CN111971053A - 靶向肿瘤微环境的嵌合抗原受体 - Google Patents

靶向肿瘤微环境的嵌合抗原受体 Download PDF

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CN111971053A
CN111971053A CN201980024375.2A CN201980024375A CN111971053A CN 111971053 A CN111971053 A CN 111971053A CN 201980024375 A CN201980024375 A CN 201980024375A CN 111971053 A CN111971053 A CN 111971053A
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car
seq
cell
amino acid
cells
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M·V·莫斯
B·崔
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General Hospital Corp
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General Hospital Corp
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CN201980024375.2A 2018-02-12 2019-02-12 靶向肿瘤微环境的嵌合抗原受体 Pending CN111971053A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862629593P 2018-02-12 2018-02-12
US62/629,593 2018-02-12
US201862658307P 2018-04-16 2018-04-16
USPCT/US2018/027783 2018-04-16
US62/658,307 2018-04-16
PCT/US2018/027783 WO2018191748A1 (en) 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment
US201862746895P 2018-10-17 2018-10-17
US62/746,895 2018-10-17
PCT/US2019/017727 WO2019157533A1 (en) 2018-02-12 2019-02-12 Chimeric antigen receptors targeting the tumor microenvironment

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CN111971053A true CN111971053A (zh) 2020-11-20

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CN201980024375.2A Pending CN111971053A (zh) 2018-02-12 2019-02-12 靶向肿瘤微环境的嵌合抗原受体

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US (1) US20210038646A1 (https=)
EP (1) EP3752170A4 (https=)
JP (2) JP2021512635A (https=)
CN (1) CN111971053A (https=)
AU (1) AU2019218989B2 (https=)
CA (1) CA3090546A1 (https=)
WO (1) WO2019157533A1 (https=)

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CN113969266A (zh) * 2021-10-26 2022-01-25 山东大学齐鲁医院 一种重组溶瘤腺病毒及其应用
CN114981441A (zh) * 2019-10-16 2022-08-30 优莫佳生物制药股份有限公司 用于通用受体疗法的逆转录病毒载体
CN115491358A (zh) * 2021-06-17 2022-12-20 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
US12215337B2 (en) 2018-04-12 2025-02-04 Umoja Biopharma, Inc. Viral vectors and packaging cell lines

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US12378297B2 (en) 2017-04-14 2025-08-05 The General Hospital Corporation Chimeric antigen receptor T cells targeting the tumor microenvironment
WO2020052645A1 (zh) * 2018-09-14 2020-03-19 上海原能细胞医学技术有限公司 表面包含免疫调节剂的细胞及其用途
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
JP7748935B2 (ja) * 2019-08-27 2025-10-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＩＬ１３Ｒα２陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成ＣＡＲ
CN112480263A (zh) * 2019-09-12 2021-03-12 普米斯生物技术(苏州)有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
EP4054602A4 (en) 2019-11-08 2023-12-06 Mayo Foundation for Medical Education and Research EPHA3 TARGETED CAR-T CELLS FOR TREATING TUMORS
CA3159050A1 (en) * 2019-11-21 2021-05-27 Jack A. Elias Bispecific antibodies against chi3l1 and ctla4 with enhanced cytotoxic effects on tumor cells
EP4138864A4 (en) * 2020-04-23 2024-07-10 Innovative Cellular Therapeutics Holdings, Ltd. Polyspecific binding molecules and their use in cell therapy
US20230203168A1 (en) * 2020-06-02 2023-06-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dual EGFR-MUC1 Chimeric Antigen Receptor T Cells
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
EP4240832A4 (en) * 2020-11-04 2025-01-01 Fate Therapeutics, Inc. Engineered ipsc and immune effector cells for heterogenous tumor control
JP2023550148A (ja) * 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
EP4267604A1 (en) 2020-12-23 2023-11-01 Gadeta B.V. Chimeric, transmembrane proteins with bidirectional signalling activity
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を治療するための方法
WO2023081808A2 (en) * 2021-11-04 2023-05-11 The General Hospital Corporation Anti-mesothelin car t cells secreting teams and methods of use thereof
WO2024148216A2 (en) * 2023-01-05 2024-07-11 Neximmune, Inc. Combination therapy with t cell engager
WO2025080994A1 (en) * 2023-10-13 2025-04-17 The General Hospital Corporation Chimeric antigen receptor (car)-t cell engaging antibody molecule (team) formulations and pharmaceutical compositions
WO2025092689A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种表达多特异性抗原结合蛋白的细胞及其应用

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