CN111701006A - Preparation method of plant water extract for preventing and treating cold - Google Patents
Preparation method of plant water extract for preventing and treating cold Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 8
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a preparation method of a plant water extract for preventing and treating cold, which comprises the following steps: s1, extracting immersion liquid: mixing and heating ginger, elsholtzia, Jianghua bitter tea and water or mixing and heating ginger, elsholtzia and water to obtain a water extracting solution; s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate; s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid; s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product. The invention fills oxygen into water extraction fine filtration liquid, mixes and oxidizes the water extraction fine filtration liquid to obtain water extraction fine filtration oxidation liquid, the water extraction liquid is oxidized before combining ginger and elsholtzia or combining the ginger and the elsholtzia with Jianghua bitter tea, and the treatment effect is obvious when the water extraction liquid is taken by Yao medicine for cold patients.
Description
Technical Field
The invention belongs to the technical field of plant extraction and biological pharmacy, and particularly relates to a preparation method of a plant water extracting solution for preventing and treating cold.
Background
At present, the oxidation of a human body is aggravated, the immunity of the human body is reduced and the resistance is reduced due to environmental pollution and food pollution; a large number of people catch the cold every year; especially children are apt to catch a cold; seriously harms the health of people, has certain side effects when being treated by chemical drugs, and is easy to generate drug resistance particularly when being used for a plurality of times.
It is known that ginger, elsholtzia herb and Jianghua bitter tea all have the functions of dispelling cold, inducing sweat and relieving exterior syndrome; the effects of dispelling cold, inducing sweat and relieving exterior syndrome are enhanced through a reasonable formula and a certain process technology, and the plant water extract oral liquid which has good effect and is used for preventing and treating cold has great significance.
Disclosure of Invention
The invention aims to: provides a preparation method of plant water extract for preventing and treating cold.
The technical scheme adopted by the invention is as follows: a method for preparing plant water extract for preventing and treating common cold comprises the following steps:
s1, extracting immersion liquid: mixing and heating ginger, elsholtzia, Jianghua bitter tea and water or mixing and heating ginger, elsholtzia and water to obtain a water extracting solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
The reaction mechanism of the invention is as follows: the key point of the invention is that ginger, elsholtzia and Jianghua bitter tea are combined or ginger and elsholtzia are combined and the water extraction fine filtration liquid is filled with oxygen to be mixed and oxidized in the step 3 to obtain water extraction fine filtration oxidation liquid, the combination of ginger, elsholtzia and Jianghua bitter tea or the combination of ginger and elsholtzia and the water extraction liquid thereof are oxidized never before for preventing and treating cold, the ginger can dispel cold, warm the stomach, induce sweat and relieve exterior syndrome, the elsholtzia kills cold viruses, the Jianghua bitter tea resists oxidation, and the cough and the taste are adjusted.
Further, the ginger extract of step S1 is: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 2-20: 1-5: 1-5: 10-100, or the ginger from which the infusion is extracted: herba Moslae: the weight ratio of water is as follows: 1-5: 1-5: 10-60, heating and extracting at 80-100 deg.C for 40-150 min; through a large number of experiments, the optimal proportion, extraction temperature and extraction time are obtained, the effective ingredients in the ginger, the elsholtzia and the Jianghua bitter tea can be fully dissolved in water, so that the raw materials are utilized to the maximum extent, and according to the proportion, the original curative effect can be obviously enhanced, and the curative effect is improved.
Further, the impurities removed by the filtration in the step S2 are substances larger than 0.3 micron, and the pore size of the filtration membrane used for the filtration is smaller than or equal to 0.3 micron; the water extraction fine filtration liquid has high purity and no precipitation impurity.
Further, the oxidation time in step S3 is: 0.3-4 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the consumption of edible or medical oxygen is 1-10 cubic meters per ton of the extracting solution under one atmosphere; through oxidation reaction, the medicine effect is better, and the effect is obvious when the medicine is taken by Yao medicine for fever patients, which proves that the actual effect is good.
Further, the temperature for sterilization in the filling and sterilizing in the step S4 is 105 to 125 ℃; the time is 10 to 90 minutes; the product is sterilized after being filled, so that the curative effect of the product during the shelf life is ensured.
Further, in the step S4, the capacity of the oral liquid bottle during filling and sterilizing is 10-50 ml/piece of the oral liquid bottle; the qualified oral liquid bottle can be selected according to the dose, and the oral liquid can be drunk after the bottle is opened, and is clean and sanitary after one bottle is used at a time.
Furthermore, the plant water extract for preventing and treating cold has the application in preparing traditional Chinese medicines for preventing and treating cold.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
the preparation method is simple and convenient, and the three plants are all medicinal and edible plants, so that the edible health-care tea is safe to eat and has no side effect; has obvious functions of preventing and treating cold.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A preparation method of plant water extract for preventing and treating cold comprises the following steps:
s1, extracting immersion liquid: mixing and heating rhizoma Zingiberis recens, herba Moslae, JIANGHUANWANGCHA, and water, or mixing and heating rhizoma Zingiberis recens, herba Moslae, and water to obtain water extractive solution; the extract is composed of ginger, elsholtzia, Jianghua bitter tea and water, wherein the ginger used for extracting the extract is as follows: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 2-20: 1-5: 1-5: 10-100, or the ginger from which the infusion is extracted: herba Moslae: the weight ratio of water is as follows: 1-5: 1-5: 10-60, heating and extracting at 80-100 deg.C for 40-150 min;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate; the impurities removed by filtration are substances larger than 0.3 micron, and the aperture of a filter membrane used for filtration is smaller than or equal to 0.3 micron;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid; the time of the oxidation is as follows: 0.3-4 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the consumption of edible or medical oxygen is 1-10 cubic meters per ton of the extracting solution under one atmosphere;
s4, filling and sterilizing: filling the water-extracted fine-filtered oxidized liquid obtained in the step S3 into 10-50 ml/oral liquid bottles, wherein the sterilization temperature in filling and sterilization is 105-125 ℃; the time is 10 to 90 minutes; sterilizing at high temperature to obtain the final product.
The rhizoma Zingiberis recens is fresh rhizome of Zingiber officinale Roscoe of Zingiberaceae; rhizoma Zingiberis recens root, herba Potentillae Discoloris, colluding finger, DIXIN, YAN LIANG XIAO ZI, fresh rhizoma Zingiberis recens, rhizoma Zingiberis recens baked with honey, rhizoma Zingiberis recens rhizome, cortex Corni and leaf can be used as medicine, rhizoma Zingiberis recens has effects of inducing sweat, relieving exterior syndrome, warming middle-jiao, relieving vomit, warming lung, relieving cough, relieving fish and crab toxicity, and relieving drug toxicity in traditional Chinese medicine, and is suitable for wind cold, headache, phlegm retention, cough, stomach cold emesis; after suffering from ice, snow, water dampness and cold, the ginger decoction is taken urgently to promote blood circulation and dispel cold evil;
herba Moslae can induce sweat, relieve exterior syndrome, eliminate dampness, regulate the middle warmer, induce diuresis and alleviate edema; after being used, the Chinese medicinal composition can also promote lung qi to promote diuresis and reduce edema, is similar to ephedra, has strong medicinal efficacy, is most suitable for treating yin cold, summer-heat retention and wind-water edema, is called ephedra in summer, and can be used for treating acute gastroenteritis, abdominal pain, vomiting and diarrhea, summer and autumn yang summer-heat, headache, fever, aversion to cold, no sweat, cholera, edema, epistaxis, halitosis and other symptoms;
the Jianghua bitter tea is used as a few large-leaf tea trees in Hunan province, and has red bright soup color, sweet, tasty and refreshing mouthfeel and no bitter.
Examples of the present invention are given below
Example 1
S1, extracting immersion liquid: 50 kg of ginger, 20 kg of elsholtzia herb and 20 kg of Jianghua bitter tea; mixing 400 liters of water, heating to 95 ℃, extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.3 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 80 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 2 cubic meters per ton of the extracting solution under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1200 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 50 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 50ml oral liquid bottles, screwing a cover, putting the bottles into a sterilization cabinet, heating to 106 ℃, and sterilizing for 30 minutes; the finished product of the plant water-extracted oral liquid for preventing and treating cold is obtained.
Through the operations, the obtained water extraction oral liquid of the ginger, the elsholtzia and the Jianghua bitter tea has obvious functions of preventing and treating cold.
Example 2
S1, extracting immersion liquid: 30 kg of ginger, 10 kg of elsholtzia herb and 10 kg of Jianghua bitter tea; mixing 300 liters of water, heating to 90 ℃, extracting for 90 minutes at constant temperature to obtain a water extracting solution;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.3 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 70 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 1.5 cubic meters per ton of extracting solution under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 40 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 50ml oral liquid bottles, screwing a cover, putting the bottles into a sterilization cabinet, heating to 110 ℃, and sterilizing for 20 minutes; the finished product of the plant water-extracted oral liquid for preventing and treating cold is obtained.
Through the operations, the obtained water extraction oral liquid of the ginger, the elsholtzia and the Jianghua bitter tea has obvious functions of preventing and treating cold.
Example 3
S1, extracting immersion liquid: 80 kg of ginger, 20 kg of elsholtzia herb and 10 kg of Jianghua bitter tea; mixing 600 liters of water, heating to 100 ℃, extracting for 50 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.25 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 70 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 1 cubic meter per ton of the extracting solution under one atmosphere; in the process of oxygen filling, a pump is used for extracting fine filter liquor from the tank to the outside of the tank and then circulating the fine filter liquor to the tank, and the flow rate of the pump is controlled to be 1500 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 50 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 10 ml oral liquid bottles, screwing a cover, and placing the bottles into a sterilization cabinet to be heated to 100 ℃ for sterilization for 10 minutes; the finished product of the plant water-extracted oral liquid for preventing and treating cold is obtained.
Through the operations, the obtained water extraction oral liquid of the ginger, the elsholtzia and the Jianghua bitter tea has obvious functions of preventing and treating cold.
Example 4
S1, extracting immersion liquid: mixing 30 kg of ginger, 10 kg of elsholtzia herb and 300 liters of water, heating to 90 ℃, and extracting for 50 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.3 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 70 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 1.5 cubic meters per ton of extracting solution under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 40 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 50ml oral liquid bottles, screwing a cover, putting the bottles into a sterilization cabinet, heating to 110 ℃, and sterilizing for 20 minutes; the finished product of the plant water-extracted oral liquid for preventing and treating cold is obtained.
Through the operations, the obtained water extraction oral liquid of the ginger and the elsholtzia has obvious functions of preventing and treating cold.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention, and the scope of the present invention is defined by the appended claims, and all changes that come within the meaning and range of equivalency of the specification are therefore intended to be embraced therein.
The product of the embodiment is used for carrying out usage test investigation on more than 60 patients in one year, the condition of treatment is tracked in an out-of-hospital mode by adopting the guidance of professor, telephone, QQ and collection, and 22 male patients and 38 female patients, by adopting the product of the embodiment 1, 21 male patients, 22 female patients and 1 male and 16 female children can be used, the early cold symptoms of 1 piece and 50ml can be diluted by boiled water by 5 times and can be slowly drunk to relieve when the patient is hot, and the early cold can be cured by 1 piece and 50ml of the extracted oral liquid; 16 patients who use the cold are often in a buccal mode under the conditions that the cold is heavy and the fever temperature exceeds 38 ℃, the effect is obviously recovered faster than that of the common cold drug used in the past, two patients take the cold drug every day, one patient takes the cold drug after breakfast and dinner every day, the cold drug is diluted by 5 times of boiled water and is slowly drunk when the cold drug is hot, the illness state can be relieved after taking two 50ml of extracted oral liquid, and after three days, the cold can be cured after taking 6 50ml of extracted oral liquid; the test is mainly aimed at the early symptom treatment of cold and fever, the testers are mainly patients with early symptoms of common cold, upper respiratory tract infection caused by other germs can be cured in early stage by adopting symptomatic treatment, the symptomatic treatment is an important treatment means of Yao medicine, and the existing cold medicine is also a compound medicine for the symptomatic treatment; the extracted oral liquid is a medicinal and edible food material, has no toxic or side effect, and can be drunk by all people for a long time; some patients have been tested for more than 1 year, even if the individual test of individual patient exceeds 20 times, the administration effect is still unchanged, and the drug resistance is not easy to generate by using the extracted oral liquid in large dose for a long time.
Claims (7)
1. A preparation method of plant water extract for preventing and treating cold is characterized by comprising the following steps:
s1, extracting immersion liquid: mixing and heating ginger, elsholtzia, Jianghua bitter tea and water or mixing and heating ginger, elsholtzia and water to obtain a water extracting solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
2. The method for preparing plant water extract for preventing and treating cold as claimed in claim 1, wherein the extract of ginger of step S1: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 2-20: 1-5: 1-5: 10-100, or the ginger from which the infusion is extracted: herba Moslae: the weight ratio of water is as follows: 1-5: 1-5: 10-60, the heating extraction temperature is 80-100 ℃, and the extraction time is 40-150 minutes.
3. The method as claimed in claim 1, wherein the impurities removed by the filtration in the step S2 are substances greater than 0.3 μm, and the pore size of the filtration membrane used for the filtration is less than or equal to 0.3 μm.
4. The method for preparing plant water extract for preventing and treating cold as claimed in claim 1, wherein the oxidation time of step S3 is: 0.3-4 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the amount of edible or medical oxygen is 1-10 cubic meters per ton of the extractive solution under one atmosphere.
5. The method for preparing a plant water extract for preventing and treating cold as claimed in claim 1, wherein the temperature for sterilization in the filling sterilization of step S4 is 105-125 ℃; the time is 10-90 minutes.
6. The method as claimed in claim 1, wherein the capacity of the oral liquid bottle in the filling and sterilizing process of step S4 is 10-50 ml/bottle.
7. The plant water extract for preventing and treating cold according to any one of claims 1 to 6 has application in preparing traditional Chinese medicine for preventing and treating cold.
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| CN202010290605.4A CN111481652A (en) | 2020-04-14 | 2020-04-14 | Preparation method of plant water extract for preventing and treating cold |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908230A (en) * | 2021-11-09 | 2022-01-11 | 任秀江 | Preparation method of plant extract for benefiting liver and improving eyesight |
| CN114010723A (en) * | 2021-11-24 | 2022-02-08 | 任秀江 | Plant extract for reducing creatinine and maintaining kidney and preparation method and application thereof |
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| CN103212079A (en) * | 2013-04-26 | 2013-07-24 | 陆媛 | Oral medical composition for preventing and/or treating cold and application thereof |
| CN105477575A (en) * | 2014-09-19 | 2016-04-13 | 蔡卫进 | Traditional Chinese medicine formula for treating anemofrigid cold |
| CN109619234A (en) * | 2018-12-14 | 2019-04-16 | 任秀江 | Preparation method and use containing xanthine oxidase and a amylase activity inhibitors |
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2020
- 2020-04-14 CN CN202010290605.4A patent/CN111481652A/en not_active Withdrawn
- 2020-08-05 CN CN202010776881.1A patent/CN111701006A/en active Pending
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| CN103212079A (en) * | 2013-04-26 | 2013-07-24 | 陆媛 | Oral medical composition for preventing and/or treating cold and application thereof |
| CN105477575A (en) * | 2014-09-19 | 2016-04-13 | 蔡卫进 | Traditional Chinese medicine formula for treating anemofrigid cold |
| CN109619234A (en) * | 2018-12-14 | 2019-04-16 | 任秀江 | Preparation method and use containing xanthine oxidase and a amylase activity inhibitors |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908230A (en) * | 2021-11-09 | 2022-01-11 | 任秀江 | Preparation method of plant extract for benefiting liver and improving eyesight |
| CN114010723A (en) * | 2021-11-24 | 2022-02-08 | 任秀江 | Plant extract for reducing creatinine and maintaining kidney and preparation method and application thereof |
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| CN111481652A (en) | 2020-08-04 |
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