CN111683664A - 具有降低的心血管作用的避孕组合物 - Google Patents

具有降低的心血管作用的避孕组合物 Download PDF

Info

Publication number
CN111683664A
CN111683664A CN201980012248.0A CN201980012248A CN111683664A CN 111683664 A CN111683664 A CN 111683664A CN 201980012248 A CN201980012248 A CN 201980012248A CN 111683664 A CN111683664 A CN 111683664A
Authority
CN
China
Prior art keywords
risk
component
effective amount
preferably less
estrol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980012248.0A
Other languages
English (en)
Chinese (zh)
Inventor
M·约斯特
G·劳辛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Estetra SRL
Original Assignee
Estetra SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra SRL filed Critical Estetra SRL
Priority to CN202211257175.1A priority Critical patent/CN115429806A/zh
Publication of CN111683664A publication Critical patent/CN111683664A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201980012248.0A 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物 Pending CN111683664A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211257175.1A CN115429806A (zh) 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18155571.5 2018-02-07
EP18155571 2018-02-07
EP18160586.6 2018-03-07
EP18160586 2018-03-07
PCT/EP2019/052980 WO2019154899A1 (en) 2018-02-07 2019-02-07 Contraceptive composition with reduced cardiovascular effects

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211257175.1A Division CN115429806A (zh) 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物

Publications (1)

Publication Number Publication Date
CN111683664A true CN111683664A (zh) 2020-09-18

Family

ID=65278388

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980012248.0A Pending CN111683664A (zh) 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物
CN202211257175.1A Pending CN115429806A (zh) 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211257175.1A Pending CN115429806A (zh) 2018-02-07 2019-02-07 具有降低的心血管作用的避孕组合物

Country Status (20)

Country Link
EP (2) EP4140489A1 (https=)
JP (2) JP2021513507A (https=)
KR (1) KR102717921B1 (https=)
CN (2) CN111683664A (https=)
AU (1) AU2019219070B2 (https=)
CA (2) CA3178181A1 (https=)
CL (1) CL2020002017A1 (https=)
EC (1) ECSP20054822A (https=)
GE (2) GEAP202215414A (https=)
IL (1) IL276584B2 (https=)
JO (1) JOP20200169A1 (https=)
MA (1) MA51733A (https=)
NZ (1) NZ766027A (https=)
PH (1) PH12020500601A1 (https=)
PY (1) PY1908892A (https=)
SG (1) SG11202007163WA (https=)
TW (1) TWI845496B (https=)
UA (1) UA126746C2 (https=)
UY (1) UY38075A (https=)
WO (1) WO2019154899A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116077454A (zh) 2015-06-18 2023-05-09 埃斯特拉有限责任公司 含雌四醇组分的口腔分散剂量单位
HUE054589T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Szájban diszpergálódó esztetrol tartalmú tabletta
RS61777B1 (sr) 2015-06-18 2021-06-30 Estetra Sprl Oralno-disperzibilna tableta koja sadrži estetrol
MD3310333T2 (ro) 2015-06-18 2020-06-30 Estetra Sprl Unitate de dozare orodispersabilă care conține un component estetrol
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
DK3781171T3 (da) 2018-04-19 2022-05-02 Estetra Srl Sammensætninger og deres anvendelser til lindring af menopause-associerede symptomer
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
TWI893101B (zh) * 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
WO2022248733A1 (en) 2021-05-28 2022-12-01 Neuralis Sa Use of estetrol in treatment of respiratory infection diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080234240A1 (en) * 2003-11-26 2008-09-25 Schering Ag Extended Use Combination Comprising Estrogens And Progestins
WO2012055840A1 (en) * 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
EP1390042B1 (en) * 2001-05-23 2007-11-28 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
EP2432474A1 (de) * 2009-05-22 2012-03-28 Bayer Pharma Aktiengesellschaft Arzneimittel zur oralen verabreichung, enthaltend mindestens ein estrogen und/oder mindestens ein gestagen und mindestens einen probiotischen bakterien-stamm
NO3079671T3 (https=) * 2013-12-12 2018-03-24
CA3178291A1 (en) * 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
KR102780201B1 (ko) 2016-10-28 2025-03-12 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080234240A1 (en) * 2003-11-26 2008-09-25 Schering Ag Extended Use Combination Comprising Estrogens And Progestins
WO2012055840A1 (en) * 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CORNELIS KLUFT: "Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol", CONTRACEPTION *
DAN APTER: "Estetrol combined with drospirenone: an oral contraceptive with high acceptability, user satisfaction, well-being and favourable body weight control", THE EUROPEAN JOURNAL OF CONTRACEPTION & REPRODUCTIVE HEALTH CARE *

Also Published As

Publication number Publication date
EP3749327A1 (en) 2020-12-16
EP4140489A1 (en) 2023-03-01
CN115429806A (zh) 2022-12-06
JP7651645B2 (ja) 2025-03-26
AU2019219070B2 (en) 2024-12-19
CA3178181A1 (en) 2019-08-15
CL2020002017A1 (es) 2020-12-04
WO2019154899A1 (en) 2019-08-15
IL276584B1 (en) 2024-06-01
KR102717921B1 (ko) 2024-10-16
TWI845496B (zh) 2024-06-21
UY38075A (es) 2019-10-01
ECSP20054822A (es) 2020-12-31
AU2019219070A1 (en) 2020-09-24
TW202011967A (zh) 2020-04-01
CA3089804A1 (en) 2019-08-15
PY1908892A (es) 2019-10-15
SG11202007163WA (en) 2020-08-28
GEAP202215414A (en) 2022-04-25
PH12020500601A1 (en) 2021-05-17
MA51733A (fr) 2020-12-16
JP2024009834A (ja) 2024-01-23
KR20200118464A (ko) 2020-10-15
IL276584B2 (en) 2024-10-01
UA126746C2 (uk) 2023-01-18
NZ766027A (en) 2026-03-27
JP2021513507A (ja) 2021-05-27
GEP20227407B (en) 2022-08-25
IL276584A (en) 2020-09-30
JOP20200169A1 (ar) 2020-07-07

Similar Documents

Publication Publication Date Title
JP7651645B2 (ja) 心臓血管系への影響を低減した避妊薬組成物
JP6557298B2 (ja) 副作用（ｖｔｅリスク、頭痛）を軽減し、月経困難症および月経痛の症状を軽減する方法
US20200046729A1 (en) Methods using combined oral contraceptive compositions with reduced cardiovascular effects
KR102780201B1 (ko) 월경통 및 생리통의 관리방법
Klipping et al. Effects of two combined oral contraceptives containing ethinyl estradiol 20 μg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism
Stanczyk et al. Gestodene: a review of its pharmacology, potency and tolerability in combined contraceptive preparations
Zahradnik et al. Efficacy, safety and sustainability of treatment continuation and results of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg chlormadinone acetate, in long-term usage (up to 45 cycles)—an open-label, prospective, noncontrolled, office-based Phase III study
US20030191096A1 (en) Method of hormonal therapy
TWI472332B (zh) 口服避孕療法
Keam et al. Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive
EP1558265A1 (en) Cardiovascular protection using anti-aldosteronic progestins
US20250360147A1 (en) Methods using combined oral contraceptive compositions with reduced cardiovascular effects
HK40081220A (en) Contraceptive composition with reduced cardiovascular effects
EA048171B1 (ru) Композиция контрацептива со сниженными эффектами в отношении сердечно-сосудистой системы
EA048537B1 (ru) Композиция контрацептива со сниженными эффектами в отношении сердечно-сосудистой системы

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: liege

Applicant after: ESTETRA S.A.

Address before: liege

Applicant before: ESTETRA S.A.

CB02 Change of applicant information