CN111699001A - 达沙替尼和其他酪氨酸激酶抑制剂对基因修饰的嵌合抗原受体t细胞的功能的控制和调节 - Google Patents

达沙替尼和其他酪氨酸激酶抑制剂对基因修饰的嵌合抗原受体t细胞的功能的控制和调节 Download PDF

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CN111699001A
CN111699001A CN201880088946.4A CN201880088946A CN111699001A CN 111699001 A CN111699001 A CN 111699001A CN 201880088946 A CN201880088946 A CN 201880088946A CN 111699001 A CN111699001 A CN 111699001A
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cells
car
cancer
dasatinib
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迈克尔·胡德克
卡特琳·梅斯特曼
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Julius Maximilians Universitaet Wuerzburg
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CN201880088946.4A 2017-12-07 2018-12-07 达沙替尼和其他酪氨酸激酶抑制剂对基因修饰的嵌合抗原受体t细胞的功能的控制和调节 Pending CN111699001A (zh)

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EP17205922.2 2017-12-07
EP17205922 2017-12-07
PCT/EP2018/084018 WO2019110815A1 (en) 2017-12-07 2018-12-07 Control and modulation of the function of gene-modified chimeric antigen receptor t cells with dasatinib and other tyrosine kinase inhibitors

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US (2) US20210169880A1 (https=)
EP (1) EP3720477A1 (https=)
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CA (1) CA3084873A1 (https=)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111892661A (zh) * 2020-08-12 2020-11-06 浙江康佰裕生物科技有限公司 一种嵌合抗原受体及其在制备治疗肿瘤的产品中的应用
CN113699107A (zh) * 2021-10-27 2021-11-26 东莞再立健生物科技有限公司 一种外周血nkt细胞培养液及培养方法
CN113728000A (zh) * 2019-03-01 2021-11-30 新加坡国立大学 工程化免疫细胞
CN116121196A (zh) * 2022-12-23 2023-05-16 广州安捷生物医学技术有限公司 一种调控car-t细胞的方法与应用
CN116322691A (zh) * 2020-09-24 2023-06-23 豪夫迈·罗氏有限公司 T细胞双特异性抗体相关不良反应的预防或减轻
CN118755668A (zh) * 2024-06-19 2024-10-11 徐州医科大学 一种提高Tscm/Tcm细胞的方法及其应用
CN119060951A (zh) * 2024-11-05 2024-12-03 星奕昂(上海)生物科技有限公司 一种高密度培养条件下提高nk细胞活率的方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018183888A2 (en) * 2017-03-31 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling
BR112022001418A2 (pt) * 2019-08-08 2022-06-07 Rigel Pharmaceuticals Inc Compostos e método para tratar a síndrome de liberação de citocinas
CN112480263A (zh) * 2019-09-12 2021-03-12 普米斯生物技术(苏州)有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
CN115348870B (zh) * 2021-03-16 2023-06-13 上海驯鹿生物技术有限公司 通用型嵌合抗原受体t细胞及其应用
WO2022210487A1 (ja) * 2021-03-29 2022-10-06 タカラバイオ株式会社 抗原に特異的な受容体を発現する免疫細胞の製造方法
EP4071248A1 (en) 2021-04-07 2022-10-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Means and methods for enhancing receptor-targeted gene transfer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011034919A2 (en) * 2009-09-15 2011-03-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Sh2 domain profiling to characterize tyrosine phosphorylation signaling in cancer
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018183888A2 (en) * 2017-03-31 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011034919A2 (en) * 2009-09-15 2011-03-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Sh2 domain profiling to characterize tyrosine phosphorylation signaling in cancer
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SAAR GILL ET AL.: "CD19 CAR-T cells combined with ibrutinib to induce complete remission in CLL", 《JOURNAL OF CLINICAL ONCOLOGY》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113728000A (zh) * 2019-03-01 2021-11-30 新加坡国立大学 工程化免疫细胞
CN111892661A (zh) * 2020-08-12 2020-11-06 浙江康佰裕生物科技有限公司 一种嵌合抗原受体及其在制备治疗肿瘤的产品中的应用
CN116322691A (zh) * 2020-09-24 2023-06-23 豪夫迈·罗氏有限公司 T细胞双特异性抗体相关不良反应的预防或减轻
CN113699107A (zh) * 2021-10-27 2021-11-26 东莞再立健生物科技有限公司 一种外周血nkt细胞培养液及培养方法
CN113699107B (zh) * 2021-10-27 2022-02-01 东莞再立健生物科技有限公司 一种外周血nkt细胞培养液及培养方法
CN116121196A (zh) * 2022-12-23 2023-05-16 广州安捷生物医学技术有限公司 一种调控car-t细胞的方法与应用
CN118755668A (zh) * 2024-06-19 2024-10-11 徐州医科大学 一种提高Tscm/Tcm细胞的方法及其应用
CN118755668B (zh) * 2024-06-19 2025-10-31 徐州医科大学 一种提高Tscm/Tcm细胞的方法及其应用
CN119060951A (zh) * 2024-11-05 2024-12-03 星奕昂(上海)生物科技有限公司 一种高密度培养条件下提高nk细胞活率的方法

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