CN111920737A - Antibacterial composition containing aloe extract - Google Patents
Antibacterial composition containing aloe extract Download PDFInfo
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- CN111920737A CN111920737A CN202010856282.0A CN202010856282A CN111920737A CN 111920737 A CN111920737 A CN 111920737A CN 202010856282 A CN202010856282 A CN 202010856282A CN 111920737 A CN111920737 A CN 111920737A
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- aloe
- aloe extract
- composition containing
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- bacteriostatic composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention belongs to the field of daily chemicals. A bacteriostatic composition containing aloe extract comprises the following components in percentage by mass: 1-10% of aloe extract microcapsule, 0.02-2% of silver ion bactericide, 0.05-0.6% of thickening agent, 0.01-2% of pH regulator and the balance of pure water. The composition has good disinfection and bacteriostasis performance, is mild and low in stimulation, is fresh and cool, is not sticky, has good moistening and moisturizing effects, and can improve the stability and the utilization rate of the aloe extract in the composition by preparing the aloe extract into microcapsules.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to an antibacterial composition containing an aloe extract.
Background
The disinfectant is mainly prepared into the dosage forms of powder, tablets, granules, aqueous solutions, sprays and gels, and the common dosage forms in the market are aqueous solutions added with a large amount of ethanol and gels thickened by thickening agents. In the gel-type disinfectant, the carbomer thickening disinfectant is mainly used as a bactericide such as triclosan, and the like, so that certain health risks exist in the products; the gel product thickened by using hydroxypropyl methyl cellulose or carboxymethyl cellulose as a thickening agent has sticky hand feeling and higher cost. Ethanol is added into the gel type disinfectant, although the viscosity of the thickening agent can be effectively reduced by the volatilization of the ethanol, the viscosity of the product is reduced by the addition of the ethanol, more thickening agent needs to be added in order to obtain the disinfectant with proper gel strength, and the viscosity is obvious after the volatilization of the ethanol. Ethanol has fat dissolving property, and has dry skin and poor moisturizing property after use. There are also products in the prior art that improve moisturizing properties and reduce irritation by adding plant extracts. The invention patent CN201210257313.6 discloses a plant extract dry-cleaning disinfection gel, which is added with a plurality of plant extracts to be compounded as effective components, and is also added with an aloe extract to be used as a moisture retention component, but the plant extracts have volatility, are unstable and easy to oxidize, the effect of the added product is greatly reduced, the effect cannot be reflected, and the added carbomer causes sticky feeling and produces unpleasant feeling when being used.
Disclosure of Invention
The technical problem to be solved by the invention is to provide the aloe extract-containing antibacterial composition which has good disinfection and antibacterial performance, is mild and low in irritation, fresh and cool, not sticky and good in moistening and moisturizing effects, and the stability and the utilization rate of the aloe extract in the composition can be improved by preparing the aloe extract into microcapsules.
The technical scheme of the invention is as follows:
a bacteriostatic composition containing aloe extract comprises the following components in percentage by mass: 1-10% of aloe extract microcapsule, 0.02-2% of silver ion bactericide, 0.05-0.6% of thickening agent, 0.01-2% of pH regulator and the balance of pure water.
Further, the preparation method of the aloe extract microcapsule comprises the following steps:
a. pretreating Aloe, removing yellow spot of Aloe leaf, cutting off hard thorn, cleaning, peeling, and sterilizing;
b. grinding pretreated Aloe, mincing into Aloe pulp, transferring into a stabilization storage tank, heating to 60-90 deg.C, soaking for 1-5 hr, and vacuum air flow wall breaking;
c. decolorizing, filtering to a stabilization tank, and performing ultrasonic circulation extraction at 20-50 deg.C and power of 100-800W for 10-60min at a feed ratio of 1-9%;
d. performing ultrasonic circulation extraction, centrifuging at 5000-6000r/min for 15-20min to obtain supernatant, vacuum rotary concentrating, precipitating with ethanol, and centrifuging at 8000-10000r/min for 5-10min to obtain supernatant;
e. dehydrating, drying and crushing the supernatant to obtain dry aloe powder, wherein the water content of the dry aloe powder is 2-8%;
f. transferring the Aloe dry powder into extraction tank, preheating pure water at 100-180 deg.C, adding into the extraction tank, and extracting under 6-12Mpa for 5-20min to obtain extractive solution;
g. adding NaCl into the extract, stirring and dissolving to play a role in demulsification; adding organic solvent, wherein the volume ratio of the extract to the organic solvent is 1:1-2, stirring, standing for 30-45min, separating, collecting filtrate, and concentrating by evaporation to obtain aloe extract;
f. mixing the aloe extract with polyglycerol ether-26 at a mass ratio of 1-3:1-5 to obtain a capsule core, using a filler as a capsule wall material, and mixing the capsule wall material and the capsule core at a mass ratio of 1-10:1-9 to obtain the aloe extract microcapsule.
Further, the filling agent is at least one of maltodextrin, cyclodextrin, starch and gelatin.
Further, the concentration of the silver ion bactericide anion is 200-2000 ppm.
Further, the thickener includes natural/modified natural polymers and organic synthetic polymers.
Further, the natural/modified natural polymers include hydroxyethyl cellulose, hydroxypropyl starch phosphate, guar gum.
Further, the organic synthetic polymer includes carbomer polymer, acrylic acid/C10-C30 alkyl acrylate copolymer, acrylate/C10-C30 alkyl acrylate cross-linked copolymer emulsifier, acrylic acid/ester copolymer, acrylic acid/stearyl alcohol polyether (20) methacrylate copolymer. Carbomer polymers are preferred.
Further, the pH regulator is aminomethyl propanol.
The invention has the following beneficial effects:
according to the invention, the aloe extract is prepared into the microcapsule, so that the volatilization of active ingredients can be effectively reduced, the stability and bioavailability of the medicine are improved, the microcapsule is added into the composition in the form of the microcapsule, the capsule core raw materials of the aloe extract and the polyglycerol ether-26 are released when the composition is used, the sticky feeling brought by the thickening agent can be effectively reduced, the compounded touch feeling of the two is smooth and fine, the refreshing, water-moistening and skin-moistening feeling of the composition is endowed, meanwhile, the moisturizing, moistening, disinfecting and bacteriostasis effects of the composition can be effectively improved, and the irritation is reduced.
Detailed Description
The present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
The formulation tables (unit:%) of 3 examples and 3 comparative examples of the bacteriostatic composition containing aloe extract according to the present invention are shown below, and the preparation method thereof is a conventional stirring and mixing method in the art.
| Components | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Aloe extract microcapsule | 2 | 5 | 10 | / | / | / |
| Aloe extract | / | / | / | 5 | / | / |
| Aloe extract from the general market | / | / | / | / | 5 | / |
| 800ppm silver ion bactericide | 0.5 | 0.25 | 0.1 | 0.25 | 0.25 | 0.25 |
| Carbomer U20 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 |
| Aminomethyl propanol | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Polyglyceryl ether-26 | / | / | / | / | 5 | 5 |
| Maltodextrin | / | / | / | 2 | 2 | 2 |
| Pure water | To 100% | To 100% | To 100% | To 100% | To 100% | To 100% |
Wherein, the preparation method of the common commercial aloe extract comprises the following steps: grinding Aloe into Aloe pulp, decolorizing, lyophilizing, and pulverizing.
The preparation method of the aloe extract microcapsule comprises the following steps:
a. pretreating Aloe, removing yellow spot of Aloe leaf, cutting off hard thorn, cleaning, peeling, and sterilizing;
b. grinding pretreated aloe, mincing into aloe pulp, transferring into a stabilization storage tank, heating to 60-90 deg.C, soaking for 3 hr, and breaking cell wall with vacuum airflow;
c. performing decolorization treatment, filtering to a stabilization tank after decolorization, and performing ultrasonic circulation extraction for 30min at 40 deg.C and power of 600W under the condition of 5% feed ratio;
d. performing ultrasonic circulation extraction, centrifuging at 5000r/min for 15min to obtain supernatant, vacuum rotary concentrating, precipitating with ethanol, and centrifuging at 8000r/min for 5min to obtain supernatant;
e. dehydrating, drying and crushing the supernatant to obtain dry aloe powder, wherein the water content of the dry aloe powder is 2-8%;
f. transferring the Aloe dry powder into an extraction tank, preheating pure water at 100 deg.C, adding into the extraction tank, setting the pressure of the extraction tank at 6Mpa, and extracting for 5min to obtain extractive solution;
g. adding NaCl into the extract, stirring and dissolving to play a role in demulsification; adding ethanol, stirring at a volume ratio of the extractive solution to ethanol of 1:1, standing for 30min, separating, collecting filtrate, and concentrating by evaporation to obtain aloe extract;
f. mixing the aloe extract with polyglycerol ether-26 at a mass ratio of 1:1 to obtain a capsule core, mixing maltodextrin to obtain a capsule wall material, and mixing the capsule wall material and the capsule core at a mass ratio of 1:5 to obtain the aloe extract microcapsule.
Efficacy evaluation tests were performed on 3 examples and 3 comparative examples of the bacteriostatic compositions containing aloe extract according to the invention:
1. testing water replenishing and moisture preserving performance: randomly selecting 120 subjects from a plurality of volunteers 25-35 years old and in good skin state, dividing the subjects into 6 groups of 20 persons, and performing stratum corneum moisture content test, epidermal water loss test and skin glossiness test after using the samples; testing the moisture content of the horny layer of a control area and a sample area of a subject by using a Corneometer moisture test probe, parallelly measuring each area for 2 times, and taking an average value as the moisture content of the basal horny layer; testing the transepidermal water loss amount of a control area and a sample area of a subject by using a Tewameter water loss probe, measuring each area for 3 times, and taking an average value as a basic transepidermal water loss amount; the Skin gloss of the control and sample areas of the subject was tested using the Skin gloss test probe Skin-gloss-test probe Skin. The test results are given in the following table:
| item | Horny layer moisture content (amount of change) | Short term test for water loss through epidermis (variable) | Skin gloss (variation) |
| Example 1 | 15 | -3.72 | 2.34 |
| Example 2 | 16 | -4.15 | 2.97 |
| Example 3 | 18 | -5.23 | 3.45 |
| Comparative example 1 | 9 | -1.82 | 1.22 |
| Comparative example 2 | 6 | -1.68 | 0.89 |
| Comparative example 3 | 3 | -1.53 | 0.35 |
Therefore, the invention can improve the moisture content and the glossiness of the skin and reduce the average moisture loss rate through the epidermis in a short period, thereby achieving the effects of no dryness of the hand skin after use and moisture retention.
2. And (3) sticky feeling test: randomly selecting 120 subjects from a plurality of volunteers 25-35 years old and having good skin state, dividing into 6 groups, wherein each group comprises 20 subjects, cleaning the forearms of the arms for 30 seconds by warm water at 40 ℃ and non-fragrant shower gel, wiping the forearms dry by a paper towel, fixing a test area on the inner side of the arms, and uniformly smearing a proper amount of product on the designated area. Then scoring, the scoring criteria are as follows: no stickiness: 5 min; slightly sticky: 4, dividing; slightly sticky: 3 min; generally sticky: 2 min; and (3) pasting: 1 minute; very sticky: and 0 point. The test results are given in the following table:
| sample (I) | Sticky feeling (median method) |
| Example 1 | 3.9 |
| Example 2 | 4.5 |
| Example 3 | 4.2 |
| Comparative example 1 | 3.3 |
| Comparative example 2 | 3.1 |
| Comparative example 3 | 3.33 |
Therefore, the composition is fresh and cool, does not stick greasy, and has good skin feel and good use experience.
3. And (3) bacteriostatic test: the test results are given in the following table:
therefore, the invention has good disinfection and bacteriostasis performance.
The antibacterial composition containing the aloe extract has good disinfection and antibacterial performance, is mild and low-irritation, is fresh and non-sticky, has good moistening and moisturizing effects, and can improve the stability and the utilization rate of the aloe extract in the composition by preparing the aloe extract into microcapsules.
Claims (8)
1. The antibacterial composition containing the aloe extract is characterized by comprising the following components in percentage by mass: 1-10% of aloe extract microcapsule, 0.02-2% of silver ion bactericide, 0.05-0.6% of thickening agent, 0.01-2% of pH regulator and the balance of pure water.
2. The bacteriostatic composition containing the aloe extract according to claim 1, wherein the preparation method of the aloe extract microcapsule comprises the following steps:
a. pretreating Aloe, removing yellow spot of Aloe leaf, cutting off hard thorn, cleaning, peeling, and sterilizing;
b. grinding pretreated Aloe, mincing into Aloe pulp, transferring into a stabilization storage tank, heating to 60-90 deg.C, soaking for 1-5 hr, and vacuum air flow wall breaking;
c. decolorizing, filtering to a stabilization tank, and performing ultrasonic circulation extraction at 20-50 deg.C and power of 100-800W for 10-60min at a feed ratio of 1-9%;
d. performing ultrasonic circulation extraction, centrifuging at 5000-6000r/min for 15-20min to obtain supernatant, vacuum rotary concentrating, precipitating with ethanol, and centrifuging at 8000-10000r/min for 5-10min to obtain supernatant;
e. dehydrating, drying and crushing the supernatant to obtain dry aloe powder, wherein the water content of the dry aloe powder is 2-8%;
f. transferring the Aloe dry powder into extraction tank, preheating pure water at 100-180 deg.C, adding into the extraction tank, and extracting under 6-12Mpa for 5-20min to obtain extractive solution;
g. adding NaCl into the extract, stirring and dissolving to play a role in demulsification; adding organic solvent, wherein the volume ratio of the extract to the organic solvent is 1:1-2, stirring, standing for 30-45min, separating, collecting filtrate, and concentrating by evaporation to obtain aloe extract;
f. mixing the aloe extract with polyglycerol ether-26 at a mass ratio of 1-3:1-5 to obtain a capsule core, using a filler as a capsule wall material, and mixing the capsule wall material and the capsule core at a mass ratio of 1-10:1-9 to obtain the aloe extract microcapsule.
3. The bacteriostatic composition containing aloe extract according to claim 2, wherein the filler is at least one of maltodextrin, cyclodextrin, starch and gelatin.
4. The bacteriostatic composition containing aloe extract according to claim 1, wherein the concentration of the silver ion bactericide anion is 200-2000 ppm.
5. The bacteriostatic composition containing aloe extract according to claim 1, wherein the thickener comprises natural/modified natural polymer and organic synthetic polymer.
6. The bacteriostatic composition containing aloe vera extract according to claim 5, wherein the natural/modified natural polymer comprises hydroxyethyl cellulose, hydroxypropyl starch phosphate, guar gum.
7. The aloe vera extract-containing bacteriostatic composition according to claim 5, wherein the organic synthetic polymer comprises carbomer polymer, acrylic acid/C10-C30 alkyl acrylate copolymer, acrylic acid salt/C10-C30 alkyl acrylate cross-linked copolymer emulsifier, acrylic acid/ester copolymer, acrylic acid/stearyl alcohol polyether (20) methacrylate copolymer.
8. The bacteriostatic composition containing aloe extract according to claim 1, wherein the PH modifier is aminomethyl propanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010856282.0A CN111920737A (en) | 2020-08-24 | 2020-08-24 | Antibacterial composition containing aloe extract |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010856282.0A CN111920737A (en) | 2020-08-24 | 2020-08-24 | Antibacterial composition containing aloe extract |
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| CN111920737A true CN111920737A (en) | 2020-11-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112889820A (en) * | 2021-01-22 | 2021-06-04 | 海韵一剑大卫生科技有限公司 | Compound quaternary ammonium salt disinfectant and preparation method and use method thereof |
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Application publication date: 20201113 |