CN111937896A - Insecticidal composition containing bistrifluron - Google Patents
Insecticidal composition containing bistrifluron Download PDFInfo
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- CN111937896A CN111937896A CN201910408264.3A CN201910408264A CN111937896A CN 111937896 A CN111937896 A CN 111937896A CN 201910408264 A CN201910408264 A CN 201910408264A CN 111937896 A CN111937896 A CN 111937896A
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- bistrifluron
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses an insecticidal composition containing bistrifluron. The composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is bistrifluron, and the active ingredient B is selected from one of cyantraniliprole and flupyradifurone. The mass ratio of the active ingredient A to the active ingredient B in the composition is 1: 80-80: 1, the total weight of the active ingredients accounts for 1% -80% of the composition, and the composition has a remarkable synergistic effect and is beneficial to overcoming and delaying the drug resistance of pests. The composition can effectively control common lepidoptera, homoptera and thysanoptera pests of crops, and particularly can be used for controlling diamond back moths and trialeurodes vaporariorum, and the effect is obviously higher than that of a single agent.
Description
Technical Field
The invention relates to an insecticidal composition, in particular to an insecticidal composition containing bistrifluron and application thereof in preventing and treating crop pests, and belongs to the field of pesticide.
Background
With the change of planting structure and agricultural production mode in China, a great amount of pesticides are frequently applied, so that the resistance of pests to pesticides rises faster and faster, and resistant pests such as whiteflies, thrips, diamondback moths and the like are more and more serious in recent years, thereby causing great loss to agricultural production. Although the nicotine medicament has good control effect on pests such as diamondback moth, whitefly and the like, the pests have obvious drug resistance after long-term use. The search for pesticides or pesticide compositions which have good control effect on resistant pests and can delay the resistance of the pests is one of the research and development subjects of pesticide manufacturers.
Bistrifluron (Bistrifluron) is a benzoylurea insecticide, and the chemical name of the Bistrifluron is as follows: 1- [ 2-chloro-3, 5-bis (trifluoromethyl) phenyl ] -3- (2, 6-difluorobenzoyl) urea with CAS number 201593-84-2. The bistrifluron is a chitin synthesis inhibitor, can obviously inhibit the production and development of insects, and enables the insects to die because of abnormal molting; can be used for preventing and controlling homoptera, lepidoptera, coleoptera and other pests.
Cyantraniliprole (Cyantraniliprole) is a bisamide insecticide, and the chemical name of the Cyantraniliprole is as follows: 3-bromo-1- (3-chloro-2-pyridinyl) -4' -cyano-2 ' -methyl-6 ' - (methylcarbamoyl) pyrazole-5-carboxamide, CAS number 736994-63-1. The action mechanism of the cyantraniliprole is to activate an insect ryanodine receptor, and the cyantraniliprole mainly acts on the insect ryanodine receptor to cause abnormal loss of calcium stored inside, so that insect muscles are paralyzed and die; the pesticide has no cross resistance with other types of pesticides, and can effectively kill lepidoptera larvae; it can also be used for killing thrips, aphid and other pests, including Coleoptera and Diptera.
Fluopyrafuranone (Flupyradifurone) is a neonicotinoid insecticide and has the chemical name: 4- [ (6-chloro-3-pyridylmethyl) (2, 2-difluoroethyl) amino ] furan-2 (5H) -one, CAS number 951659-40-8. Fluopyranone acts on the central nervous system of target pests and is an agonist of the nicotinic acetylcholine receptor (nAChR) of insects. It acts like natural neurotransmitter acetylcholine, selectively acts on insect central nervous system, binds to receptor protein, and then activates receptor to generate biological response, so that nerve cell is in excited state; however, unlike acetylcholine, fluoropyrazine is not inactivated by acetylcholinesterase binding and thus postsynaptic receptors are continuously opened, and its persistence results in a disorder of the insect nervous system, which in turn leads to a collapse of the insect nervous system. The flupyradifurone has the functions of systemic absorption, contact killing, stomach toxicity and osmosis, and has the advantages of quick acting, high efficiency, lasting effect, environmental friendliness and low toxicity. The flupyradifurone can enable pests to stop eating quickly, and can effectively prevent and control vector pests which transmit viruses and bacteria; due to its osmotic action, the agent can successfully control pests feeding on the bottom even if it is sprayed only to the top of the leaves, and is also effective in sequestering pests.
At present, in the use of pesticides, active ingredients with different action mechanisms are compounded, so that the method is an effective method for delaying the resistance of pests. The compounded product can effectively improve the control effect and reduce the use amount of pesticide, thereby greatly delaying the generation of drug resistance of pests and being an important means for comprehensively controlling the pests. The prior art does not disclose the compound report of bistrifluron and cyantraniliprole or flupyradifurone.
Disclosure of Invention
The invention aims to provide a pesticide composition containing bistrifluron, which can be used for controlling crop pests, can effectively reduce the application dosage of active ingredients, reduce environmental pollution and delay the generation of drug resistance of the pests.
The technical scheme of the invention is as follows:
an insecticidal composition containing bistrifluron comprises an active component A and an active component B, wherein the active component A is bistrifluron, and the active component B is selected from one of cyantraniliprole and flupyradifurone.
The weight ratio of the active ingredient A to the active ingredient B of the insecticidal composition is 1: 80-80: 1;
further, the weight ratio of the active ingredient A to the active ingredient B is 1: 50-50: 1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1: 40-40: 1;
further, the mass ratio of cyantraniliprole to bistrifluron is 1: 2-1: 20; the mass ratio of the flupyradifurone to the bistrifluron is 2: 1-1: 10.
The weight sum of the active ingredients in the insecticidal composition is 1-80%, preferably 10-50% of the composition.
The insecticidal composition can be prepared into agriculturally acceptable preparations together with pesticide auxiliary components;
further, the auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent;
further, the carrier is any one, two or three of water, a solvent or a filler, and the water is preferably deionized water;
further, the solvent is selected from one or a mixture of more of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;
further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;
furthermore, the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements;
further, the surfactant is selected from one or more of an emulsifier, a dispersant, a wetting agent or a penetrant;
further, the other functional auxiliary agents are selected from one or more of an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent or an antifoaming agent;
further, the emulsifier is selected from one or more of agricultural milk 500# (calcium alkyl benzene sulfonate), OP series phosphate ester (nonylphenol polyoxyethylene ether phosphate ester), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether ammonium sulfate salt, magnesium salt of alkyl diphenyl ether disulfonate, triethanolamine salt, agricultural milk 400# (benzyldimethylphenol polyoxyethylene ether), agricultural milk 700# (alkylphenol formaldehyde resin polyoxyethylene ether), Ningru 36# (phenethylphenol formaldehyde resin polyoxyethylene ether), agricultural milk 1600# (phenethylphenol polyoxyethylene polyoxypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), agricultural dehydrated milk 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether) A mixture of seed constituents;
further, the dispersing agent is selected from one or a mixture of a plurality of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, sodium salt of naphthalene sulfonic acid formaldehyde polymer, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene or glycerol fatty acid ester polyoxyethylene;
further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, Chinese honeylocust fruit powder, silkworm excrement or soapberry powder;
further, the penetrating agent is selected from a mixture consisting of one or more of penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon;
further, the antifreezing agent is a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea;
further, the thickening agent is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;
further, the stabilizer is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate;
further, the disintegrating agent is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;
further, the defoaming agent is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds;
all of the above are commercially available.
The compositions of the present invention may be formulated into pesticidally acceptable dosage forms, including solid, liquid, seed treatment, other formulations, according to methods well known to those skilled in the art;
further, the solid preparation is powder, dispersible tablets, granules, soluble powder, soluble granules, soluble tablets, milk powder, milk granules, water dispersible granules, wettable powder, micro-capsule granules, powder, macro-granules and water dispersible tablets;
further, the liquid preparation is microcapsule suspending agent, dispersible agent, missible oil, emulsion granules, oil emulsion, emulsion powder, aqueous emulsion, microemulsion, dispersible oil suspending agent, oil dispersion powder, suspending agent, suspoemulsion, soluble solution and ultra-low volume liquid;
further, the seed treatment preparation is a suspended seed coating agent, a seed treatment dry powder agent, a seed treatment dispersible powder agent, a seed treatment suspending agent and a seed treatment liquid agent;
further, the other preparations are bait, concentrated bait, gas preparation, aerosol, smoke agent;
furthermore, the preparation formulation is preferably a suspending agent, an aqueous emulsion, missible oil, wettable powder and water dispersible granules;
further, the composition is prepared into a suspending agent, and the components and the content of the suspending agent are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 2-10% of dispersing agent, 2-10% of wetting agent, 0.01-2% of defoaming agent, 0-2% of thickening agent, 0-8% of antifreeze agent and the balance of deionized water;
further, the composition is prepared into an aqueous emulsion, and the components and the content of the composition are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 10-25% of solvent, 5-15% of emulsifier and the balance of deionized water;
further, the composition is prepared into missible oil, and the missible oil preferably comprises the following components in percentage by weight: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 1-10% of emulsifier and the balance of solvent;
further, the composition is prepared into wettable powder, and the components and the content of the wettable powder are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 2-10% of dispersing agent, 2-10% of wetting agent and the balance of filler;
further, the composition is prepared into water dispersible granules, and the components and the content of the water dispersible granules are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 3-12% of dispersing agent, 1-8% of wetting agent, 1-10% of disintegrating agent and the balance of filler.
The insecticidal composition is used for preventing and controlling hemiptera, thysanoptera, lepidoptera and homoptera pests of crops.
Further, the pests are specifically plutella xylostella and trialeurodes vaporariorum.
Compared with the prior art, the invention has the following beneficial effects: the insecticidal composition provided by the invention can generate a higher synergistic effect, is high in insecticidal speed, overcomes and delays the drug resistance of pests, can expand an insecticidal spectrum and reduce the drug cost, and has an effect obviously superior to that of a single agent.
Detailed Description
The present invention will be described in more detail with reference to examples. The practice of the invention is not limited to the following examples, and any variations or modifications in practice of the invention are intended to fall within the scope of the invention. The methods in the following examples are conventional in the art unless otherwise specified.
Preparation of the preparation
Example 1: 20% bistrifluron-cyantraniliprole suspending agent (10:10)
The formula is as follows: 10% of bistrifluron, 10% of cyantraniliprole, 6% of sodium salt of naphthalene sulfonic acid formaldehyde polymer, 7% of sodium lauryl sulfate, 1% of silicone oil, 1% of sodium acrylate, 7% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients of bistrifluron, cyantraniliprole, surfactant and other functional additives are sequentially placed in a reaction kettle, water is added for uniform mixing, and the product is obtained through high-speed shearing, wet sanding and finally homogeneous filtration.
Example 2: 10% bistrifluron-flurbiprofuranone suspension (5:5)
The formula is as follows: 5% of bistrifluron, 5% of flupyradifurone, 7% of polycarboxylate, 7% of saponin powder, 1% of silicone, 1% of sodium tripolyphosphate and the balance of deionized water.
The preparation method comprises the following steps: the same as in example 1.
Example 3: 30% bistrifluron-cyantraniliprole emulsion in water (20:10)
The formula is as follows: 20% of bistrifluron, 10% of cyantraniliprole, 4% of calcium dodecyl benzene sulfonate, 8% of phenethyl phenol polyoxyethylene ether phosphate, 33# 6% of agricultural emulsion, 2% of alkylphenol polyoxyethylene ether, 4% of isopropanol and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of bistrifluron and cyantraniliprole are added together with a solvent, an emulsifier and a cosolvent to be dissolved into a uniform oil phase; mixing part of water, antifreeze agent, antimicrobial agent and other pesticide auxiliary agents together to form a uniform water phase; adding the oil phase into the water phase while stirring at high speed in the reaction kettle, slowly adding water until reaching a phase inversion point, starting a shearing machine to shear at high speed, adding the rest water, and shearing for about half an hour to form the oil-in-water type emulsion in water.
Example 4: 30% bistrifluron-flupyradifurone emulsion in water (10:20)
The formula is as follows: 10% of bistrifluron, 20% of fluropyrone, 5% of N, N-dimethylformamide, 2% of cyclohexanone, 2% of nonylphenol polyoxyethylene ether phosphate, 1% of phenylphenol polyoxyethylene ether phosphate and the balance of deionized water.
The preparation method comprises the following steps: the same as in example 3.
Example 5: 20% bistrifluron-cyantraniliprole emulsifiable concentrate (10:10)
The formula is as follows: 10% of bistrifluron, 10% of cyantraniliprole, 3% of alkylphenol polyoxyethylene, 12% of phenethylphenol polyoxyethylene, and the balance of xylene.
The preparation method comprises the following steps: adding effective components of bistrifluron and cyantraniliprole into a carrier according to the proportion of the formula of the embodiment, adding a surfactant and other functional auxiliaries, and uniformly stirring and mixing in a stirring and mixing kettle to prepare the emulsifiable concentrate.
Example 6: 20% bistrifluron-flurbiprofuranone suspension (10:10)
The formula is as follows: 5% of bistrifluron, 5% of flupyradifurone, 3% of alkylphenol polyoxyethylene, 10.5% of phenethyl phenol polyoxyethylene ether and the balance of xylene.
The preparation method comprises the following steps: the same as in example 5.
Example 7: 18% Diflufenuron-cyantraniliprole wettable powder (10:8)
The formula is as follows: 10% of bistrifluron, 8% of cyantraniliprole, 5% of polyoxyethylene octylphenol ether, 6% of sodium dodecyl benzene sulfonate and the balance of white carbon black.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, active ingredients of bistrifluron and cyantraniliprole are added into a carrier, and a surfactant and other functional auxiliaries are added into the carrier, mixed, subjected to air flow crushing and then mixed to prepare the wettable powder.
Example 8: 22% Diflufenuron-Fluopyranone wettable powder (2:20)
The formula is as follows: 2% of bistrifluron, 20% of flupyradifurone, 3% of lignosulfonate, BX 7% of nekal and the balance of kaolin.
The preparation method comprises the following steps: the same as in example 7.
Example 9: 30% bistrifluron-cyantraniliprole water dispersible granule (20:10)
The formula is as follows: 20% of bistrifluron, 10% of cyantraniliprole, 4% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 5% of aluminum chloride and the balance of white carbon black.
The preparation method comprises the following steps: adding active ingredients of bistrifluron and cyantraniliprole into a carrier according to the formula proportion of an embodiment, adding a surfactant and other functional auxiliaries, mixing, carrying out air flow crushing, adding 10-25% of water, kneading, granulating, drying and screening to obtain a water dispersible granule product; or spraying water to the pulverized powder in a boiling granulator, granulating, drying, and sieving to obtain the water dispersible granule.
Example 10: 15% bistrifluron-fluridone water dispersible granule (10:5)
The formula is as follows: 10% of bistrifluron, 5% of flupyradifurone, 5% of naphthalene sulfonic acid formaldehyde polymer sodium salt, 5% of nekal BX 5%, 3% of bentonite and the balance of kaolin.
The preparation method comprises the following steps: the same as in example 9.
Indoor activity
Example 11: combined toxicity of cyantraniliprole and bistrifluron to cabbage diamondback moth
The test basis is as follows: NY/T1154.6-2006 section 6 pesticide laboratory bioassay guidelines for pesticides: insect immersion method for insecticidal activity test.
Test targets: diamondback moth (Plutella xylostella), 2-3 instar larvae of consistent instar were selected.
The instrument equipment comprises: electronic balances, insect-dipping cages, container bottles, petri dishes, beakers, pipettes, tweezers, filter paper, marker pens, stopwatches, and the like.
Test agents: 95% of bistrifluron technical, and 94% of cyantraniliprole technical.
Preparing a medicament: the two raw materials are dissolved in dimethylformamide, diluted with 0.01% Tween 80 aqueous solution, and set to 5 series of mass concentrations.
Medicament treatment: soaking diamondback moth in the medicinal liquid for 10s, sucking the redundant medicinal liquid with filter paper, and transferring the test insect to normal condition for feeding. Each treatment was repeated 4 times, each time 30-head soaking, and a blank control was set.
Data investigation: and investigating the death condition of the test insects 24 hours after treatment, recording the total number of the insects and the number of the dead insects, and calculating the corrected mortality of each treatment.
Mortality (%). percent (dead/total treated) x 100
Corrected mortality (%) - (treatment zone mortality-control zone mortality)/(100-control zone mortality) ] × 100
If the mortality rate of the control area is less than 5 percent, no correction is needed; if the mortality rate of the control area is between 5% and 20%, the mortality rate needs to be corrected; if the control zone mortality is > 20%, the test needs to be re-run.
And (3) statistics and analysis: performing data analysis using a data processing system to calculate LC for each agent50The test agent was evaluated.
Inputting the log of the drug concentration (g/L) as independent variable (X) and the corrected mortality rate as dependent variable (Y) into CASIO fx-180 p calculator to obtain LC of each drug50Value, coefficient of Synergy (SR) was calculated. The synergistic coefficient (SR) is more than or equal to 1.5, which shows that the composition has synergistic effect; SR < 0.5 shows antagonistic action; an SR between 0.5 and 1.5 indicates additive effect.
Theoretical LC of synergistic coefficient (SR) ═ mixture50Actual measurement of LC/mixture50
The test results are shown in table 1:
TABLE 1 Cyantraniliprole and bistrifluron combined virulence results for cabbage diamondback moth
| Medicament | Regression equation of virulence | Correlation coefficient | Measured LC50 | Theoretical LC50 | SR | Type of action |
| Cyantraniliprole bromide | Y＝1.9260X+3.7079 | 0.9976 | 4.6867 | / | / | / |
| Bistrifluron | Y＝1.6298X+3.3616 | 0.9982 | 10.1222 | / | / | / |
| Bromine: bis (40: 1) | Y＝1.8910X+3.7543 | 0.9977 | 4.5579 | 4.8193 | 1.06 | Additive effect |
| Bromine: bis (20: 1) | Y＝1.8983X+3.7454 | 0.9979 | 4.5805 | 4.9455 | 1.08 | Additive effect |
| Bromine: bis (10: 1) | Y＝1.8244X+3.7679 | 0.9986 | 4.7352 | 5.1808 | 1.09 | Additive effect |
| Bromine: bis (5: 1) | Y＝1.8022X+3.7595 | 0.9987 | 4.8792 | 5.5926 | 1.15 | Additive effect |
| Bromine: bis (2: 1) | Y＝1.7712X+3.7416 | 0.9975 | 5.1344 | 6.4985 | 1.27 | Additive effect |
| Bromine: bis (1: 1) | Y＝1.8611X+3.5816 | 0.9953 | 5.7827 | 7.4044 | 1.28 | Additive effect |
| Bromine: bis (1: 2) | Y＝1.8265X+3.7558 | 0.9955 | 4.7994 | 8.3103 | 1.73 | Synergistic action |
| Bromine: bis (1: 5) | Y＝1.8682X+3.6254 | 0.9981 | 5.4423 | 9.2163 | 1.69 | Synergistic action |
| Bromine: bis (1: 10) | Y＝1.8904X+3.5526 | 0.9977 | 5.8298 | 9.6280 | 1.65 | Synergistic action |
| Bromine: bis (1: 20) | Y＝1.8817X+3.5034 | 0.9988 | 6.2419 | 9.8633 | 1.58 | Synergistic action |
| Bromine: bis (1: 40) | Y＝1.5130X+3.6611 | 0.9951 | 7.6716 | 9.9896 | 1.30 | Additive effect |
Indoor activity tests show that (shown in table 1), the mixture of cyantraniliprole and bistrifluron has good indoor activity on cabbage diamondback moths, and when the mixture ratio of the cyantraniliprole to the bistrifluron is 1:2, 1:5, 1:10 and 1:20, the synergistic coefficient is more than 1.5, which shows that the synergistic effect is achieved.
TABLE 2 original data of combined toxicity of Cyantraniliprole and diflubenzuron for cabbage diamondback moth
Example 12: joint toxicity of Fluopyranone and bistrifluron mixed pairing tomato whitefly
The test basis is as follows: NY/T1154.9-2006 "indoor bioassay of pesticides Experimental guidelines part 9: spray method for testing insecticidal activity.
Test targets: tomato whitefly. White whitefly (Trialeurodes vaporariorum) healthy, consistent age of insects were selected for use.
The culture conditions are as follows: the culture conditions of the test target and the post-test target are temperature (26 +/-2) DEG C, relative humidity of 70% +/-4%, and light period of 14/10h (L/D).
The instrument comprises the following steps: electronic balance (sensing quantity is 0.1mg), quartz sand, artificial intelligence incubator, graduated cylinder, culture dish, brush pen, disposable plastic cup, beaker and the like, tweezers, scissors, glass stirring rod and the like.
Test agents: 95% of bistrifluron technical, and 96% of flupyradifurone technical.
Preparing a medicament: dissolving the raw material of bistrifluron and the raw material of flupyradifurone in dimethylformamide, diluting with 0.01% Tween 80 aqueous solution, and setting to 5 series of mass concentrations.
Medicament treatment: cutting tomato leaf with handle, placing in culture dish, and introducing CO240-50 heads of the narcotized trialeurodes vaporariorum are put under a Potter spray tower for quantitative (2.5mL) spray treatment (the pressure is 5 lb/in)2The sedimentation amount is 4.35mg/cm2) And in the test, clear water containing a corresponding organic solvent is treated as a control, the treatment is repeated for 4 times, the clear water is covered by a transparent plastic cup after spraying, the clear water is placed in an observation room with the temperature of 25-27 ℃ and the illumination for 14 hours, and the result is checked after 48 hours, and the pest is regarded as dead pest if the body is touched by a writing brush and no reaction occurs.
Investigation time and method: and investigating the death condition of the test insects 24 hours after the treatment of the medicament, and recording the number of live insects and the number of dead insects.
Data statistical analysis: based on the results of the investigation, the corrected mortality rate in percent (%) for the test insects was calculated for each treatment concentration according to the following formula.
Mortality (%). percent (dead/total treated) x 100
Corrected mortality (%) - (treatment zone mortality-control zone mortality)/(100-control zone mortality) ] × 100
If the mortality rate of the control area is less than 5 percent, no correction is needed; mortality correction is required if the control zone mortality is between 5% and 20%; if the control zone mortality is > 20%, the test needs to be re-run.
Inputting the log of the drug concentration (g/L) as independent variable (X) and the corrected mortality rate as dependent variable (Y) into CASIO fx-180 p calculator to obtain LC of each drug50Value, coefficient of Synergy (SR) was calculated. Coefficient of Synergy (SR) is more than or equal to 1.5Has the function of synergy; SR < 0.5 shows antagonistic action; an SR between 0.5 and 1.5 indicates additive effect.
Theoretical LC of synergistic coefficient (SR) ═ mixture50Actual measurement of LC/mixture50
The test results are shown in table 3:
TABLE 3 Combined virulence results for Fluopyranone and bistrifluron in combination for tomato whitefly
| Medicament | y＝Ax+B | Correlation coefficient | Measured LC50 | Theoretical LC50 | SR | Combined action |
| Fluopyrafuranones | Y＝1.5214X+4.3141 | 0.9941 | 2.8238 | / | ||
| Bistrifluron | Y＝1.3464X+4.0461 | 0.9837 | 5.1107 | / | ||
| Fluorine: bis (40: 1) | Y＝1.8910X+4.3235 | 0.9977 | 2.2789 | 2.8796 | 1.26 | Additive effect |
| Fluorine: bis (20: 1) | Y＝1.8983X+4.3168 | 0.9979 | 2.2903 | 2.9327 | 1.28 | Additive effect |
| Fluorine: bis (10: 1) | Y＝1.8757X+4.3711 | 0.9999 | 2.1642 | 3.0317 | 1.40 | Additive effect |
| Fluorine: bis (5: 1) | Y＝1.8460X+4.3601 | 0.9991 | 2.2214 | 3.2050 | 1.44 | Additive effect |
| Fluorine: bis (2: 1) | Y＝1.7953X+4.4158 | 0.9952 | 2.1154 | 3.5861 | 1.70 | Synergistic action |
| Fluorine: bis (1: 1) | Y＝1.7041X+4.3326 | 0.9967 | 2.4641 | 3.9673 | 1.61 | Synergistic action |
| Fluorine: bis (1: 2) | Y＝1.5764X+4.3237 | 0.9872 | 2.6856 | 4.3484 | 1.62 | Synergistic action |
| Fluorine: bis (1: 5) | Y＝1.4215X+4.3317 | 0.9872 | 2.9524 | 4.7296 | 1.60 | Synergistic action |
| Fluorine: bis (1: 10) | Y＝1.4662X+4.2640 | 0.9971 | 3.1768 | 4.9028 | 1.54 | Synergistic action |
| Fluorine: bis (1: 20) | Y＝1.6036X+4.1536 | 0.9867 | 3.3713 | 5.0018 | 1.48 | Additive effect |
| Fluorine: bis (1: 40) | Y＝1.7424X+4.0625 | 0.9992 | 3.4521 | 5.0549 | 1.46 | Additive effect |
Indoor activity tests show that the mixture of the flupyradifurone and the bistrifluron has good indoor activity for the tomato whitefly, wherein when the mixture ratio of the flupyradifurone to the bistrifluron is 2:1, 1:2, 1:5 and 1:10, the synergistic coefficient SR is more than 1.5, which shows synergistic effect.
TABLE 4 initial joint toxicity data of Fluopyranone and Biflumuron mixed paired tomato whitefly
Test of field drug effect
Example 13: in order to verify the field efficacy of cyantraniliprole and bistrifluron on diamondback moth, the inventor carried out a field efficacy test in the haili test base of Qingdao Shifengshi in 2018 and 5 months. When the pesticide is applied, the cabbage is in a vigorous growth stage, the growth is uniform, the incidence of the diamondback moth is large, and the cabbage is mainly provided with low-age larvae. The test was conducted with 7 treatments and a blank control (see table 5), using a randomized block arrangement, with a cell area of 20 squares, repeated 4 times per treatment, and the population base was investigated before the drug, and 1 was investigated 3 days, 7 days, and 15 days after the drug, for a total of 4 investigations. Randomly marking 5 points per cell, investigating 2 plants per point, and respectively investigating the number of live insects on each cabbage leaf, calculating the number of live insects, and calculating the reduction rate of insect population and the prevention and treatment effect, wherein the total number of the investigated plants is 10.
Percent reduction rate (%) of population (number of population before treatment-number of population after treatment) × 100/number of population before treatment
Control effect (%) (treatment area population reduction rate-control area population reduction rate)' 100/(1-control area population reduction rate)
TABLE 5 field control of Cyantraniliprole and diflubenzuron in combination with cabbage diamondback moth
The mixture of cyantraniliprole and bistrifluron has good control effects on cabbage diamondback moths in different proportions, the control effect after 3 days of application is not much different from that of a single agent, but the control effect after 7 days and 15 days of application is better than that of the single agent.
Example 14: in order to verify the field efficacy of the flupyradifurone and the bistrifluron on the trialeurodes vaporariorum, the inventor carried out a field efficacy test in 6 months in 2018 at the haili test base of the Qingdao Shifengshi. When the pesticide is applied, trialeurodes vaporariorum occurs seriously at the test point, mainly larvae, 7 treatments are set in the test, blank controls (shown in table 6) are set, random block arrangement is adopted, and the population base number of the trialeurodes vaporariorum and the pest amount of 1 time of each of 1 day, 3 days and 7 days after pesticide application are investigated respectively for 4 times. Sampling 5 points in each cell, fixing 2 plants in each point, carefully checking the back of the leaf, investigating the head number of the trialeurodes vaporariorum on the fixed plant in the case that the adult insects do not move and do not frighten the insects in the morning, and calculating the reduction rate of the insect population and the control effect.
Percent reduction rate (%) of population (number of population before treatment-number of population after treatment) × 100/number of population before treatment
Control effect (%) (treatment area population reduction rate-control area population reduction rate)' 100/(100-control area population reduction rate)
TABLE 6 field control of tomato whitefly by combination of Fluopyranone and Bisfluorfen
The test results show (see table 6): the mixture of the flupyradifurone and the bistrifluron has good control effect on the tomato whitefly, and has long lasting period, and the control effect is more than 90% in 7 days after the pesticide is applied.
Claims (9)
1. The insecticidal composition containing bistrifluron is characterized in that the effective components contain an active component A and an active component B, the active component A is bistrifluron, and the active component B is selected from one of cyantraniliprole and flupyradifurone.
2. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1: 80-80: 1.
3. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1:50 to 50: 1.
4. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1:40 to 40: 1.
5. The insecticidal composition according to claim 1, wherein the mass ratio of cyantraniliprole to bistrifluron is 1: 2-1: 20; the mass ratio of the flupyradifurone to the bistrifluron is 2: 1-1: 10.
6. An insecticidal composition according to claim 1, wherein the sum of the active ingredients in the composition is from 1% to 80%, preferably from 10% to 50% by weight of the total composition.
7. The insecticidal composition according to claim 1, wherein the composition is formulated in an agriculturally acceptable formulation in combination with a pesticidal adjuvant.
8. The insecticidal composition of claim 7, wherein said composition can be prepared into any one of agriculturally acceptable formulation forms including powder, dispersible tablet, granule, soluble powder, soluble granule, soluble tablet, emulsion powder, emulsion granule, water dispersible granule, wettable powder, microcapsule granule, powder, macrogranule, water dispersible tablet, microcapsule suspension, dispersible solution, emulsifiable concentrate, emulsion granule, oil emulsion, emulsion powder, water emulsion, microemulsion, oil dispersible suspension, oil dispersible powder, suspension, suspoemulsion, soluble solution, ultra-low volume liquid, suspended seed coating, dry seed treatment powder, dispersible seed treatment powder, suspension treatment suspension, seed treatment liquid; the preferable preparation formulation is suspending agent, aqueous emulsion, missible oil, wettable powder and water dispersible granule.
9. Use of the pesticidal composition according to claims 1-8 for controlling hemiptera, thysanoptera, lepidoptera, homoptera pests.
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| CN103636642A (en) * | 2013-11-30 | 2014-03-19 | 海利尔药业集团股份有限公司 | Insecticide composition containing chlorantraniliprole and bistrifluron |
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| CN106614680A (en) * | 2016-10-11 | 2017-05-10 | 深圳诺普信农化股份有限公司 | Insecticidal combination containing flupyradifurone |
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| CN103636642A (en) * | 2013-11-30 | 2014-03-19 | 海利尔药业集团股份有限公司 | Insecticide composition containing chlorantraniliprole and bistrifluron |
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