CN111936145A - γ聚谷氨酸化氨甲蝶呤及其用途 - Google Patents

γ聚谷氨酸化氨甲蝶呤及其用途 Download PDF

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CN111936145A
CN111936145A CN201980024560.1A CN201980024560A CN111936145A CN 111936145 A CN111936145 A CN 111936145A CN 201980024560 A CN201980024560 A CN 201980024560A CN 111936145 A CN111936145 A CN 111936145A
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gamma
composition
methotrexate
cancer
pmtx
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Chinese (zh)
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C·尼基萨
V·M·莫约
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LEAF Holdings Group LLC
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LEAF Holdings Group LLC
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980024560.1A 2018-02-14 2019-02-07 γ聚谷氨酸化氨甲蝶呤及其用途 Pending CN111936145A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862630713P 2018-02-14 2018-02-14
US62/630,713 2018-02-14
US201862662372P 2018-04-25 2018-04-25
US62/662,372 2018-04-25
US201862702774P 2018-07-24 2018-07-24
US62/702,774 2018-07-24
US201862764945P 2018-08-17 2018-08-17
US62/764,945 2018-08-17
PCT/US2019/016960 WO2019160733A1 (en) 2018-02-14 2019-02-07 Gamma polyglutamated methotrexate and uses thereof

Publications (1)

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CN111936145A true CN111936145A (zh) 2020-11-13

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US (3) US12290518B2 (https=)
EP (1) EP3752155A4 (https=)
JP (3) JP7462950B2 (https=)
CN (1) CN111936145A (https=)
CA (1) CA3090989A1 (https=)
WO (1) WO2019160733A1 (https=)

Cited By (1)

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US12239734B2 (en) 2018-02-07 2025-03-04 L.E.A.F. Holdings Group Llc Gamma polyglutamated raltitrexed and uses thereof
US12246015B2 (en) 2018-02-07 2025-03-11 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
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WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
JP7491573B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化メトトレキセートおよびその使用
WO2019157123A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
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