CN111888326B - 羟甲唑啉组合物和用于治疗眼障碍的方法 - Google Patents

羟甲唑啉组合物和用于治疗眼障碍的方法 Download PDF

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Publication number
CN111888326B
CN111888326B CN202010249167.7A CN202010249167A CN111888326B CN 111888326 B CN111888326 B CN 111888326B CN 202010249167 A CN202010249167 A CN 202010249167A CN 111888326 B CN111888326 B CN 111888326B
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formulation
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Chinese (zh)
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CN111888326A (zh
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T·德弗里斯
D·雅各布斯
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RVL Pharmaceuticals Inc
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RVL Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202010249167.7A 2019-05-06 2020-04-01 羟甲唑啉组合物和用于治疗眼障碍的方法 Active CN111888326B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310901249.9A CN117045596A (zh) 2019-05-06 2020-04-01 羟甲唑啉组合物和用于治疗眼障碍的方法

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201962844069P 2019-05-06 2019-05-06
US201962843819P 2019-05-06 2019-05-06
US62/844,069 2019-05-06
US62/843,819 2019-05-06
US16/715,998 2019-12-16
US16/716,014 2019-12-16
US16/716,014 US10799481B1 (en) 2019-05-06 2019-12-16 Compositions and methods for treating ocular disorders
US16/715,998 US10814001B1 (en) 2019-05-06 2019-12-16 Oxymetazoline compositions

Related Child Applications (1)

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CN202310901249.9A Division CN117045596A (zh) 2019-05-06 2020-04-01 羟甲唑啉组合物和用于治疗眼障碍的方法

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CN111888326A CN111888326A (zh) 2020-11-06
CN111888326B true CN111888326B (zh) 2023-07-21

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EP (1) EP3965737A1 (enExample)
JP (3) JP7141420B2 (enExample)
KR (3) KR102410503B1 (enExample)
CN (2) CN117045596A (enExample)
AU (1) AU2020268329A1 (enExample)
BR (1) BR112021022404A2 (enExample)
CA (1) CA3139443A1 (enExample)
CL (1) CL2021002918A1 (enExample)
CO (1) CO2021015265A2 (enExample)
IL (1) IL287831A (enExample)
MA (1) MA55895A (enExample)
MX (1) MX2021013516A (enExample)
PE (1) PE20220384A1 (enExample)
SG (1) SG11202112272TA (enExample)
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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120225918A1 (en) * 2011-03-03 2012-09-06 Voom, Llc Compositions and Methods for Non-Surgical Treatment of Ptosis
US10799481B1 (en) * 2019-05-06 2020-10-13 Rvl Pharmaceuticals, Inc. Compositions and methods for treating ocular disorders
WO2022187306A1 (en) 2021-03-03 2022-09-09 Voom, Llc Compositions and methods for treatment of blepharitis
WO2023079427A1 (en) * 2021-11-03 2023-05-11 Avaca Pharma Private Limited Ophthalmic compositions and methods thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006131628A (ja) * 2004-10-08 2006-05-25 Rohto Pharmaceut Co Ltd オキシメタゾリン含有水性組成物
CN1832726A (zh) * 2003-08-13 2006-09-13 默克专利有限公司 包含羟甲唑啉和/或赛洛唑啉的水性药物溶液
CN101951886A (zh) * 2007-12-21 2011-01-19 先灵-普劳健康护理产品公司 增强羟甲唑啉的光稳定性
CN103501771A (zh) * 2011-03-03 2014-01-08 沃姆有限责任公司 用于上睑下垂的非手术治疗的组合物和方法
CN104023707A (zh) * 2011-04-26 2014-09-03 睿德制药有限公司 用于治疗肛门直肠疾患的羟甲唑啉

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51421B1 (en) 1980-08-01 1986-12-24 Smith & Nephew Ass Ophthalmic compositions containing triamterene
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
US5888493A (en) 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
US7812049B2 (en) 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
KR101454674B1 (ko) 2006-03-17 2014-10-27 존슨 앤드 존슨 비젼 케어, 인코포레이티드 산화에 불안정한 성분을 포함하는 안정화된 안과용 조성물
EP2015733A2 (en) 2006-04-26 2009-01-21 Aciex, Inc. Compositions for the treatment and prevention of eyelid swelling
US8466203B2 (en) 2006-12-06 2013-06-18 David Choohyun Paik Method of stabilizing human eye tissue by reaction with nitrite and related agents such as nitro compounds
CN101959519B (zh) * 2008-03-11 2013-03-20 爱尔康研究有限公司 用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液
MX2011013060A (es) * 2009-06-05 2012-02-28 Aciex Therapeutics Inc Formulaciones oftalmicas, metodos de preparacion y metodos para utilizarlas.
US20120082625A1 (en) 2010-09-28 2012-04-05 Michael Graeber Combination treatment for rosacea
EP2637684A4 (en) * 2010-11-08 2014-05-07 Healor Ltd BUFFERED OPHTHALMIC COMPOSITIONS AND USER METHOD THEREFOR
DK2645993T3 (en) 2010-12-03 2017-02-13 Allergan Inc Pharmaceutical cream compositions comprising oxymetazoline
KR20150011807A (ko) 2012-05-25 2015-02-02 질리어, 인크. 자일리톨계 항-점액성 조성물과 관련 방법 및 조성물
UA119324C2 (uk) 2013-04-02 2019-06-10 Теміс Медікер Лімітед Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
EP3047712B1 (en) 2013-09-18 2021-04-21 Mycronic AB Method, system and device for handling pallets in a smt system
CA2951725C (en) 2014-06-11 2022-06-07 Allergan, Inc. Stabilized oxymetazoline formulations and their uses
HK1248570A1 (zh) 2015-05-29 2018-10-19 西德奈克西斯公司 D2o稳定化的药物制剂
US20170312335A1 (en) * 2015-12-30 2017-11-02 Lubris Llc Topical use of prg4 for treatment of allergy and symptoms of inflammation
CN115006537A (zh) 2016-01-26 2022-09-06 利维申制药有限公司 α-肾上腺素能药剂的组合物和用途
CN105997856A (zh) * 2016-06-24 2016-10-12 魏威 盐酸羟甲唑啉滴眼液及其制备方法
US11246816B2 (en) 2016-06-30 2022-02-15 The Procter And Gamble Company Shampoo compositions comprising a chelant
US10799481B1 (en) 2019-05-06 2020-10-13 Rvl Pharmaceuticals, Inc. Compositions and methods for treating ocular disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1832726A (zh) * 2003-08-13 2006-09-13 默克专利有限公司 包含羟甲唑啉和/或赛洛唑啉的水性药物溶液
JP2006131628A (ja) * 2004-10-08 2006-05-25 Rohto Pharmaceut Co Ltd オキシメタゾリン含有水性組成物
CN101951886A (zh) * 2007-12-21 2011-01-19 先灵-普劳健康护理产品公司 增强羟甲唑啉的光稳定性
CN103501771A (zh) * 2011-03-03 2014-01-08 沃姆有限责任公司 用于上睑下垂的非手术治疗的组合物和方法
CN104023707A (zh) * 2011-04-26 2014-09-03 睿德制药有限公司 用于治疗肛门直肠疾患的羟甲唑啉

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The effects of nasal decongestion on obstructive sleep apnoea;Yunsong An等;《Am J Otolaryngol》;第40卷;52-56 *

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US10799481B1 (en) 2020-10-13
ZA202212328B (en) 2025-03-26
US20230355587A1 (en) 2023-11-09
PE20220384A1 (es) 2022-03-18
JP7705326B2 (ja) 2025-07-09
US11541036B2 (en) 2023-01-03
US20210137889A1 (en) 2021-05-13
US10814001B1 (en) 2020-10-27
US20200353083A1 (en) 2020-11-12
WO2020227260A1 (en) 2020-11-12
CN111888326A (zh) 2020-11-06
JP2021191802A (ja) 2021-12-16
CN117045596A (zh) 2023-11-14
MA55895A (fr) 2022-03-16
MX2021013516A (es) 2022-01-24
SG11202112272TA (en) 2021-12-30
AU2020268329A1 (en) 2022-01-06
CO2021015265A2 (es) 2022-02-28
US11701343B2 (en) 2023-07-18
CL2021002918A1 (es) 2022-08-19
US20210386711A1 (en) 2021-12-16
US20240033250A1 (en) 2024-02-01
ZA202108950B (en) 2023-10-25
US11103482B2 (en) 2021-08-31
KR102859351B1 (ko) 2025-09-12
EP3965737A1 (en) 2022-03-16
NZ782902A (en) 2024-09-27
JP7141420B2 (ja) 2022-09-22
KR20240060580A (ko) 2024-05-08
BR112021022404A2 (pt) 2022-01-18
JP2025065198A (ja) 2025-04-17
CA3139443A1 (en) 2020-11-12
KR20220084264A (ko) 2022-06-21
JP2020183373A (ja) 2020-11-12
KR20200128629A (ko) 2020-11-16
US10940138B2 (en) 2021-03-09
US20210015795A1 (en) 2021-01-21
KR102410503B1 (ko) 2022-06-17
US20220257566A1 (en) 2022-08-18
US11311515B2 (en) 2022-04-26
US10898573B1 (en) 2021-01-26
IL287831A (en) 2022-01-01
US20210023222A1 (en) 2021-01-28
US11324722B2 (en) 2022-05-10
KR102663319B1 (ko) 2024-05-03
US20210212992A1 (en) 2021-07-15
US20220273621A1 (en) 2022-09-01

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