CN111494593A - Preparation method and application of plant extract for inhibiting xanthine oxidase activity - Google Patents
Preparation method and application of plant extract for inhibiting xanthine oxidase activity Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a preparation method and application of a plant extract for inhibiting xanthine oxidase activity, which is used for inhibiting the xanthine oxidase activity of a human body and preventing and treating gout and hyperuricemia, and relates to the technical field of plant extraction and biological pharmacy, and the invention comprises the following steps: s1, extracting immersion liquid: mixing rhizoma Polygonati, radix Angelicae sinensis, pericarpium Citri Tangerinae, rhizoma Zingiberis recens, and water, and heating to obtain water extractive solution; s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate; s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid; s4, filling and sterilizing: filling the water-extracted fine-filtered oxidized liquid obtained in the step S3 into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product; the preparation method is simple and convenient, and the four plants are medicinal and edible plants, so that the edible health-care tea is safe to eat and has no side effect; has the function of obviously inhibiting the activity of xanthine oxidase.
Description
Technical Field
The invention belongs to the technical field of plant extraction and biological pharmacy, and particularly relates to a preparation method and application of a plant extract for inhibiting xanthine oxidase activity, which has the application in preparing traditional Chinese medicines for reducing uric acid and treating gout.
Background
Xanthine oxidase is a flavoprotein enzyme widely existing in organisms, belongs to a molybdenum protease family, and is a key enzyme of nucleic acid metabolic pathways in the bodies; xanthine oxidase catalyzes the oxidation of the substrates xanthine and hypoxanthine to uric acid, and produces superoxide anion and hydrogen peroxide; hyperuricemia is caused by hyperuricemia, gout attacks can be caused by deposition and crystallization of uric acid at joints, and superoxide anion free radicals are related to inflammation, canceration and aging; research in recent years has also found that xanthine oxidase also plays an important role in ischemia-reperfused tissue and vascular injury, inflammatory diseases and chronic heart failure; hyperuricemia and gout belong to major metabolic diseases of human bodies, and gout patients in China exceed 8 million people.
Because of environmental pollution and food pollution, the human body oxidation is aggravated, the human body immunity is reduced, the resistance is reduced, the human body metabolic disturbance is caused, xanthine oxidase is overactive, the human body metabolizes excessive uric acid, and many people cannot normally discharge the generated uric acid, so that the concentration of blood uric acid is continuously increased, when the concentration reaches the solubility saturation, urate is generated and is crystallized in the kidney and joints to bring severe pain, various uric acid-reducing chemical medicaments have side effects to a certain extent, and particularly, the side effect that the heart, the liver and the kidney have a problem is larger; and the gout can not be cured, so that the gout is repeatedly attacked, and the health of people is seriously harmed.
The oral liquid prepared by a reasonable formula and a certain process technology can obviously inhibit the activity of xanthine oxidase, and fundamentally reduce the formation of uric acid from xanthine and oxygen, thereby radically treating hyperuricemia and gout; the traditional Chinese medicine composition is prepared from medicinal and edible materials, has no toxic or side effect on human bodies, and is a great breakthrough in the technical field of biological pharmacy and medicine.
Disclosure of Invention
The invention aims to: provides a preparation method and application of a plant extract for inhibiting xanthine oxidase activity.
The technical scheme adopted by the invention is as follows: a preparation method of plant extract for inhibiting xanthine oxidase activity is characterized by comprising the following steps:
s1, extracting immersion liquid: mixing rhizoma Polygonati, radix Angelicae sinensis, pericarpium Citri Tangerinae, rhizoma Zingiberis recens, and water, and heating to obtain water extractive solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
The reaction mechanism of the invention is as follows: the invention combines rhizoma polygonati, angelica, dried orange peel and ginger, then fills oxygen into water extraction fine filtration liquid to mix and oxidize, thus obtaining water extraction fine filtration oxidation liquid, the prior art never combines rhizoma polygonati, angelica, dried orange peel and ginger separately, and oxidizes the water extraction liquid, and the plant extraction liquid can obviously inhibit the activity of xanthine oxidase.
Further, the step S1 is to extract the extract of polygonatum: chinese angelica: dried orange peel: ginger: the weight ratio of water is as follows: 1-3: 1-3: 1-3: 1-3: 10-80 deg.C, heating to 80-100 deg.C, and extracting for 40-150 min.
Further, the impurities removed by the filtration in the step S2 are substances larger than 0.3 micron, and the pore size of the filtration membrane used for the filtration is smaller than or equal to 0.3 micron.
Further, the oxidation time in step S3 is: 0.2-5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the amount of edible or medical oxygen is 0.5-15 cubic meters per ton of the extractive solution under one atmosphere.
Further, the temperature for sterilization in the filling and sterilizing process of step S4 is 105-; the time is 10-90 minutes.
Further, in the step S4, the capacity of the oral liquid bottle during filling and sterilizing is 10-50 ml/bottle.
The plant extract for inhibiting the xanthine oxidase activity has the application in preparing the traditional Chinese medicine for reducing uric acid and treating gout.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
the preparation method is simple and convenient, and the four plants are medicinal and edible plants, so that the edible health-care tea is safe to eat and has no side effect; has the function of obviously inhibiting the activity of xanthine oxidase.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without any creative work based on the embodiments of the present invention belong to the protection scope of the present invention.
A preparation method of plant extract for inhibiting xanthine oxidase activity is characterized by comprising the following steps:
s1, extracting immersion liquid: the sealwort, the angelica, the dried orange peel, the ginger and the water are mixed according to the weight proportion: 1-3: 1-3: 1-3: 1-3: 10-80, mixing and heating, wherein the heating extraction temperature is 80-100 ℃, and the extraction time is 40-150 minutes to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore diameter of less than or equal to 0.3 micron to remove impurities, so as to obtain water extract fine filtrate;
s3, oxidation: and (S2) filling edible or medical oxygen into the water extraction fine filtration liquid obtained in the step (S2) for mixed oxidation, wherein the oxidation time is as follows: 0.2-5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the amount of edible or medical oxygen is 0.5-15 cubic meters per ton of the extract under one atmosphere to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (4) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle with the volume of 10-50 ml/bottle, and sterilizing at high temperature to obtain a finished product.
Examples of the present invention are given below
Example 1
S1, extracting immersion liquid: mixing 10 kg of rhizoma polygonati, 10 kg of angelica, 8 kg of dried orange peel, 12 kg of ginger and 500 liters of water, heating to 90 ℃, extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.25 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 85 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 1 cubic meter per ton of the extracting solution under one atmosphere; in the process of oxygen filling, a pump is used for extracting fine filter liquor from the tank to the outside of the tank and then circulating the fine filter liquor to the tank, and the flow rate of the pump is controlled to be 1500 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 120 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 50 ml oral liquid bottles, screwing a cover, putting the bottles into a sterilization cabinet, heating to 110 ℃, and sterilizing for 40 minutes; obtaining the finished product of the plant water-extracted oral liquid for clearing heat and reducing fever.
The obtained water extraction oral liquid of the sealwort, the angelica, the dried orange peel and the ginger can obviously inhibit the activity of xanthine oxidase.
Example 2
S1, extracting immersion liquid: 12 kg of rhizoma polygonati, 10 kg of angelica and 5 kg of dried orange peel; 10 kg of ginger; mixing 420 liters of water, heating to 95 ℃, extracting for 60 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.2 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 75 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 3 cubic meters per ton of the extracting solution under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation is 100 minutes;
s4, bottling and sterilizing: filling the oxidized water-extracted fine-filtered oxidized liquid into 50 ml oral liquid bottles, screwing covers, and placing the bottles into a sterilization cabinet to be heated to 115 ℃ for sterilization for 20 minutes; obtaining the finished product of the plant water-extracted oral liquid for clearing heat and reducing fever.
The obtained water extraction oral liquid of the sealwort, the angelica, the dried orange peel and the ginger can obviously inhibit the activity of xanthine oxidase.
Example 3
S1, extracting immersion liquid: 22 kg of rhizoma polygonati, 15 kg of angelica and 12 kg of dried orange peel; 8 kg of ginger; mixing 1000 liters of water, heating to 80 ℃, extracting for 100 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.2 micron to obtain water extract fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 95 ℃, and then filling edible or medical oxygen into the water extraction fine filtrate, wherein the total amount is 4 cubic meters per ton of the extracting solution under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the oxidation time from the start of oxygenation to the end of oxygenation was 120 minutes;
s4, bottling and sterilizing: filling the oxidized water extraction fine filtration oxidation liquid into 10 ml oral liquid bottles, screwing a cover, and placing the bottles into a sterilization cabinet to be heated to 105 ℃ for sterilization for 10 minutes; obtaining the finished product of the plant water-extracted oral liquid for clearing heat and reducing fever.
The obtained water extraction oral liquid of the sealwort, the angelica, the dried orange peel and the ginger can obviously inhibit the activity of xanthine oxidase.
Sealwort, also known as: rhizoma Polygonati, herba Elsholtziae Penduliforare, rhizoma Gynurae Divaricatae, rhizoma Zingiberis recens, and radix Codonopsis Lanceolatae; is a polygonatum plant, the rhizome of which is horizontally moved, is cylindrical, the nodule is enlarged, the tuber is grown without a handle; the medicinal plants have the functions of tonifying spleen, moistening lung, promoting fluid production, resisting aging, reducing weight, prolonging life, lowering blood pressure, preventing arteriosclerosis, resisting bacteria, diminishing inflammation and enhancing immunity, and the rhizoma polygonati is sweet in taste and tasty and refreshing to eat; the fleshy rhizome is fat and thick, contains a large amount of starch, sugar, fat, protein, carotene, vitamins and various other nutritional ingredients, can allay hunger when eaten raw or stewed, has the function of body building, can multiply the vitality of people, has abundant muscles and strong bone marrow, is very beneficial to the body, has the inhibiting effect of different degrees on common pathogenic fungi, and also has the anti-fatigue and hemostatic effects;
the angelica is a perennial herb of angelica of umbelliferae, is sweet and pungent in taste and warm in nature by taking dry roots as a medicine, and has the effects of enriching and activating blood, regulating menstruation and relieving pain, moistening dryness and lubricating intestines and the like; the angelica has high medicinal value, is an important variety of the traditional Chinese medicine, is loaded in the Shen nong's herbal Jing of east Han and is listed as a Chinese product; the Ming Zhang Jingyue (materia medica) is called as the 'Xuezhongsheng Yao'; li Shizhen (compendium of materia Medica) is listed as a grass of herbage department, called as ' essential drug for women ', in modern Chinese materia medica ', Chinese angelica is listed as the first variety of blood tonics, Chinese angelica is also one of the traditional Chinese medicines commonly used in clinical practice of traditional Chinese medicine, and is called as ' ten prescriptions and nine guidances '; in Rihuazi Bencao, it is said that Dang Gui has obvious and definite therapeutic effects on wind-cold-evil, blood-stasis, fatigue, malignant blood, and new blood-nourishment, and is regarded as important by ancient people; the angelica has bidirectional effect on the uterus, is used as a traditional gynecological medicine, is also used for senile diseases, cardiovascular and cerebrovascular diseases, respiratory diseases, osteoarthropathy, muscle tissue diseases and the like, and has definite curative effect.
The dried orange peel is dried mature peel of citrus and cultivated varieties thereof in citrus of Rutaceae, is fragrant in smell and bitter in taste as a traditional Chinese medicinal material, has the effects of expelling in-vivo moisture, regulating qi, strengthening spleen, eliminating dampness and phlegm and the like, is mainly used for treating incoordination between spleen and stomach, fullness and distention in chest and abdomen, poor appetite, cough and excessive phlegm and the like, belongs to a medicinal and edible congener, has good safety performance and wide application range;
the rhizoma Zingiberis recens is fresh rhizome of Zingiber officinale Roscoe of Zingiberaceae; rhizoma Zingiberis recens root, herba Potentillae Discoloris, colluding finger, DIXIN, YAN LIANG XIAO ZI, fresh rhizoma Zingiberis recens, rhizoma Zingiberis recens baked with honey, rhizoma Zingiberis recens rhizome, cortex Corni and leaf can be used as medicine, rhizoma Zingiberis recens has effects of inducing sweat, relieving exterior syndrome, warming middle-jiao, relieving vomit, warming lung, relieving cough, relieving fish and crab toxicity, and relieving drug toxicity in traditional Chinese medicine, and is suitable for wind cold, headache, phlegm retention, cough, stomach cold emesis; when the patient suffers from ice, snow, water dampness and cold, the decoction of ginger is taken quickly to promote blood circulation and dispel cold evil.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention, and the scope of the present invention is defined by the appended claims, and all changes that come within the meaning and range of equivalency of the specification are therefore intended to be embraced therein.
Claims (7)
1. The preparation method of the plant extract for inhibiting the xanthine oxidase activity is characterized by comprising the following steps of:
s1, extracting immersion liquid: mixing rhizoma Polygonati, radix Angelicae sinensis, pericarpium Citri Tangerinae, rhizoma Zingiberis recens, and water, and heating to obtain water extractive solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
2. The method according to claim 1, wherein the extract of the plant having xanthine oxidase activity extracted therefrom in step S1 is prepared by: chinese angelica: dried orange peel: ginger: the weight ratio of water is as follows: 1-3: 1-3: 1-3: 1-3: 10-80 deg.C, heating to 80-100 deg.C, and extracting for 40-150 min.
3. The method according to claim 1, wherein the impurities removed by filtration in step S2 are substances larger than 0.3 μm, and the pore size of the filtration membrane used for filtration is 0.3 μm or smaller.
4. The method according to claim 1, wherein the oxidation time in step S3 is: 0.2-5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 5 times per hour; the amount of edible or medical oxygen is 0.5-15 cubic meters per ton of the extractive solution under one atmosphere.
5. The method according to claim 1, wherein the temperature for sterilization in the filling and sterilizing step S4 is 105 to 130 degrees; the time is 10-90 minutes.
6. The method of claim 1, wherein the capacity of the oral liquid bottle in the filling and sterilizing step S4 is 10-50 ml/bottle.
7. The plant extract for inhibiting xanthine oxidase according to any of claims 1-6, which is used for preparing Chinese medicine for reducing uric acid and treating gout.
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| CN202010777259.2A CN111888455A (en) | 2020-04-26 | 2020-08-05 | Preparation method and application of plant extract for inhibiting xanthine oxidase activity |
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| CN111166805A (en) * | 2020-03-20 | 2020-05-19 | 任秀江 | Preparation method and application of plant extract for treating tonsillitis and pharyngolaryngitis |
| CN111494593A (en) * | 2020-04-26 | 2020-08-07 | 任秀江 | Preparation method and application of plant extract for inhibiting xanthine oxidase activity |
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