CN111727255A - 修饰后诺如病毒vp1蛋白和包含修饰后诺如病毒vp1蛋白的vlp - Google Patents

修饰后诺如病毒vp1蛋白和包含修饰后诺如病毒vp1蛋白的vlp Download PDF

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CN111727255A
CN111727255A CN201880077956.8A CN201880077956A CN111727255A CN 111727255 A CN111727255 A CN 111727255A CN 201880077956 A CN201880077956 A CN 201880077956A CN 111727255 A CN111727255 A CN 111727255A
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gii
seq
norovirus
plant
protein
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皮尔-奥利弗·拉沃伊
马克-安德鲁·德奥斯特
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Medicago Inc
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Medicago Inc
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/05—Epstein-Barr virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
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    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Epidemiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
CN201880077956.8A 2017-11-30 2018-11-30 修饰后诺如病毒vp1蛋白和包含修饰后诺如病毒vp1蛋白的vlp Pending CN111727255A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762593006P 2017-11-30 2017-11-30
US62/593,006 2017-11-30
US201862712744P 2018-07-31 2018-07-31
US62/712,744 2018-07-31
PCT/CA2018/051530 WO2019104439A1 (en) 2017-11-30 2018-11-30 Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins

Publications (1)

Publication Number Publication Date
CN111727255A true CN111727255A (zh) 2020-09-29

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CN201880077956.8A Pending CN111727255A (zh) 2017-11-30 2018-11-30 修饰后诺如病毒vp1蛋白和包含修饰后诺如病毒vp1蛋白的vlp

Country Status (15)

Country Link
US (2) US11602558B2 (https=)
EP (1) EP3717648A4 (https=)
JP (2) JP7579143B2 (https=)
KR (1) KR102878449B1 (https=)
CN (1) CN111727255A (https=)
AU (1) AU2018375695B2 (https=)
BR (1) BR112020010799A2 (https=)
CA (1) CA3083857A1 (https=)
IL (1) IL274736A (https=)
MX (1) MX2020005530A (https=)
PH (1) PH12020550732A1 (https=)
RU (1) RU2020116307A (https=)
SG (1) SG11202004668WA (https=)
WO (1) WO2019104439A1 (https=)
ZA (2) ZA202003831B (https=)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
CN113481328A (zh) * 2021-07-23 2021-10-08 中国科学院微生物研究所 用于检测临床样本中gi.5型诺如病毒的试剂盒及专用引物
CN118126202A (zh) * 2024-05-07 2024-06-04 上海瑞宙生物科技有限公司 一种诺如病毒类病毒颗粒及其应用
WO2024140251A1 (zh) * 2022-12-27 2024-07-04 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途
WO2025077808A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Methods of preparing norovirus vaccine with low amounts of adjuvant
WO2025077799A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Method of preparing norovirus vaccine without adjuvant

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JP7420339B2 (ja) * 2019-10-11 2024-01-23 学校法人北里研究所 変異ノロウイルス粒子とその生産方法
WO2022081870A1 (en) * 2020-10-14 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stabilized norovirus virus-like particles as vaccine immunogens
EP4422681A4 (en) * 2021-10-27 2025-11-19 Univ Pennsylvania VACCINE AGAINST A NOROVIRUS AND METHODS OF USE
CN118773218B (zh) * 2024-08-22 2025-09-30 中国医学科学院医学生物学研究所 一种诺如病毒gii.17型病毒样颗粒及其制备方法与应用

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113481328A (zh) * 2021-07-23 2021-10-08 中国科学院微生物研究所 用于检测临床样本中gi.5型诺如病毒的试剂盒及专用引物
CN113481328B (zh) * 2021-07-23 2023-10-27 中国科学院微生物研究所 用于检测临床样本中gi.5型诺如病毒的试剂盒及专用引物
WO2024140251A1 (zh) * 2022-12-27 2024-07-04 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途
WO2025077808A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Methods of preparing norovirus vaccine with low amounts of adjuvant
WO2025077799A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Method of preparing norovirus vaccine without adjuvant
CN118126202A (zh) * 2024-05-07 2024-06-04 上海瑞宙生物科技有限公司 一种诺如病毒类病毒颗粒及其应用

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BR112020010799A2 (pt) 2020-11-10
PH12020550732A1 (en) 2021-04-19
SG11202004668WA (en) 2020-06-29
EP3717648A4 (en) 2021-12-01
WO2019104439A1 (en) 2019-06-06
KR102878449B1 (ko) 2025-10-30
AU2018375695A1 (en) 2020-06-11
KR20200092363A (ko) 2020-08-03
US20200330583A1 (en) 2020-10-22
EP3717648A1 (en) 2020-10-07
ZA202003831B (en) 2023-10-25
JP2024109835A (ja) 2024-08-14
US12076388B2 (en) 2024-09-03
US11602558B2 (en) 2023-03-14
IL274736A (en) 2020-07-30
JP2021503962A (ja) 2021-02-15
CA3083857A1 (en) 2019-06-06
US20230293663A1 (en) 2023-09-21
AU2018375695B2 (en) 2025-01-02
RU2020116307A (ru) 2021-12-30
JP7579143B2 (ja) 2024-11-07
MX2020005530A (es) 2021-01-15
ZA202306500B (en) 2024-10-30

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