CN105727031A - Formula of LouBeiZhiJuMuGen decoction for treating chronic obstructive pulmonary disease - Google Patents
Formula of LouBeiZhiJuMuGen decoction for treating chronic obstructive pulmonary disease Download PDFInfo
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- CN105727031A CN105727031A CN201610185871.4A CN201610185871A CN105727031A CN 105727031 A CN105727031 A CN 105727031A CN 201610185871 A CN201610185871 A CN 201610185871A CN 105727031 A CN105727031 A CN 105727031A
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- chronic obstructive
- obstructive pulmonary
- pulmonary disease
- treating chronic
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Abstract
The invention relates to the field of traditional Chinese medicine decoctions, and discloses a formula of a LouBeiZhiJuMuGen decoction for treating chronic obstructive pulmonary disease. By virtue of reasonable combination of traditional Chinese medicines, the formula selects the raw materials of snakegourd fruit, thunberg fritillary bulb, Indian trumetflower seed, reed rhizome, pinellia tuber, tangerine peel, bitter orange, platycodon root, largehead atractylodes rhizome, and tuckahoe, and the raw materials are prepared into a decoction which has the effects of regulating the flow of qi and relieving chest oppression, dissipating phlegm and resolving masses, and relieving cough and asthma, is used for treating chronic obstructive pulmonary disease, is beneficial for patients to be treated at home after leaving hospital, and is practical and convenient. Moreover, the traditional Chinese medicine decoction, in comparison with Western medicines, has an effect of conditioning multiple aspects of a body, can realize body healthcare during treatment, and can reduce the probability of relapse.
Description
Technical field
The present invention relates to Chinese medicine decoction field, particularly the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease.
Background technology
Chronic obstructive pulmonary disease is a kind of flow limitation disease, and flow limitation is not fully reversible, develops in Progressive symmetric erythrokeratodermia, with pulmonary, the abnormal inflammatory reaction of harmful gas or deleterious particle is relevant, is a kind of destructive pulmonary disease.Prevent and treat this disease to focus on stoping development and the disease recurrent exerbation of symptom, increasing the weight of, improve quality of life, block and develop to its pulmonary heart disease.But there is no effective Therapeutic Method so far both at home and abroad.Modern medicine uses antibiotic, 17-hydroxy-11-dehydrocorticosterone and bronchodilators based on heavy dose, though pulmonary function can be improved, delays PD, but occurs the multiple complications such as fungal infection, function of intestinal canal imbalance.The application of Chinese medicine can reduce the use of antibiotic and hormone, alleviates outbreak symptom, reduces attack times.
Primary disease is belonged to the category of " pulmonary distension " by theory of Chinese medical science.Basic pathogenesis is that lungs are repeatedly by heresy, mechanism of qi blocking.Mistake department, essential resistance of turbid phlegm drop in a surname, and lung qi is stopped up stagnant, deficient airway.Not healing, trauma lung qi so that it is physiological function goes down, lobe of the lung distension can not be restrained.Clinical to cough, to breathe heavily, expectorant, swollen for 4 big main symptoms., at lung, continue, relate to spleen kidney in its sick position." lung do not hinder do not cough, spleen does not hinder not chronic cough, and kidney does not hinder not cough with asthma " such as Huangdi's Internal Classics institute cloud.The generation of this disease, weighing apparatus rushes chief physician and thinks many because insufficiency of lung-QI is for originally, accompanying the turbid retention of expectorant, often show effect because of being invaded by exogenous pathogen more.Pathologic is complicated, and its pathological factor is mainly that expectorant is turbid to be jammed, and movement of QI being out of order, mental disorder hands over resistance.The generation of expectorant, sick just by lung qi closing, gas is cloth Tianjin not；Disease is entered, and " child-organ disease involving its motherorgan " causes dysfunction of the spleen in transportation, and body fluid not reforming forms expectorant, is with the passing of time developing progressively and can not change Tianjin for the deficiency of the lung, insufficiency of the spleen can not transfer, and suffers from a deficiency of the kidney and can not evaporate, and the turbid retention of expectorant is breathed with cough and continued endlessly.Pulmonary distension protracted course of disease, increases the weight of repeatedly, and lung qi blocks, and a surname drops not normal, must affect lung and help the effect of heart promoting the circulation of blood, and the stagnant card of expectorant stasis blocking occurs, make mechanism of qi more be jammed not smooth.Say as " Zhengzi Huibu cough ": " breath weight out of breath, or left or right, insomnia person is also for pulmonary distension person, dynamic then dyspnea with fullness of the chest.Hinder gas as expectorant adds congestion, should nourish blood with the gas-pathogenic fire reducing that flows with clear its expectorant of profit ".The turbid obstruction of visible expectorant, movement of QI being out of order is the important pathological factor of pulmonary distension.Therefore side uses Fructus Trichosanthis, Bulbus Fritillariae Thunbergii, Semen Oroxyli, Rhizoma Phragmitis removing heat-phlegm eliminating stagnation, the chest stuffiness relieving is regulated the flow of vital energy；Radix Platycodonis, Fructus Aurantii, one rise and one drop, Radix Platycodonis lung qi dispersing, both can declare and dissipate the lung qi being jammed, medicine-carried is up to lung again, and Fructus Aurantii promoting the circulation of QI to alleviate the stagnation in middle-JIAO and Rhizoma Atractylodis Macrocephalae compatibility, takes the meaning of Aurantii Immaturi and Atractylodis Pill, spleen invigorating disappears painful abdominal mass, ascending the clear and descending the turbid, Pericarpium Citri Reticulatae, Poria, the clear water Rhizoma Pinelliae, Rhizoma Atractylodis Macrocephalae (parched), invigorating the spleen and benefiting QI are reduced phlegm, with exhausted the source of producing phlegm, Fructus Trichosanthis, Rhizoma Atractylodis Macrocephalae (parched), Fructus Aurantii compatibility can eliminating heat pathogen by purging the bowels, make heresy have outlet.The lung and the large intestine being interior-exteriorly related, obstruction of lung-QI, FU QI being obstructed, then breathing hard, it is more than to breath with cough, if internal organs gas leads to, lung qi a surname send out, then cough with asthma is from flat.
Summary of the invention
It is an object of the invention to provide the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease, can be used for treating chronic obstructive pulmonary disease, be conducive to patient's treatment at home after leaving hospital, practical and convenient.
For realizing above-mentioned technical purpose, reaching above-mentioned technique effect, the invention discloses the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease, formula is made up of by weight following raw materials according:
Fructus Trichosanthis 15g, Radix Platycodonis 15g, Semen Oroxyli 15g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Phragmitis 12g, Radix Platycodonis 12g, Pericarpium Citri Reticulatae 12g, clear water Rhizoma Pinelliae 10g, each 10g of Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae 10g.
Preferably, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Semen Lepidii (Semen Descurainiae) 15-10g, Fructus Perillae 15-10g are also included.
Preferably, Concretio Silicea Bambusae, Pheretima, Concretio Silicea Bambusae 15-10g, Pheretima 15-10g are also included.
Preferably, also including Bombyx Batryticatus, Semen Raphani, Bombyx Batryticatus 15-10g, Semen Raphani 15-10g, Radix Glycyrrhizae all replaces with Radix Glycyrrhizae Preparata.
Preferably, also including Radix Pseudostellariae, the Radix Astragali, Radix Pseudostellariae 15-10g, Radix Astragali 15-10g, the clear water Rhizoma Pinelliae replaces with Pinellia leaven.
Preferably, Fructus Psoraleae, Fructus Schisandrae Chinensis, Semen Cuscutae, Fructus Psoraleae 15-10g, Fructus Schisandrae Chinensis 15-10g, Semen Cuscutae 15-10g are also included.
The method have the advantages that
1. the present invention is by reasonable compatibility to Chinese medicine, makes decoction, have the chest stuffiness relieving regulate the flow of vital energy, dissipating phlegm and resolving masses, relieving cough and asthma effect, be used for treating chronic obstructive pulmonary disease, be conducive to patient's treatment at home after leaving hospital, practical and convenient.
2. the present invention uses Chinese medicine decoction to have the effect that health many-side is nursed one's health compared with Western medicine, carries out health care of body while treatment, reduces the probability of recurrence.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1
The invention discloses the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease, formula is made up of by weight following raw materials according:
Fructus Trichosanthis 15g, Radix Platycodonis 15g, Semen Oroxyli 15g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Phragmitis 12g, Radix Platycodonis 12g, Pericarpium Citri Reticulatae 12g, clear water Rhizoma Pinelliae 10g, each 10g of Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae 10g.
When the disease of sputum Yong Sheng occurs in patient, above-mentioned formula is augmented Semen Lepidii (Semen Descurainiae) 15-10g, Fructus Perillae 15-10g；
When the disease that expectorant heat very presss from both sides blood stasis occurs in patient, above-mentioned formula is augmented Concretio Silicea Bambusae 15-10g, Pheretima 15-10g；
When the disease of asthma occurs in patient, above-mentioned formula is augmented Bombyx Batryticatus 15-10g, Semen Raphani 15-10g, Radix Glycyrrhizae is all replaced with Radix Glycyrrhizae Preparata；
When the disease of asthenia of pulmonosplenic qi occurs in patient, above-mentioned formula is augmented Radix Pseudostellariae 15-10g, Radix Astragali 15-10g, the clear water Rhizoma Pinelliae is replaced with Pinellia leaven；
When the disease of deficiency of kidney-QI nocturia, shortness of breath occurs in patient, above-mentioned formula is augmented Fructus Psoraleae 15-10g, Fructus Schisandrae Chinensis 15-10g, Semen Cuscutae 15-10g.
Embodiment 2
Experiment purpose and method: in order to verify effectiveness of the invention and feasibility, the present embodiment carries out related experiment with certain hospital's chronic obstructive pulmonary disease inpatient, wherein patient populations is 74 people, it is divided into treatment group 38 people and matched group 36 people, wherein potion every day in sufferer while in hospital, every day is administered orally for three times, within 10 days, is a course for the treatment of.All treat by chronic obstructive pulmonary disease for 2 groups, do Sputum bacterial culture selection sensitive antibiotic, cooperation dead point doxofylline spasmolytic relievings asthma treatment, if desired oxygen uptake, and complicated hypertension person takes depressor, heart failure person's dead point energy, polarized solution, oral diuretics, add if desired with expanding blood vessel medicine and cardiac tonic.Curative effect is observed after treating 10 days.After leaving hospital treatment group interruption take beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup carry out treatment treatment.The matched group catabasis does not take traditional Chinese medicine.
Criterion is as follows:
By observe patients symptomatic (cough, cough up phlegm, uncomfortable in chest, pant, breathe hard, xerostomia, heating, abdominal distention, poor appetite etc.) and sign (pulmonary's dry and wet sound and wheezing sound) and lab testing etc. carry out comprehensive descision curative effect.With reference to the scoring method in " new Chinese medicine guideline of clinical investigations (tries) ", with integration mutation analysis clinical efficacy.Heating, the amount chromaticness of expectorant, cough are divided into 4 grades, respectively count 0,2,3,4 points；It is 3 grades by asthma, xerostomia, pulmonary's cent, respectively counts 0,1,2 points；Changed by x line, sputum etiological examination is divided into 2 grades, respectively counts 0,2 points；Tongue arteries and veins exception person is had to be calculated as 1 point.Calculate the symptom total score after treatment, try to achieve therapeutic index, it is determined that curative effect.Its computing formula is: before therapeutic index-(before treatment total score after total score-treatment)/treatment, total score is multiplied by 100%.And add up in 1 year admission rate again.
Criterion of therapeutical effect: draft according to relevant standard in " new Chinese medicine guideline of clinical investigations (tries) " III.Effective: in 10 days, cardinal symptom sign disappears substantially, can leave hospital, therapeutic index >=70%；Effective: in 10 days, symptom takes a turn for the better and alleviates, therapeutic index >=30% and < 70%；Invalid: therapeutic index < 30% in 10 days, symptom and sign is all unchanged or increases the weight of.
Experimental result:
Effective 30 examples for the treatment of group, effective 5 examples, invalid 3 examples；Effective 20 examples of matched group, effective 7 examples, no effect 9, treatment group obvious effective rate 78.9%, hence it is evident that higher than matched group (55.6%), difference has significance, P < 0.05；Treatment group and matched group total effective rate are 92.1% and 75% respectively, have significant difference, P < 0.05.
Two groups of cardinal symptoms and sign comparitive study: table one formula, check through X2, two groups cough and expectoration, asthma, abdominal distention poor appetite, heating, uncomfortable in chest in improvement difference have significance (P < 0.05), but in dry and wet sound, improve no significant difference (P > 0.05).Admission rate again in 1 year: in 1 year, hospitalizing's treatment group is 8 examples (21.1%) again, and matched group is 16 examples (44.4%).Two groups again admission rate have significant difference, P < 0.05.
The above; being only the present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, any those familiar with the art is in the technical scope that the invention discloses; the change that can readily occur in or replacement, all should be encompassed within protection scope of the present invention.
Claims (6)
1. the formula of the beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease, it is characterised in that described formula is made up of by weight following raw materials according:
Fructus Trichosanthis 15g, Radix Platycodonis 15g, Semen Oroxyli 15g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Phragmitis 12g, Radix Platycodonis 12g, Pericarpium Citri Reticulatae 12g, clear water Rhizoma Pinelliae 10g, each 10g of Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae 10g.
2. the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that: also include Semen Lepidii (Semen Descurainiae), Fructus Perillae, described Semen Lepidii (Semen Descurainiae) 15-10g, described Fructus Perillae 15-10g.
3. the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that: also include Concretio Silicea Bambusae, Pheretima, described Concretio Silicea Bambusae 15-10g, described Pheretima 15-10g.
4. the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that: also including Bombyx Batryticatus, Semen Raphani, described Bombyx Batryticatus 15-10g, described Semen Raphani 15-10g, described Radix Glycyrrhizae all replaces with Radix Glycyrrhizae Preparata.
5. the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease as claimed in claim 1, it is characterised in that: also including Radix Pseudostellariae, the Radix Astragali, described Radix Pseudostellariae 15-10g, described Radix Astragali 15-10g, the described clear water Rhizoma Pinelliae replaces with Pinellia leaven.
6. the formula of a kind of beach wormwood shellfish trifoliate orange Fructus Citri tangerinae wood root soup treating chronic obstructive pulmonary disease as claimed in claim 1, it is characterized in that: also include Fructus Psoraleae, Fructus Schisandrae Chinensis, Semen Cuscutae, described Fructus Psoraleae 15-10g, described Fructus Schisandrae Chinensis 15-10g, described Semen Cuscutae 15-10g.
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| CN111870651A (en) * | 2020-07-28 | 2020-11-03 | 中南大学湘雅医院 | Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease in stationary phase and preparation method thereof |
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