31 2019-01-31 Anti-ms4a4a antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
CN111971301A CN111971301A (zh) 2020-11-20
CN111971301B true CN111971301B (zh) 2025-01-07

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Family Applications (1)

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CN201980023444.8A Active CN111971301B (zh) 2018-01-31 2019-01-31 抗ms4a4a抗体及其使用方法

Country Status (5)

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US (3) US11472874B2 (https=)
EP (1) EP3746476A1 (https=)
JP (2) JP7268038B2 (https=)
CN (1) CN111971301B (https=)
WO (1) WO2019152715A1 (https=)

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JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
CN112204050B (zh) 2018-01-31 2025-03-14 艾莱克特有限责任公司 抗ms4a6a抗体及其使用方法
CN111971301B (zh) 2018-01-31 2025-01-07 艾莱克特有限责任公司 抗ms4a4a抗体及其使用方法
MX2022001260A (es) 2019-07-31 2022-04-18 Alector Llc Anticuerpos anti-ms4a4a y metodos de uso de los mismos.
CN113248609B (zh) * 2021-07-14 2021-09-10 深圳市盛波尔生命科学技术有限责任公司 针对再生胰岛衍生蛋白1α的抗体组合以及包含其的检测试剂盒
JP2025503437A (ja) 2021-12-17 2025-02-04 デナリ セラピューティクス インコーポレイテッド ポリペプチド操作、ライブラリー、ならびに操作されたｃｄ９８重鎖及びトランスフェリン受容体結合ポリペプチド
EP4455275A4 (en) * 2021-12-22 2026-03-18 Univ Kagoshima MACROPHAGE PRODUCTION METHOD, DIFFERENCE-INDUCING AGENT, DIFFERENCE-INDUCING KIT, MACROPHAGE CULTIVATION METHOD, MACROPHAGE PROPAGATION-PROMOTING AGENT, MACROPHAGE PROLIFERATION-PROMOTING KIT, MACROPHAGE PROLIFERATION METHOD, AND MACROPHAGES
EP4562184A2 (en) * 2022-07-29 2025-06-04 Anavex Life Sciences Corp. Therapy selection and treatment of neurodegenerative disorders
WO2024086796A1 (en) 2022-10-20 2024-04-25 Alector Llc Anti-ms4a4a antibodies with amyloid-beta therapies
CN115850460B (zh) * 2022-11-21 2025-10-17 浙江大学医学院附属第一医院 抗y系乙型流感病毒血凝素蛋白单克隆抗体2h6及其在检测中的应用
CN116789821A (zh) * 2022-12-07 2023-09-22 南方医科大学南方医院 Ms4a4a作为靶点或抗ms4a4a单克隆抗体在制备治疗结直肠癌的药物中的应用
JPWO2024262577A1 (https=) * 2023-06-21 2024-12-26
WO2025049981A1 (en) * 2023-09-01 2025-03-06 Institute For Environmental Health, Inc. Variably deamidated gluten polypeptides and antibodies against same
US20250134920A1 (en) 2023-10-30 2025-05-01 Regeneron Pharmaceuticals, Inc. Treatment Of Myeloid Cell Dysfunction With Membrane Spanning 4-Domains A6A (MS4A6A) Inhibitors
CN119431583B (zh) * 2024-12-19 2025-09-30 重庆国际免疫创新中心有限公司 靶向cd155的抗体或抗原结合片段及其应用

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US11472874B2 (en) 2022-10-18
WO2019152715A1 (en) 2019-08-08
JP2023093624A (ja) 2023-07-04
US12331111B2 (en) 2025-06-17
JP7268038B2 (ja) 2023-05-02
US20230126400A1 (en) 2023-04-27
US20210040200A1 (en) 2021-02-11
US12331112B2 (en) 2025-06-17
CN111971301A (zh) 2020-11-20
JP7486636B2 (ja) 2024-05-17
JP2021513329A (ja) 2021-05-27
EP3746476A1 (en) 2020-12-09
US20230142579A1 (en) 2023-05-11

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