CN111920892A - A Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases - Google Patents
A Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and discloses a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases, which comprises, by mass, 4-8 parts of bighead atractylodes rhizome, 3-4 parts of earthworm, 2-3 parts of a dried orange peel extract, 3-4 parts of almond, 1-2 parts of a salvia miltiorrhiza extract, 4-5 parts of liquorice, 6-8 parts of trichosanthes bark, 4-6 parts of a platycodon grandiflorum extract, 6-7 parts of astragalus membranaceus, 2-3 parts of schisandra chinensis, 3-6 parts of agilawood and 5-7 parts of Chinese yam. The traditional Chinese medicine composition is a pure traditional Chinese medicine composition, and has low cost and wide medicinal material sources; the medicine property is mild, and no toxic or side effect exists; the combination of the medicinal materials can realize the effects of regulating the immunologic function, strengthening the physique, strengthening the body resistance function, reducing the frequency and the severity of the attack of the chronic obstructive pulmonary disease, blocking the development of the chronic obstructive pulmonary disease to the pulmonary heart disease, preventing the patients from complicating cardiovascular and cerebrovascular diseases and preventing the decline of the pulmonary function.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases.
Background
At present: chronic obstructive pulmonary disease is a group of pulmonary diseases characterized by airflow limitation, which is not completely reversible and progresses progressively. "Chronic obstructive pulmonary disease is not a single disease but a generic term used to describe chronic pulmonary disease that causes airflow limitation in the lungs. In recent years, the number of people who die due to respiratory diseases always accounts for the first few causes of death of people in China, no matter in cities or rural areas. Clinical manifestations of chronic obstructive pulmonary disease: the chronic bronchitis, obstructive emphysema and pulmonary heart disease are called as three stages of chronic obstructive pulmonary disease, which are greatly different according to different stages and severity of disease progression.
The chronic obstructive pulmonary disease is divided into an acute exacerbation phase and a stable phase, wherein the acute exacerbation phase refers to exacerbation of symptoms such as cough, expectoration, dyspnea and the like, and the chronic obstructive pulmonary disease enters the stable phase after the acute exacerbation phase is passed safely. Even in the stationary phase, lung function continues to decline at a much faster rate than the rate of natural decline of non-function. Over time, lung function deteriorates gradually, and the acute exacerbation period is more and more frequent. The chronic obstructive pulmonary disease still cannot be completely cured at present, and no specific medicine exists. The existing chronic pulmonary obstruction treatment medicine can only relieve symptoms and reduce the frequency and severity of acute exacerbation, but cannot block the development of pulmonary heart disease and is easy to cause heart, brain and blood vessel diseases.
Through the above analysis, the problems and defects of the prior art are as follows: the existing chronic pulmonary obstruction treatment medicine can only relieve symptoms and reduce the frequency and severity of acute exacerbation, but cannot block the development of pulmonary heart disease and is easy to cause heart, brain and blood vessel diseases.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases.
The invention is realized in such a way that a preparation method of a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases comprises the following steps:
step one, respectively putting bighead atractylodes rhizome, earthworm, dried orange peel, almond, salvia miltiorrhiza, liquorice, trichosanthes peel, platycodon grandiflorum, astragalus mongholicus, schisandra chinensis, agilawood and Chinese yam into clear water, removing surface impurities, cleaning, and draining surface water;
step two, putting the flaky atractylodes into a frying pan, frying the flaky atractylodes with strong fire until the surface of the atractylodes turns to be brown, spraying clear water, taking out and drying the atractylodes to obtain the brown atractylodes;
step three, mixing the earthworm, the almond, the agilawood and the Chinese yam, adding clear water to immerse the medicinal materials for 6-8 hours; then adding liquorice and schisandra chinensis, and continuing to soak for 8-12 h;
step four, putting the medicinal materials soaked in the step three and the soaking solution into a marmite, boiling the medicinal materials with medium fire, turning to small fire, and decocting for 3-4 hours; filtering and retaining the filtrate;
step five, adding water into the filter residue filtered in the step four, decocting for 1 hour with medium fire, filtering to obtain filtrate, and combining the two filtrates to obtain a mixed extract;
step six, drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder;
the drying method of the snakegourd peel comprises the following steps:
(6.1) slicing the washed snakegourd peel; placing the sliced pericarpium trichosanthis on a drying plate for drying;
(6.2) preheating the dryer, and placing the dried snakegourd peel sheets in the preheated dryer for drying;
(6.3) taking out the snakegourd peel sheets every 3 minutes, turning over and drying, and repeating for 2-3 times to obtain dried snakegourd peel;
seventhly, adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
the honey-fried astragalus slices with honey comprises the following steps:
(7.1) mixing honey and purified water according to the proportion of 1:1, and stirring uniformly to prepare honey water;
(7.2) soaking the flaky astragalus in prepared honey water for 6 hours;
(7.3) putting the soaked astragalus into a frying pan, frying for a period of time, and naturally cooling to obtain honey-fried astragalus;
step eight, mixing the scorched largehead atractylodes rhizome prepared in the step two, the mixed extracting solution prepared in the step five, the snakegourd peel powder prepared in the step six and the radix astragali preparata prepared in the step seven, adding the dried orange peel extract, the red sage root extract and the platycodon root extract, and uniformly stirring to obtain a mixed solution;
step nine, placing the mixed solution in a vacuum concentrator for concentration to obtain a concentrated solution; pouring the concentrated solution into a granulator, and granulating to obtain medicine granules;
step ten, placing the medicine particles in a drying box for drying, and stirring the medicine particles during drying;
step eleven, taking out the dried medicine particles, sieving, and reserving the particles with the particle size of 1.5-2.3mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
Further, in step six, the drying includes: the drying temperature is 50-70 deg.C, and the drying time is 10-15 min.
Further, in the step (6.1), the airing includes: and (3) turning the drying surfaces of the snakegourd peel sheets in turn every 3 hours, and adjusting the positions of the drying plates in turn every 2 hours to enable the drying plates to be directly sunned.
Further, in the seventh step, the honey-roasting with honey comprises: roasting with honey for 30 min; the honey consumption in honey moxibustion is 1/3 of the quality of the flaky astragalus root.
Further, in the eighth step, the preparation method of the dried orange peel extract comprises the following steps:
1) soaking pericarpium Citri Tangerinae with clear water for 1-2 hr, heating in marmite for 30-35min, and filtering;
2) adding clear water into the filtered pericarpium Citri Tangerinae to submerge the pericarpium Citri Tangerinae, decocting for 30-50min, and filtering again;
3) decocting for the third time, and filtering;
4) combining the filtrates for 3 times; heating and sterilizing the filtrate;
5) and concentrating the sterilized filtrate to be equivalent to 1g/mL of crude drug content to obtain the dried orange peel extract.
Further, in the eighth step, the preparation method of the salvia miltiorrhiza extract comprises the following steps:
step A, airing the cleaned salvia miltiorrhiza till the water content is not more than 5%;
b, putting the dried salvia miltiorrhiza into a grinder, and grinding into mud residue;
step C, soaking the mud-residue-shaped salvia miltiorrhiza in 75% ethanol for 6-8 days;
d, putting the soaked salvia miltiorrhiza into a spin dryer for spin-drying, and canning separated liquid;
and E, standing and precipitating, and taking supernatant liquor of the upper layer after 20 hours, namely the salvia miltiorrhiza extract.
Further, in the eighth step, the preparation method of the platycodon grandiflorum extract comprises the following steps:
step I, rolling platycodon grandiflorum to obtain solid-liquid coexisting platycodon grandiflorum slurry;
step II, adding 70% ethanol with the mass 10 times that of the platycodon grandiflorum slurry into an extraction device;
step III, heating and extracting for 4-5 h;
step IV, after extraction is finished, decompressing and concentrating to 1/4 of the volume of the initial mixed liquid;
and step V, carrying out spray drying to obtain the platycodon extract particles.
Further, in the ninth step, the concentrating specifically comprises: the concentration time is 40-50 deg.C, and the concentration temperature is 30-40 deg.C.
Further, in the tenth step, the drying specifically comprises: setting the drying temperature at 30-50 deg.C and the drying time at 40-60 min.
The invention also aims to provide a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases, which is prepared by the preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases, and the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases comprises, by mass, 4-8 parts of bighead atractylodes rhizome, 3-4 parts of earthworm, 2-3 parts of dried orange peel extract, 3-4 parts of almond, 1-2 parts of salvia miltiorrhiza extract, 4-5 parts of liquorice, 6-8 parts of trichosanthes bark, 4-6 parts of platycodon grandiflorum extract, 6-7 parts of astragalus mongholicus, 2-3 parts of schisandra chinensis, 3-6 parts of agilawood and 5-7 parts of Chinese yam.
By combining all the technical schemes, the invention has the advantages and positive effects that: the traditional Chinese medicine composition is a pure traditional Chinese medicine composition, and has low cost and wide medicinal material sources; the medicine property is mild, and no toxic or side effect exists; has effects in clearing away heat, eliminating phlegm, relieving cough and asthma, relieving chest stuffiness, and dispersing pathogen accumulation; tonifying lung, invigorating spleen, invigorating kidney, tonifying heart, lowering qi, and regulating appetite. The combination of the medicinal materials can realize the effects of regulating the immunologic function, strengthening the physique, strengthening the body resistance function, reducing the frequency and the severity of the attack of the chronic obstructive pulmonary disease, blocking the development of the chronic obstructive pulmonary disease to the pulmonary heart disease, preventing the patients from complicating cardiovascular and cerebrovascular diseases, preventing the lung function from being reduced and improving the life quality of the patients.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
Fig. 1 is a flow chart of a preparation method of a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases provided by the embodiment of the invention.
Fig. 2 is a flowchart of a preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases provided by the embodiment of the invention.
Fig. 3 is a flow chart of a method for preparing a dried orange peel extract according to an embodiment of the present invention.
FIG. 4 is a flow chart of a method for preparing a Salvia miltiorrhiza extract according to an embodiment of the present invention.
Fig. 5 is a flowchart of a method for preparing a platycodon grandiflorum extract according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The present invention provides a solution to the problems of the prior art, and is described in detail below with reference to the accompanying drawings.
The traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases, provided by the embodiment of the invention, comprises, by mass, 4-8 parts of bighead atractylodes rhizome, 3-4 parts of lumbricus, 2-3 parts of dried orange peel extract, 3-4 parts of almond, 1-2 parts of salvia miltiorrhiza extract, 4-5 parts of liquorice, 6-8 parts of trichosanthes peel, 4-6 parts of platycodon grandiflorum extract, 6-7 parts of astragalus membranaceus, 2-3 parts of schisandra chinensis, 3-6 parts of agilawood and 5-7 parts of Chinese yam.
As shown in fig. 1, the preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases provided by the embodiment of the invention comprises the following steps:
s101, respectively putting bighead atractylodes rhizome, earthworm, dried orange peel, almond, salvia miltiorrhiza, liquorice, trichosanthes peel, platycodon grandiflorum, astragalus mongholicus, schisandra chinensis, agilawood and Chinese yam into clear water, removing surface impurities, cleaning, and draining off surface water;
s102, putting the flaky atractylodes into a frying pan, frying the flaky atractylodes with strong fire until the surface of the atractylodes turns to be brown, spraying clear water, taking out and drying the atractylodes to obtain the brown atractylodes;
s103, mixing the earthworm, the almond, the agilawood and the Chinese yam, adding clear water to immerse the medicinal materials for 6-8 hours; then adding liquorice and schisandra chinensis, and continuing to soak for 8-12 h;
s104, putting the medicinal materials soaked in the step S103 and the soaking solution into a marmite, boiling with medium fire, turning to small fire, and decocting for 3-4 hours; filtering and retaining the filtrate;
s105, adding water into the filter residue filtered in the step S104, decocting for 1 hour with medium fire, filtering to obtain filtrate, and combining the two filtrates to obtain a mixed extract;
s106, drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder;
s107, adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
and S108, mixing the scorched largehead atractylodes rhizome prepared in the step S102, the mixed extracting solution prepared in the step S105, the snakegourd peel powder prepared in the step S106 and the roasted astragalus root prepared in the step S107, adding the tangerine peel extract, the salvia miltiorrhiza extract and the platycodon root extract, and uniformly stirring to obtain a mixed solution.
As shown in fig. 2, the preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases provided by the embodiment of the present invention further comprises:
s201, concentrating the mixed solution in a vacuum concentrator to obtain a concentrated solution;
s202, pouring the concentrated solution into a granulator for granulation to obtain medicine granules;
s203, placing the medicine particles in a drying box for drying, and stirring the medicine particles during drying;
s204, taking out the dried medicine particles, sieving, and keeping the particles with the particle size of 1.5-2.3mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
In step S106, the drying provided in the embodiment of the present invention specifically includes: the drying temperature is 50-70 deg.C, and the drying time is 10-15 min.
In step S106, the snakegourd peel drying method provided by the embodiment of the invention includes:
slicing the washed snakegourd peel; placing the sliced pericarpium trichosanthis on a drying plate for drying; preheating a dryer, and placing the dried snakegourd peel sheets in the preheated dryer for drying; taking out the snakegourd peel sheets every 3 minutes, turning over and drying, and repeating for 2-3 times to obtain the dried snakegourd peel.
In step S107, the honey-roasting of the sliced astragalus membranaceus with honey according to the embodiment of the present invention includes the following steps:
(7.1) mixing honey and purified water according to the proportion of 1:1, and stirring uniformly to prepare honey water;
(7.2) soaking the flaky astragalus in prepared honey water for 6 hours;
(7.3) putting the soaked astragalus into a frying pan, frying for a period of time, and naturally cooling to obtain the honey-fried astragalus.
In step S107, the honey-roasting with honey provided by the embodiment of the present invention specifically comprises: roasting with honey for 30 min; the honey consumption in honey moxibustion is 1/3 of the quality of the flaky astragalus root.
As shown in fig. 3, in step S108, the method for preparing the dried orange peel extract provided by the embodiment of the present invention includes:
s301, soaking the dried orange peel for 1-2 hours by using clear water, putting the soaked orange peel into a marmite, heating for 30-35min, and filtering;
s302, adding clear water into the filtered tangerine peel to immerse the tangerine peel, continuously decocting for 30-50min, and filtering again;
s303, carrying out third decoction and filtering;
s304, combining the filtrates for 3 times; heating and sterilizing the filtrate;
s305, concentrating the sterilized filtrate to be equivalent to 1g/mL of crude drug to obtain the dried orange peel extract.
As shown in fig. 4, in step S108, the preparation method of the salvia miltiorrhiza extract provided by the embodiment of the invention comprises:
s401, airing the cleaned salvia miltiorrhiza till the water content is not more than 5%;
s402, putting the dried salvia miltiorrhiza into a grinder, and grinding into mud residue;
s403, soaking the muddy salvia miltiorrhiza in 75% ethanol for 6-8 days;
s404, putting the soaked salvia miltiorrhiza into a spin dryer for spin-drying, and canning separated liquid;
s405, standing and precipitating, and taking supernatant liquid after 20 hours, namely the salvia miltiorrhiza extract.
As shown in fig. 5, in step S108, the method for preparing the platycodon grandiflorum extract provided by the embodiment of the present invention includes:
s501, rolling the platycodon grandiflorum to obtain solid-liquid coexisting platycodon grandiflorum slurry;
s502, adding 70% ethanol with the mass 10 times that of the platycodon grandiflorum slurry into an extraction device;
s503, heating and extracting for 4-5 h;
s504, after extraction is finished, decompressing and concentrating to 1/4 of the volume of the initial mixed liquid;
and S505, carrying out spray drying to obtain the platycodon extract particles.
The embodiment of the invention provides the following concrete steps of: the concentration time is 40-50 deg.C, and the concentration temperature is 30-40 deg.C.
The drying provided by the embodiment of the invention specifically comprises the following steps: setting the drying temperature at 30-50 deg.C and the drying time at 40-60 min.
The technical effects of the present invention are further described below in conjunction with pharmacological analysis.
Bai Zhu is bitter and sweet in flavor and warm in nature. It enters spleen and stomach meridians. Has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, eliminating phlegm, and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. The raw Bai Zhu is mainly used for strengthening spleen, drying dampness, inducing diuresis to alleviate edema, and can be used for phlegm-fluid retention, edema and wind-damp arthralgia. Stir-baked Bai Zhu with earth can help spleen by assisting qi, tonify spleen and check diarrhea, and is indicated for spleen deficiency with poor appetite, diarrhea, loose stool and threatened abortion. Largehead atractylodes rhizome stir-baked with bran can alleviate dryness, and strengthen the function of invigorating spleen and relieving distension by entering bran into the middle. Can be used for treating incoordination between spleen and stomach, disorder of transportation and transformation, anorexia, distention, listlessness, debilitation, exterior deficiency and spontaneous perspiration.
The earthworm is salty in taste and cold in nature, enters liver, spleen and bladder channels, has the effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma and inducing diuresis, and is used for high fever, coma, convulsion, arthralgia, numbness of limbs, hemiplegia, lung heat, cough and asthma, edema and oliguria. The wine earthworm is beneficial to crushing, removing fishy smell and correcting flavor, is convenient to take orally and externally, can enhance the effects of clearing and activating the channels and collaterals, and is used for treating migraine and headache, cold-dampness arthralgia and fracture swelling and pain.
Chen Pi can purge dryness due to its bitter flavor, can disperse pungent flavor and warm and harmonize. For all kinds of diseases, it is always used to regulate qi and dry dampness, tonics are used to tonify qi, purgatives are used to purge qi, ascending qi and descending qi. Has the effects of regulating qi, invigorating spleen, eliminating dampness, and eliminating phlegm.
The almond has the effects of relieving cough and asthma, enhancing human immunity, delaying aging, regulating blood fat, tonifying brain and improving intelligence.
Radix astragali is warm in nature and sweet in taste, and has effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, expelling pus, promoting granulation, and relieving swelling and diuresis. It can be used for treating spontaneous perspiration due to asthenia, internal injury due to overstrain, loose stool, diarrhea, edema due to qi deficiency, carbuncle, cellulitis, and skin ulcer.
The salvia miltiorrhiza is bitter in taste and slightly cold in nature, enters heart and liver channels, has the effects of removing blood stasis, stimulating the menstrual flow, relieving pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle, and is used for treating chest stuffiness and pains, epigastric and abdominal hypochondriac pain, abdominal mass and accumulation, heat arthralgia pain, vexation and insomnia, irregular menstruation, dysmenorrheal and amenorrhea, sore and ulcer with swelling and pain. Raw Danshen root has the functions of removing blood stasis, alleviating pain, clearing heart fire, relieving restlessness and promoting blood circulation, and is good at regulating female irregular channels and vessels, so it is often used for treating sores and abscess, postpartum stasis and pain, amenorrhea and abdominal pain, heart and abdomen pain and limb pain caused by blood heat and stasis due to cold and cool nature.
The liquorice is sweet in taste and neutral in nature, has the functions of entering heart, lung, spleen and stomach channels, clearing away heat and toxic materials, relieving cough and eliminating phlegm, tonifying spleen and stomach and harmonizing the drugs. The medicines are used for treating diarrhea due to spleen deficiency, stomach deficiency, thirst, cough due to lung deficiency, sore throat, palpitation, chest pain, carbuncle, swelling and pain, gastrointestinal ulcer, etc. Wang ang yun gan cao: raw material can smooth qi, tonify spleen and stomach deficiency and purge heart fire; the moxibustion is warm in nature and can tonify the triple energizer's original qi to dissipate exterior cold. The harmonizing agent can tonify the body, the liver-soothing agent can dispel the muscles, the cooling agent can dispel the pathogenic heat, and the moistening agent can nourish the blood, so as to harmonize the effects of the drugs.
Gua Lou Pi can clear and resolve heat-phlegm, induce qi and relieve chest stuffiness. Can be used for treating cough due to phlegm-heat, chest distress, and hypochondriac pain.
Platycodon grandiflorum is bitter and pungent in flavor and mild in nature; enter lung and stomach meridians. Has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus, and can be used for treating cough with excessive phlegm, chest distress, sore throat, bronchitis, lung abscess, and pleurisy. Radix Platycodi has effects of dispersing lung qi, eliminating phlegm, relieving sore throat, and expelling pus, and can be used for treating common cold with cough, excessive phlegm, sore throat, hoarseness, fullness and oppression in chest, lung carbuncle, cough with purulent blood.
Schisandra chinensis is sour and warm. Enter lung and kidney meridians. Sour, salty and warm in nature. Wu Wei Zi has the actions of astringing lung and nourishing kidney, stopping fluid and checking sweating, checking diarrhea with astringents and tranquilizing mind. It is used to treat chronic cough, asthma, diabetes, dry mouth, spontaneous perspiration, night sweat, spermatorrhea, chronic diarrhea, mydriasis, amnesia, and insomnia. It is used for reducing glutamic-pyruvic transaminase. Fructus Schisandrae has effects of astringing lung, relieving cough, invigorating kidney, and stopping nocturnal emission. It can be used for treating cough and asthma due to lung deficiency, spontaneous perspiration, night sweat, kidney deficiency, spermatorrhea, and chronic diarrhea.
Chenxiang is pungent and bitter in flavor and warm in nature; enter kidney, spleen and stomach meridians. Chenxiang is slightly warm in nature and pungent and bitter in flavor. Lignum Aquilariae Resinatum has effects of activating qi-flowing, relieving pain, warming middle energizer, relieving vomit, and absorbing qi and relieving asthma. Can be used for treating chest and abdomen distention, pain, stomach cold, emesis, singultus, kidney deficiency, reversed flow of qi, and dyspnea. The agilawood has the effects of promoting qi circulation, relieving pain, warming middle-jiao, lowering adverse qi, absorbing qi and relieving asthma: it is indicated for abdominal psychroalgia, dyspnea with dyspnea, stomach cold with vomiting and hiccup, deficiency cold of waist and knee, constipation due to deficiency of large intestine, and stranguria due to urinary qi.
The Chinese yam is sweet in taste and neutral in nature, enters spleen, stomach and kidney channels, has the effects of tonifying spleen and nourishing stomach, promoting fluid production and benefiting lung, and tonifying kidney and arresting seminal emission, and is used for treating spleen deficiency and poor appetite, chronic diarrhea, lung deficiency and cough, kidney deficiency and spermatorrhea, leukorrhagia, frequent micturition, deficiency heat and thirst quenching and the like.
The invention is further described below in connection with clinical trials.
1, medical record:
young women, 56 years old, workers, coughing for ten years, and examination results show that the lung is slowly obstructed and is more severe; after the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases is taken for one month, cough symptoms are relieved, the medicine is taken for 7 months for recovery, and relapse does not occur in three years.
Case 2:
mr. Li, man, 38 years old, examined for chronic obstruction of the lung due to chest and lung pain. After the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases is taken for one week, the pain is relieved, and the cough and pain symptoms disappear after the traditional Chinese medicine composition is taken for 1 month.
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1:
respectively placing Atractylodis rhizoma, Lumbricus, pericarpium Citri Tangerinae, semen Armeniacae amarum, radix astragali, Saviae Miltiorrhizae radix, Glycyrrhrizae radix, pericarpium Trichosanthis, radix Platycodi, fructus Schisandrae chinensis, lignum Aquilariae Resinatum and rhizoma Dioscoreae in clear water, removing surface impurities, cleaning, and draining off surface water;
putting the flaky atractylodes macrocephala koidz into a frying pan, frying the atractylodes macrocephala koidz with strong fire until the surface of the atractylodes macrocephala koidz is scorched, spraying clear water, taking out and airing to obtain scorched atractylodes macrocephala koidz; mixing Lumbricus, semen Armeniacae amarum, lignum Aquilariae Resinatum, and rhizoma Dioscoreae, adding clear water to submerge the medicinal materials, and soaking for 8 hr; then adding liquorice and schisandra chinensis, and continuing to soak for 12 h; placing the soaked medicinal materials and the soaking solution in a casserole, boiling with medium fire, turning to small fire, and decocting for 4 hr; filtering and retaining the filtrate; adding water into the filtered residue, decocting with medium fire for 1 hr, filtering to obtain filtrate, and mixing the filtrates to obtain mixed extractive solution; drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder; adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
mixing the prepared charred rhizoma Atractylodis Macrocephalae, the mixed extract, the pericarpium Trichosanthis powder and the radix astragali Preparata, adding the pericarpium Citri Reticulatae extract, the radix Salviae Miltiorrhizae extract and the radix Platycodonis extract, and stirring to obtain a mixture;
concentrating the mixed solution in a vacuum concentrator to obtain a concentrated solution; pouring the concentrated solution into a granulator, and granulating to obtain medicine granules; drying the medicine particles in a drying box, and stirring the medicine particles during drying; taking out the dried medicine particles, sieving, and keeping the particles with the particle size of 1.5mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
Example 2:
respectively placing Atractylodis rhizoma, Lumbricus, pericarpium Citri Tangerinae, semen Armeniacae amarum, radix astragali, Saviae Miltiorrhizae radix, Glycyrrhrizae radix, pericarpium Trichosanthis, radix Platycodi, fructus Schisandrae chinensis, lignum Aquilariae Resinatum and rhizoma Dioscoreae in clear water, removing surface impurities, cleaning, and draining off surface water;
putting the flaky atractylodes macrocephala koidz into a frying pan, frying the atractylodes macrocephala koidz with strong fire until the surface of the atractylodes macrocephala koidz is scorched, spraying clear water, taking out and airing to obtain scorched atractylodes macrocephala koidz; mixing Lumbricus, semen Armeniacae amarum, lignum Aquilariae Resinatum, and rhizoma Dioscoreae, adding clear water to submerge the medicinal materials, and soaking for 6 hr; then adding liquorice and schisandra chinensis, and continuing soaking for 8 hours; placing the soaked medicinal materials and the soaking solution in a casserole, boiling with medium fire, turning to small fire, and decocting for 3 hr; filtering and retaining the filtrate; adding water into the filtered residue, decocting with medium fire for 1 hr, filtering to obtain filtrate, and mixing the filtrates to obtain mixed extractive solution; drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder; adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
mixing the prepared charred rhizoma Atractylodis Macrocephalae, the mixed extract, the pericarpium Trichosanthis powder and the radix astragali Preparata, adding the pericarpium Citri Reticulatae extract, the radix Salviae Miltiorrhizae extract and the radix Platycodonis extract, and stirring to obtain a mixture;
concentrating the mixed solution in a vacuum concentrator to obtain a concentrated solution; pouring the concentrated solution into a granulator, and granulating to obtain medicine granules; drying the medicine particles in a drying box, and stirring the medicine particles during drying; taking out the dried medicine particles, sieving, and keeping the particles with the particle size of 2.3mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
Example 3:
respectively placing Atractylodis rhizoma, Lumbricus, pericarpium Citri Tangerinae, semen Armeniacae amarum, radix astragali, Saviae Miltiorrhizae radix, Glycyrrhrizae radix, pericarpium Trichosanthis, radix Platycodi, fructus Schisandrae chinensis, lignum Aquilariae Resinatum and rhizoma Dioscoreae in clear water, removing surface impurities, cleaning, and draining off surface water;
putting the flaky atractylodes macrocephala koidz into a frying pan, frying the atractylodes macrocephala koidz with strong fire until the surface of the atractylodes macrocephala koidz is scorched, spraying clear water, taking out and airing to obtain scorched atractylodes macrocephala koidz; mixing Lumbricus, semen Armeniacae amarum, lignum Aquilariae Resinatum, and rhizoma Dioscoreae, adding clear water to submerge the medicinal materials, and soaking for 7 hr; then adding liquorice and schisandra chinensis, and continuing to soak for 10 h; placing the soaked medicinal materials and the soaking solution in a casserole, boiling with medium fire, turning to small fire, and decocting for 3 hr; filtering and retaining the filtrate; adding water into the filtered residue, decocting with medium fire for 1 hr, filtering to obtain filtrate, and mixing the filtrates to obtain mixed extractive solution; drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder; adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
mixing the prepared charred rhizoma Atractylodis Macrocephalae, the mixed extract, the pericarpium Trichosanthis powder and the radix astragali Preparata, adding the pericarpium Citri Reticulatae extract, the radix Salviae Miltiorrhizae extract and the radix Platycodonis extract, and stirring to obtain a mixture;
concentrating the mixed solution in a vacuum concentrator to obtain a concentrated solution; pouring the concentrated solution into a granulator, and granulating to obtain medicine granules; drying the medicine particles in a drying box, and stirring the medicine particles during drying; taking out the dried medicine particles, sieving, and keeping the particles with the particle size of 2.0mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any modification, equivalent replacement, and improvement made by those skilled in the art within the technical scope of the present invention disclosed herein, which is within the spirit and principle of the present invention, should be covered by the present invention.
Claims (10)
1. A preparation method of a traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases is characterized in that the preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases comprises the following steps:
step one, respectively putting bighead atractylodes rhizome, earthworm, dried orange peel, almond, salvia miltiorrhiza, liquorice, trichosanthes peel, platycodon grandiflorum, astragalus mongholicus, schisandra chinensis, agilawood and Chinese yam into clear water, removing surface impurities, cleaning, and draining surface water;
step two, putting the flaky atractylodes into a frying pan, frying the flaky atractylodes with strong fire until the surface of the atractylodes turns to be brown, spraying clear water, taking out and drying the atractylodes to obtain the brown atractylodes;
step three, mixing the earthworm, the almond, the agilawood and the Chinese yam, adding clear water to immerse the medicinal materials for 6-8 hours; then adding liquorice and schisandra chinensis, and continuing to soak for 8-12 h;
step four, putting the medicinal materials soaked in the step three and the soaking solution into a marmite, boiling the medicinal materials with medium fire, turning to small fire, and decocting for 3-4 hours; filtering and retaining the filtrate;
step five, adding water into the filter residue filtered in the step four, decocting for 1 hour with medium fire, filtering to obtain filtrate, and combining the two filtrates to obtain a mixed extract;
step six, drying the snakegourd peel by using a dryer, and crushing the snakegourd peel after drying to obtain snakegourd peel powder;
the drying method of the snakegourd peel comprises the following steps:
(6.1) slicing the washed snakegourd peel; placing the sliced pericarpium trichosanthis on a drying plate for drying;
(6.2) preheating the dryer, and placing the dried snakegourd peel sheets in the preheated dryer for drying;
(6.3) taking out the snakegourd peel sheets every 3 minutes, turning over and drying, and repeating for 2-3 times to obtain dried snakegourd peel;
seventhly, adding honey into the flaky astragalus root to be roasted with honey; oven drying at 70 deg.C for 20min after honey roasting to obtain radix astragali Preparata;
the honey-fried astragalus slices with honey comprises the following steps:
(7.1) mixing honey and purified water according to the proportion of 1:1, and stirring uniformly to prepare honey water;
(7.2) soaking the flaky astragalus in prepared honey water for 6 hours;
(7.3) putting the soaked astragalus into a frying pan, frying for a period of time, and naturally cooling to obtain honey-fried astragalus;
step eight, mixing the scorched largehead atractylodes rhizome prepared in the step two, the mixed extracting solution prepared in the step five, the snakegourd peel powder prepared in the step six and the radix astragali preparata prepared in the step seven, adding the dried orange peel extract, the red sage root extract and the platycodon root extract, and uniformly stirring to obtain a mixed solution;
step nine, placing the mixed solution in a vacuum concentrator for concentration to obtain a concentrated solution; pouring the concentrated solution into a granulator, and granulating to obtain medicine granules;
step ten, placing the medicine particles in a drying box for drying, and stirring the medicine particles during drying;
step eleven, taking out the dried medicine particles, sieving, and reserving the particles with the particle size of 1.5-2.3mm to obtain the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases.
2. The preparation method of the Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the sixth step, the drying comprises: the drying temperature is 50-70 deg.C, and the drying time is 10-15 min.
3. The preparation method of the Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the step (6.1), the air-drying comprises: and (3) turning the drying surfaces of the snakegourd peel sheets in turn every 3 hours, and adjusting the positions of the drying plates in turn every 2 hours to enable the drying plates to be directly sunned.
4. The preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases as claimed in claim 1, wherein in the seventh step, the honey-roasting with honey comprises: roasting with honey for 30 min; the honey consumption in honey moxibustion is 1/3 of the quality of the flaky astragalus root.
5. The preparation method of the Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the eighth step, the preparation method of the dried orange peel extract comprises the following steps:
1) soaking pericarpium Citri Tangerinae with clear water for 1-2 hr, heating in marmite for 30-35min, and filtering;
2) adding clear water into the filtered pericarpium Citri Tangerinae to submerge the pericarpium Citri Tangerinae, decocting for 30-50min, and filtering again;
3) decocting for the third time, and filtering;
4) combining the filtrates for 3 times; heating and sterilizing the filtrate;
5) and concentrating the sterilized filtrate to be equivalent to 1g/mL of crude drug content to obtain the dried orange peel extract.
6. The method for preparing a Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in step eight, the preparation method of the salvia miltiorrhiza extract comprises the following steps:
step A, airing the cleaned salvia miltiorrhiza till the water content is not more than 5%;
b, putting the dried salvia miltiorrhiza into a grinder, and grinding into mud residue;
step C, soaking the mud-residue-shaped salvia miltiorrhiza in 75% ethanol for 6-8 days;
d, putting the soaked salvia miltiorrhiza into a spin dryer for spin-drying, and canning separated liquid;
and E, standing and precipitating, and taking supernatant liquor of the upper layer after 20 hours, namely the salvia miltiorrhiza extract.
7. The preparation method of the Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the eighth step, the platycodon grandiflorum extract is prepared by the following steps:
step I, rolling platycodon grandiflorum to obtain solid-liquid coexisting platycodon grandiflorum slurry;
step II, adding 70% ethanol with the mass 10 times that of the platycodon grandiflorum slurry into an extraction device;
step III, heating and extracting for 4-5 h;
step IV, after extraction is finished, decompressing and concentrating to 1/4 of the volume of the initial mixed liquid;
and step V, carrying out spray drying to obtain the platycodon extract particles.
8. The method for preparing a Chinese medicinal composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the ninth step, the concentrating is specifically: the concentration time is 40-50 deg.C, and the concentration temperature is 30-40 deg.C.
9. The preparation method of the traditional Chinese medicine composition for preventing and treating chronic obstructive pulmonary disease and cardiovascular and cerebrovascular diseases according to claim 1, wherein in the tenth step, the drying specifically comprises: setting the drying temperature at 30-50 deg.C and the drying time at 40-60 min.
10. The traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases, which is prepared by the preparation method of the traditional Chinese medicine composition for preventing and treating the chronic obstructive pulmonary disease and the cardiovascular and cerebrovascular diseases as claimed in claims 1 to 9, is characterized by comprising, by mass, 4-8 parts of bighead atractylodes rhizome, 3-4 parts of earthworm, 2-3 parts of dried orange peel extract, 3-4 parts of almond, 1-2 parts of salvia miltiorrhiza extract, 4-5 parts of liquorice, 6-8 parts of snakegourd peel, 4-6 parts of platycodon grandiflorum extract, 6-7 parts of astragalus membranaceus, 2-3 parts of schisandra chinensis, 3-6 parts of agilawood and 5-7 parts of Chinese yam.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113785977A (en) * | 2021-03-11 | 2021-12-14 | 重庆师范大学 | Health food for clearing heat from throat, relieving cough and moistening lung and preparation method thereof |
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Application publication date: 20201113 |