CN111751480A - 一种维生素e琥珀酸聚乙二醇酯的应用 - Google Patents
一种维生素e琥珀酸聚乙二醇酯的应用 Download PDFInfo
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 title claims abstract description 15
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Abstract
本发明涉及一种维生素E琥珀酸聚乙二醇酯的应用，属于气相色谱技术领域。将所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相；其中，所述维生素E琥珀酸聚乙二醇酯的平均分子量大于等于1000，所述固定相不仅能与非极性或弱极性物质发生π‑π作用、CH‑π作用和范德华力作用；还能与极性物质发生氢键作用、偶极作用和范德华力作用。上述各种分子作用有益于提高所述固定相对不同性质分析物的色谱分离能力，能够实现高选择性分离从非极性到极性的各类分析物及其异构体。
Description
技术领域
本发明涉及一种维生素E琥珀酸聚乙二醇酯的应用，属于气相色谱技术领域。
背景技术
在气相色谱分析中，固定相的选择性是决定样品中各组分色谱峰间分离程度及其测定结果准确性的关键。商品聚乙二醇固定相为极性固定相，经常使用的是平均分子量为20000的聚乙二醇，聚乙二醇固定相适于极性物质的分离；当温度低于聚乙二醇熔点(约60℃)时，其分离性能明显下降。将聚乙二醇与硝基对苯二甲酸进行缩聚反应可获得一种酸改性的聚乙二醇固定相，主要用于脂肪酸的分离测定。然而现有的聚乙二醇类固定相已经难以满足各领域样品组分的分析测定需求。因此，发展高分离性能的气相色谱固定相对于满足实际分析测定需求具有重要应用价值。
维生素E琥珀酸聚乙二醇酯(tocopherol polyethylene glycol succinate，TPGS)是由维生素E琥珀酸与聚乙二醇经酯化反应生成的聚合物，其结构中具有非极性的维生素E单元、极性的琥珀酰基单元和聚乙二醇单元，是一种典型的非离子型表面活性剂，TPGS常作为吸收促进剂、增溶剂、脂溶性药物的转运载体等应用于药物制剂中。将TPGS作为色谱固定相并应用于气相色谱分析技术领域，目前尚未见相关报道。
发明内容
有鉴于此，本发明的目的在于提供一种维生素E琥珀酸聚乙二醇酯的应用，将所述TPGS作为色谱固定相用于气相色谱分析，能够高选择性分离不同极性的各类分析物及其异构体。
为实现上述目的，本发明的技术方案如下：
一种维生素E琥珀酸聚乙二醇酯的应用，将其作为气相色谱固定相；其中，所述维生素E琥珀酸聚乙二醇酯的平均分子量大于等于1000，结构式为：
优选的，所述维生素E琥珀酸聚乙二醇酯的平均分子量为1000～3000。
优选的，所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相，用于分离极性或非极性物质的同分异构体。
优选的，所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相，用于分离苯胺类异构体、酚类异构体、烷基苯异构体、醇类异构体或烷烃异构体。
有益效果
本发明采用维生素E琥珀酸聚乙二醇酯作为色谱固定相用于气相色谱分析测定。所述固定相不仅能与非极性或弱极性物质发生π-π作用、CH-π作用和范德华力作用；还能与极性物质发生氢键作用、偶极作用和范德华力作用。上述各种分子作用有益于提高所述固定相对不同性质分析物的色谱分离能力，能够实现高选择性分离从非极性到极性的各类分析物及其异构体。将维生素E琥珀酸聚乙二醇酯作为色谱固定相用于气相色谱分析具有重要应用价值。
附图说明
图1为TPGS色谱柱气相色谱分析测定甲苯胺异构体的色谱图。
图2为TPGS色谱柱气相色谱分析测定二甲苯酚异构体的色谱图。
图3为TPGS色谱柱气相色谱分析测定二乙苯异构体的色谱图。
图4为TPGS色谱柱气相色谱分析测定戊醇异构体的色谱图。
图5为TPGS色谱柱气相色谱分析测定辛烷异构体的色谱图。
具体实施方式
下面结合具体实施例对本发明作进一步详细的说明。
以下实施例中：采用平均分子量为1500的维生素E琥珀酸聚乙二醇酯作为色谱固定相，采用静态法制备毛细管色谱柱的方法如下：
将TPGS固定相溶于二氯甲烷中，配制成固定相溶液(0.25％，w/v)，并将该溶液通入熔融石英毛细管柱内，将毛细管柱一端密封并将另一端连接真空系统，溶剂挥散完全后取下毛细管柱置于柱箱内，在氮气保护下进行老化，然后用于气相色谱分析测定。
实施例1
采用TPGS色谱柱气相色谱分析测定甲基苯胺异构体：
色谱条件如下：以高纯氮气为载气，载气流速1mL/min，进样口温度250℃，检测器温度300℃，柱温110℃。
分离结果如图1所示，图中色谱峰峰号1-3依次为邻甲苯胺、对甲苯胺和间甲苯胺。由图可见，TPGS色谱柱能够基线分离甲苯胺异构体并且色谱峰对称性良好，表明该色谱柱对极性苯胺类异构体具有高选择性分离能力和良好惰性，满足样品组分色谱分析测定的要求。
实施例2
采用TPGS色谱柱气相色谱分析测定二甲苯酚异构体：
色谱条件如下：以高纯氮气为载气，载气流速为1mL/min，进样口温度250℃，检测器温度300℃，柱温为120℃。
分离结果如图2所示，图中色谱峰峰号1-5依次为2,6-二甲苯酚、2,5-二甲苯酚、2,3-二甲苯酚、3,5-二甲苯酚和3,4-二甲苯酚。由图可见，TPGS色谱柱能够分离酚类异构体并且色谱峰对称性良好，表明该色谱柱对极性酚类异构体具有高选择性分离能力和良好惰性，满足样品组分色谱分析测定的要求。
实施例3
采用TPGS色谱柱气相色谱分析测定二乙苯异构体：
色谱条件如下：以高纯氮气为载气，载气流速为1mL/min，进样口温度250℃，检测器温度300℃，柱温80℃。
分离结果如图3所示，图中色谱峰峰号1-3依次为间二乙苯、对二乙苯和邻二乙苯。由图可见，TPGS色谱柱能够分离二乙苯异构体并且色谱峰对称性良好，表明该色谱柱对弱极性二乙苯异构体具有高选择性分离能力和良好惰性，满足样品组分色谱分析测定的要求。
实施例4
采用TPGS色谱柱气相色谱分析测定戊醇异构体：
色谱条件如下：以高纯氮气为载气，载气流速为0.4mL/min，进样口温度250℃，检测器温度300℃，柱温40℃。
分离结果如图4所示，图中色谱峰峰号1-4依次为2-甲基-2-丁醇、3-戊醇、2-戊醇和1-戊醇。由图可见，TPGS色谱柱能够基线分离戊醇异构体并且色谱峰对称性良好，表明该色谱柱对极性戊醇异构体具有高选择性分离能力和良好惰性，满足样品组分色谱分析测定的要求。
实施例5
采用TPGS色谱柱气相色谱分析测定辛烷异构体：
色谱条件如下：以高纯氮气为载气，载气流速为1mL/min，进样口温度250℃，检测器温度300℃，柱温40℃。
分离结果如图5所示，图中色谱峰峰号1-4依次为异辛烷、2,2-二甲基己烷、3-甲基庚烷和正辛烷。由图可见，TPGS色谱柱能够基线分离辛烷异构体并且色谱峰对称性良好，表明该色谱柱对非极性辛烷异构体具有高选择性分离能力和良好惰性，满足样品组分色谱分析测定的要求。
以上实施例表明，维生素E琥珀酸聚乙二醇酯固定相色谱柱能够高选择性分离从非极性到极性的各类分析物，表现出高选择性分离性能和良好惰性。
综上所述，发明包括但不限于以上实施例，凡是在本发明的精神和原则之下进行的任何等同替换或局部改进，都将视为在本发明的保护范围之内。
Claims (4)
1.一种维生素E琥珀酸聚乙二醇酯的应用，其特征在于：将所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相；其中，所述维生素E琥珀酸聚乙二醇酯的平均分子量大于等于1000，结构式为：
2.如权利要求1所述的一种维生素E琥珀酸聚乙二醇酯的应用，其特征在于：所述维生素E琥珀酸聚乙二醇酯的平均分子量为1000～3000。
3.如权利要求1或2所述的一种维生素E琥珀酸聚乙二醇酯的应用，其特征在于：所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相，用于分离极性或非极性物质的同分异构体。
4.如权利要求1或2所述的一种维生素E琥珀酸聚乙二醇酯的应用，其特征在于：所述维生素E琥珀酸聚乙二醇酯作为气相色谱固定相，用于分离苯胺类异构体、酚类异构体、烷基苯异构体、醇类异构体或烷烃异构体。
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