CN103566236B - 一种祛湿通络中药制剂 - Google Patents
一种祛湿通络中药制剂 Download PDFInfo
- Publication number
- CN103566236B CN103566236B CN201310552277.0A CN201310552277A CN103566236B CN 103566236 B CN103566236 B CN 103566236B CN 201310552277 A CN201310552277 A CN 201310552277A CN 103566236 B CN103566236 B CN 103566236B
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- chinese medicine
- medicine preparation
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000001737 promoting effect Effects 0.000 title claims abstract description 17
- 206010003246 arthritis Diseases 0.000 title claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract description 14
- 241000903946 Clematidis Species 0.000 claims abstract description 14
- 241001251068 Formica fusca Species 0.000 claims abstract description 14
- 241000866536 Odontotermes formosanus Species 0.000 claims abstract description 14
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 14
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 14
- 241000131808 Scolopendra Species 0.000 claims abstract description 14
- 235000008434 ginseng Nutrition 0.000 claims abstract description 14
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 12
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 12
- 241000522620 Scorpio Species 0.000 claims abstract description 11
- 239000009490 scorpio Substances 0.000 claims abstract description 11
- 241000628997 Flos Species 0.000 claims abstract description 8
- 239000009636 Huang Qi Substances 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 23
- 201000010099 disease Diseases 0.000 abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 abstract description 8
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 abstract description 8
- 229940039750 aconitine Drugs 0.000 abstract description 8
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 abstract description 8
- 210000004185 liver Anatomy 0.000 abstract description 7
- 231100000614 poison Toxicity 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 239000003440 toxic substance Substances 0.000 abstract description 5
- 230000008485 antagonism Effects 0.000 abstract description 3
- 238000000354 decomposition reaction Methods 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 239000007788 liquid Substances 0.000 description 9
- 230000008961 swelling Effects 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000000629 knee joint Anatomy 0.000 description 7
- 230000036407 pain Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000009534 blood test Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 4
- 239000001685 glycyrrhizic acid Substances 0.000 description 4
- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 4
- 210000004247 hand Anatomy 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 241000905957 Channa melasoma Species 0.000 description 3
- 241000239226 Scorpiones Species 0.000 description 3
- 210000003423 ankle Anatomy 0.000 description 3
- 210000003797 carpal joint Anatomy 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000002310 elbow joint Anatomy 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- -1 filter Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 201000003068 rheumatic fever Diseases 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000000707 wrist Anatomy 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 208000008765 Sciatica Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000000878 metatarsophalangeal joint Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 241000227129 Aconitum Species 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010048610 Cardiotoxicity Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000004889 Interleukin-6 Human genes 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 102000003945 NF-kappa B Human genes 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- JJVGFDTWFVSBIM-UHFFFAOYSA-N Phillyrin Natural products COc1ccc(cc1OC)C2OCC3C2COC3c4ccc(OC)c(OC5OC(CO)C(O)C(O)C5O)c4 JJVGFDTWFVSBIM-UHFFFAOYSA-N 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000002201 avitaminosis Nutrition 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 231100000259 cardiotoxicity Toxicity 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000012669 compression test Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 238000001612 separation test Methods 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种中药制剂，特别涉及一种祛湿通络中药制剂。一种祛湿通络中药制剂，它由下列原料制成：黑蚂蚁、黑翅土白蚁、人参、黄芪、白术、当归、丹参、制川乌、鸡血藤、巴戟天、淫羊藿、牛膝、威灵仙、蜈蚣、全蝎、红花、枸杞子、薏苡仁、白芍、甘草、木瓜、连翘、三七。不仅具有活血通络、祛风除湿、补肝补气的功效，还能对制川乌的毒性成分乌头碱有促进分解作用、解毒拮抗的作用。本发明对于风湿及类风湿疾病的疗效作用更加显著，安全性能更高。
Description
技术领域
本发明涉及一种中药制剂，特别涉及一种祛湿通络中药制剂。
背景技术
川乌是一种中药，在医学上可以治疗很多疾病，但是川乌也是有副作用的，川乌的副作用主要表现在川乌本身有毒。川乌为乌头的干燥母根或较小的子根，功效与附子相似但毒性更大，属大毒药。主要用于风寒湿痹。肢体及关节冷痛，寒疝腹痛，半身不遂，头风头痛，坐骨神经痛，跌打剧痛；川乌在临床上一般用其炮制品配伍应用，以尽量避免出现中毒反应，中毒时对神经系统和循环系统为主，其次是消化系统症状，如口腔灼热、发麻（从指头开始渐及全身），流涎、恶心、疲倦、呼吸困难，肌肉麻痹，脉膊不规则，血压下降，面色发白，瞳孔散大，可能突然死亡。
制川乌为川乌的炮制加工品，临床应用制川乌发生中毒反应的原因是多方面的。如临床应用时会因配伍、用药量、加工炮制、个体差异等等情况而产生。
双蚁祛湿通络胶囊，专利申请号为：200410053648.1，具有活血通络、祛风除湿的功效，可明显改善肝肾两亏、气血不足引起的腰漆疼痛、肢节肿痛、麻木不仁、酸软乏力、屈伸不利等痹症症状，在治疗风湿性关节炎、累风湿性关节炎、坐骨神经痛、骨质增生性疾病领域疗效良好，但是，该胶囊含有制川乌，存在一定的安全隐患。
发明内容
本发明的目的在于提供一种祛湿通络中药制剂。
本发明的目的通过如下技术方案实现：
一种祛湿通络中药制剂，它由下列原料按重量份数制成：黑蚂蚁15～25份、黑翅土白蚁4～8份、人参0.8～1.2份、黄芪10～15份、白术2～6份、当归8～15份、丹参1～5份、制川乌0.5～1.0份、鸡血藤2～6份、巴戟天1～5份、淫羊藿1～5份、牛膝0.8～1.2份、威灵仙10～15份、蜈蚣0.2～0.8份、全蝎0.5～1.0份、红花1～5份、枸杞子6～12份、薏苡仁1～5份、白芍3～6份、甘草4～8份、木瓜3～6份、连翘1～3份、三七5～8份。
优选的是：它由下列原料按重量份数制成：黑蚂蚁20份、黑翅土白蚁7份、人参1.0份、黄芪13份、白术4份、当归10份、丹参3份、制川乌0.7份、鸡血藤3份、巴戟天2份、淫羊藿2份、牛膝1.0份、威灵仙12份、蜈蚣0.4份、全蝎0.6份、红花3份、枸杞子8份、薏苡仁4份、白芍3份、甘草6份、木瓜4份、连翘2份、三七7份。
所述的祛湿通络中药制剂的剂型包括胶囊制剂、片剂、颗粒剂、散剂。
本发明在双蚁祛湿通络胶囊（专利申请号为：200410053648.1）配方的基础上增加白芍、甘草、木瓜、连翘、三七共五味中药。
白芍味苦、性微寒、归肝经、具有清热凉血、散瘀止痛的功效，主治四肢挛急、跌打损伤、肝血亏虚、肝脾不和、养血敛阴、柔肝止痛之功能。毒理学研究发现，制川乌与白芍配伍后，制川乌的毒性成分乌头碱煎出量减少，白芍的有效成分芍药苷煎出量增多。白芍与制川乌配伍后，镇痛、抗炎、免疫调节作用增强。
甘草有补脾益气，清热解毒，祛痰止咳，缓急止痛功效，用于脾胃虚弱，倦怠乏力，心悸气短，四肢挛急疼痛，痈肿疮毒，缓解药物毒性、调和诸药。甘草与制川乌配伍，首先甘草中的有效成分甘草酸和制川乌的毒性成分乌头碱结合成盐，此盐水解逐步释放出游离的乌头碱和甘草酸，而释放出的甘草酸又能促进乌头碱的水解，因此甘草酸对乌头碱有控释和促进水解的双重功效。
木瓜有舒肝活络，健脾开胃，舒肝止痛，祛风除湿之效，可用于风湿、风湿性关节炎、腰膝酸痛、霍乱、痢疾、肠炎、脚气病和维生素缺乏症等。
连翘味苦，性微寒，清热解毒，散结消肿，具有解毒止痛功效。连翘的有效成分连翘苷对兴奋迷走神经有抑制作用，对中枢神经系统有镇静作用，特别是对大脑皮质有抑制作用，能拮抗乌头碱对迷走神经兴奋作用，中枢神经毒性作用和心脏毒性作用。
三七和营止血，通脉行瘀，行瘀血而敛新血。具有止血、抗血栓、造血补血、抗炎、保肝、抗肿瘤及镇痛的功效。三七的主要成分三七总皂苷能改善类风湿关节炎，主要是通过抑制炎性细胞因子TNF-α、IL-1β、IL-1和IL-6，下调NO和NF-κB，纠正CCP抗原特异性T细胞导致的INF-γ/IL-4失衡而产生药效。
本中药制剂搭配合理，治疗风湿及类风湿疾病疗效佳、标本兼治、见效快、无毒副作用，痊愈后不复发。它不仅具有加强了活血通络、祛风除湿、补肝补气的功效，还能对制川乌的毒性成分乌头碱有促进分解作用、解毒拮抗的作用。本发明对于风湿及类风湿疾病的疗效作用更加显著，安全性能更高。
具体实施方式
下面结合具体实施例，对本发明作进一步详细的阐述，但本发明的实施方式并不局限于实施例表示的范围。这些实施例仅用于说明本发明，而非用于限制本发明的范围。此外，在阅读本发明的内容后，本领域的技术人员可以对本发明作各种修改，这些等价变化同样落于本发明所附权利要求书所限定的范围。
实施例1
按照如下重量（克）配比取：
黑蚂蚁1500、黑翅土白蚁400、人参80、黄芪1000、白术200、当归800、丹参100、制川乌50、鸡血藤200、巴戟天100、淫羊藿100、牛膝80、威灵仙1000、蜈蚣20、全蝎50、红花100、枸杞子600、薏苡仁100、白芍300、甘草400、木瓜300、连翘100、三七500。
将人参、威灵仙粉碎，过120目筛，备用；把黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎粉碎，过80目筛，加4～6倍60%乙醇40～60分钟，加热至70℃～80℃进行提取，加60%乙醇重复提取三次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的十七味药加6～9倍质量的水，煎煮1～2小时，提取液体，往提取药渣中加6～9倍质量的水，重复提取一次，合并两次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达50%～70%，搅拌均匀、静置24小时。与黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎提取液混合，回收乙醇，浓缩至相对密度为1.3～1.35（70℃）的稠膏，加入人参、威灵仙细粉，混匀，干燥，过100～120目筛，分装，制成每份装0.3g散剂。
实施例2
按照如下重量（克）配比取：
黑蚂蚁2000、黑翅土白蚁700、人参100、黄芪1300、白术400、当归1000、丹参300、制川乌70、鸡血藤300、巴戟天200、淫羊藿200、牛膝1000、威灵仙1200、蜈蚣40、全蝎60、红花300、枸杞子800、薏苡仁400、白芍300、甘草600、木瓜400、连翘200、三七700。
将人参、威灵仙粉碎，过120目筛，备用；把黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎粉碎，过80目筛，加4～6倍60%乙醇40～60分钟，加热至70℃～80℃进行提取，加60%乙醇重复提取三次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的十七味药加6～9倍质量的水，煎煮1～2小时，提取液体，往提取药渣中加6～9倍质量的水，重复提取一次，合并两次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达50%～70%，搅拌均匀、静置24小时。与黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎提取液混合，回收乙醇，浓缩至相对密度为1.3～1.35（70℃）的稠膏，加入人参、威灵仙细粉，混匀，干燥，过100～120目筛制成散剂。加入淀粉、糊精等辅料，制粒、干燥后分装，制得0.4g颗粒剂和0.5g胶囊剂。
实施例3
按照如下重量（克）配比取：
黑蚂蚁2500、黑翅土白蚁800、人参120、黄芪1500、白术600、当归1500、丹参500、制川乌100、鸡血藤600、巴戟天500、淫羊藿500、牛膝120、威灵仙1500、蜈蚣80、全蝎100、红花500、枸杞子1200、薏苡仁500、白芍600、甘草800、木瓜600、连翘300、三七800。
将人参、威灵仙粉碎，过120目筛，备用；把黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎粉碎，过80目筛，加4～6倍60%乙醇40～60分钟，加热至70℃～80℃进行提取，加60%乙醇重复提取三次，每次间隔2小时，合并提取液，过滤，滤液备用。将余下的十七味药加6～9倍质量的水，煎煮1～2小时，提取液体，往提取药渣中加6～9倍质量的水，重复提取一次，合并两次提取液，浓缩至相对密度1.2（70℃）的清膏，加乙醇使乙醇含量达50%～70%，搅拌均匀、静置24小时。与黑蚂蚁、黑翅土白蚁、蜈蚣、全蝎提取液混合，回收乙醇，浓缩至相对密度为1.3～1.35（70℃）的稠膏，加入人参、威灵仙细粉，混匀，干燥，过100～120目筛制成散剂，加入淀粉、糊精等辅料，混合压片后可制得0.6g片剂。
用上述实施例1中制成的散剂治疗效果典型案例
例1：患者李某，女，42岁，主因间断性全身小关节肿痛3年于2006年9月6日入院检查症状：双膝关节肿痛，屈伸不利，右侧为甚，双侧腕关节、肘关节、跖趾关节、掌指关节肿胀、疼痛，活动受限，畸形，肘关节局部皮下结节，皮肤颜色正常。辅助检查：血常规示：HB80g/L(血红蛋白测定)，RF(+)(类风湿因子)，ESR142mm/h(血沉)。精神倦怠，双手掌指、跖趾关节畸形，双膝关节、腕关节、肘关节活动受限，双肾区叩击痛，双下肢凹性水肿Ⅱ度,舌质暗红，苔白，脉沉细涩。服用上述实施例1中制成的散剂，每日3次，服药1周后前症改善缓和，2周后关节肿痛诸症消失。复检血常规正常，HB：101g/L，(血红蛋白测定)，RF(-)(类风湿因子)，ESR：40mm/h(血沉)，达到治愈目的。随访一年，病情未复发。
例2：患者张某，男，42岁，因四肢关节间断肿痛4年，加重2月余前来就医发育正常，营养中等，表情痛苦。全身无皮疹、无皮下结节，双腕关节Ⅱ;肿胀，皮温高，压痛(+)，屈左5，右5，左手背Ⅱ浮肿，骨盆挤压分离试验(-)，双膝Ⅲ;肿胀，压痛(+)，屈左30，右45，伸左-15，右-5，双踝Ⅱ肿胀，皮温高，压痛(+)，双足背Ⅱ肿，余关节无肿胀。辅助检查：血常规示：HB80g/L(血红蛋白测定)，余正常，RF(+)(类风湿因子)，ESR142mm/h(血沉)。X线片示：双手骨质疏松，部分掌指、近指关节狭窄，模糊，小囊样变，关节软组织肿胀，双腕软组织肿胀，间隙变窄，双膝关节软组织肿胀，关节间隙变窄，骨质疏松，关节缘骨赘形成。服用上述实施例1中制成的散剂，每日3次，服药1周后前症改善缓和，2周后关节肿痛诸症消失。复检血常规正常，HB：90g/L，(血红蛋白测定)，RF(-)(类风湿因子)，ESR：30mm/h(血沉)，达到治愈目的。随访一年，病情未复发。
例3：患者，女，40岁，该患者于16年前分娩后出现小腿酸痛，未经系统诊治，现在患者双腕、双踝、双膝肿痛，脊柱生理弯曲存在，各双肩压痛（+）；各棘突无压痛；双肘压痛（+）；双腕Ⅱ度肿，压痛（+）；双手各指掌近指关节2度肿，压痛（+）；各远指关节压痛（+）双膝Ⅲ度肿，压痛（+）；皮温高，左膝伸–30度；双踝Ⅱ度肿，压痛（+）；双路跖趾骨关节压痛（+）；骨盆挤压分离测试（–）。辅助化验：HB：112g/L，(血红蛋白测定)、RF(+)(类风湿因子)、ERS：115mm/h，双手X线：骨质普遍疏松，掌指多个间隙变窄。服用上述实施例1中制成的散剂，每日3次，服药2周后前症改善缓和，3周后关节肿痛诸症消失。复检血常规正常，HB：110g/L，(血红蛋白测定)，RF(-)(类风湿因子)，ESR：21mm/h(血沉)，达到治愈目的。随访一年，病情未复发。
Claims (3)
1.一种祛湿通络中药制剂，其特征在于：它由下列原料按重量份数制成：黑蚂蚁15～25份、黑翅土白蚁4～8份、人参0.8～1.2份、黄芪10～15份、白术2～6份、当归8～15份、丹参1～5份、制川乌0.5～1.0份、鸡血藤2～6份、巴戟天1～5份、淫羊藿1～5份、牛膝0.8～1.2份、威灵仙10～15份、蜈蚣0.2～0.8份、全蝎0.5～1.0份、红花1～5份、枸杞子6～12份、薏苡仁1～5份、白芍3～6份、甘草4～8份、木瓜3～6份、连翘1～3份、三七5～8份。
2.根据权利要求1所述的祛湿通络中药制剂，其特征在于：它由下列原料按重量份数制成：黑蚂蚁20份、黑翅土白蚁7份、人参1.0份、黄芪13份、白术4份、当归10份、丹参3份、制川乌0.7份、鸡血藤3份、巴戟天2份、淫羊藿2份、牛膝1.0份、威灵仙12份、蜈蚣0.4份、全蝎0.6份、红花3份、枸杞子8份、薏苡仁4份、白芍3份、甘草6份、木瓜4份、连翘2份、三七7份。
3.根据权利要求1或2所述的祛湿通络中药制剂，其特征在于：其剂型包括胶囊制剂、片剂、颗粒剂、散剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310552277.0A CN103566236B (zh) | 2013-11-08 | 2013-11-08 | 一种祛湿通络中药制剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310552277.0A CN103566236B (zh) | 2013-11-08 | 2013-11-08 | 一种祛湿通络中药制剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103566236A CN103566236A (zh) | 2014-02-12 |
| CN103566236B true CN103566236B (zh) | 2015-08-19 |
Family
ID=50039517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310552277.0A Active CN103566236B (zh) | 2013-11-08 | 2013-11-08 | 一种祛湿通络中药制剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103566236B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984162A (zh) * | 2015-06-30 | 2015-10-21 | 天峨县平昌生态农业有限公司 | 一种具有祛湿通络功效的中药制剂 |
| CN105031407B (zh) * | 2015-08-27 | 2018-12-25 | 北京新世纪达康生物科技开发有限责任公司 | 一种治疗风湿、类风湿的中药组合物、其制备方法及应用 |
| CN105902983A (zh) * | 2016-05-24 | 2016-08-31 | 内蒙古中安类风湿骨关节病专科医院有限责任公司 | 一种治疗风寒湿痹症的中药制剂 |
| CN106389972A (zh) * | 2016-10-25 | 2017-02-15 | 张春 | 一种治疗风湿性疾病的稔子酒及其制备方法 |
| CN111803598A (zh) * | 2020-07-22 | 2020-10-23 | 昆明科晔生物技术有限公司 | 一种祛湿通络的中药制剂 |
| CN117959401B (zh) * | 2024-01-17 | 2025-05-30 | 宋东红 | 一种治疗类风湿性关节炎的中药组合与制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557383A (zh) * | 2004-02-10 | 2004-12-29 | 广西来宾金钱草药业有限公司 | 双蚁祛湿通络胶囊 |
-
2013
- 2013-11-08 CN CN201310552277.0A patent/CN103566236B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557383A (zh) * | 2004-02-10 | 2004-12-29 | 广西来宾金钱草药业有限公司 | 双蚁祛湿通络胶囊 |
Non-Patent Citations (2)
| Title |
|---|
| 川乌与白芍配伍前后乌头碱和芍药苷煎出量的测定;何伟等;《中国药学杂志》;20020930;第37卷(第09期);680-683 * |
| 附子甘草配伍减毒增效机理探析;杨明等;《时珍国医国药》;20031231;第14卷(第04期);197-198 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103566236A (zh) | 2014-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103566236B (zh) | 一种祛湿通络中药制剂 | |
| CN100423761C (zh) | 一种治疗骨折、跌打损伤的中药制剂 | |
| CN102327380A (zh) | 一种治疗膝关节骨性关节炎的中药组合物 | |
| CN101066303B (zh) | 治疗脑血栓、脑血管硬化和中风偏瘫的药物及其制备方法 | |
| CN101537093A (zh) | 预防和治疗骨质疏松、骨折的中药及其制备方法 | |
| CN102091311B (zh) | 一种治疗类风湿性关节炎的中药组合物及其制备方法 | |
| CN104758659A (zh) | 一种治疗筋骨病的中药膏剂 | |
| CN101112537A (zh) | 治疗骨质增生疾病的中药制剂 | |
| CN104000890B (zh) | 调和肝脾、祛风除湿、养血止痹痛的中药 | |
| CN104000933A (zh) | 一种治疗骨质增生的中药口服液 | |
| CN103550380A (zh) | 一种治疗骨质增生的中药组合物 | |
| CN102784332A (zh) | 一种治疗脉管炎的药物 | |
| CN1079029C (zh) | 骨痹胶囊及其制备方法 | |
| CN105326939A (zh) | 一种治疗心脑血管病的中药及其制备方法 | |
| CN102018815A (zh) | 用于治疗腰椎结核的中药制剂 | |
| CN101284087B (zh) | 一种治疗腰椎病的药物组合物 | |
| CN105412692A (zh) | 一种用于治疗鹤膝风的中药制剂 | |
| CN104138479A (zh) | 一种治疗胆囊结石的药物 | |
| CN102028810B (zh) | 一种治疗腰椎间盘突出症的中药 | |
| CN103623085B (zh) | 一种治疗风湿性关节炎的中药组合物及其制备方法 | |
| CN102526365B (zh) | 一种治疗跌打损伤的接骨胶囊 | |
| CN102631435A (zh) | 一种治疗类风湿性关节炎的药物 | |
| CN102872287A (zh) | 一种治疗股骨头坏死的中药组合物及其制备方法 | |
| CN102091265A (zh) | 一种治疗糖尿病痛风的中药 | |
| CN109432309A (zh) | 中药组合物、外用药酒及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A traditional Chinese medicine preparation for removing dampness and dredging collaterals Effective date of registration: 20211129 Granted publication date: 20150819 Pledgee: Guangxi Laibin Rural Commercial Bank Co.,Ltd. Pledgor: GUANGXI DOUBLE ANT PHARMACEUTICAL Co.,Ltd. Registration number: Y2021450000047 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220802 Granted publication date: 20150819 Pledgee: Guangxi Laibin Rural Commercial Bank Co.,Ltd. Pledgor: GUANGXI DOUBLE ANT PHARMACEUTICAL Co.,Ltd. Registration number: Y2021450000047 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A kind of traditional Chinese medicine preparation for removing dampness and dredging collaterals Effective date of registration: 20220905 Granted publication date: 20150819 Pledgee: Guangxi Laibin Rural Commercial Bank Co.,Ltd. Pledgor: GUANGXI DOUBLE ANT PHARMACEUTICAL Co.,Ltd. Registration number: Y2022450000147 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |