CN111787949A - 变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途 - Google Patents

变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途 Download PDF

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CN111787949A
CN111787949A CN201980013427.6A CN201980013427A CN111787949A CN 111787949 A CN111787949 A CN 111787949A CN 201980013427 A CN201980013427 A CN 201980013427A CN 111787949 A CN111787949 A CN 111787949A
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domain
seq
binding
cancer
amino acid
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埃兹奥·泊韦尼
黄菱
郭家颖
G·R·齐齐李
拉尔夫·F·奥尔德森
保罗·A·摩尔
莱斯利·S·约翰逊
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Macrogenics Inc
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Macrogenics Inc
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN201980013427.6A 2018-02-15 2019-02-13 变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途 Pending CN111787949A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862631043P 2018-02-15 2018-02-15
US62/631,043 2018-02-15
US201862738632P 2018-09-28 2018-09-28
US62/738,632 2018-09-28
PCT/US2019/017772 WO2019160904A1 (en) 2018-02-15 2019-02-13 Variant cd3-binding domains and their use in combination therapies for the treatment of disease

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CN111787949A true CN111787949A (zh) 2020-10-16

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US (2) US11685781B2 (https=)
EP (1) EP3752196A4 (https=)
JP (3) JP7337079B2 (https=)
KR (1) KR20200121834A (https=)
CN (1) CN111787949A (https=)
AU (2) AU2019222666B2 (https=)
BR (1) BR112020016485A2 (https=)
CA (1) CA3089877A1 (https=)
IL (1) IL276713A (https=)
MX (3) MX2020008489A (https=)
SG (1) SG11202007572VA (https=)
TW (2) TW202440646A (https=)
WO (1) WO2019160904A1 (https=)
ZA (1) ZA202004681B (https=)

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MX375669B (es) * 2014-09-26 2025-03-06 Macrogenics Inc Diacuerpos monovalentes biespecificos que son capaces de unir cd19 y cd3, y usos de los mismos.
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CA3217391A1 (en) * 2020-07-27 2022-02-03 Youwei ZHU Formulation of novel bispecific anti-cd3/cd20 polypeptide complex
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