CN111956506A

CN111956506A - Active ingredient fixed-point pressing release type skin care pad pasting

Info

Publication number: CN111956506A
Application number: CN201910417920.6A
Authority: CN
Inventors: 刘宇航; 岳娟; 陈玉燕; 王虹霞; 刘晓青; 席长洪; 蒋丽刚; 邵平
Original assignee: Proya Cosmetics Co Ltd
Current assignee: Proya Cosmetics Co Ltd
Priority date: 2019-05-20
Filing date: 2019-05-20
Publication date: 2020-11-20
Anticipated expiration: 2039-05-20
Also published as: CN111956506B

Abstract

The invention relates to an active ingredient fixed-point pressing release type skin care pad pasting, which is characterized in that: the cosmetic active substance pressing device is characterized by comprising a non-woven fabric, a plurality of flaky microcapsules pasted on the front surface of the non-woven fabric and a plurality of round hard pressing particles pasted on the back surface of the non-woven fabric, wherein the flaky microcapsules are formed by wrapping cosmetic active substances by bag bodies with breaking force of 10-15N, the thickness of the flaky microcapsules is 0.5-1mm, the diameter of the flaky microcapsules is 3-6mm, and the positions of the round hard pressing particles on the back surface of the non-woven fabric correspond to the positions of the flaky microcapsules one by one. The invention has the advantages of good stability, strong efficacy, simple and convenient use mode and the like.

Description

Active ingredient fixed-point pressing release type skin care pad pasting

Technical Field

The invention relates to the technical field of cosmetics, in particular to an active ingredient fixed-point pressing release type skin care adhesive film.

Background

With the rapid development of the economic society, skin-sticking nursing products represented by the adhesive film are taken as skin care products with the effects of moisturizing, cleaning and the like, are produced and are widely concerned and loved by consumers. The adhesive film can be divided into a plurality of types such as a face adhesive film, a neck adhesive film, a foot adhesive film, a hand adhesive film and the like according to the nursing position, a relatively closed environment can be formed by covering the nursing position in a short time, and the relatively closed environment is temporarily isolated from the outside air and pollution, so that the temperature of the skin is raised, and the expansion of skin pores and the metabolism are promoted. Compared with other skin care products, the skin care film is rich in essence, a closed environment is created in the application process, moisture and other nutrient substances in the skin care film can better permeate into the horny layer of the skin, and the skin becomes soft, natural, bright and elastic.

At present, basic functions of skin care adhesive films such as initial moisture retention and cleaning cannot meet the requirements of consumers, and accordingly, effective and interesting skin care adhesive films such as wrinkle removal, oil control, ultra-time saving and self-foaming are provided by various brand manufacturers. Skin care patches, such as facial patches, are typically prepared by soaking a facial patch cloth in a facial patch solution that is uniform, i.e., provides consistent efficacy to the skin when applied. However, in practical situations, different parts of the skin may have different requirements, for example, a spot position needs to be spot-removed, a wrinkle position needs to be wrinkle-removed, if a corresponding problem-solving active ingredient can be provided on the face mask for the part, the effect provided by the product is richer, and one face mask can provide multiple effects, so that the use is more convenient.

In addition, most of the active substances with definite efficacies of whitening, antioxidation and the like, such as coenzyme Q10, resveratrol, glutathione and the like, are active in chemical properties and unstable when contacting water and light, so that the stability is poor when the active substances are directly added into the skin care film essence, and the efficacy is limited, for example, the active substances are wrapped by cyclodextrin inclusion, nano liposome, polymer micelle and the like, and the actual effective active substance loading capacity is low because the adding amount in the product formula is limited, on the other hand, the active substance carriers are uniformly distributed when being added into the product essence, and the problem that different efficacy active substances are required to be provided for the skin in different areas is not solved.

Disclosure of Invention

The invention aims to solve the technical problem of providing an active ingredient fixed-point pressing release type skin care pad pasting, which releases functional active ingredients in a fixed-point pressing mode, has the advantages of good product stability, high active substance absorption rate, convenient use and convenience for preparing pad pasting type cosmetics with different functional requirements.

In order to solve the technical problems, the invention adopts the following technical scheme: an active ingredient fixed point pressing release type skin care pad pasting is characterized in that: the cosmetic active substance pressing device is characterized by comprising a non-woven fabric, a plurality of flaky microcapsules pasted on the front surface of the non-woven fabric and a plurality of round hard pressing particles pasted on the back surface of the non-woven fabric, wherein the flaky microcapsules are formed by wrapping cosmetic active substances by bag bodies with breaking force of 10-15N, the thickness of the flaky microcapsules is 0.5-1mm, the diameter of the flaky microcapsules is 3-6mm, and the positions of the round hard pressing particles on the back surface of the non-woven fabric correspond to the positions of the flaky microcapsules one by one.

Further, the flaky microcapsules are adhered to the non-woven fabric through sticky glutinous rice, the round hard pressing particles are adhered to corresponding positions of the flaky microcapsules on the reverse side of the non-woven fabric through sticky rice, the round hard pressing particles are one of carbon fibers, tourmaline, far infrared ceramics and magnetic metals, and the size of the round hard pressing particles is equivalent to the size of the flaky microcapsules.

The active ingredient fixed-point pressing release type skin care film is characterized in that a sheet microcapsule wrapped with an active ingredient and round hard pressing particles for assisting the release of the active ingredient are respectively stuck to the front side and the back side of the same position on a non-woven fabric material which is prepared into a face shape or other shapes of parts to be stuck; wherein, the front side refers to the side of the skin care film contacting with the skin, and the back side refers to the other side of the non-woven fabric.

Because the sheet-shaped microcapsules enclosing the active ingredient are adhered to the front surface of the skin care patch without being broken before being pressed by an external force, even in an aqueous environment such as soaking in essence. Only when the round hard press particles are pressed with a force exceeding a certain level, the sheet-shaped microcapsules having adsorbed the active ingredient are broken, and the active ingredient contained therein is released. Therefore, in the present invention, the skin care patch and the product essence containing the active ingredient in the form of a spot-on press-release can be packaged in a conventional soak type, i.e., in a manner that the skin care patch and the product essence are mixed before use. The dry-wet separation type package can also be adopted, namely the skin care adhesive film and the product essence are separated by the separation type package which can be squeezed and cracked in the middle, the middle seal strip is broken by external force before use, the essence and the skin care adhesive film can be contacted and soaked, and the skin care adhesive film can be used after being thoroughly wetted.

The action part of the active ingredient fixed-point press-release type skin care sticking film can be a body part with specific skin problems, such as the face, the neck, the back, the legs, the feet, the hands and the like, the corresponding active ingredient fixed-point press-release type skin care sticking film is selected according to the effect requirement of the action part, and the effects of the flaky microcapsules at different positions of the same skin care sticking film can be the same or different.

Further, the sheet-shaped microcapsule is a whitening microcapsule, an anti-wrinkle microcapsule, an oil control microcapsule or a soothing microcapsule, and the wrapping mass ratio of the whitening microcapsule is 1-3: 1-8: 1: 1-5: 60-90 parts of 4-methoxy potassium salicylate, phenethyl resorcinol, resveratrol, glutathione and polyalcohol mixture; the anti-wrinkle microcapsule has a wrapping mass ratio of 1: 1-3: 5: 1-8: 65-85 coenzyme Q10, ribose, tretinoin, digalactosyldiglyceride, and a polyol mixture; the wrapping mass ratio of the oil-control microcapsule is 1-10: 2: 3: 1-3: 70-90% vitamin B6, salicylic acid, linoleic acid, green tea extract and a mixture of polyols; the weight ratio of the slow microcapsules to the coating is 1-5: 5: 1-9: 5: 50-70 of centella asiatica extract, allantoin, heparin sodium, licochalcone A and a polyol mixture.

The preparation method of the flaky microcapsule comprises the following steps:

A. according to the mass ratio of 1-3: 1-8: 1: 1-5: 60-90 weighing 4-methoxy potassium salicylate, phenethyl resorcinol, resveratrol, glutathione and polyhydric alcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain whitening effect active solution; according to the mass ratio of 1: 1-3: 5: 1-8: 65-85 weighing coenzyme Q10, ribose, vitamin A alcohol, digalactosyldiglyceride and polyalcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain active solution with anti-wrinkle effect; according to the mass ratio of 1-10: 2: 3: 1-3: 70-90 weighing vitamin B6, salicylic acid, linoleic acid, green tea extract and polyalcohol, mixing, heating, stirring to dissolve completely, and cooling to room temperature to obtain oil control effect active solution; according to the mass ratio of 1-5: 5: 1-9: 5: 50-70 weighing herba Centellae extract, allantoin, heparin sodium, licochalcone A and polyalcohol, mixing, heating, stirring to dissolve completely, and cooling to room temperature to obtain relieving effect active solution; the polyalcohol is one or a mixture of glycerol, butanediol, propylene glycol, dipropylene glycol, diglycerol, pentanediol and hexanediol;

B. according to the mass ratio of 1-5: 1-30: 50, weighing hydrophilic mesoporous silicon, the whitening effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed whitening effect active solution into the mesoporous silicon suspension, stirring at the speed of 400-600rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with the deionized water, and freeze-drying at-40 ℃ to obtain whitening effect mesoporous silicon powder;

C. according to the mass ratio of 1-5: 1-30: 50, weighing hydrophilic mesoporous silicon, the anti-wrinkle effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed anti-wrinkle effect active solution into the mesoporous silicon suspension, stirring at the speed of 400rpm and 600rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with the deionized water, and freeze-drying at the temperature of-40 ℃ to obtain anti-wrinkle effect mesoporous silicon powder;

D. according to the mass ratio of 1-5: 1-30: 50, weighing hydrophilic mesoporous silicon, the oil control effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed oil control effect active solution into the mesoporous silicon suspension, stirring at the speed of 400-600rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with the deionized water, and freeze-drying at-40 ℃ to obtain oil control effect mesoporous silicon powder;

E. according to the mass ratio of 1-5: 1-30: 50, weighing hydrophilic mesoporous silicon, the soothing effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed soothing effect active solution into the mesoporous silicon suspension, stirring at the speed of 400-600rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain soothing effect mesoporous silicon powder;

F. according to the mass ratio of 1-3: 1-2: 1: 1: 85-95 weighing the carrageen crispus extract, sodium alginate, gum arabic, sodium hyaluronate and deionized water, stirring at the speed of 800 plus 1500rpm for 0.5-2h to obtain a colloidal solution, and then heating to 60 ℃ for heat preservation for later use;

G. according to the mass ratio of 1-3: 1: 1-3, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

H. according to the mass ratio of 1-10: 60-80: 3-5: 1 weighing the whitening mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at the speed of 800-1500rpm for 10-30min, and controlling the temperature at 60 ℃ to obtain a whitening premixed solution;

I. according to the mass ratio of 1-10: 60-80: 3-5: 1, weighing the anti-wrinkle mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at the speed of 800-1500rpm for 10-30min, and controlling the temperature at 60 ℃ to obtain an anti-wrinkle premixed solution;

J. according to the mass ratio of 1-10: 60-80: 3-5: 1 weighing the oil-control functional mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at the speed of 800-1500rpm for 10-30min, and controlling the temperature at 60 ℃ to obtain an oil-control premixed solution;

K. according to the mass ratio of 1-10: 60-80: 3-5: 1, weighing the soothing mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at the speed of 800-1500rpm for 10-30min, and controlling the temperature at 60 ℃ to obtain a soothing premixed solution;

l, preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of each groove is 8-20mm, the height of each groove is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the whitening premixed solution prepared in the step H is dripped into each groove, and after the whitening premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ to be dried and demoulded to obtain the whitening microcapsules; and under the same condition, respectively dropwise adding the anti-wrinkle premixed solution, the oil-control premixed solution and the relieving premixed solution to prepare the anti-wrinkle microcapsule, the oil-control microcapsule and the relieving microcapsule.

Further, the active ingredient fixed-point pressing release type skin care pad pasting is a face pad pasting, and is characterized in that: the whitening microcapsules correspond to the left and right four hundred points, the left and right juliano points and the left and right dichondra points of the face, the anti-wrinkle microcapsules are adhered to the left and right Chengqi points, the left and right zanzhu points, the left and right Tongziliao points, the left and right bamboo holes, the left and right Yuyao points, the left and right retrobulbar points and the left and right Jingming points corresponding to the left and right Yangbai points, the Inula points, the Suliao points and the left and right Yingxiang points of the face, and the soothing microcapsules correspond to the left and right temple points, the left and right four hundred points, the left and right julian points, the left and right dichondra points.

The active ingredient fixed-point pressing release type skin care pad pasting is a foot pad pasting and is characterized in that: the soothing microcapsules correspond to the points of the feet, such as the points of the ruins, the points of the streams, the points of the Zhongfeng, the points of the Zulinqie, the points of the sunken valley, the Taichong, the Neiting, the points of the Xingjian and the Xiancui.

The active ingredient fixed point presses release formula pad pasting for skin care to be hand pad pasting or arm pad pasting or leg pad pasting, its characterized in that: the whitening microcapsules are distributed at an interval of 1cm between an upper point, a lower point, a left point and a right point. When in use, the whitening mask is applied by aiming at the corresponding positions of the hands, the arms and the legs to be whitened.

The active ingredient fixed-point pressing release type skin care pad pasting is a neck pad pasting and is characterized in that: the anti-wrinkle microcapsules and/or the whitening microcapsules are distributed at an interval of 1cm between an upper point and a lower point and between a left point and a right point. When in use, the patch is applied to the corresponding position of the neck to be anti-wrinkle or whitened.

The active ingredient fixed-point pressing release type skin care pad pasting is a back pad pasting and is characterized in that: the oil control microcapsules and/or the whitening microcapsules are distributed at an interval of 1cm between an upper point, a lower point, a left point and a right point. When in use, the patch is applied to the corresponding position of the back to be controlled with oil or whitened.

The active ingredient fixed-point pressing release type skin care pad pasting is an abdomen pad pasting and is characterized in that: the anti-wrinkle microcapsules and/or the whitening microcapsules are distributed at an interval of 1cm between an upper point and a lower point and between a left point and a right point. When in use, the plaster is applied to the corresponding position of the abdomen to be anti-wrinkle or whitened.

The active ingredient fixed-point pressing release type skin care film is packaged in an aluminum-plastic composite film bag, 20-40g of essence is further filled in the aluminum-plastic composite film bag, and the essence is prepared from the following raw materials in percentage by mass: 0.5-3.0% of thickening agent, 3-6% of functional emollient, 2-8% of humectant, 0.08-0.45% of pH regulator, 0.5-1.5% of preservative, 0.01-0.03% of essence and the balance of deionized water. The thickening agent is one or a mixture of more than two of carbomer, sodium hyaluronate, sodium polyacrylate, hydroxyethyl cellulose, xanthan gum and agar; the functional emollient is one or a mixture of more than two of trehalose, panthenol, betaine, glyceryl polyether-26 and PEG/PPG-17/6 copolymer; the humectant is any one or a mixture of more than two of glycerol, butanediol, pentanediol, hexanediol and propylene glycol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is one or a mixture of phenoxyethanol, ethylhexyl glycerol and caprylyl hydroximic acid.

The rupture force of the active ingredient sheet-shaped microcapsule in the active ingredient fixed-point press release type skin care adhesive film is 10-15N measured by a mechanical property measuring device, namely the rupture of the sheet-shaped microcapsule needs to apply a pressing force more than 10N, and the rupture of the sheet-shaped microcapsule can be ensured in the process of pasting, transportation and the like.

The separation force between the membrane cloth and the microcapsules and the round hard pressing particles in the active ingredient fixed-point pressing release type skin care sticking membrane is measured to be more than 50N through a mechanical property measuring device, namely the separation force more than 50N needs to be applied to separate the microcapsules and the round hard pressing particles from the sticking membrane cloth, and the sticking membrane cloth can be ensured not to fall off in the transportation and storage processes.

The POTASSIUM 4-METHOXYSALICYLATE of the present invention is named POTASSIUM METHOXYSALICYLATE (NCI), number 03354 in the catalogue of used cosmetic raw materials (2015 edition) in China, and is available from Shanghai Galangal leaf industries, Inc., with the trade name of 4-MSK. The action principle of the 4-methoxy potassium salicylate is that the skin with black spots and freckles caused by the disorder and overlapping of horny layers and the generation of chronic abnormal keratinization after being irradiated by ultraviolet rays returns to normal, and the generation of melanin is inhibited from the source.

The aforementioned phenethylresorcinol, having an INCI name PHENYLETHYL RESORCINOL, was numbered 01299 in the catalogue of names of used cosmetic raw materials (2015 edition) in china, and was purchased from shin (shanghai) ltd, de, under the name symbhite 377. The principle of the function of the phenethyl resorcinol is that the activity of tyrosinase is inhibited, so that the generation of black is inhibited, and the excellent whitening effect is achieved.

The RESVERATROL, having an English INCI name RESVERATROL, has a serial number of 01152 in the catalogue of used cosmetic raw material names (2015 edition) in China, and is available under the trade name of GEGU-FADE from DSM corporation. Resveratrol can be used as tyrosinase activity inhibitor, and can also be used as melanin oxidation synthesis inhibitor.

The GLUTATHIONE, having the English INCI name GLUTATHIONE, was numbered 02586 in the catalogue of used cosmetic raw materials (2015 edition) in China, and was purchased from Cosphatech under the trade name iWhite GLUTATHIONE. Glutathione can inhibit the oxidation pathway of melanin formation, thereby achieving the effect of whitening.

The coenzyme Q10, UBIQINONE named in INCI, No. 02297 in catalog of used cosmetic raw materials (2015 edition) in China, available from Sabinsa, Inc., trade name Co Q₁₀. Coenzyme Q10 has effects of promoting skin metabolism, eliminating skin stress caused by aging, lack of nutrition, and illumination by promoting respiratory chain transmission of epithelial cells of face and hand and ATP production, inhibiting skin lipid peroxidation, and nourishing and activating skin.

The RIBOSE, designated RIBOSE by INCI, was numbered 02786 in catalog of names of used cosmetic raw materials (2015 edition) in China, and was available from Lucas Meyer Cosmetics, Inc., under the trade name Riboxyl. Ribose is used as a precursor for synthesizing ATP nucleotide, adenine and hypoxanthine, plays an important role in the metabolic process of a human body, can improve oxygen supply of skin cells, and has the effect of delaying senility.

The vitamin A alcohol, called RETINOL in INCI name, has a serial number of 06162 in catalog of names of used cosmetic raw materials (2015 edition) in China, and is purchased from Tianjian Biotech, Inc., Hebei, under the trade name of vitamin A powder. The function principle of the retinol is that the retinol can increase the collagen content in the dermis and the mucopolysaccharide content in the epidermis, and can promote the metabolism of the stratum corneum to jointly act on the skin to play the role of anti-aging.

The digalactosyldiglyceride, CAS number 92457-02-8, is available from Shanghai Huichi Biotech, Inc. under the trade name DGDGDG. The action principle of the digalactosyl diglyceride is that the structural characteristics of hydrophilic and hydrophobic groups of the digalactosyl diglyceride endow the digalactosyl diglyceride with certain surface activity, so that the digalactosyl diglyceride can promote the permeation of other active ingredients, and in addition, the digalactosyl diglyceride and phospholipid belong to endogenous substances, and are natural, safe and mild.

Vitamin B6, known as PYRIDOXINE (English name), has a serial number of 01320 in the catalogue of used cosmetic raw materials (2015 edition) in China, and is available under the trade name of Pyridoxine Hydrochloride from DSM. Vitamin B6 can inhibit 5 alpha-reductase activity, reduce DHT production, reduce oil secretion, and control oil.

The salicylic acid, having an INCI name SALICYLIC ACID, serial number 06405 in the catalogue of names of used cosmetic raw materials (2015 edition) in China, was purchased from ENGELHARD ANG (BASF) under the name BETA-HYDROXYDE ACSD. The salicylic acid has the action principle of normally keratinizing the skin and normally discharging oil and fat by dredging pores, thereby playing a role in controlling oil.

The LINOLEIC ACID is called LINOLEIC ACID by INCI name, has a serial number of 07338 in catalog of used cosmetic raw materials (2015 edition) in China, and is purchased from Bai Wei Biotech limited company in Hebei under the trade name of alpha-LINOLEIC ACID. Linoleic acid can act as an oil control by reducing pore clogging.

The green tea EXTRACT, having an english INCI name CAMELLIA SINENSIS extact, was numbered 01600 in chinese catalogue of used cosmetic raw material names (2015 edition), and was purchased from korea mol corporation, under the trade name green tea EXTRACT. The green tea extract has the action principle that the tea polyphenol contained in the green tea extract has astringency and can denature protein precipitates, so that the green tea extract has strong antibacterial effect.

The CENTELLA asiatica EXTRACT, having an English INCI name OF CENTELLA ASIATICA EXTRACT, was numbered 03171 in the catalogue OF used cosmetic raw materials (2015 edition) in China, and was purchased from Greentech under the name COSMELENE OF CENTELLA. The centella asiatica extract can tighten the connecting part of the epidermis and the dermis, can soften the skin, is beneficial to solving the phenomenon of skin relaxation, enables the skin to be smooth and elastic, and can also help promote the formation of collagen in the dermis to regenerate fibrin so as to enable the skin to achieve the effects of tightening and smoothing.

ALLANTOIN, known by the INCI name ALLANTOIN, was purchased from Ashland, Inc. under the trade name Allantoin, with the serial number 04823 in the catalogue of used cosmetic raw materials (2015 edition) in China. Allantoin accelerates epidermal cell renewal by reducing the adhesion of stratum corneum cells, thereby achieving the effects of soothing and promoting cell repair.

The SODIUM HEPARIN, sold under the INCI name SODIUM HEPARIN, is numbered 02502 in the catalogue of used cosmetic raw materials (2015 edition) in China, and is available from Shandong Zhongshan company under the trade name SODIUM HEPARIN. The heparin sodium can increase the vascular permeability of the skin, improve the local vascular circulation, promote the supply of skin nutrition and the excretion of metabolic waste, and has good health care and maintenance functions on the skin.

The licochalcone A has CAS number of 58749-22-7, and is available from Shanghai Zhenzhong Kogyo Co., Ltd, with a trade name of licochalcone A and a purity of 98%. The licochalcone A is extracted from radix Glycyrrhizae, and has effects of inhibiting activity of plasmin, repairing stratum corneum, restoring elasticity of capillary vessel, and relieving repair.

The particle size of the hydrophilic mesoporous silicon is 200nm, and the specific surface area is as follows: 500m²Per g, pore volume: 0.5cm²(ii)/g, available from Sai-An-Rexi Biotechnology Ltd, under the trade name mesoporus silica nanoparticles.

The Chondrus CRISPUS EXTRACT, Chondrus CRISPUS (Carrageenan) EXTRACT, English INCI name, in the catalogue of used cosmetic raw materials (2015 edition) in China, with a serial number of 08631, was purchased from Cargill corporation, with a trade name of SATIAGEL VPC 508.

The sodium alginate, known as the English INCI name ALGIN, has a serial number of 08484 in the directory of used cosmetic raw materials (2015 edition) in China, and is purchased from Qingdao Xiangyu seaweed Co., Ltd, and has a trade name of food-grade sodium alginate.

The GUM arabic, having an INCI name ACACIA SENEGAL GUM, serial number 01017 in chinese catalogue of used cosmetic raw materials (2015 edition), was purchased from Aqia, inc, under the trade name plantentcol.

The SODIUM HYALURONATE, sold under the English INCI name SODIUM HYALURONATE, HAs the serial number of 06722 in the catalogue of used cosmetic raw material names (2015 edition) in China, and is purchased from Shandong Xibai company under the trade name SODIUM HYALURONATE (HA-TLM) Hybloom.

The GLYCERIN is named GLYCERIN by INCI, and is numbered 02421 in catalog of names of used cosmetic raw materials (2015 edition) in China; the BUTANEDIOL is 1,2-BUTANEDIOL in English INCI name, and has the serial number of 00003 in catalog of names of used cosmetic raw materials (2015 edition) in China; the propylene glycol is PROPANEDIOL (English name), and has a serial number of 00006 in catalog of used cosmetic raw material names (2015 edition) in China; the DIPROPYLENE GLYCOL is named Dipropyrene GLYCOL by English INCI, and the serial number of the DIPROPYLENE GLYCOL in Chinese catalogue of names of used cosmetic raw materials (2015 edition) is 06223; the diglycerol is English INCI name DIGLYCERIN, and has a serial number of 06233 in the directory of names of used cosmetic raw materials (2015 edition) in China; the pentanediol is called INCI name PENTYLENE GLYCOL, and the serial number in the catalogue of names of used cosmetic raw materials (2015 edition) in China is 00005; the HEXANEDIOL is 1,2-HEXANEDIOL with English INCI name, and the serial number in the directory of names of used cosmetic raw materials (2015 edition) in China is 00004; the LYSOLECITHIN is called LYSOLECITHIN by the English INCI name, and the serial number of the LYSOLECITHIN in the catalogue of names of used cosmetic raw materials (2015 edition) in China is 05562; the CALCIUM CHLORIDE is named as CALCIUM CHLORIDE by INCI, and the serial number of the CALCIUM CHLORIDE in catalog (2015 edition) of used cosmetic raw materials in China is 04512; the ethylhexyl glycerin has an English INCI name of ethyllhexylglutamic acid, and has a serial number of 07706 in Chinese catalogue of names of used cosmetic raw materials (2015 edition); the CAPRYLHYDROXAMIC ACID is the INCI name caprylhydroxami ACID, and the serial number in the directory of names of used cosmetic raw materials (2015 edition) in china is 07218; the CARBOMER, English INCI name CARBOMER, in Chinese catalog of names of used cosmetic raw materials (2015 edition), has a serial number of 04079; the SODIUM HYALURONATE, English INCI name SODIUM HYALURONATE, in Chinese catalog of names of used cosmetic raw materials (2015 edition), has a serial number of 06722; the number of the SODIUM POLYACRYLATE is 03707 in the index of used cosmetic raw materials (2015 edition) in China; the hydroxyethyl cellulose has an INCI name of HYDROXYYETHYLCELLULOSE, and has a serial number of 05294 in catalog of used cosmetic raw material names (2015 edition) in China; the number of the XANTHAN GUM, English INCI name XANTHAN GUM, in catalog of names of used cosmetic raw materials (2015 edition) in China is 03086; the AGAR, the English INCI name AGAR, has a serial number of 05440 in the catalogue of names of used cosmetic raw materials (2015 edition) in China; the TREHALOSE is represented by the English INCI name TREHALOSE, and has the serial number of 02745 in the catalogue of names of used cosmetic raw materials (2015 edition) in China; the PANTHENOL, having an INCI name of PANTHENOL, was numbered 02292 in the catalogue of names of used cosmetic raw materials (2015 edition) in china; the number of the BETAINE, English INCI name BETAINE, in the catalogue of names of used cosmetic raw materials (2015 edition) in China is 06665; the number of the glyceryl polyether-26 and English INCI name GLYCERETH-26 in the catalog of used cosmetic raw material names (2015 edition) in China is 02450; the PEG/PPG-17/6 COPOLYMER is named PEG/PPG-17/6 COPOLYMER by INCI, and is numbered 00445 in catalog of used cosmetic raw material names (2015 edition) in China; the citric acid is represented by the English INCI name CITRIC ACID, and the serial number in the catalogue of names of used cosmetic raw materials (2015 edition) in China is 04849; the number of SODIUM CITRATE, the English INCI name SODIUM CITRATE, in the catalog of names of used cosmetic raw materials (2015 edition) in China is 04856.

Compared with the commercially available efficacy-type skin care adhesive film, the active ingredient fixed-point pressing release type skin care adhesive film prepared by the invention has the following advantages:

(1) through the modes of mesoporous silicon adsorption and macromolecule wrapping and loading, the limitations of poor stability, low loading capacity and unobvious effect of directly adding an efficacy type active substance into a product are overcome, and the activity of the active substance is retained to the maximum extent;

(2) by pressing the product near the circular salient point area when the product is applied and used, on one hand, the effective active substances can be promoted to be released and absorbed to the maximum extent in a short time, on the other hand, the absorption of product essence can be enhanced, the blood circulation and the metabolism are promoted, and the effect is remarkable;

(3) the flaky microcapsules in different positions of the same skin care adhesive film have different efficacies and are used for meeting the requirements of skins in different areas on different efficacies, and one product can simultaneously solve various skin problems and is more convenient to use.

To confirm that the patch for skin care of the site-specific pressure-release type of active ingredient prepared by the present invention has the above advantages, the present invention has conducted the following tests.

Experiment I, experiment for maintaining stability of active ingredients of the active ingredient fixed-point pressing release type skin care adhesive film prepared by the invention

The reduction percentages of the whitening active ingredients 4-methoxysalicylate, phenethyl resorcinol, resveratrol, glutathione, anti-aging active ingredient coenzyme Q10, ribose, retinol, digalactosyl diglyceride in the active ingredient fixed-point press-release type mask prepared in example 1 after being placed at 50 ℃ for one month, six months, 1 year, 2 years are respectively detected by High Performance Liquid Chromatography (HPLC) and are shown in table 1. The data in the table show that the active substance with the efficacy is adsorbed, wrapped and loaded in the flaky microcapsule and loaded on the product, and the active ingredient can still keep more than 90 percent after being placed at 50 ℃ for two years, which shows that the invention can effectively improve the stability of the active substance and reduce the reduction of the active ingredient.

TABLE 1 percent reduction of active ingredient before and after high temperature

Active ingredient	1 month/%)	6 month/%)	1 year/%)	2 years/%)
					4-Methoxysalicylic acid potassium salt	1.53	3.47	6.92	9.56
Phenethylresorcinol	1.81	2.96	5.44	8.25
					Resveratrol	2.04	3.61	6.32	9.27
Glutathione	1.96	3.22	5.95	8.81
					Coenzyme Q10	1.21	2.54	4.87	6.65
Ribose	1.92	2.78	5.63	7.89
					Vitamin A alcohol	2.01	3.52	6.38	9.21
Digalactosyl diglyceride	1.56	2.88	4.27	5.81

Experiment II, efficacy determination experiment of the active ingredient fixed-point pressing release type skin care adhesive film prepared by the invention

60 female volunteers between 30-50 years of age were selected on a voluntary basis and divided into 2 groups for parallel testing. Experimental group 1 required the use of the active ingredient fixed-point press-release type facial mask prepared in example 1 of the present invention (the content of the active ingredient was measured by high performance liquid chromatography HPLC), and experimental group 2 added the same content of the active ingredient to the same facial mask essence, and the same non-woven fabric was used as the mask in example 1. Subjects were asked to use three times a week, before use and after 1 month of use for follow-up tests, totaling 2 times, with follow-up being the same time of day and no other products of the same type being used during the trial. During the follow-up period, the phenomena of skin allergy, erythema, itching and the like caused by using the test sample do not occur to the user. Before the test, the tested subject needs to sit still for 20min in a constant temperature and humidity environment (room temperature is 22 ℃ plus or minus 2 ℃, and relative humidity is 45 percent plus or minus 5 percent), then the elasticity, wrinkle and whiteness change ratio of the corresponding position of the skin before use and after 1 month of use are measured and analyzed by an MPA580 skin elasticity tester, a PRIMOS PICO skin wrinkle detector and a Mentota CM-700D spectrophotometer, and the results are respectively shown in Table 2.

Table 2 skin elasticity, wrinkle and whiteness change ratio test data before and after use

	△R2	△Wv	ITA°
				Experimental group 1	92.53%	-49.22%	41.85%
Experimental group 2	65.15%	-31.17%	20.12%

R2 is the ratio of the rebound quantity of the skin without negative pressure to the maximum stretching quantity with negative pressure, and can represent the elasticity of the skin, Wv is a comprehensive parameter representing the severity of wrinkles, and ITA DEG is a comprehensive parameter representing the whiteness of the skin. In Table 2, Δ R2, Δ Wv and Δ ITA ° represent the change ratios of elasticity, wrinkles and whiteness of the skin at the corresponding positions before and after the use of the samples in 4 parallel experimental groups, respectively. As can be seen from table 2, the elasticity and whiteness of the corresponding positions of the skin in the 2 groups of experiments are improved, wrinkles become shallow, the anti-wrinkle and whitening effects of the experimental group 1 using the active ingredient fixed-point pressing release type face mask are obviously higher than those of the experimental group 2, and the whitening and tightening effects of the active ingredients with efficacy can be better exerted.

While the self-evaluation questionnaire results for 60 subjects showed: the irritation of eyes is obviously higher than that of the experimental group 1 when the product of the experimental group 2 is used, which shows that the fixed-point pressing release type facial mask containing the active ingredients prepared in the embodiment 1 can effectively improve facial spots and simultaneously can avoid the irritation of whitening active ingredients to thinner skin around eyes.

In conclusion, the active ingredient fixed-point pressing release type skin care adhesive film prepared by the invention keeps the efficacy of the active substance by adopting a mesoporous silicon adsorption and polymer wrapping and loading mode, promotes the release and absorption of the active substance by utilizing a massage mode, increases the pertinence of the product on the basis of the efficacy of the product by adopting a regional nursing mode, and has the advantages of novel and unique use mode, small irritation, good safety and stability of the product and the like.

Drawings

FIG. 1 is a schematic view of a face mask structure in example 1;

FIG. 2 is a schematic view of a structure of a face mask in accordance with embodiment 2;

FIG. 3 is a schematic view of a structure of a face mask of embodiment 3;

FIG. 4 is a schematic view of a neck patch of example 4;

FIG. 5 is a schematic view of the structure of the foot patch of example 5;

fig. 6 is a schematic structural view of the abdomen cover of the embodiment 6.

Detailed Description

The present invention will be further described with reference to the following examples, but the present invention is not limited to the following examples.

Example 1: an active ingredient fixed-point press-release type face mask is characterized in that active ingredient fixed-point press-release type face mask cloth is prepared by the following method:

A. according to the mass ratio of 2: 5: 1: 3: 70 weighing 4-methoxy potassium salicylate, phenethyl resorcinol, resveratrol, glutathione and polyhydric alcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain whitening effect active solution; according to the mass ratio of 1: 1: 5: 6: 72 weighing coenzyme Q10, ribose, vitamin A alcohol, digalactosyldiglyceride and polyalcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain an anti-wrinkle effect active solution; the polyalcohol is a mixture of glycerol, dipropylene glycol and diglycerol;

B. according to the mass ratio of 5: 18: 50, weighing hydrophilic mesoporous silicon, the whitening effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed whitening effect active solution into the mesoporous silicon suspension, stirring at the speed of 500rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain whitening effect mesoporous silicon powder;

C. according to the mass ratio of 3: 14: 50, weighing hydrophilic mesoporous silicon, the anti-wrinkle active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed anti-wrinkle active solution into the mesoporous silicon suspension, stirring at the speed of 400rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain anti-wrinkle mesoporous silicon powder;

D. according to the mass ratio of 3: 1: 1: 1: 85 weighing the extract of Chondrus crispus, sodium alginate, Arabic gum, sodium hyaluronate and deionized water, stirring at 800rpm for 0.5h to obtain mixed colloidal solution with mass concentration of 4-8%, heating to 60 deg.C, and keeping the temperature for later use;

E. according to the mass ratio of 3: 1: 1, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

F. according to the mass ratio of 6: 70: 5: 1, weighing the whitening mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at 1500rpm for 30min, and controlling the temperature at 60 ℃ to obtain a whitening premixed solution;

G. according to the mass ratio of 1: 60: 3: 1, weighing the anti-wrinkle mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at 1500rpm for 30min, and controlling the temperature at 60 ℃ to obtain an anti-wrinkle premixed solution;

H. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of the grooves is 8-20mm, the height of the grooves is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the whitening premixed solution prepared in the step H is dripped into each groove, and after the whitening premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ for drying and demolding to obtain the whitening microcapsules; and under the same condition, dripping the anti-wrinkle premixed solution to prepare the anti-wrinkle microcapsule.

I. Sticking anti-wrinkle active ingredient sheet microcapsule on the corresponding positions of the front surface of the facial mask cloth by using glutinous rice glue, wherein the microcapsule is a 1-left Tongziliao acupoint, a 2-left retrobulbar acupoint, a 3-left Chengqi acupoint, a 4-left Jingming acupoint, a 5-left Zanzhu acupoint, a 6-left Yuyao acupoint, a 7-left Sizhukong acupoint, a 8-right Tongziliao acupoint, a 9-right retrobulbar acupoint, a 10-right Chengqi acupoint, a 11-right Jingming acupoint, a 12-right Zanzhu acupoint, a 13-right Yuyao acupoint and a 14-right Sizhukong acupoint (a real heart point, see attached figure 1), the whitening active ingredient sheet microcapsules are stuck to corresponding positions on the front surface of the facial mask cloth, namely 15 points of Zuojuliano, 16 points of Zuoquan, 17 points of Zuodian, 18 points of Zuojuliano, 19 points of Zuoquan and 20 points of Zuodian (hollow points, see attached figure 1), and round hard pressing particles which are made of tourmaline and have the same diameter and size and are used for assisting the release of the active ingredient are stuck to the positions on the back surface of the facial mask cloth, which are the same as the positions of the sheet microcapsules, so that the active ingredient fixed-point pressing release type skin care facial mask cloth is prepared.

The product essence is prepared from the following raw materials in percentage by mass: 1.2% of thickening agent, 4% of functional emollient, 3% of humectant, 0.45% of pH regulator, 1.5% of preservative, 0.03% of essence and the balance of deionized water. The thickening agent is a mixture of carbomer, sodium hyaluronate and agar; the functional emollient is a mixture of trehalose and betaine; the humectant is a mixture of glycerol, butanediol and propylene glycol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is a mixture of phenoxyethanol and ethylhexyl glycerin.

And (4) filling 25g of the product essence into an aluminum-plastic composite film bag containing the active ingredient fixed-point press-release type facial mask cloth obtained in the step (I), and sealing to obtain the active ingredient fixed-point press-release type facial mask.

The minimum breaking force of the microcapsules is 12.3N and the minimum separating force between the microcapsules and the round hard pressing particles and the active ingredient fixed-point pressing release type face mask cloth is 54.4N.

The prepared active ingredient fixed-point press-release type face mask is placed in a constant-temperature drying oven at 50 +/-0.5 ℃ for three-month high-temperature stability test, and the phenomenon that microcapsules and round hard press particles adhered to the active ingredient fixed-point press-release type face mask cloth fall off or break is not found.

Example 2: an active ingredient fixed-point press-release type face mask is characterized in that active ingredient fixed-point press-release type face mask cloth is prepared by the following method:

A. according to the mass ratio of 1: 3: 5: 8: 70, weighing coenzyme Q10, ribose, vitamin A alcohol, digalactosyldiglyceride and polyalcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain an anti-wrinkle effect active solution; according to the mass ratio of 5: 5: 7: 5: 60 weighing herba Centellae extract, allantoin, heparin sodium, licochalcone A and polyalcohol, mixing, heating, stirring to dissolve completely, and cooling to room temperature to obtain a soothing active solution; the polyhydric alcohol is a mixture of glycerol, butanediol and propylene glycol;

B. according to the mass ratio of 2: 15: 50, weighing hydrophilic mesoporous silicon, the anti-wrinkle active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain a mesoporous silicon suspension, adding the weighed anti-wrinkle active solution into the mesoporous silicon suspension, stirring at the speed of 400rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain anti-wrinkle mesoporous silicon powder;

C. according to the mass ratio of 5: 6: 50, weighing hydrophilic mesoporous silicon, the soothing effect active solution and deionized water, mixing the hydrophilic mesoporous silicon and the deionized water, stirring at the speed of 600rpm for 1min to obtain mesoporous silicon suspension, adding the weighed soothing effect active solution into the mesoporous silicon suspension, stirring at the speed of 400rpm for 0.5h, centrifuging at the speed of 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain soothing effect mesoporous silicon powder;

D. according to the mass ratio of 1: 1: 1: 1: 85 weighing the extract of Chondrus crispus, sodium alginate, Arabic gum, sodium hyaluronate and deionized water, stirring at 800rpm for 0.5h to obtain mixed colloidal solution with mass concentration of 4-8%, heating to 60 deg.C, and keeping the temperature for later use;

E. according to the mass ratio of 1: 1: 1, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

F. according to the mass ratio of 1: 60: 3: 1, weighing the anti-wrinkle mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at 1500rpm for 30min, and controlling the temperature at 60 ℃ to obtain an anti-wrinkle premixed solution;

G. according to the mass ratio of 2: 60: 3: 1, weighing the soothing mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at 1500rpm for 10min, and controlling the temperature at 60 ℃ to obtain a soothing premixed solution;

H. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of each groove is 8-20mm, the height of each groove is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the crease-resistant premixed solution prepared in the step F is dripped into each groove, and after the crease-resistant premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ to be dried and demoulded to obtain the crease-resistant microcapsules; under the same condition, dripping the relieving premixed solution to prepare a relieving microcapsule;

I. sticking anti-wrinkle active ingredient sheet-shaped microcapsules at the corresponding positions of the front surface of the facial mask cloth at 1 point of Zhangzi Liao, 2 points of Zhangheng, 3 points of Zhangqi, 4 points of Jingming, 5 points of Zhanzhu, 6 points of Yuyao, 7 points of Sizhu, 8 points of Zhangzi Liquao, 9 points of Zhangheng, 10 points of Zhaqi, 11 points of Zhangming, 12 points of Zhanzhu, 13 points of Zhangyao, 14 points of Zhangzhun (center point, see figure 2), sticking soothing active ingredient sheet-shaped microcapsules at the corresponding positions of the front surface of the facial mask cloth at 15 points of Zhangiao, 16 points of Zhangzhai, 17 points of Zhancang, 18 points of Zhangqi, 19 points of Zhanzhanghanzhang, 20 points of Zhanshuang, 21 points of Zhanyang, 22 points of Zhanjiang (hollow points, see figure 2), sticking round pressing particles of auxiliary active ingredients with the same diameter and size of carbon fiber material at the same positions of the back surface mask cloth, the facial mask cloth for skin care with the fixed-point pressing and releasing active ingredients is prepared.

The product essence is prepared from the following raw materials in percentage by mass: 1.0% of thickening agent, 3% of functional emollient, 5% of humectant, 0.35% of pH regulator, 1.5% of preservative, 0.01% of essence and the balance of deionized water. The thickening agent is a mixture of carbomer, sodium hyaluronate and sodium polyacrylate; the functional emollient is a mixture of trehalose, panthenol and betaine; the humectant is a mixture of glycerin and butanediol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is a mixture of phenoxyethanol and ethylhexyl glycerin.

The minimum breaking force of the microcapsules is 12.1N and the minimum separating force between the microcapsules and the round hard pressing particles and the active ingredient fixed-point pressing release type face mask cloth is 54.3N through the test of a mechanical property measuring device.

Example 3: an active ingredient fixed-point press-release type face mask is characterized in that active ingredient fixed-point press-release type face mask cloth is prepared by the following method:

A. according to the mass ratio of 1: 11: 5: 3: 70, weighing coenzyme Q10, ribose, vitamin A alcohol, digalactosyldiglyceride and polyalcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain an anti-wrinkle effect active solution; according to the mass ratio of 2: 2: 3: 3: 80 weighing vitamin B6, salicylic acid, linoleic acid, green tea extract and polyalcohol, mixing, heating, stirring to dissolve completely, and cooling to room temperature to obtain oil-controlling effective active solution; the polyhydric alcohol is a mixture of propylene glycol, dipropylene glycol and pentanediol;

B. according to the mass ratio of 2: 5: 50, weighing hydrophilic mesoporous silicon with the average particle size of 50-100nm, the anti-wrinkle effect active solution and deionized water, stirring at 600rpm for 1min to disperse the mesoporous silicon in the deionized water, adding the effect solution into the nanoparticle suspension after the nanoparticles are uniformly dispersed, stirring at 600rpm for 0.5h, then centrifuging at 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain anti-wrinkle effect mesoporous silicon powder;

C. according to the mass ratio of 1: 5: 50, weighing hydrophilic mesoporous silicon with the average particle size of 50-100nm, the oil control effect active solution and deionized water, stirring at 600rpm for 1min to disperse the mesoporous silicon in the deionized water, adding the effect solution into the nanoparticle suspension after the nanoparticles are uniformly dispersed, stirring at 600rpm for 0.5h, then centrifuging at 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain oil control effect mesoporous silicon powder;

D. according to the mass ratio of 2: 1: 1: 1: 90 weighing the carrageen crispus extract, sodium alginate, gum arabic, sodium hyaluronate and deionized water, stirring at 1500rpm for 1h to obtain a mixed colloidal solution with the mass concentration of 4-8%, heating to 60 ℃, and keeping the temperature for later use;

E. according to the mass ratio of 2: 1: 2, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

F. according to the mass ratio of 5: 70: 3: 1, weighing the anti-wrinkle mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, mixing, stirring at 1500rpm for 30min, and controlling the temperature at 60 ℃ to obtain an anti-wrinkle premixed solution;

G. according to the mass ratio of 5: 70: 3: 1, weighing the oil-control functional mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, stirring at 800rpm for 10min, and controlling the temperature at 60 ℃ to obtain an oil-control premixed solution;

H. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of each groove is 8-20mm, the height of each groove is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the crease-resistant premixed solution prepared in the step F is dripped into each groove, and after the crease-resistant premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ to be dried and demoulded to obtain the crease-resistant microcapsules; under the same condition, dripping the slow premixed solution to prepare the oil-controlling microcapsule;

I. sticking anti-wrinkle active ingredient sheet microcapsule on the corresponding positions of the front surface of the facial mask cloth by using glutinous rice glue, wherein the microcapsule is a 1-left Tongziliao acupoint, a 2-left retrobulbar acupoint, a 3-left Chengqi acupoint, a 4-left Jingming acupoint, a 5-left Zanzhu acupoint, a 6-left Yuyao acupoint, a 7-left Sizhukong acupoint, a 8-right Tongziliao acupoint, a 9-right retrobulbar acupoint, a 10-right Chengqi acupoint, a 11-right Jingming acupoint, a 12-right Zanzhu acupoint, a 13-right Yuyao acupoint and a 14-right Sizhukong acupoint (a real heart point, see attached figure 3), the oil-control active ingredient flaky microcapsules are stuck to corresponding positions on the front side of the facial mask cloth, namely, a 24-left Yangbai point, a 25-Yintang point, a 26-right Yangbai point, a 27-left Yingxiang point, a 28-Suliao point and a 29-right Yingxiang point (hollow points, see attached figure 3), and round hard pressing particles made of far infrared ceramic materials and having the same diameter and size and assisting in releasing the active ingredients are stuck to the positions on the back side of the facial mask cloth, which are the same as the flaky microcapsules, so that the active ingredient fixed-point pressing and releasing type skin care facial mask cloth is prepared.

The product essence is prepared from the following raw materials in percentage by mass: 1.0% of thickening agent, 4% of functional emollient, 5% of humectant, 0.3% of pH regulator, 1% of preservative, 0.02% of essence and the balance of deionized water. The thickening agent is a mixture of sodium hyaluronate, sodium polyacrylate and hydroxyethyl cellulose; the functional emollient is a mixture of panthenol and glyceryl polyether-26; the humectant is a mixture of glycerol and hexanediol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is caprylyl hydroximic acid.

And (4) filling 30g of the product essence into an aluminum-plastic composite film bag containing the active ingredient fixed-point press-release type facial mask cloth obtained in the step (I), and sealing to obtain the active ingredient fixed-point press-release type facial mask.

The minimum breaking force of the microcapsules is 11.7N and the minimum separating force between the microcapsules and the round hard pressing particles and the active ingredient fixed-point pressing release type face mask cloth is 52.1N through the test of a mechanical property measuring device.

Example 4: an active ingredient fixed-point press-release type neck pad pasting is prepared by adopting the following method:

A. according to the mass ratio of 2: 3: 1: 4: 80 weighing 4-methoxy potassium salicylate, phenethyl resorcinol, resveratrol, glutathione and polyhydric alcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain whitening effect active solution; the polyhydric alcohol is a mixture of glycerol, butanediol and hexanediol;

B. according to the mass ratio of 3: 1: 50, weighing hydrophilic mesoporous silicon with the average particle size of 50-100nm, the anti-wrinkle effect active solution and deionized water, stirring at 600rpm for 1min to disperse the mesoporous silicon in the deionized water, adding the effect solution into the nanoparticle suspension after the nanoparticles are uniformly dispersed, stirring at 500rpm for 0.5h, then centrifuging at 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain whitening effect mesoporous silicon powder;

C. according to the mass ratio of 2: 1: 1: 1: 92 weighing the carrageen crispus extract, sodium alginate, gum arabic, sodium hyaluronate and deionized water, stirring at the speed of 800rpm for 0.5h to obtain a mixed colloidal solution with the mass concentration of 4-8%, heating to 60 ℃, and keeping the temperature for later use;

D. according to the mass ratio of 1: 1: 3, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

E. according to the mass ratio of 2: 70: 3: 1, weighing the whitening mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, stirring at 1000rpm for 30min, and controlling the temperature at 60 ℃ to obtain a whitening premixed solution;

F. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of the grooves is 8-20mm, the height of the grooves is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the whitening premixed solution prepared in the step E is dripped into each groove, and after the whitening premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ for drying and demolding to obtain whitening microcapsules;

G. the whitening active ingredient flaky microcapsules are adhered to corresponding positions (solid points, see attached figure 4) on the front surface of the neck patch film cloth by using sticky rice glue at the interval of 1cm between the upper point and the lower point and the left point and the right point, and the circular hard pressing particles which are made of magnetic metal and have the same diameter and size and are used for assisting the release of the active ingredient are adhered to the positions, which are the same as the flaky microcapsules, on the back surface of the face patch film cloth, so that the neck patch film cloth for the skin care with the fixed-point pressing and releasing of the active.

The product essence is prepared from the following raw materials in percentage by mass: 1.5% of thickening agent, 5% of functional emollient, 3% of humectant, 0.10% of pH regulator, 1.5% of preservative, 0.01% of essence and the balance of deionized water. The thickening agent is a mixture of carbomer, sodium hyaluronate, sodium polyacrylate, hydroxyethyl cellulose, xanthan gum and agar; the functional emollient is trehalose; the humectant is a mixture of pentanediol and hexanediol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is phenoxyethanol.

And G, filling 40G of product essence into an aluminum-plastic composite separation type membrane bag containing the active ingredient fixed-point press-release type neck patch cloth obtained in the step G, and sealing to obtain the active ingredient fixed-point press-release type neck patch.

The minimum breaking force of the microcapsules was 13.2N and the minimum separation force between the microcapsules and the circular hard press particles and the active ingredient fixed-point press-release neck wrap film cloth was 55.3N, as measured by a mechanical property measurement apparatus.

The prepared active ingredient fixed-point press-release type face-pasting film is placed in a constant-temperature drying oven at the temperature of 50 +/-0.5 ℃ for three-month high-temperature stability test, and the phenomenon that microcapsules and round hard press particles adhered to the active ingredient fixed-point press-release type neck-pasting film cloth fall off or break is not found.

Example 5: an active ingredient fixed-point pressing release type foot pad pasting is prepared by the following method:

A. according to the mass ratio of 2: 5: 9: 5: 60 weighing herba Centellae extract, allantoin, heparin sodium, licochalcone A and polyalcohol, mixing, heating, stirring to dissolve completely, and cooling to room temperature to obtain a soothing active solution; the polyhydric alcohol is a mixture of glycerol, butanediol, propylene glycol, dipropylene glycol and hexanediol;

B. according to the mass ratio of 4: 15: 50, weighing hydrophilic mesoporous silicon with the average particle size of 50-100nm, the soothing effect active solution and deionized water, stirring at 600rpm for 1min to disperse the mesoporous silicon in the deionized water, adding the effect solution into the nanoparticle suspension after the nanoparticles are uniformly dispersed, stirring at 600rpm for 0.5h, then centrifuging at 2000rpm for 10min, washing with deionized water, and freeze-drying at-40 ℃ to obtain soothing effect mesoporous silicon powder;

C. according to the mass ratio of 3: 1: 1: 1: 95 weighing the carrageen crispus extract, sodium alginate, gum arabic, sodium hyaluronate and deionized water, stirring at the speed of 800rpm for 1h to obtain a mixed colloidal solution with the mass concentration of 4-8%, heating to 60 ℃, and keeping the temperature for later use;

E. according to the mass ratio of 8: 65: 3: 1, weighing the soothing mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, stirring at 1200rpm for 20min, and controlling the temperature at 60 ℃ to obtain a soothing premixed solution;

F. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of the grooves is 8-20mm, the height of the grooves is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the relieving premixed solution prepared in the step E is dripped into each groove, and after the solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ for drying and demolding to obtain the relieving microcapsules;

G. sticking the soothing active ingredient sheet microcapsules on corresponding positions of the front surface of the foot film sticking cloth by using sticky rice glue, namely, sticking 30 ruin points, 31 jixi points, 32 zhong feng points, 33 zui linqi points, 34 chong yang points, 35 sinking valley points, 36 taichong points, 37 Xiaxi points, 38 Neiting points and 39 Row-to-Row points (solid points, see figure 5), sticking round hard pressing particles which are prepared by carbon fibers, tourmaline, far infrared ceramics, magnetic metals and other materials and have the same diameter and size and are used for assisting the release of active ingredients on the same positions of the back surface of the foot film sticking cloth, and thus obtaining the active ingredient pressing fixed-point release type foot film sticking cloth;

the product essence is prepared from the following raw materials in percentage by mass: 0.5% of thickening agent, 3% of functional emollient, 8% of humectant, 0.08% of pH regulator, 1.5% of preservative, 0.03% of essence and the balance of deionized water. The thickening agent is a mixture of carbomer, sodium hyaluronate, sodium polyacrylate, hydroxyethyl cellulose and xanthan gum; the functional emollient is a mixture of trehalose, betaine and glyceryl polyether-26; the humectant is glycerin; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and caprylyl hydroximic acid.

And G, filling 30G of product essence into an aluminum-plastic composite film bag containing the active ingredient fixed-point press-release type foot pad pasting cloth obtained in the step G, and sealing to obtain the active ingredient fixed-point press-release type foot pad pasting.

The minimum breaking force of the microcapsule is 12.5N and the minimum separating force between the microcapsule, the round hard pressing particles and the active ingredient fixed-point pressing release type foot pad pasting cloth is 56.3N through the test of a mechanical property measuring device.

The prepared active ingredient fixed-point press-release type face-covering film is placed in a constant-temperature drying oven at 50 +/-0.5 ℃ for three-month high-temperature stability test, and the phenomenon that microcapsules and round hard press particles adhered to the active ingredient fixed-point press-release type foot-covering film cloth fall off or break is not found.

Example 6: an active ingredient fixed-point press-release type abdomen sticking film is prepared by adopting the following method:

A. according to the mass ratio of 1: 3: 5: 6: 65 weighing coenzyme Q10, ribose, vitamin A alcohol, digalactosyldiglyceride and polyalcohol, mixing, heating, stirring to completely dissolve, and cooling to room temperature to obtain an anti-wrinkle effect active solution; the polyhydric alcohol is a mixture of glycerol, butanediol, propylene glycol, dipropylene glycol, diglycerol, pentanediol and hexanediol;

B. according to the mass ratio of 5: 12: 50, weighing hydrophilic mesoporous silicon with the average particle size of 50-100nm, the anti-wrinkle effect active solution and deionized water, stirring at the speed of 600rpm for 1min to disperse the mesoporous silicon in the deionized water, adding the effect solution into the nanoparticle suspension after the nanoparticles are uniformly dispersed, stirring at the speed of 400rpm for 0.5h, then centrifuging at the speed of 2000rpm for 10min, washing with the deionized water, and freeze-drying at the temperature of-40 ℃ to obtain anti-wrinkle effect mesoporous silicon powder;

C. according to the mass ratio of 2: 1: 1: 1: 95 weighing the carrageen crispus extract, sodium alginate, gum arabic, sodium hyaluronate and deionized water, stirring at the speed of 800rpm for 0.8h to obtain a mixed colloidal solution with the mass concentration of 4-8%, heating to 60 ℃, and keeping the temperature for later use;

D. according to the mass ratio of 1: 1: 2, weighing hexanediol, ethylhexyl glycerol and caprylyl hydroximic acid, and uniformly mixing to obtain a mixed preservative solution;

E. according to the mass ratio of 5: 70: 3: 1, weighing the anti-wrinkle mesoporous silicon powder, the colloidal solution, the mixed preservative solution and lysolecithin, stirring at 900rpm for 20min, and controlling the temperature at 60 ℃ to obtain an anti-wrinkle premixed solution;

F. preparing a plurality of plastic molds with 100 grooves of 10 multiplied by 10, wherein the diameter of the grooves is 8-20mm, the height of the grooves is 5mm, 0.2ml of 2% calcium chloride aqueous solution is added in advance, 0.5ml of the crease-resistant premixed solution prepared in the step E is dripped into each groove, and after the crease-resistant premixed solution is gelatinized and condensed, the molds are placed in a vacuum drying oven at 40 ℃ for drying and demolding to obtain crease-resistant microcapsules;

G. adhering anti-wrinkle active ingredient sheet microcapsules at the corresponding positions (solid points, see figure 6) on the front surface of the abdomen sticking film cloth at the interval of 1cm between an upper point and a lower point and a left point and a right point by using glutinous rice glue, and adhering round hard pressing particles which are prepared by carbon fibers, tourmaline, far infrared ceramics, magnetic metal and other materials and have the same diameter and size and are used for assisting the release of active ingredients to the same positions on the back surface of the abdomen sticking film cloth to obtain the fixed-point pressing and releasing type abdomen sticking film cloth of the active ingredients;

the product essence is prepared from the following raw materials in percentage by mass: 2.0% of thickening agent, 6% of functional emollient, 7% of humectant, 0.4% of pH regulator, 1% of preservative, 0.01% of essence and the balance of deionized water. The thickening agent is a mixture of sodium polyacrylate, hydroxyethyl cellulose and xanthan gum; the functional emollient is a mixture of glyceryl polyether-26 and PEG/PPG-17/6 copolymer; the humectant is a mixture of butanediol and pentanediol; the pH regulator is a mixture of citric acid and sodium citrate; the preservative is a mixture of phenoxyethanol and ethylhexyl glycerin.

And G, filling 40G of product essence into an aluminum-plastic composite film bag containing the active ingredient fixed-point press-release type abdomen sticking film cloth obtained in the step G, and sealing to obtain the active ingredient fixed-point press-release type abdomen sticking film.

The minimum breaking force of the microcapsules is 14.8N and the minimum separating force between the microcapsules and the round hard pressing particles and the active ingredient fixed-point pressing release type belly pasting film cloth is 53.7N through the test of a mechanical property measuring device.

The prepared active ingredient fixed-point press-release type face adhesive film is placed in a constant-temperature drying oven at the temperature of 50 +/-0.5 ℃ for three-month high-temperature stability test, and the phenomenon that microcapsules and round hard press particles adhered to the active ingredient fixed-point press-release type belly adhesive film cloth fall off or break is not found.

Claims

1. An active ingredient fixed point pressing release type skin care pad pasting is characterized in that: the cosmetic active substance pressing device is characterized by comprising a non-woven fabric, a plurality of flaky microcapsules pasted on the front surface of the non-woven fabric and a plurality of round hard pressing particles pasted on the back surface of the non-woven fabric, wherein the flaky microcapsules are formed by wrapping cosmetic active substances by bag bodies with breaking force of 10-15N, the thickness of the flaky microcapsules is 0.5-1mm, the diameter of the flaky microcapsules is 3-6mm, and the positions of the round hard pressing particles on the back surface of the non-woven fabric correspond to the positions of the flaky microcapsules one by one.

2. The patch for skin care with site-specific pressure-release of active ingredient according to claim 1, characterized in that: the sticky subsides of sticky glutinous rice for the slice microcapsule on the non-woven fabrics, granule is pressed to circular stereoplasm adopts sticky the corresponding position of pasting at non-woven fabrics reverse side slice microcapsule of glutinous rice, granule is pressed to circular stereoplasm is one of carbon fiber, tourmaline, far infrared pottery, magnetic metal, and its size is equivalent with slice microcapsule size.

3. The patch for skin care with site-specific pressure-release of active ingredient according to claim 1, characterized in that: the sheet-shaped microcapsule is a whitening microcapsule, an anti-wrinkle microcapsule, an oil control microcapsule or a soothing microcapsule, and the wrapping mass ratio of the whitening microcapsule is 1-3: 1-8: 1: 1-5: 60-90 parts of 4-methoxy potassium salicylate, phenethyl resorcinol, resveratrol, glutathione and polyalcohol mixture; the anti-wrinkle microcapsule has a wrapping mass ratio of 1: 1-3: 5: 1-8: 65-85 coenzyme Q10, ribose, tretinoin, digalactosyldiglyceride, and a polyol mixture; the wrapping mass ratio of the oil-control microcapsule is 1-10: 2: 3: 1-3: 70-90% vitamin B6, salicylic acid, linoleic acid, green tea extract and a mixture of polyols; the weight ratio of the slow microcapsules to the coating is 1-5: 5: 1-9: 5: 50-70 of centella asiatica extract, allantoin, heparin sodium, licochalcone A and a polyol mixture.

4. The patch for skin care with site-specific pressure-release of active ingredient according to claim 3, characterized in that: the patch film is a face patch film, the whitening microcapsule corresponds to the left and right four hundred points, the left and right juliano points and the left and right dichlord points of the face, the wrinkle resistant microcapsule corresponds to the left and right Chengqi points, the left and right zanzhu points, the left and right Tongziliao points, the left and right Sizhu holes, the left and right Yuyao points, the left and right retrobulbar points and the left and right Jingming points of the face, the oil control microcapsule corresponds to the left and right Yangbai points, the Ingtang points, the Suliao points and the left and right Yingxiang points of the face, and the soothing microcapsule corresponds to the left and right Taiyang points, the left and right four hundred points, the left and right Julian.

5. The patch for skin care with site-specific pressure-release of active ingredient according to claim 3, characterized in that: the pad pasting is a foot pad pasting, and the relieving microcapsules correspond to a hill ruin acupoint, a Jiexi acupoint, a Zhongfeng acupoint, a Zulinqi acupoint, a sunken valley acupoint, a Taichong acupoint, an Neiting acupoint, a Xinjian acupoint and a Xiancui acupoint of the foot.

6. The patch for skin care with site-specific pressure-release of active ingredient according to claim 3, characterized in that: the adhesive film is a hand adhesive film or an arm adhesive film or a leg adhesive film, and the whitening microcapsules are distributed at an interval of 1cm between an upper point, a lower point, a left point and a right point.

7. A process for producing the sheet-like microcapsule according to claim 1 or 2 or 3, characterized by comprising the steps of: