CN111773342A - Traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treating colorectal cancer - Google Patents

Traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treating colorectal cancer Download PDF

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CN111773342A
CN111773342A CN202010771342.9A CN202010771342A CN111773342A CN 111773342 A CN111773342 A CN 111773342A CN 202010771342 A CN202010771342 A CN 202010771342A CN 111773342 A CN111773342 A CN 111773342A
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parts
chinese medicine
traditional chinese
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王西勤
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Abstract

The invention discloses a traditional Chinese medicine formula for treating chronic colorectal inflammation and assisting in treating colorectal cancer, which comprises the following traditional Chinese medicine raw materials in parts by weight: 25-30 parts of kudzuvine root, 4-6 parts of costus root, 9-12 parts of garden burnet root, 6-9 parts of Chinese gall, 4-6 parts of myrobalan, 9-12 parts of Chinese magnoliavine fruit, 10-12 parts of wrinkled gianthyssop herb, 9-12 parts of prepared rehmannia root, 4-6 parts of Chinese date, 9-12 parts of summer heat, 9-12 parts of poria, 6-8 parts of honey-fried licorice root, 15-20 parts of katsumade galangal seed, 9-12 parts of long pepper, 10-20 parts of hairyvein agrimonia herb and bud, 12-20 parts of paniculate swallowwort root, 18-25 parts of seaweed, 10-15 parts of panax notoginseng and 25-35. The traditional Chinese medicine provided by the invention has the advantages of reasonable formula compatibility, no toxic or side effect, convenience in processing, low cost and obvious effects of treating chronic colorectal inflammation and adjuvant therapy of colorectal cancer.

Description

Traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treating colorectal cancer
Technical Field
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treatment of colorectal cancer.
Background
Chronic colorectal inflammation refers to a group of inflammatory diseases of colon and rectum, the pathological changes of which are recurrent attacks and are chronic processes, and the diseases are usually called as follows in traditional Chinese medicine: intestine exorcising, chronic dysentery, diarrhea, etc.
The causes of chronic colorectal inflammation are not clear, and the traditional Chinese medicine generally considers that the chronic colorectal inflammation is related to seven emotions and stagnation, improper diet, chronic dysentery, external infection of six excesses, spleen and stomach disorder caused by damp-heat accumulation, spleen and kidney deficiency and other causes; the western medicine considers that the disease is related to environmental factors, immune factors, psychologic factors, genetics and other factors.
The main symptoms of chronic colorectal inflammation are: abnormal defecation: most patients have constipation, diarrhea or alternating constipation and diarrhea. Bloody stool, mucous stool, or purulent mucous stool: most patients have mucus or mucus bloody stool, and bloody stool or purulent stool can be seen when proctitis is obvious. ③ Abdominal pain: there may be mild to moderate dull pain in the lower abdomen, with the rule of abdominal pain-desire to urinate-relief after defecation. Fourthly, anomalar sensation: patients with proctitis often have incomplete stool and serious feeling after tenesmus, and also have abnormal sensations such as burning sensation and pain in the anus.
At present, the clinical diagnosis method mainly comprises enteroscopy, congestion and edema of mucosa and even multiple superficial ulcer or polyp formation can be seen, and the diagnosis can be confirmed basically according to the clinical and enteroscopy.
The existing medicines for treating enteritis are various and comprise traditional Chinese medicines and western medicines. Western medicines have relatively large side effects and bring harm to health after being taken for a long time. The Chinese patent medicines also have a plurality of varieties and characteristics, but the curative effect of some medicines is not ideal. However, the report and the application of the same medicament as the invention are not seen at present.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treatment of colorectal cancer and a traditional Chinese medicine extract prepared from the traditional Chinese medicine formula.
The invention aims to provide application of the traditional Chinese medicine formula and the traditional Chinese medicine extract in preparation of medicines for treating chronic colorectal inflammation and auxiliary treatment of colorectal cancer.
In order to achieve the purpose, the invention adopts the following technical scheme:
according to one aspect of the invention, the invention provides a traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treatment of colorectal cancer, and the traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials: radix Puerariae, radix aucklandiae, radix Sangusorbae, Galla chinensis, fructus Chebulae, fructus Schisandrae chinensis, herba Agastaches, radix rehmanniae Preparata, fructus Jujubae, rhizoma Pinelliae, Poria, radix Glycyrrhizae Preparata, semen Alpiniae Katsumadai, fructus Piperis Longi, herba et Gemma Agrimoniae, radix Cynanchi Paniculati, Sargassum, Notoginseng radix, and radix astragali.
Further, the traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 25-30 parts of kudzuvine root, 4-6 parts of costus root, 9-12 parts of garden burnet root, 6-9 parts of Chinese gall, 4-6 parts of myrobalan, 9-12 parts of Chinese magnoliavine fruit, 10-12 parts of wrinkled gianthyssop herb, 9-12 parts of prepared rehmannia root, 4-6 parts of Chinese date, 9-12 parts of summer heat, 9-12 parts of poria, 6-8 parts of honey-fried licorice root, 15-20 parts of katsumade galangal seed, 9-12 parts of long pepper, 10-20 parts of hairyvein agrimonia herb and bud, 12-20 parts of paniculate swallowwort root, 18-25 parts of seaweed, 10-15 parts of panax notoginseng and 25-35.
Furthermore, the traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 30 parts of kudzuvine root, 6 parts of costus root, 9 parts of garden burnet root, 6 parts of Chinese gall, 6 parts of myrobalan fruit, 9 parts of Chinese magnoliavine fruit, 12 parts of wrinkled gianthyssop herb, 12 parts of prepared rehmannia root, 6 parts of Chinese date, 9 parts of summer heat, 12 parts of poria, 6 parts of honey-fried licorice root, 15 parts of katsumadai seed, 9 parts of long pepper, 10 parts of hairyvein agrimony, 12 parts of paniculate swallowwort root, 18 parts of seaweed, 10 parts of panax notoginseng and 25 parts of.
According to another aspect of the invention, the invention provides a traditional Chinese medicine extract for treating chronic colorectal inflammation and auxiliary treatment of colorectal cancer, which is prepared from the traditional Chinese medicine formula.
According to still another aspect of the present invention, the present invention provides a pharmaceutical preparation for treating chronic colorectal inflammation and for adjuvant treatment of colorectal cancer, wherein the active ingredients of the pharmaceutical preparation are the traditional Chinese medicine extracts described above.
Furthermore, the dosage form of the pharmaceutical preparation comprises a conventional oral dosage form in pharmaceutics.
The oral preparation is prepared by matching the traditional Chinese medicine extract with a pharmaceutically acceptable carrier.
Pharmaceutically acceptable carriers of the present invention include, but are not limited to, the following:
diluent agent: starch, powdered sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, sugar alcohols, etc.
Wetting agent and binder: purified water, ethanol, gelatin, polyethylene glycol, cellulose derivatives, and the like.
Disintegrating agent: starch, sodium carboxymethyl starch, cellulose derivatives, crospovidone, and the like.
Lubricant: magnesium stearate, aerosil, talcum powder, polyethylene glycol and the like.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid paraffin, vegetable oil, etc.
Flavoring agent: sucrose, monosaccharide, aromatic, etc.
Preservative: benzoic acid, sorbic acid, methyl esters, ethyl esters, propyl esters, and the like.
Further, the oral dosage form comprises oral liquid, syrup, granules, pills, tablets, capsules and mixture.
According to another aspect of the present invention, the present invention provides a method for preparing the above mentioned Chinese medicine extract, the method comprises the following specific steps:
according to still another aspect of the present invention, there is provided the method for preparing the aforementioned pharmaceutical preparation, the method for preparing the oral liquid comprising the steps of:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common adjuvants of oral liquid, and preparing oral liquid according to conventional production method;
the preparation method of the syrup comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common syrup adjuvants, and preparing syrup by conventional method;
the preparation method of the tablet comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common auxiliary materials of the tablets, and preparing the tablets according to a conventional production method;
the preparation method of the capsule comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common adjuvants for capsule, and making capsule according to conventional production method;
the preparation method of the granules comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common adjuvants, and making into granule by conventional method;
the preparation method of the pill comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) making the soft extract into pill;
the preparation method of the mixture comprises the following steps:
(1) preparing the Chinese medicinal extract according to the preparation method;
(2) adding common adjuvants, and preparing into mixture by conventional method.
The common auxiliary materials of the oral liquid comprise one or more of diluent, flavoring agent, preservative and wetting agent.
The common auxiliary materials of the tablets comprise one or more of diluent, wetting agent, adhesive, disintegrating agent and lubricant.
The common adjuvants for the granule include one or more of diluent, wetting agent, binder, and disintegrating agent.
The common adjuvants for the capsule comprise one or more of diluent, wetting agent, binder, disintegrating agent, and lubricant.
The syrup common adjuvants comprise one or more of correctant, antiseptic, and cosolvent.
The common auxiliary materials of the mixture comprise one or more of flavoring agent and preservative.
Diluents which may be used in the present invention include starch, dextrin, sucrose, lactose, mannitol, microcrystalline cellulose.
Wetting agents that may be used in the present invention include water, ethanol.
Binders useful in the present invention include hypromellose, povidone, starch slurry, syrup.
Disintegrants that can be used in the present invention include dry starch, sodium hydroxymethyl starch, low substituted hydroxypropyl cellulose, effervescent disintegrants, crospovidone.
Lubricants useful in the present invention include magnesium stearate, talc, hydrogenated vegetable oil, polyethylene glycol, aerosil.
Flavors useful in the present invention include: sweeteners, such as sucrose, fruit syrups having an aromatic taste, and the like, which are not only taste-correcting but also odor-correcting; aromatic such as natural volatile aromatic oil (such as oleum Menthae Dementholatum, etc.) or preparation (such as tincture of citric acid, etc.) or artificially synthesized essence (such as fructus Musae, essence, etc.), mucilage which is sticky and can interfere taste buds to correct taste, can reduce irritation to irritant medicine, and can also correct astringent sour taste, effervescent agent which uses acid carbonate and organic acid (such as citric acid) to generate carbon dioxide together to paralyze taste buds to correct taste.
Preservatives that may be used in the present invention include benzoic acid, sodium benzoate, parabens, sorbic acid, ethanol, phenols, glycerol.
Cosolvents useful in the present invention include two classes, one class being certain organic acids and their sodium salts, such as: sodium benzoate, sodium salicylate, p-aminobenzoic acid, etc.; another class is amides, such as: urea, nicotinamide, acetamide, etc.
According to a further aspect of the invention, the invention provides the use of a Chinese medicinal formulation as hereinbefore described in the manufacture of a medicament for the treatment of chronic colorectal inflammation.
According to another aspect of the present invention, the present invention provides the use of the above-mentioned herbal extract in the preparation of a medicament for treating chronic colorectal inflammation.
According to the traditional and modern medical analysis, the traditional Chinese medicine has the following medicinal properties and pharmacological effects:
radix Puerariae (Radix Pueraria)
[ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is cool in nature, sweet and pungent in flavor. It enters spleen and stomach meridians.
[ EFFECT AND ACTION ] can relieve muscular dystrophy, promote salivation, promote eruption, and tonify yang to arrest diarrhea. Belongs to the category of exterior-releasing herbs.
Costus root (Radix Aucklandiae)
[ PROPERTIES AND FLAVOUR GUIDING JING ] has pungent, bitter and warm properties.
[ EFFECT AND ACTION ] has effects of activating qi-flowing, relieving pain, invigorating spleen and promoting digestion.
Radix Sangusorbae (Sanguisorba officinalis L.)
[ PROPERTIES, WESTERN AND CHANNEL TROPISM ] is slightly cold in nature, bitter, sour and astringent in flavor. It enters liver meridian and large intestine meridian.
[ EFFECT AND ACTION ] can remove heat from the blood, stop bleeding, remove toxicity and heal wound. Blood-cooling hemostatics belonging to the category of hemostatics.
Galla chinensis (Rhus chinensis Mill.)
[ PROPERTIES AND FLAVOUR-RESERVING CHANNEL ] is cold in nature, sour and astringent in taste. It enters lung meridian, large intestine meridian and kidney meridian.
[ EFFECT AND ACTION ] astringe lung to reduce pathogenic fire, astringe intestine to check diarrhea, astringe lung, stop bleeding, astringe dampness to heal wound. Astringents the herbs with lung astringents are classified under astringents.
Myrobalan (Terminalia Linn.)
[ PROPERTIES, WESTERN AND CHANNEL FENCH ] has mild nature and bitter, sour and astringent taste. It enters lung and large intestine meridians.
[ EFFECT AND ACTION ] astringe intestines to astringe lung, reduce water and relieve sore throat. Astringents the herbs with lung astringents are classified under astringents.
Fructus Schisandrae chinensis (Schisandra chinensis (Turcz.) Baill.)
[ PROPERTIES AND FLAVOUR-END CHANNEL ] is warm in nature and sour and sweet in taste. It enters lung meridian, heart meridian and kidney meridian.
[ EFFECT AND ACTION ] can astringe, arrest discharge, invigorate qi, promote fluid production, tonify kidney, and calm heart. They belong to the category of astringents.
Agastache rugosa (Fisch. et Mey.) O.Ktze.)
[ PROPERTIES, WESTERN AND CHANNEL tropism ] is slightly warm in nature and pungent in flavor. It enters lung, spleen and stomach meridians.
[ EFFECT AND ACTION ] can promote the circulation of qi, regulate the middle warmer, repel filth, and dispel dampness. Belongs to qi-regulating herbs.
Prepared Rehmannia root (Rehmannia glutinosa (Gaetn.) Libosch.ex Fisch.et Mey.)
[ PROPERTIES, WESTERN AND CHANNEL TROPISM ] is slightly warm in nature and sweet in flavor. It enters liver and kidney meridians.
[ EFFECT AND ACTION ] can nourish blood, nourish yin, replenish vital essence and replenish marrow. Belongs to the category of tonifying drugs under deficiency-tonifying drugs.
Chinese date (Ziziphus jujuba Mill.)
[ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is sweet in nature and taste and warm in nature. The meridian entered spleen and stomach.
[ EFFECT AND ACTION ] the product has effects of invigorating spleen, replenishing qi, nourishing blood, and tranquilizing mind. Can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.
Summer (Rhizoma Pinelliae)
[ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is pungent, warm and toxic. Enter spleen and stomach meridians.
[ EFFECT AND ACTION ] eliminate dampness and phlegm, check adverse rise of qi to arrest vomiting, relieve stuffiness and dissipate nodulation. It is indicated for cold drink of damp-phlegm manifested as vomiting, regurgitation, cough, dyspnea, profuse phlegm, fullness and distention in chest and diaphragm, phlegm syncope, headache, dizziness and insomnia. Abscess and swelling in the exterior.
Poria (Poria cos (Schw.) Wolf)
[ PROPERTIES AND FLAVOUR-END CHANNEL ] has sweet, light and mild nature and taste. Meridian tropism includes heart, lung, spleen and kidney meridians.
[ EFFECT AND ACTION ] can induce diuresis, drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Radix Glycyrrhizae Preparata (radix glycyrrhizae)
[ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is warm in nature and sweet in taste. They enter heart, lung, stomach and spleen meridians.
[ EFFECT AND ACTION ] can tonify spleen and stomach, replenish qi and recover pulse. They belong to qi tonics classified under deficiency tonics.
Alpinia katsumadai Hayata (Alpinia katsumadai)
[ PROPERTIES AND FLAVOUR-END CHANNEL ] is pungent in nature and warm in nature. The meridian entered spleen and stomach.
[ EFFECT AND ACTION ] can eliminate dampness, invigorate the spleen, warm the stomach and arrest vomiting. Can be used for treating cold-dampness retention, abdominal distention, psychroalgia, belch, vomiting, and anorexia.
Long pepper (Piper longum L.)
[ PROPERTIES, WEI DING JING ] is pungent in flavor and hot in nature. It enters stomach meridian and large intestine meridian.
[ EFFECT AND ACTION ] can warm the middle-jiao to dispel cold, and expel qi to alleviate pain. It belongs to interior-warming herbs.
Summer (Pinellia ternata (thunnb.) Breit.)
[ PROPERTIES AND FLAVOUR GUIDING CHANNEL ] is pungent, warm and toxic. Enter spleen and stomach meridians.
[ EFFECT AND ACTION ] eliminate dampness and phlegm, check adverse rise of qi to arrest vomiting, relieve stuffiness and dissipate nodulation. It is indicated for cold drink of damp-phlegm manifested as vomiting, regurgitation, cough, dyspnea, profuse phlegm, fullness and distention in chest and diaphragm, phlegm syncope, headache, dizziness and insomnia. Abscess and swelling in the exterior.
Agrimonia pilosa (Herba Agrimoniae)
[ PROPERTIES AND WESTERN CHANNELS ] is neutral in nature, bitter and astringent in taste. It enters heart and liver meridians.
[ EFFECT AND ACTION ] astringe to stop bleeding, check malaria, stop dysentery, remove toxic substance. Astringent hemostatics belong to the category of hemostatics.
Paniculate swallowwort root (Cynanchum paniculatum)
[ PROPERTIES AND FLAVOUR-RESTRICTING CHANNEL ] is warm in nature and pungent in flavor. It enters liver meridian and stomach meridian.
[ EFFECT AND ACTION ] can dispel pathogenic wind, remove dampness, promote the circulation of qi, and dredge collaterals. Belongs to the wind-damp-dispelling and tendon and bone-strengthening herbs classified under the wind-damp-dispelling herbs.
Seaweed (Sargassum)
[ PROPERTIES, WESTERN AND CHANNEL FENCH ] is cold in nature, bitter and salty in taste. It enters liver meridian, stomach meridian and kidney meridian.
[ EFFECT AND ACTION ] DAOSHI-DECORATIVE AND DRUG-DISTILLATING, expectorant, and diuretic effects. Herbs that can clear and resolve heat-phlegm belong to the category of phlegm-resolving, cough-relieving and dyspnea-relieving herbs.
Radix Notoginseng (Radix Notoginseng)
[ PROPERTIES AND DENSITY ] is warm in nature, sweet in flavor and slightly bitter in taste. It enters liver meridian and stomach meridian.
[ EFFECT AND ACTION ] the medicine has effects of dispelling blood stasis, stopping bleeding, eliminating swelling and relieving pain. Belongs to the category of hemostatics and blood stasis-resolving hemostatics.
Radix astragali (Legominosae)
[ PROPERTIES, WESTERN AND CHANNEL FENCH ]: sweet, slightly warm; it enters spleen and lung meridians.
[ EFFECT AND ACTION ]: benefiting wei-defensive qi, consolidating superficial resistance, invigorating qi, invigorating yang, expelling toxin, promoting granulation, inducing diuresis, and relieving swelling. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, spontaneous perspiration, night sweat, blood deficiency, sallow complexion, dorsal furuncle, edema, internal heat, and diabetes.
The invention has the following advantages and beneficial effects:
1. the technical scheme of the invention accords with the mechanism of treatment based on syndrome differentiation of traditional Chinese medicine, and is based on the origin of diseases, and the formula is reasonable and scientific.
2. The traditional Chinese medicine formula disclosed by the invention is low in production cost and simple in process.
3. The traditional Chinese medicine formula and the pharmaceutical preparation of the invention are proved to have good curative effect, small toxic and side effect and low price, and are suitable for clinical popularization and use.
Detailed Description
For a better understanding and practice, the present invention is further illustrated below with reference to the following examples. Unless otherwise specified, the examples of the present invention are only for explaining the present invention and are not meant to limit the scope of the present invention.
Example 1 preparation of herbal extracts
1. Accurately weighing the following traditional Chinese medicine raw materials: 30 parts of kudzuvine root, 6 parts of costus root, 9 parts of garden burnet root, 6 parts of Chinese gall, 6 parts of myrobalan fruit, 9 parts of Chinese magnoliavine fruit, 12 parts of wrinkled gianthyssop herb, 12 parts of prepared rehmannia root, 6 parts of Chinese date, 9 parts of summer heat, 12 parts of poria, 6 parts of honey-fried licorice root, 15 parts of katsumadai seed, 9 parts of long pepper, 10 parts of hairyvein agrimony, 12 parts of paniculate swallowwort root, 18 parts of seaweed, 10 parts of panax notoginseng and 25 parts of.
2. Decocting the above Chinese medicinal materials with water twice, and mixing the two liquids to obtain Chinese medicinal extract.
Example 2 preparation of herbal extracts
1. Accurately weighing the following traditional Chinese medicine raw materials: 25 parts of kudzuvine root, 4 parts of costus root, 12 parts of garden burnet root, 9 parts of Chinese gall, 4 parts of myrobalan fruit, 12 parts of Chinese magnoliavine fruit, 10 parts of wrinkled gianthyssop herb, 9 parts of prepared rehmannia root, 4 parts of Chinese date, 12 parts of summer heat, 9 parts of poria, 8 parts of honey-fried licorice root, 20 parts of katsumadai seed, 12 parts of long pepper, 20 parts of hairyvein agrimony, 20 parts of paniculate swallowwort root, 25 parts of seaweed, 15 parts of panax notoginseng and 35 parts of astragalus.
2. Decocting the above Chinese medicinal materials with water twice, and mixing the two liquids to obtain Chinese medicinal extract.
Example 3 preparation of herbal extracts
1. Accurately weighing the following traditional Chinese medicine raw materials: 28 parts of kudzuvine root, 5 parts of costus root, 10 parts of garden burnet root, 7 parts of Chinese gall, 5 parts of myrobalan fruit, 10 parts of Chinese magnoliavine fruit, 11 parts of wrinkled gianthyssop herb, 10 parts of prepared rehmannia root, 5 parts of Chinese date, 10 parts of summer heat, 10 parts of poria, 7 parts of honey-fried licorice root, 18 parts of katsumadai seed, 10 parts of long pepper, 15 parts of hairyvein agrimony, 16 parts of paniculate swallowwort root, 22 parts of seaweed, 12 parts of panax notoginseng and 30 parts of astragalus.
2. Decocting the above Chinese medicinal materials with water twice, and mixing the two liquids to obtain Chinese medicinal extract.
EXAMPLE 4 therapeutic effects of the Chinese medicinal composition
One, general data
120 patients with chronic colorectal inflammation and colorectal cancer were treated according to the randomized principle and divided into treatment groups and control groups.
The treatment group had 60 cases, 42 men and 18 women, the ages of 30-65 years, and the average age of 48 years;
wherein:
15 patients with sexual proctitis;
② 11 cases of patients with rectal cancer complicated with chronic colorectal inflammation;
③ 9 patients with colon cancer complicated with chronic colorectal inflammation;
10 patients with rectal cancer;
8 colon cancer patients;
sixthly, 7 cases of colorectal cancer;
control group 60, 43 men and 17 women, aged 30-64 years, mean age 47 years;
wherein:
14 cases of patients with chronic colorectal inflammation;
② 12 cases of patients with rectal cancer complicated with chronic colorectal inflammation;
③ 9 patients with colon cancer complicated with chronic colorectal inflammation,
(iv) 9 cases of patients with rectal cancer,
8 cases of colon cancer patients,
sixthly, 8 cases of colorectal cancer;
the average disease course of the two groups is more than 3 years, and the two groups have symptoms of hematochezia, mucus and stool, abdominal pain and discomfort and the like.
There were no statistical differences in gender, age, etc. between the groups.
II, diagnosis standard
Refer to ' 2019CSCO diagnosis and treatment guideline for colorectal cancer ', Chinese standard for diagnosis and treatment of common malignant tumors ' and ' Chinese clinical diagnosis and treatment road channel ' for diagnosis and treatment of colorectal cancer and chronic colorectal inflammation.
Third, therapeutic methods
Treatment groups: the traditional Chinese medicine formula is used for treatment. The use method comprises the following steps: one dose of the traditional Chinese medicine is decocted with water twice every day, and the traditional Chinese medicine is taken in the morning and at night. After 10 days, the procedure was changed to: the raw materials are ground into fine powder, and the fine powder is watered into pills, which are taken twice a day, 6g each time, and one material is taken as a course of treatment.
Fourthly, the result of the therapeutic effect
The effective rate of the traditional Chinese medicine prescription is 92%, and the cure rate is 89%.
Fifth, typical cases
When the chronic colitis is cured, women are 45 years old and 7 years old, the chronic colitis has been cured for 7 years, the patients defecate 4-5 times a day, sometimes with purulent blood, and the anus falls to pain after defecating, sometimes with paroxysmal abdominal pain, and the patients want to defecate when the pain is relieved, but sometimes with constipation, inappetence, soreness and weakness of waist and knees, the body is gradually weakened, the complexion is dark yellow, the tongue coating is thin and white, and the pulse is deep and thready. Sigmoidoscopy before 3 years shows that the surface of the colon mucosa is scattered on most ulcers with different depths, and the ulcerative colitis is diagnosed. The doctor visits this year in 3 months, and recommends to review sigmoidoscope, and the results show: colorectal cancer is also subjected to gene detection, gene results report KRAS and VEGF gene mutation, and clinical recommendation shows that cetuximab is taken. After the Chinese medicinal preparation is taken for half a month, hematochezia, mucus and abdominal discomfort occur, so that the Chinese medicinal preparation is used for assisting in relieving clinical symptoms, and the symptoms are distinguished as spleen and kidney deficiency and toxic material accumulation flourishing, so that the Chinese medicinal preparation is used for tonifying spleen and kidney, relieving diarrhea with astringents, clearing symptoms and dissipating stagnation. After 2 months of treatment by using the traditional Chinese medicine formula, the sigmoidoscope is rechecked again: intestinal polyp becomes small and light, abdominal pain and discomfort of grasping hands and foul stool basically disappear, anemia symptoms are improved, the patient can continue to take the medicine for 5 months, the state of the patient is stable, and the patient can basically recover to normal after eating the rice and taking the meal for weight rest.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.

Claims (10)

1. A traditional Chinese medicine formula for treating chronic colorectal inflammation and assisting in treating colorectal cancer is characterized by comprising the following traditional Chinese medicine raw materials: radix Puerariae, radix aucklandiae, radix Sangusorbae, Galla chinensis, fructus Chebulae, fructus Schisandrae chinensis, herba Agastaches, radix rehmanniae Preparata, fructus Jujubae, rhizoma Pinelliae, Poria, radix Glycyrrhizae Preparata, semen Alpiniae Katsumadai, fructus Piperis Longi, herba et Gemma Agrimoniae, radix Cynanchi Paniculati, Sargassum, Notoginseng radix, and radix astragali.
2. The traditional Chinese medicine formula of claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 25-30 parts of kudzuvine root, 4-6 parts of costus root, 9-12 parts of garden burnet root, 6-9 parts of Chinese gall, 4-6 parts of myrobalan, 9-12 parts of Chinese magnoliavine fruit, 10-12 parts of wrinkled gianthyssop herb, 9-12 parts of prepared rehmannia root, 4-6 parts of Chinese date, 9-12 parts of summer heat, 9-12 parts of poria, 6-8 parts of honey-fried licorice root, 15-20 parts of katsumade galangal seed, 9-12 parts of long pepper, 10-20 parts of hairyvein agrimonia herb and bud, 12-20 parts of paniculate swallowwort root, 18-25 parts of seaweed, 10-15 parts of panax notoginseng and 25-35; preferably, the traditional Chinese medicine formula comprises the following traditional Chinese medicine raw materials in parts by weight: 30 parts of kudzuvine root, 6 parts of costus root, 9 parts of garden burnet root, 6 parts of Chinese gall, 6 parts of myrobalan fruit, 9 parts of Chinese magnoliavine fruit, 12 parts of wrinkled gianthyssop herb, 12 parts of prepared rehmannia root, 6 parts of Chinese date, 9 parts of summer heat, 12 parts of poria, 6 parts of honey-fried licorice root, 15 parts of katsumadai seed, 9 parts of long pepper, 10 parts of hairyvein agrimony, 12 parts of paniculate swallowwort root, 18 parts of seaweed, 10 parts of panax notoginseng and 25 parts of.
3. A traditional Chinese medicine extract for treating chronic colorectal inflammation and assisting in treating colorectal cancer, which is prepared from the traditional Chinese medicine formula of claim 1 or 2.
4. A pharmaceutical preparation for treating chronic colorectal inflammation and for adjuvant therapy of colorectal cancer, which is characterized in that the effective component of the pharmaceutical preparation is the traditional Chinese medicine extract of claim 3.
5. The pharmaceutical formulation of claim 4, wherein the dosage form of the pharmaceutical formulation is a pharmaceutically conventional oral dosage form.
6. The pharmaceutical formulation according to claim 5, wherein the oral dosage form is oral liquid, syrup, granule, pill, tablet, capsule, mixture.
7. The preparation method of the traditional Chinese medicine extract as claimed in claim 3, which is characterized in that the specific operation steps of the preparation method are as follows:
(1) weighing the traditional Chinese medicine raw materials according to the traditional Chinese medicine formula of claim 1 or 2;
(2) decocting the Chinese medicinal materials with water twice, and mixing the two liquids to obtain Chinese medicinal extract.
8. The method for preparing a pharmaceutical formulation according to claim 6, wherein the method for preparing the oral liquid comprises the steps of:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common adjuvants of oral liquid, and preparing oral liquid according to conventional production method;
the preparation method of the syrup comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common syrup adjuvants, and preparing syrup by conventional method;
the preparation method of the tablet comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common auxiliary materials of the tablets, and preparing the tablets according to a conventional production method;
the preparation method of the capsule comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common adjuvants for capsule, and making capsule according to conventional production method;
the preparation method of the granules comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common adjuvants, and making into granule by conventional method;
the preparation method of the pill comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) making the soft extract into pill;
the preparation method of the mixture comprises the following steps:
(1) preparing a herbal extract according to the method of claim 7;
(2) adding common adjuvants, and preparing into mixture by conventional method.
9. Use of a traditional Chinese medicine formulation according to claim 1 or 2 for the preparation of a medicament for the treatment of chronic colorectal inflammation and for the adjuvant treatment of colorectal cancer.
10. The use of the herbal extract of claim 3 in the manufacture of a medicament for the treatment of chronic colorectal inflammation and for the adjunctive treatment of colorectal cancer.
CN202010771342.9A 2020-08-04 2020-08-04 Traditional Chinese medicine formula for treating chronic colorectal inflammation and auxiliary treating colorectal cancer Pending CN111773342A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771621A (en) * 2015-03-24 2015-07-15 首都医科大学附属北京友谊医院 Chinese medicinal prescription for treating cough and asthma, preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771621A (en) * 2015-03-24 2015-07-15 首都医科大学附属北京友谊医院 Chinese medicinal prescription for treating cough and asthma, preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘建民等: "藿香茯苓散治疗慢性非特异性溃疡性结肠炎84 例", 《河北中医》 *
王传明等: "祝德军辨治溃疡性结肠炎的经验", 《中医杂志》 *

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