CN111770918B - Trpc6的抑制剂 - Google Patents
Trpc6的抑制剂 Download PDFInfo
- Publication number
- CN111770918B CN111770918B CN201980013417.2A CN201980013417A CN111770918B CN 111770918 B CN111770918 B CN 111770918B CN 201980013417 A CN201980013417 A CN 201980013417A CN 111770918 B CN111770918 B CN 111770918B
- Authority
- CN
- China
- Prior art keywords
- mmol
- methoxy
- trpc6
- carboxylic acid
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862630907P | 2018-02-15 | 2018-02-15 | |
| US62/630,907 | 2018-02-15 | ||
| PCT/EP2019/053525 WO2019158572A1 (en) | 2018-02-15 | 2019-02-13 | Inhibitors of trpc6 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111770918A CN111770918A (zh) | 2020-10-13 |
| CN111770918B true CN111770918B (zh) | 2024-02-27 |
Family
ID=65496750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980013417.2A Active CN111770918B (zh) | 2018-02-15 | 2019-02-13 | Trpc6的抑制剂 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11485740B2 (https=) |
| EP (1) | EP3752499B1 (https=) |
| JP (1) | JP7291711B2 (https=) |
| CN (1) | CN111770918B (https=) |
| WO (1) | WO2019158572A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10202011632RA (en) * | 2017-10-27 | 2021-01-28 | Boehringer Ingelheim Int | Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors |
| WO2019241131A1 (en) | 2018-06-11 | 2019-12-19 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine m1 receptor antagonists |
| US12054487B2 (en) | 2018-09-04 | 2024-08-06 | Contineum Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| IL326597A (en) * | 2019-10-07 | 2026-04-01 | Contineum Therapeutics Inc | Muscarinic M1 acetylcholine receptor antagonists |
| US11752149B2 (en) | 2019-12-02 | 2023-09-12 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| AR121846A1 (es) | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | Derivado de arilo o heteroarilo |
| JP7502462B2 (ja) * | 2020-04-16 | 2024-06-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器状態を処置するためのｔｒｐｃ６阻害剤 |
| US20250042873A1 (en) * | 2021-08-24 | 2025-02-06 | The Johns Hopkins University | Compositions and methods for treating proteotoxicity-associated diseases |
| CN121729232A (zh) * | 2023-08-18 | 2026-03-24 | 勃林格殷格翰国际有限公司 | 用于治疗局灶节段性肾小球硬化症的trpc6抑制剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1516691A (zh) * | 2001-06-15 | 2004-07-28 | ֮����ҩ��ʽ���� | 苯基吡啶甲酰哌嗪衍生物 |
| WO2012037349A2 (en) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Compounds |
| EP2556829A1 (en) * | 2011-08-10 | 2013-02-13 | Universität Leipzig | Bicyclic labdane diterpenes for use in the treatment of TRPC6 associated diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759348B2 (en) * | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| CN102970965A (zh) | 2010-04-05 | 2013-03-13 | Sk化学公司 | 含有pde5抑制剂的减少皮肤皱纹的合成物 |
| GB2497476B (en) * | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
| WO2014192865A1 (ja) * | 2013-05-30 | 2014-12-04 | 大日本住友製薬株式会社 | フェニルピペラジン誘導体 |
| CN103694242B (zh) * | 2013-12-10 | 2016-01-06 | 昆明翔昊科技有限公司 | 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用 |
| CN107253952B (zh) * | 2017-08-01 | 2019-07-30 | 烟台大学 | 具有抗胃癌活性的trpc6抑制剂及其制备方法和用途 |
| SG10202011632RA (en) * | 2017-10-27 | 2021-01-28 | Boehringer Ingelheim Int | Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors |
| CN111868055B (zh) * | 2018-02-16 | 2024-03-08 | 勃林格殷格翰国际有限公司 | Trpc6的抑制剂 |
| JP7585227B2 (ja) * | 2019-04-12 | 2024-11-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔｒｐｃ６阻害剤 |
| JP7502462B2 (ja) * | 2020-04-16 | 2024-06-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器状態を処置するためのｔｒｐｃ６阻害剤 |
-
2019
- 2019-02-13 JP JP2020543611A patent/JP7291711B2/ja active Active
- 2019-02-13 US US16/970,129 patent/US11485740B2/en active Active
- 2019-02-13 EP EP19706258.1A patent/EP3752499B1/en active Active
- 2019-02-13 WO PCT/EP2019/053525 patent/WO2019158572A1/en not_active Ceased
- 2019-02-13 CN CN201980013417.2A patent/CN111770918B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1516691A (zh) * | 2001-06-15 | 2004-07-28 | ֮����ҩ��ʽ���� | 苯基吡啶甲酰哌嗪衍生物 |
| WO2012037349A2 (en) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Compounds |
| EP2556829A1 (en) * | 2011-08-10 | 2013-02-13 | Universität Leipzig | Bicyclic labdane diterpenes for use in the treatment of TRPC6 associated diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| US11485740B2 (en) | 2022-11-01 |
| JP2021513984A (ja) | 2021-06-03 |
| EP3752499A1 (en) | 2020-12-23 |
| WO2019158572A1 (en) | 2019-08-22 |
| CN111770918A (zh) | 2020-10-13 |
| JP7291711B2 (ja) | 2023-06-15 |
| EP3752499B1 (en) | 2024-03-27 |
| US20200399282A1 (en) | 2020-12-24 |
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| HK40045092B (en) | Pyridine derivatives and therapeutic uses thereof as trpc6 inhibitors | |
| HK40045092A (en) | Pyridine derivatives and therapeutic uses thereof as trpc6 inhibitors | |
| HK40035138B (en) | Inhibitors of trpc6 | |
| HK40035138A (en) | Inhibitors of trpc6 | |
| EA040737B1 (ru) | Пиридинкарбонильные производные и их терапевтические применения в качестве ингибиторов trpc6 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20250219 Address after: Germany's Rhine River Ingelheim Patentee after: BOEHRINGER INGELHEIM INTERNATIONAL GmbH Country or region after: Germany Address before: Germany's Rhine River Ingelheim Patentee before: BOEHRINGER INGELHEIM INTERNATIONAL GmbH Country or region before: Germany Patentee before: Hyderabad bioscience Co.,Ltd. Country or region before: U.S.A. |