CN111671087A - Fat-reducing and muscle-increasing nutritional food - Google Patents

Fat-reducing and muscle-increasing nutritional food Download PDF

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CN111671087A
CN111671087A CN202010297713.4A CN202010297713A CN111671087A CN 111671087 A CN111671087 A CN 111671087A CN 202010297713 A CN202010297713 A CN 202010297713A CN 111671087 A CN111671087 A CN 111671087A
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muscle
glutamine
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vitamin
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陈彬合
袁振海
贾婵媛
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Shandong Academy of Pharmaceutical Sciences
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

A nutritional food for reducing fat and improving muscle comprises glutamine 4-15 parts or alanyl glutamine 6-22 parts, soybean peptide 4-10g parts, calcium pyruvate 2-5 parts, β -hydroxy β -calcium methylbutyrate 1-3 parts, and optionally vitamin B10.0005-0.004 portion of vitamin B20.0005 to 0.002 part and 0 to 2 parts of L-carnitine. Is used for people who lose weight, build body and build body, and is matched with exercise to reduce fat and increase muscle. The nutritional food can be made into granule, solid beverage or oral liquid. And can alsoIs formulated into nutritional composition for separate administration before and after exercise.

Description

Fat-reducing and muscle-increasing nutritional food
Technical Field
The invention belongs to the field of nutritional and health-care foods, and particularly relates to a nutritional food for reducing fat and increasing muscle.
Background
To evaluate the degree of overweight and obesity in adults, the medical community has introduced the concept of Body Mass Index (BMI). BMI is calculated as weight/height2(kg/m2). According to the actual situation of adults in China, the following regulations are currently specified: BMI of 18.5 or less<24kg/m2The BMI is within the normal weight range and is more than or equal to 24<28kg/m2Is overweight, and has a BMI of more than or equal to 28kg/m2It is obese. Obesity is caused by excess energy and deficiency of proteins and certain minerals, vitamins, body fat volume and/or fat finesIncreased cell numbers and excessive deposition in certain parts of the body, leading to malnutrition with abnormally increased body weight or body fat rate (percentage of body fat in body weight). Overweight (overweight) is an intermediate state between normal and obese.
In recent years, the incidence of overweight/obesity in our country has been growing year by year. Data reported by Chinese residents in 2015 shows that the overweight rate of Chinese adults in 2012 is 30.1% and the obesity rate is 11.9%. Overweight and obesity not only affect stature, confidence and socialization; as an independent influence factor, metabolic diseases such as type 2 diabetes, hyperlipidemia and fatty liver, cardiovascular diseases such as hypertension, coronary heart disease and cerebral apoplexy, and even the incidence of tumors can be increased. High energy intake, unbalanced diet, and lack of exercise are major causes of obesity.
With the popularization of health knowledge, weight loss and body building become fashionable. Weight loss, also known as fat loss, refers to the reduction of body weight and body fat rate by reducing body fat, especially abdominal and visceral fat, with less muscle loss. It has been demonstrated that weight loss can only be achieved by ensuring that energy expenditure is greater than energy intake, achieving a negative balance of energy. Sufficient muscle not only guarantees the motor ability, but also can protect the joints, improve the insulin sensitivity and prevent the occurrence and the development of diabetes. The muscle of the same mass has a higher basal metabolic rate than the fat, so the higher the body muscle proportion is, the higher the energy consumption is, and the more beneficial the control of the body weight is. Therefore, scientific weight loss must be achieved by reducing body fat while maintaining or even increasing body muscle mass to prevent obesity-related diseases. Body building and fitness people seek to increase muscle building and shaping besides reducing fat. Diet is beneficial for weight loss, and while energy intake is reduced, the intake of nutrients, especially insufficient protein, vitamins and the like, is reduced, so that the basal metabolic rate is reduced, the weight loss is difficult to continue, the metabolic disturbance and muscle loss are aggravated, and the healthy southern thill northern rut is also aggravated.
Exercise not only increases energy expenditure, but also enhances heart and lung function, prevents osteoporosis, thickens muscle fibers, and increases muscle mass. Therefore, exercise for weight loss is the main way. Exercise is accomplished by coordinated contraction and relaxation of muscles in the muscle group. Muscle contraction requires energy support. The energy supply for sports has the sequence that muscle fibers firstly supply energy by utilizing ATP stored in muscle cells and high-energy phosphate bonds in phosphocreatine, then blood sugar is consumed for supplying energy, after the blood sugar is reduced, muscle can mobilize muscle glycogen for supplying energy, and when the muscle glycogen is greatly consumed, fat and protein can be mobilized for supplying energy. Only when the body consumes fat to supply energy can the weight-reducing process be started. However, fat and protein breakdown is not in sequence when exercise is powered. The muscle protein energy supply is completed by decomposing protein into amino acid, performing biological transformation such as deamination and the like, and performing biological oxidation and ATP release. Muscle breakdown energy supply is faster during high intensity exercises because muscle breakdown energy supply is performed inside the exercising muscles, and mobilizing fat requires transportation from a remote location. Although muscle proteins are constantly in metabolism (1% -2% of muscle protein breakdown and synthesis per day), muscle proteins used for exercise energization, under conditions of adequate muscle glycogen stores, typically do not exceed 5% of total energy consumption. At muscle glycogen depletion, protein energy supply can increase to 10% -15% or even up to 18% of the total calories. Once the energy supply of muscle protein exceeds 5%, muscle decomposition is caused. So exercise weight loss must be accompanied by muscle loss.
In order to reduce muscle loss during exercise and weight loss, the protein intake is increased to 1.2 g/kg-d or more, and the protein intake of the people with muscle building and shaping needs to reach 1.5-2.0 g/kg-d. Secondly, the proportion of high-quality protein is ensured to be not less than 50 percent. In the high-quality protein, the essential amino acids which can not be synthesized by human body are complete in variety, sufficient in quantity and proper in proportion, and are high-quality raw materials for muscle protein synthesis. And supplementing nutrient factors for promoting muscle protein synthesis and inhibiting decomposition. In addition, total energy intake (less than or equal to 1200 kcal/day, vegetables with low content of edible starch, fruits and snacks for reducing hunger sensation) needs to be controlled in order to achieve the goal of weight loss.
Amino acids closely related to muscle include arginine, branched chain amino acids (BCAA, meaning leucine, isoleucine and valine) and glutamine. Arginine increases muscle blood supply and promotes muscle growth. The branched chain amino acid not only has high content (up to 35%) in muscle protein, but also can prevent muscle from decomposing, promote muscle protein synthesis and make muscle more full. Glutamine is the largest amount of free amino acid in human body, accounts for about 60% of the total amount of free amino acid in human body, is mainly synthesized in muscle, can neutralize acidic products accumulated in human body in anaerobic exercise, and has certain effect on delaying sports fatigue. As a main energy source of immune cells and intestinal mucosa cells, glutamine has great significance in maintaining the immune function of human bodies and the integrity of intestinal mucosa. During strenuous exercise, the consumption of glutamine in muscles is enormous, which is also the main reason for the decline of body resistance after exercise.
Beta-hydroxy beta-methylbutyrate (HMB), a leucine metabolite naturally occurring in human skeletal muscle, has a significantly higher intensity of action than equivalent leucine. Recent studies have found that HMB affects skeletal muscle metabolism mainly through the following mechanisms: 1) activating mammalian Target of rapamycin (mTOR, a protein kinase, which plays a central role in controlling mRNA translation efficiency) signaling pathway, stimulating protein synthesis; 2) inhibition of Ubiquitin Proteasome Pathway (UPP), reduction of muscle protein breakdown; 3) the compound is converted into beta-hydroxy beta-methylglutaryl coenzyme A (HMG-CoA) in vivo, thereby promoting the synthesis of cholesterol, supporting the rapid repair of muscle and immune system cell damage and maintaining the integrity of cell membranes; 4) stimulating muscle satellite cells to promote muscle regeneration; 5) increase endoplasmic reticulum calcium release. Studies at the loving state university have demonstrated that HMB can increase more muscle and reduce nearly one-fold fat in a motor-assisted setting. In 2011, the domestic approval of the beta-hydroxy beta-methylbutyrate calcium (HMBCa) as a new food raw material is that the daily consumption is less than or equal to 3 g. In 2017, the application range of HMBCa is expanded to beverages, milk and dairy products, cocoa products, chocolate and chocolate products, candies, baked foods, sports nutrition foods and special medical purpose formula foods.
For the intervention of exercise, the theory of aerobic fat reduction and anaerobic muscle increase is available, namely on the premise of ensuring certain amount of exercise, aerobic exercise has positive effects on improving the functions of heart and lung, reducing visceral fat and abdominal fat and enhancing physical ability; anaerobic exercise is more effective in increasing muscle (increasing lean body mass). According to the exercise energy supply sequence, ATP in the body can only support exercise for a plurality of seconds, creatine phosphate can support 2-3 minutes, muscle glycogen stored in the human body can support exercise for about 30 minutes, and then the process of fat reduction for consuming fat is carried out. Because energy can be supplied only by glycolysis of glucose during anaerobic exercise, it is recommended that before each exercise, the patient should be warmed up for several minutes, then subjected to several groups of high-intensity intermittent anti-impedance (HITT) anaerobic exercises for about 30 minutes to consume glycogen in the body, and finally subjected to aerobic exercises such as jogging and the like to enter the process of reducing fat. Just as the fatty deposits that lead to overweight and obesity do not develop in a short time, the fat reduction and muscle enhancement achieved by nutritional and motor interventions also require long-term persistence to be effective.
The pyruvic acid and the L-carnitine are supplemented during aerobic exercise, so that target people can mobilize and decompose fat to supply energy to organisms, and the goal of reducing fat is achieved more easily. At present, more than 300 weight-losing health-care foods approved by China exist, more than eighty raw materials are used, and the proportion of plants and related products exceeds 75%. The 5 raw materials with the highest use frequency comprise lotus leaves (45.3%), cassia seeds (40.6%), L-carnitine (36.1%), tea (26.1%) and rhizoma alismatis (23.9%) in sequence. Calcium pyruvate is also used as a raw material for certain health foods, and the use frequency is 6.1%.
It has been mentioned previously that imbalances in nutrient intake are one of the major causes of obesity. Protein, calcium, iron, zinc, magnesium, potassium, vitamin A, and vitamin B1Vitamin B2Vitamin B6Vitamin B12Vitamin C, vitamin D, vitamin E, folic acid and nicotinic acid are all factors influencing obesity. There are few foods on the market that aim to regulate the imbalance of nutrients. Some foods claiming to lose weight use coarse food grains or add dietary fibers into the products to increase satiety, so as to achieve the effect of losing weight by reducing the intake of food and energy. The food is really not different from diet weight loss, has poor taste and is difficult to persistIn addition, the protein content is seriously insufficient, and the muscle loss is easily caused. Some so-called weight-losing foods which are added with a large amount of saturated fat such as palm oil and cover high dietary fiber and have rough mouthfeel actually belong to high-energy, high-fat and high-fiber products; if the health-care food is eaten for a long time, the health-care food has no weight-losing effect, can increase blood cholesterol and aggravate lipid metabolism disorder. The currently sold muscle-increasing products mainly comprise protein powder and creatine. According to the regulations of our national laws, creatine is allowed to be used in sports nutritional foods, and is not allowed to be used for developing health-care foods. At present, fat-reducing and muscle-increasing products are not available in the market.
Disclosure of Invention
The invention provides a nutritional food for reducing fat and increasing muscle, which is used for people who lose weight, build body and build body, and is matched with aerobic and anaerobic exercises to reduce fat and increase muscle. The nutritional food can supplement glutamine consumed during exercise, and has effects of relieving exercise fatigue and enhancing immunity; use of calcium pyruvate and L-carnitine to increase fat mobilization during aerobic exercise, vitamin B1And B2β -hydroxyl β -calcium methylbutyrate prevents muscle protein from decomposing, promotes muscle protein synthesis, stimulates muscle growth, provides amino acid essential for human body, provides raw material for repairing muscle injury caused by exercise, and is beneficial to muscle increase.
Technical scheme
A nutritional food for reducing fat and increasing muscle comprises the following nutritional ingredients: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, 4-10 parts of soybean peptide, 2-5 parts of calcium pyruvate and 1-3 parts of beta-hydroxy beta-methylbutyrate calcium.
Glutamine in muscle can neutralize acidic product accumulated in body in anaerobic exercise, and has effect in delaying sports fatigue. Glutamine is of great significance in maintaining the immune function of the human body and the integrity of the intestinal mucosa. During strenuous exercise, the consumption of glutamine in muscles is huge, so that the body resistance is reduced after exercise, and the cold is easily caused. In addition, glutamine can also promote skeletal muscle protein synthesis. The nutritional food uses glutamine or alanylglutamine as a raw material to supplement glutamine for target people. The nutritional food can be prepared into granules, solid beverages or oral liquid. When making into granule or solid beverage, glutamine is used in an amount of 4-15 parts. When the preparation is made into oral liquid, alanyl glutamine is used, the dosage of which is 6 to 22 parts, and water is added to 500 parts.
When the nutritious food is prepared into oral liquid, the nutritious food is canned in a sterilizable and sealed plastic, glass or metal container. The liquid was subjected to autoclaving (115 ℃ C., 10 minutes). Because glutamine has poor heat stability and alanyl glutamine can endure a high-temperature sterilization process, the alanyl glutamine is used for replacing glutamine when the nutritional food is prepared into oral liquid. Alanylglutamine is a dipeptide synthesized by condensing alanine and glutamine, has high bioavailability, and can be rapidly decomposed into glutamine and alanine in vivo after being orally absorbed so as to be used for synthesizing body substances and consuming energy.
The soybean protein belongs to high-quality protein, the arginine content of the soybean protein is three times of that of whey protein, and the BCAA content is up to 20 percent. Arginine can promote muscle growth, BCAA can prevent muscle decomposition, and accelerate muscle protein synthesis. In addition, the soybean protein also has the function of reducing blood fat. The soybean peptide is hydrolyzed from soybean protein, has moderate molecular weight, good water solubility, and no denaturation under heating, and can be directly absorbed into blood in intestinal tract without digestion. The soybean peptide can be supplemented before exercise to inhibit muscle decomposition and prevent muscle loss. 30 to 60 minutes after exercise, the muscle cell membrane absorption channel is in an open state, and can rapidly absorb small molecular nutrients in blood and tissue fluid, which is called as a 'window period' of muscle nutrition supplementation. The soybean peptide is supplemented in the 'window period' after exercise, so that BCAA and arginine can be supplemented for muscle cells, muscle protein synthesis is promoted, muscle injury caused by exercise is repaired, muscle fatigue is eliminated, and muscle strength is enhanced.
The nutritional food disclosed by the invention uses calcium pyruvate as a raw material, and enhances the exercise fat-reducing effect. Pyruvate is an intermediate product of sugar metabolism, lipid metabolism, and various amino acid metabolism in the human body. Exogenous pyruvate supplementation plays a role in reducing body weight and body fat through the following two ways: first, pyruvate can increase the activity of rate-limiting enzyme pyruvate dehydrogenase complex, accelerate the conversion of pyruvate to NADH and acetyl CoA, and allow the Krebs cycle to proceed continuously, thereby accelerating the rate of sugar and fat catabolism in vivo. Secondly, pyruvate can increase pyruvate-phosphoenolpyruvate cycle in muscle and other tissues, increasing human energy expenditure. The literature reports that the fat reducing effect is better when the pyruvic acid is supplemented by combining aerobic exercise.
As described above, β -hydroxy β -methylbutyrate (HMB) stimulates protein synthesis, inhibits muscle protein degradation, stimulates muscle satellite cells, and promotes muscle regeneration. Clinical research shows that the appropriate amount of supplementary HMB, in combination with resistance exercise, has certain effect on improving muscle quality and strengthening muscle strength. The calcium beta-hydroxy beta-methylbutyrate used in the nutritional food according to the invention is the calcium salt of HMB and has the same efficacy as HMB.
There is literature showing that obesity is associated with calcium deficiency. The chinese resident nutritional and chronic condition report (2015) shows that 96.6% of residents have lower dietary calcium intake than EAR (average required), and most people are at risk of insufficient dietary calcium intake. The nutritional food disclosed by the invention uses calcium salts of pyruvic acid and beta-hydroxy beta-methylbutyric acid, and can supplement insufficient intake of dietary calcium.
Vitamin B1With vitamin B2The report of Chinese residents on nutrition and chronic disease conditions (2015) shows that 77.8% of residents in China have the risk of insufficient intake of vitamin B1, 90.2% of residents have the risk of insufficient intake of vitamin B2, and L-carnitine is a transport carrier for long-chain fatty acid in vivo to enter mitochondria and has the effects of promoting fatty acid β -oxidation, glucose oxidation and utilization and aerobic metabolism.
Preferably, the nutritional food for reducing fat and enhancing muscle can also comprise vitamin B10.0005-0.004 portion of vitamin B20.0005 to 0.002 part of L-carnitine and 0 to 2 parts of L-carnitine。
The nutritional food can be prepared into a single product and is taken by target people before or during exercise. Or can be made into combination product for taking before and after exercise. As mentioned above, vitamin B1With vitamin B2The calcium pyruvate and L-carnitine which belong to cofactors with irresistible or deficient energy metabolism have the functions of promoting lipolysis and energy supply, β -hydroxy β -calcium methylbutyrate can promote muscle protein synthesis, inhibit muscle protein decomposition and prevent muscle loss, the nutritional factors are supplemented before exercise, fat can be effectively mobilized to supply energy for exercise, glutamine or alanyl glutamine can supplement the consumption of glutamine in muscle after strenuous exercise, the exercise fatigue is relieved, the body resistance is increased, soybean peptide is supplemented after the exercise, the essential amino acids including branched chain amino acids can be rapidly supplemented, raw materials are provided for repairing muscle injury, the muscle is favorably increased, proper water supplement is realized, and the exercise is favorably realized.
Preferably, the pre-exercise product comprises: 2-5 parts of calcium pyruvate and 1-3 parts of beta-hydroxy beta-methylbutyrate calcium. When the Chinese medicinal composition is prepared into granules and solid beverages, 150 parts of water is added for taking after mixing; when the medicine is prepared into oral liquid, water is added to 150 parts. The product taken after exercise comprises: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, and 4-10g parts of soybean peptide. When the preparation is prepared into granules and solid beverages, 4-15 parts of glutamine is taken with 350 parts of water; when the preparation is made into oral liquid, 6-22 parts of alanyl glutamine is used, and water is added to 350 parts.
Further preferably, the product taken before exercise comprises 2-5 parts of calcium pyruvate, 1-3 parts of β -hydroxyl β -calcium methylbutyrate and vitamin B10.0005-0.004 portion of vitamin B20.0005 to 0.002 part and 0 to 2 parts of L-carnitine. When the Chinese medicinal composition is prepared into granules and solid beverages, 150 parts of water is added for taking after mixing; when the medicine is prepared into oral liquid, water is added to 150 parts. The post-exercise administration of the product comprises: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, and 4-10g parts of soybean peptide. When the preparation is prepared into granules and solid beverages, 4-15 parts of glutamine is taken with 350 parts of water; when the preparation is made into oral liquid, 6-22 parts of alanyl glutamine is used, and water is added to 350 parts.
The product can be taken after exercise, not only in the intermission of exercise, but also after the exercise is finished. After exercise, the effect of muscle increase is more obvious when the patient is matched with sleep for 1.5 to 2 hours, because muscle repair and growth are generally carried out in the sleep period.
In the process of exercise, the body loses part of sodium, potassium and magnesium along with sweat, and the body is lack of intake of iron, zinc, magnesium, potassium, vitamin A, vitamin D, vitamin E, folic acid, vitamin B6, vitamin B12, vitamin C and nicotinic acid, so that the body has certain correlation with obesity. The nutrient food can be added with the nutrient, and the specific dosage refers to the national food safety standard food nutrient supplement use standard (GB 14880).
When the nutritional food is prepared into granules, binders such as xanthan gum, polyvinylpyrrolidone (PVP) K30 and hydroxypropyl methylcellulose are used. The usage amount is determined according to production requirements.
The nutritional food can be added with xylo-oligosaccharide, isomalto-oligosaccharide, fructo-oligosaccharide, galacto-oligosaccharide and soybean oligosaccharide, and is used for conditioning intestinal functions and improving diarrhea and constipation. The dosage of oligosaccharide refers to the national food safety standard dietary supplement use standard (GB 14880).
The nutritional food can be flavored by using edible essence; sweeteners without energy, such as stevioside, glycyrrhizin, sodium cyclamate, acesulfame potassium, sucralose and aspartame, can also be used, and the dosage of the essence and the sweeteners is referred to the national food additive standard of food safety (GB 2760).
Advantageous effects
Calcium pyruvate, vitamin B1Vitamin B2β -hydroxy β -calcium methylbutyrate can promote muscle protein synthesis, inhibit muscle protein decomposition, prevent muscle loss, supply raw materials for muscle protein synthesis and injury repair, and promote muscle growth, glutamine or alanyl glutamine can supplement glutamine consumption during exercise, and enhance immunityThe synergistic effect is realized, and the goals of reducing fat, increasing muscle and improving health are realized together by matching with exercise.
Detailed Description
Example 1 granules
The formula comprises 1kg of soybean peptide, 0.5kg of calcium pyruvate, 0.4kg of glutamine, 0.3kg of β -hydroxyl β -calcium methylbutyrate, 10g of sucralose and vitamin B10.4g, vitamin B20.2g, 6.8g of silicon dioxide and hydroxypropyl methylcellulose E550 g;
the preparation method comprises the following steps: 1. preparing a binder solution, weighing hydroxypropyl methylcellulose E5 with the amount of 1.1 times of the formula amount, adding 20 times of hot water with the temperature of 70 ℃, and stirring to dissolve for later use;
2. weighing the materials, except hydroxypropyl methylcellulose E5, and weighing the raw materials in the sequence from small to large;
3. premixing the small materials and vitamin B1Vitamin B2Mixing with sucralose.
4. Dry mixing, premixing the small materials, beta-hydroxy beta-methylbutyrate calcium, glutamine, calcium pyruvate and soybean peptide, and mixing uniformly;
5. wet mixing, namely slowly adding the adhesive solution into the dry mixture while stirring, and continuously stirring until the mixture is uniform after the adhesive solution is added;
6. granulating by swinging a granulator and a 20-mesh screen;
7. drying and granulating, drying the granules with hot air at 65-70 deg.C until the water content is less than 3%, and granulating with 16 mesh sieve;
8. cooling, mixing, cooling the granules to room temperature, adding silicon dioxide, and mixing;
9. subpackaging and packaging, subpackaging in aluminum plastic film bags, each bag is 22.7g, sealing by heat seal, and boxing to obtain the finished product.
Dosage and application method: the medicine is taken 1 bag each time, dissolved in 500ml of warm water, and taken separately before, during and after exercise.
Example 2 solid beverage
The formula comprises 1.5kg of glutamine, 0.4kg of soybean peptide, 0.2kg of calcium pyruvate, 0.1kg of L-carnitine, 0.1kg of β -hydroxy β -calcium methylbutyrate, 0.1kg of orange essence, 30g of aspartame, vitamin B10.3g of vitaminElement B20.2g；
The preparation method comprises the following steps: 1. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
2. premixing the small materials and vitamin B1Vitamin B2Mixing with aspartame;
3. mixing the premixed small materials with beta-hydroxy beta-methylbutyrate calcium, orange essence, L-carnitine, calcium pyruvate, soybean peptide and glutamine
4. Subpackaging and packaging, subpackaging in aluminum plastic film bags, each bag for 24.3g, and sealing by heat sealing.
5. Labeling and boxing, labeling and boxing to obtain the finished product.
Dosage and application method: the medicine is taken 1 bag each time, dissolved in 500ml of warm water, and taken separately before, during and after exercise.
EXAMPLE 3 solid beverage
The formula comprises 0.8kg of glutamine, 0.8kg of soybean peptide, 0.4kg of calcium pyruvate, 0.2kg of β -hydroxy β -calcium methylbutyrate, 0.1kg of L-carnitine, 0.1kg of lemon essence, 30g of acesulfame potassium, vitamin B10.2g, vitamin B20.15g；
The preparation method comprises the following steps: 1. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
2. premixing the small materials and vitamin B1Vitamin B2Mixing with acesulfame potassium, and keeping;
3, mixing the premixed small materials with L-carnitine, lemon essence, beta-hydroxy beta-methylbutyrate calcium, calcium pyruvate, soybean peptide and glutamine uniformly;
4. subpackaging and packaging, subpackaging in aluminum plastic film bags, each bag is 24.3g, and sealing by heat sealing;
5. labeling and boxing, labeling and boxing to obtain the finished product.
Dosage and application method: the medicine is taken by 1 bag each time, dissolved in 500ml of warm water, and taken several times before, during and after exercise.
EXAMPLE 4 solid beverage combination
One of the combined products (for before sports)
The formula is as follows: 0.3kg of calcium pyruvate0.2kg of carnitine, 0.1kg of β -hydroxyl β -calcium methylbutyrate, 30g of lemon essence, 9g of acesulfame potassium and vitamin B10.35g, vitamin B20.05g；
The preparation method comprises the following steps: 1. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
2. premixing the small materials and vitamin B1Vitamin B2Mixing the acesulfame potassium and the lemon essence uniformly for later use;
3. mixing, namely uniformly mixing the premixed small materials with beta-hydroxy beta-methylbutyrate calcium, L-carnitine and calcium pyruvate;
4. subpackaging, subpackaging in aluminum plastic film bags (6.4 g each), and sealing by heat sealing.
5. Labeling and boxing, labeling and boxing to obtain the finished product.
Dosage and application method: the composition is administered before exercise after dissolving in 150ml warm water 1 bag each time.
The second combination product (for sports and after sports)
The formula is as follows: 1.2kg of glutamine, 0.6kg of soybean peptide, 70g of lemon essence and 21g of acesulfame;
the preparation method comprises the following steps: 1. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
2. mixing, and mixing acesulfame potassium, lemon essence, soybean peptide, and glutamine;
3. subpackaging, subpackaging in aluminum plastic film bags, each bag is 18.9g, and sealing by heat sealing;
4. labeling and boxing, labeling and boxing to obtain the finished product.
Dosage and application method: the medicine is taken by 1 bag each time, dissolved in 350ml of warm water, and taken separately during and after exercise.
EXAMPLE 5 oral liquid
The formula comprises 1kg of soybean peptide, 0.6kg of alanyl glutamine, 0.5kg of calcium pyruvate, 0.3kg of β -hydroxy β -calcium methylbutyrate, 0.2kg of L-carnitine, 0.1kg of mango essence, 30g of aspartame, vitamin B10.3g, vitamin B20.1g and 47.3kg of deionized water;
the preparation method comprises the following steps: cleaning and drying a 1.500ml screwed glass bottle and a bottle cap for later use;
2. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
3. proportioning, namely adding deionized water with the formula amount of 80% into a proportioning tank, sequentially adding the raw materials in the weight sequence from small to large under stirring, and stirring until the raw materials are completely dissolved;
4. filtering and supplementing water, filtering with 0.22 μm microporous membrane, and supplementing deionized water to full volume;
5. canning, namely canning the liquid in a screw-mouth glass bottle with 500ml per bottle, and rotating a bottle cap to seal;
6. sterilizing at 115 deg.C for 10 min;
7. cooling, labeling and packaging to obtain the finished product.
The dose is as follows: the composition is administered in 1 bottle each time before, during and after exercise.
EXAMPLE 6 oral liquid
The formula comprises 1.7kg of alanyl glutamine, 0.6kg of soybean peptide, 0.3kg of calcium pyruvate, 0.1kg of β -hydroxy β -calcium methylbutyrate, 0.1kg of L-carnitine, 0.1kg of lemon essence, 10g of sucralose, and vitamin B10.05g, vitamin B20.15g and 47.1kg of deionized water;
the preparation method comprises the following steps: cleaning and drying a 1.500ml screwed glass bottle and a bottle cap for later use;
2. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
3. proportioning, namely adding deionized water with the formula amount of 80% into a proportioning tank, sequentially adding the raw materials in the weight sequence from small to large under stirring, and stirring until the raw materials are completely dissolved;
4. filtering and supplementing water, filtering with 0.22 μm microporous membrane, and supplementing deionized water to full volume;
5. canning, namely canning the liquid in a screw-mouth glass bottle with 500ml per bottle, and rotating a bottle cap to seal;
6. sterilizing at 115 deg.C for 10 min;
7. cooling, labeling and packaging to obtain the finished product.
The dose is as follows: the composition is administered in 1 bottle each time before, during and after exercise.
Example 7 oral liquid
The formula comprises 2.2kg of alanyl glutamine, 0.4kg of soybean peptide, 0.2kg of calcium pyruvate, 0.1kg of β -hydroxy β -calcium methylbutyrate, 0.1kg of orange essence, 25g of stevioside and vitamin B10.25g, vitamin B20.2g and 47kg of deionized water;
the preparation method comprises the following steps: cleaning and drying a 1.500ml screwed glass bottle and a bottle cap for later use;
2. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
3. proportioning, namely adding deionized water with the formula amount of 80% into a proportioning tank, sequentially adding the raw materials in the weight sequence from small to large under stirring, and stirring until the raw materials are completely dissolved;
4. filtering and supplementing water, filtering with 0.22 μm microporous membrane, and supplementing deionized water to full volume;
5. canning, namely canning the liquid in a screw-mouth glass bottle with 500ml per bottle, and rotating a bottle cap to seal;
6. sterilizing at 115 deg.C for 10 min;
7. cooling, labeling and packaging to obtain the finished product.
The dose is as follows: the composition is administered in 1 bottle each time before, during and after exercise.
EXAMPLE 8 oral liquid combination
One of the combined products (for before sports)
The formula comprises 0.4kg of calcium pyruvate, 0.2kg of β -calcium hydroxy β -methylbutyrate, 0.1kg of L-carnitine, 30g of orange essence, 7.5g of stevioside and vitamin B10.4g, vitamin B20.05g and 14.3kg of deionized water;
the preparation method comprises the following steps: cleaning and drying a 1.150ml screwed glass bottle and a bottle cap for later use;
2. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
3. proportioning, namely adding deionized water with the formula amount of 80% into a proportioning tank, sequentially adding the raw materials in the weight sequence from small to large under stirring, and stirring until the raw materials are completely dissolved;
4. filtering and supplementing water, filtering with 0.22 μm microporous membrane, and supplementing deionized water to full volume;
5. canning, namely canning the liquid in a rotary-mouth glass bottle with 150ml per bottle, and rotating a bottle cap to seal;
6. sterilizing at 115 deg.C for 10 min;
7. cooling, labeling and packaging to obtain the finished product.
The dose is as follows: the composition is administered in 1 bottle (150ml) before exercise.
The second combination product (for sports and after sports)
The formula is as follows: 1.2kg of alanyl glutamine, 0.8kg of soybean peptide, 70g of orange essence, 17.5g of stevioside and 32.9kg of deionized water; the preparation method comprises the following steps: cleaning a 1.350ml screwed glass bottle and a bottle cap, respectively packaging and sterilizing for later use;
2. weighing the raw materials, and weighing the raw materials in the sequence from small to large;
3. proportioning, namely adding deionized water with the formula amount of 80% into a proportioning tank, sequentially adding the raw materials in the weight sequence from small to large under stirring, and stirring until the raw materials are completely dissolved;
4. filtering and supplementing water, filtering with 0.22 μm microporous membrane, and supplementing deionized water to full volume;
5. canning, namely canning the liquid in a screw-top glass bottle with 350ml per bottle, and rotating a bottle cap to seal;
6. sterilizing at 115 deg.C for 10 min;
7. cooling, labeling and packaging to obtain the finished product.
The dose is as follows: the product is administered in 1 bottle (350ml) each time, and during and after exercise.
Example 9 population test
A certain gymnasium in the south of the Jinan selects 16 healthy overweight or obese men and women, and randomly divides the overweight or obese men and women into a test group and a control group with informed consent to inform daily diet and exercise attention.
Three meals, oil-less and salt-less diets, matched meat and vegetables, eight times full in the morning and seven times full in the evening, fasted snacks and unlimited drinking water. For example, hunger is caused by cucumber, tomato, etc. after exercise, and little or no fruit is eaten.
The exercise mode and exercise intensity were the same for the test group and the control group. At least 5 days of exercise every week, before each exercise, warming up and moving the wrist, elbow, shoulder, hip, knee and ankle joints, carrying out several groups of high-strength apparatus exercises for about 30 minutes, having a rest between groups for 10-15 seconds, selecting the apparatus by self, enabling the large muscle groups of the whole body to participate in the exercise as much as possible, and finally jogging for more than 30 minutes.
The test period was one month. The test group took one of the solid drink combination products of the practice 4 of the present invention before exercise (dedicated before exercise), took one of the solid drink combination products of the practice 4 of the present invention during and after exercise (dedicated during and after exercise), and drunk mineral water as a control group. Before and after the test, an Inbody520 human body composition analyzer is used for respectively measuring the height, the weight, the body fat and the skeletal muscle content, and calculating the BMI, the body fat rate and the related change. The test results are shown in the following table, and it can be seen that the muscle-increasing and fat-reducing effects of the test group eating the product of the invention are more obvious compared with the control group.
Figure BDA0002452828350000111

Claims (5)

1. A nutritional food for reducing fat and increasing muscle, which is characterized by comprising the following nutritional ingredients: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, 4-10 parts of soybean peptide, 2-5 parts of calcium pyruvate and 1-3 parts of beta-hydroxy beta-methylbutyrate calcium.
2. The nutritional food according to claim 1, further comprising vitamin B10.0005-0.004 portion of vitamin B20.0005 to 0.002 part and 0 to 2 parts of L-carnitine.
3. The nutritional food according to claim 1 or 2, which can be prepared as a granule, a solid beverage or an oral liquid; when preparing into granules or solid beverage, glutamine is used, and the dosage is 4-15 parts; when the preparation is made into oral liquid, alanyl glutamine is used, the dosage of which is 6 to 22 parts, and water is added to 500 parts.
4. The nutritional food product according to claim 1, characterized in that it can be made as a sports nutritional combination product, the product to be taken before a sport comprising: 2-5 parts of calcium pyruvate and 1-3 parts of beta-hydroxy beta-methylbutyrate calcium; when the Chinese medicinal composition is prepared into granules and solid beverages, 150 parts of water is added for taking after mixing; when the medicine is prepared into oral liquid, water is added to 150 parts; the post-exercise administration of the product comprises: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, and 4-10g parts of soybean peptide; when the preparation is prepared into granules and solid beverages, 4-15 parts of glutamine is taken with 350 parts of water; when the preparation is made into oral liquid, 6-22 parts of alanyl glutamine is used, and water is added to 350 parts.
5. The nutritional food product of claim 2 which is formulated as a sports nutritional combination product and which is administered prior to exercise comprises 2 to 5 parts calcium pyruvate, 1 to 3 parts calcium β -hydroxy β -methylbutyrate, and vitamin B10.0005-0.004 portion of vitamin B20.0005 to 0.002 part of L-carnitine and 0 to 2 parts of L-carnitine; when the Chinese medicinal composition is prepared into granules and solid beverages, 150 parts of water is added for taking after mixing; when the medicine is prepared into oral liquid, water is added to 150 parts; the post-exercise administration of the product comprises: 4-15 parts of glutamine or 6-22 parts of alanyl glutamine, and 4-10g parts of soybean peptide; when the preparation is prepared into granules and solid beverages, 4-15 parts of glutamine is taken with 350 parts of water; when the preparation is made into oral liquid, 6-22 parts of alanyl glutamine is used, and water is added to 350 parts.
CN202010297713.4A 2020-04-16 2020-04-16 Fat-reducing and muscle-increasing nutritional food Pending CN111671087A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692836A (en) * 2005-06-16 2005-11-09 欧阳康乐 Multiple elements solid beverage for quickly supplementing energy and nutrition
CN106666303A (en) * 2016-11-15 2017-05-17 昆山国元生物科技有限公司 Vitamin sports beverage containing soybean peptide
CN108142927A (en) * 2017-12-25 2018-06-12 诺和生物技术（天津）有限公司 It is a kind of to be used to meet composition of motion control weight demand and preparation method thereof
CN109198347A (en) * 2017-06-30 2019-01-15 浙江京新生物科技有限公司 A kind of soybean peptide solid beverage and its application
CN109892555A (en) * 2019-02-28 2019-06-18 珠海市优尼赞经贸有限公司 A kind of diet food and preparation method thereof for hindering Fatty synthesis to accelerate oil extraction fat reducing
CN110464010A (en) * 2019-08-14 2019-11-19 中国农业大学 A kind of weight-reducing cereal meal replacement powder
CN112655977A (en) * 2021-01-04 2021-04-16 湖南慧泽生物医药科技有限公司 Diet nutritional supplement for obese people

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692836A (en) * 2005-06-16 2005-11-09 欧阳康乐 Multiple elements solid beverage for quickly supplementing energy and nutrition
CN106666303A (en) * 2016-11-15 2017-05-17 昆山国元生物科技有限公司 Vitamin sports beverage containing soybean peptide
CN109198347A (en) * 2017-06-30 2019-01-15 浙江京新生物科技有限公司 A kind of soybean peptide solid beverage and its application
CN108142927A (en) * 2017-12-25 2018-06-12 诺和生物技术（天津）有限公司 It is a kind of to be used to meet composition of motion control weight demand and preparation method thereof
CN109892555A (en) * 2019-02-28 2019-06-18 珠海市优尼赞经贸有限公司 A kind of diet food and preparation method thereof for hindering Fatty synthesis to accelerate oil extraction fat reducing
CN110464010A (en) * 2019-08-14 2019-11-19 中国农业大学 A kind of weight-reducing cereal meal replacement powder
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