CN111803598A - 一种祛湿通络的中药制剂 - Google Patents

一种祛湿通络的中药制剂 Download PDF

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CN111803598A
CN111803598A CN202010714226.3A CN202010714226A CN111803598A CN 111803598 A CN111803598 A CN 111803598A CN 202010714226 A CN202010714226 A CN 202010714226A CN 111803598 A CN111803598 A CN 111803598A
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李燕梅
于富强
李仲昆
杨桂兰
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Kunming Keye Biotechnology Co ltd
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Abstract

本发明属于中药制剂研发技术领域，特别涉及一种祛湿通络的中药制剂。一种祛湿通络中药制剂，它由下列原料按重量份数制成：黑翅土白蚁2‑10份、黄芪10‑20份、当归5‑20份、巴戟天2‑10份、牛膝0.5‑2份、蜈蚣0.2‑1份、红花2‑10份、薏苡仁2‑10份、甘草2‑10份和连翘0.5‑5份。本发明的祛湿通络的中药制剂对于风湿及类风湿疾病的疗效作用显著，安全性能更高。

Description

一种祛湿通络的中药制剂
技术领域
本发明涉及一种中药制剂，特别涉及一种祛湿通络的中药制剂。
背景技术
专利申请号为：200410053648.1的《双蚁祛湿通络胶囊》具有活血通络、祛风除湿的功效，可明显改善肝肾两亏、气血不足引起的腰漆疼痛、肢节肿痛、麻木不仁、酸软乏力、屈伸不利等痹症症状，在治疗风湿性关节炎、累风湿性关节炎、坐骨神经痛、骨质增生性疾病领域疗效良好，但是，该胶囊含有制川乌，存在一定的安全隐患。
发明内容
本发明的目的在于提供一种祛湿通络的中药制剂。
本发明的目的通过如下技术方案实现：
一种祛湿通络的中药制剂，它由下列原料按重量份数制成：黑翅土白蚁2-10份、黄芪10-20份、当归5-20份、巴戟天2-10份、牛膝0.5-2份、蜈蚣0.2-1份、红花2-10份、薏苡仁2-10份、甘草2-10份和连翘0.5-5份。
作为优选，所述的中药制剂由下列原料按重量份数制成：黑翅土白蚁5份、黄芪15份、当归12份、巴戟天4份、牛膝1份、蜈蚣0.5份、红花5份、薏苡仁6份、甘草5份和连翘3份。
所述的祛湿通络中药制剂的剂型包括胶囊制剂、片剂、颗粒剂、散剂。
与现有技术相比，本发明具有如下有益效果：
（1）本发明的中药制剂搭配合理，治疗风湿及类风湿疾病疗效佳、标本兼治、见效快、无毒副作用，痊愈后不复发；具有活血通络、祛风除湿、补肝补气的功效；（2）本发明对于风湿及类风湿疾病的疗效作用更加显著，安全性能更高。
具体实施方式
下面结合具体实施例，对本发明作进一步详细的阐述，但本发明的实施方式并不局限于实施例表示的范围。这些实施例仅用于说明本发明，而非用于限制本发明的范围。此外，在阅读本发明的内容后，本领域的技术人员可以对本发明作各种修改，这些等价变化同样落于本发明所附权利要求书所限定的范围。
实施例1
按照如下重量（g）配比取：黑翅土白蚁400、黄芪1000、当归800、巴戟天100、牛膝80、蜈蚣20、红花100、薏苡仁100、甘草400、连翘100。
把黑翅土白蚁、蜈蚣粉碎，过80目筛，加4倍60%乙醇40分钟，加热至70℃进行提取，加60%乙醇重复提取3次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的八味药加6倍质量的水，煎煮1小时，提取液体，往提取药渣中加6倍质量的水，重复提取一次，合并两次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达50%，搅拌均匀、静置24小时。与黑翅土白蚁、蜈蚣提取液混合，回收乙醇，浓缩至相对密度为1.3（70℃）的稠膏，加入、细粉，混匀，干燥，过100目筛，分装，制成每份装0.3g散剂。
实施例2
按照如下重量（g）配比取：黑翅土白蚁700、黄芪1300、当归1000、巴戟天200、牛膝1000、蜈蚣40、红花300、薏苡仁400、甘草600、连翘200。
把黑翅土白蚁、蜈蚣粉碎，过80目筛，加6倍60%乙醇60分钟，加热至80℃进行提取，加60%乙醇重复提取2次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的八味药加9倍质量的水，煎煮2小时，提取液体，往提取药渣中加9倍质量的水，重复提取一次，合并两次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达70%，搅拌均匀、静置24小时。与黑翅土白蚁、蜈蚣提取液混合，回收乙醇，浓缩至相对密度为1.35（70℃）的稠膏，加入细粉，混匀，干燥，过120目筛制成散剂。加入淀粉、糊精等辅料，制粒、干燥后分装，制得0.4g颗粒剂和0.5g胶囊剂。
实施例3
按照如下重量（克）配比取：黑翅土白蚁800、黄芪1500、当归1500、巴戟天500、牛膝120、蜈蚣80、红花500、薏苡仁500、甘草800、连翘300。
将黑翅土白蚁、蜈蚣粉碎，过80目筛，加5倍60%乙醇50分钟，加热至75℃进行提取，加60%乙醇重复提取3次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的八味药加8倍质量的水，煎煮2小时，提取液体，往提取药渣中加8倍质量的水，重复提取1次，合并2次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达60%，搅拌均匀、静置24小时。与黑翅土白蚁、蜈蚣提取液混合，回收乙醇，浓缩至相对密度为1.3（70℃）的稠膏，加入细粉，混匀，干燥，过100目筛制成散剂，加入淀粉、糊精等辅料，混合压片后，制得0.6g片剂。
为检验本发明中药制剂的治疗效果，选取150例类风湿关节炎者分别服用本发明上述实施例1-3中制备方法得的中药制剂进行治疗，平均随机分为3组，每组50例；其中男性70例，女性80例，年龄 41-66岁，平均年龄52岁。病程0.5-12年。
临床表现主要为关节疼痛、关节肿胀、骨质疏松，严重者活动障碍、关节畸形。
服用方法为：每日1剂，每剂分3次服用，1个月为一疗程。
疗效评定标准：
（1）治愈：服用本发明中药制剂1个疗程后，关节疼痛、关节肿胀消失，活动障碍、关节畸形部分明显好转；
（2）有效：服用本发明中药制剂1个疗程后，关节疼痛、关节肿胀减轻，活动障碍、关节畸形部分逐步好转；
（3）无效：服用本发明中药制剂1个疗程后，关节疼痛、关节肿胀、活动障碍、关节畸形无任何改善。
表1 本发明的中药制剂治疗类风湿关节炎临床效果
Figure 333492DEST_PATH_IMAGE002
从表1可知，实施例1-3中3组类风湿关节炎者分别服用本发明中药制剂1个疗程后，3组类风湿关节炎者的有效率均在94%以上。

Claims (3)

1.一种祛湿通络的中药制剂，其特征在于：它由下列原料按重量份数制成：黑翅土白蚁2-10份、黄芪10-20份、当归5-20份、巴戟天2-10份、牛膝0.5-2份、蜈蚣0.2-1份、红花2-10份、薏苡仁2-10份、甘草2-10份和连翘0.5-5份。
2.根据权利要求1所述的祛湿通络的中药制剂，其特征在于：它由下列原料按重量份数制成：黑翅土白蚁5份、黄芪15份、当归12份、巴戟天4份、牛膝1份、蜈蚣0.5份、红花5份、薏苡仁6份、甘草5份和连翘3份。
3.根据权利要求1或2所述的祛湿通络的中药制剂，其特征在于：所述中药制剂的剂型为胶囊制剂、片剂、颗粒剂或散剂。
CN202010714226.3A 2020-07-22 2020-07-22 一种祛湿通络的中药制剂 Pending CN111803598A (zh)

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CN103566236A (zh) * 2013-11-08 2014-02-12 广西双蚁药业有限公司 一种祛湿通络中药制剂
CN104667044A (zh) * 2015-02-15 2015-06-03 广西双蚁药业有限公司 一种治疗痹症的中药制剂及其制备方法
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