CN111643556A - Medicine for preventing and treating hemorrhoids and application thereof - Google Patents
Medicine for preventing and treating hemorrhoids and application thereof Download PDFInfo
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Abstract
A medicine for preventing and treating hemorrhoids and application thereof, belonging to the technical field of traditional Chinese medicines. The medicine comprises one or more of herba Gei extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract. Use of herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and/or herba et Gemma Agrimoniae extract in preparing medicine for preventing and treating hemorrhoid is provided. The medicament of the invention reduces the inflammation at the wound of the hemorrhoid and the damage and the destruction of corresponding tissues caused by secondary bacterial infection, reduces clinical symptoms, can inhibit bacteria or sterilize, astringe the wound at the damaged part, promote the microvascular regeneration of tissues around the wound, promote the healing of the wound and the tissue repair regeneration, improve the damage of the hemorrhoid diseases and the complications to the organism and help to recover the functions of the damaged tissues. The medicine meets the quality standard of the traditional Chinese medicine active site composition, has repeatable production program quality control, safe and reliable products, remarkable treatment effect and convenient use.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicine for preventing and treating hemorrhoids and application thereof.
Background
Hemorrhoids are a common disease in the anal area and are soft venous pockets formed by the dilatation and flexion of the submucosal plexus at the end of the rectum and the subclavian skin. The etiology and pathogenesis of the hemorrhoids are various, wherein the main cause of the hemorrhoids is long standing or long sitting, or long-time weight bearing walking, or long-term constipation, which affects pelvic cavity vein reflux, makes the blood flow in the pelvic cavity slow and corresponding organs congestion, causes hemorrhoid vein overfilling, vein wall tension reduction and further blood stasis expansion. A series of pathological changes of hemorrhoids can be induced by anatomical physiological defects and inducements such as improper diet, constipation, chronic diarrhea and dysentery, increased abdominal pressure during pregnancy, excessive sexual intercourse and no ejaculation.
Hemorrhoids are simply divided into three types according to the site of occurrence, (1) internal hemorrhoids, and the common symptoms are bleeding, prolapse, swelling, and pain. (2) External hemorrhoids usually have no special symptoms, and have swelling and pain when thrombosis and inflammation occur. (3) Mixed hemorrhoids are mainly characterized by the presence of both internal and external hemorrhoids. The common symptoms of patients with hemorrhoids include hematochezia, pain in defecation, and swelling and prolapse of anus and secretion flowing from anus when internal hemorrhoids are serious, so that skin around the anus is wet all the day, and eczema and pruritus of the anus are caused, and the life quality and physical and psychological health of the patients are seriously affected.
The common treatment methods of the western medicine for the hemorrhoids include operation treatment, ultralow temperature and ultrahigh temperature treatment, ligation and injection treatment and the like. The above treatments such as western medicine operation can rapidly eliminate focus and symptoms, but complications often occur, and postoperative recurrence is easy. The curative effect of ultra-low temperature and ultra-high temperature therapy is similar to that of surgical therapy, and the recurrence rate after treatment is high. The ligation and ligation often cause the local blood circulation of the anus to be blocked, and complications such as extravasated blood and edema, pain, difficult defecation and the like are easy to generate. The injection therapy is simple and convenient in clinical operation, but the precise selection of the injection part and the control of the dosage are difficult, and the excessive dosage control can cause tissue necrosis, heavy bleeding, serious infection and the like of the hand injection part. Although a plurality of treatment methods in traditional Chinese medicine comprise oral decoction, acupuncture and moxibustion, external application paste and the like, the traditional Chinese medicine has slow effect and is difficult to radically cure.
According to the characteristics and the defects of different traditional Chinese and western medicine therapies, an effective medicine for treating hemorrhoids, which has the advantages of quick response, obvious effect, stable drug effect, treatment of both symptoms and root causes and convenient treatment method, is found, and is an urgent clinical requirement at present.
Disclosure of Invention
In view of the problems in the prior art, the present invention is to design and provide a drug for preventing and treating hemorrhoids and a technical solution for the application thereof.
In order to realize the purpose, the following technical scheme is adopted:
a medicine for preventing and treating hemorrhoid is characterized by comprising one or more of herba Gei extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract.
The medicine for preventing and treating hemorrhoids is characterized in that the aleppo avens bunge extract, the rabdosia rubescens extract and the hairyvein agrimony extract are alcohol extracts of corresponding raw materials.
The drug for preventing and treating hemorrhoids is characterized in that the drug contains 0.01 to 99.99 percent by weight of the extract.
The medicine for preventing and treating the hemorrhoids is characterized by further comprising a pharmaceutically acceptable carrier and/or an auxiliary agent.
Use of herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and/or herba et Gemma Agrimoniae extract in preparing medicine for preventing and treating hemorrhoid is provided.
The application is characterized in that the aleppo avens linne extract, the rabdosia rubescens extract and the hairyvein agrimony extract are alcohol extracts of corresponding raw materials.
The use according to the above, characterized in that the hemorrhoid comprises: internal hemorrhoid, mixed hemorrhoid, external hemorrhoid, anal cryptitis, anal fissure, anal carbuncle, anal fistula, rectocele or hemorrhoid complications.
Preferably, the aleppodamia bigelovii extract, the rabdosia rubescens extract and the agrimonia pilosa extract are obtained by ethanol extraction; more preferably, the alepponica avellana extract, the rabdosia rubescens extract and the agrimonia pilosa extract are obtained by the following steps: selecting herba Gei aleppici, Rabdosia rubescens and/or herba et Gemma Agrimoniae, cleaning, removing impurities, drying respectively, pulverizing, sieving with 80-100 mesh sieve to obtain herba Gei aleppici coarse powder, Rabdosia rubescens coarse powder and/or herba et Gemma Agrimoniae coarse powder, mixing each coarse powder with 60% ethanol 1: adding 60% ethanol at a mass volume ratio of 8-10, respectively, leaching at 40 deg.C for 3-8 hr, reflux extracting at 60 deg.C for 2 hr, cooling to room temperature, filtering to obtain filtrate, concentrating under reduced pressure, and spray drying to obtain herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract.
Preferably, a medicament for preventing and treating hemorrhoids is an ointment, a spray or an oral preparation, and the ointment or the spray respectively has the following scheme: firstly, alcohol/water extraction is respectively carried out on traditional Chinese medicines of aleppo avens, rabdosia rubescens and hairyvein agrimony, the traditional Chinese medicines are sprayed and dried into powder, then the extracted traditional Chinese medicine powder is mixed with auxiliary materials into paste according to a proportion, and then the traditional Chinese medicine paste is pushed into an anus through a pushing device, so that the medicines directly act on the hemorrhoid part. Or dissolving the extracted Chinese medicinal powder in 5% ethanol water, and making into spray, which can be directly sprayed on affected part to make the medicine directly act on hemorrhoid. The concentration percentage ratio of the medicinal powder is as follows: 7% of aleppo avens extract, 1% of rabdosia rubescens extract, 1% of hairyvein agrimony extract, 70% of vaseline and 21% of lanolin as auxiliary materials. Or: 9% of rabdosia rubescens extract, 70% of vaseline and 21% of lanolin as auxiliary materials. Or 9% of agrimony extract, 70% of vaseline and 21% of lanolin as auxiliary materials. Preferably, the traditional Chinese medicine ointment or spray comprises 5% of aleppo avens extract, 2% of rabdosia rubescens extract, 2% of hairyvein agrimony extract, 70% of vaseline and 21% of lanolin.
A use method of a medicine for preventing and treating hemorrhoids comprises the following steps: directly applying on affected part, or injecting 3g Chinese medicinal preparation into small diameter head of injection tube, loading into push core, matching with Chinese medicinal ointment, inserting small diameter head of injection tube into anus for 5-7 cm, pushing core to the bottom, pulling out injection tube to complete administration, and administering once per day before morning and before sleep; the use method of the traditional Chinese medicine preparation is as follows: spraying the ointment on the affected part with hemorrhoid; the use method of the traditional Chinese medicine preparation is as follows: orally administered at a dose of 0.1-10 g/kg body weight per day.
The invention has the following beneficial effects:
the medicament of the invention reduces the inflammation at the wound of the hemorrhoid and the damage and the destruction of corresponding tissues caused by secondary bacterial infection, reduces clinical symptoms, can inhibit bacteria or sterilize, astringe the wound at the damaged part, promote the microvascular regeneration of tissues around the wound, promote the healing of the wound and the tissue repair and regeneration, greatly and substantially improve the damage of the hemorrhoidal disease and the complications to the organism, and help to recover the functions of the damaged tissues. The medicine meets the quality standard of the traditional Chinese medicine active site composition, has repeatable production program quality control, safe and reliable products, remarkable treatment effect and convenient use.
Detailed Description
The invention will be further illustrated by the following specific examples.
Example 1: composition analysis of drugs and adjuvants
Extract of aleppodamia bigelovii: traditional Chinese medicine of blue cloth (Geumjaponicum Thunb. var. chinenseBolle) is used as monarch drug of the prescription, and is mainly used for treating hypertension, dizziness and headache, irregular menstruation, lower abdominal pain, leucorrhea, infantile convulsion, rheumatism lumbocrural pain, carbuncle, furuncle and pyogenic infections and traumatic injury. The blue cloth contains active polyphenol compounds, can help to remove necrotic soft tissues of wound surfaces, astringe wound surfaces, promote the regeneration of capillary vessels in the process of tissue repair, stop bleeding, promote tissue regeneration, clear away heat and toxic materials, relieve swelling, dissipate stagnation and have strong antibacterial and anti-inflammatory effects. The pentacyclic triterpenoid contained in the composition can promote the regeneration and repair of soft tissues of wounds.
Extract of rabdosia rubescens: the traditional Chinese medicine (Potentilla chinensis Ser) is used as a ministerial medicine of the prescription and is mainly used for clearing heat and detoxicating, cooling blood and stopping dysentery, red dysentery and abdominal pain, chronic dysentery, haemorrhoids and carbuncle and sore toxicity. The total flavonoids contained in Rabdosia rubescens can reduce insulin resistance and repair islet cells, and thus can be used for treating type II diabetes. It contains active polyphenol compounds, wherein fumaric acid, gallic acid, protocatechuic acid, quercetin, naringenin, etc. have antibacterial and antibacterial antiinflammatory effects on bacteria, especially dysentery bacillus, and can be used for treating dysentery, scabies, astringing wound surface, and promoting micro-blood vessel regeneration in tissue repair process. The triterpene compounds contained in the preparation can promote the regeneration and repair of soft tissues of wounds.
Extract of hairyvein agrimony: a traditional Chinese medicine of dried aerial parts of herba et Gemma Agrimoniae (Agrimonia Pilosa Ldb) is used as adjuvant of the composition, and is mainly used as strong astringent hemostatic. It mainly contains agrimonine, agrimonolide, tannin (pyrocatechol tannin, gallotannin, etc.), sterol, organic acid, phenolic component, saponin, etc. The extract can be used for astringing wound surface of hemorrhoid, and has strong effects of astringing hemorrhoid wound and stopping bleeding of hemorrhoid. The obtained agrimonine, agrimonolide, polyphenol, saponin, and polysaccharide have cardiotonic effect, and can be used for stopping bleeding caused by pulmonary disease such as hemoptysis, intestinal hemorrhage, gastric ulcer hemorrhage, metrorrhagia, dental hemorrhage, and hemorrhoidal bleeding.
The extract of the radix cynanchi bungei also plays a role of a medicine, has the functions of diminishing inflammation, relieving pain, clearing heat and removing toxicity, and harmonizing the medicines, so that the medicines are matched and cooperated to achieve the effects of resisting bacteria, diminishing inflammation, clearing heat and removing toxicity, eliminating edema, debriding necrotic tissues, stopping bleeding, dissipating blood stasis, promoting blood circulation, promoting tissue regeneration and repairing, and has very obvious treatment effects on internal hemorrhoids, mixed hemorrhoids and external hemorrhoids.
Vaseline: plays the roles of bearing the drug adhesive matrix and lubricating.
Lanolin: plays a role in adhesion and lubrication.
Example 2: preparation and application of Chinese medicinal ointment for treating hemorrhoid
Selecting traditional Chinese medicine raw materials for removing impurities, respectively taking herba Gerberae Piloselloidis (Guizhou), herba Rabdosiae Glaucocalycis (Henan), and herba et Gemma Agrimoniae (Shandong), cleaning to remove impurities, drying, pulverizing, and sieving with 80-100 mesh sieve to obtain herba Gerberae Piloselloidis coarse powder, herba Rabdosiae Glaucocalycis coarse powder, and herba et Gemma Agrimoniae coarse powder. Mixing the coarse powder and 60% ethanol in a mass-volume ratio of 1: 9 extracting with 60% ethanol at 40 deg.C for 7 hr, reflux extracting at 60 deg.C for 2 hr, cooling to room temperature, filtering to obtain filtrate, concentrating under reduced pressure, and spray drying to obtain herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract. Mixing 5% of herba Gei extract, 2% of herba Rabdosiae Glaucocalycis extract and 2% of herba et Gemma Agrimoniae extract, adding 70% of vaseline and 21% of lanolin, and concocting to obtain Chinese medicinal paste.
The using method comprises the following steps: the application method comprises directly applying on affected part, or injecting 3g of Chinese medicinal preparation into small-diameter head of injection tube, loading into push core, making the push core coincide with Chinese medicinal ointment, inserting the small-diameter head of injection tube into anus for 5-7 cm, pushing to the bottom of the push core, and pulling out the injection tube to complete administration, which is administered once each day in the morning and before sleep.
Example 3: preparation of Chinese medicinal ointment for treating hemorrhoid
Selecting traditional Chinese medicine raw materials for removing impurities, respectively taking herba Gerberae Piloselloidis (Guizhou), herba Rabdosiae Glaucocalycis (Henan), and herba et Gemma Agrimoniae (Shandong), cleaning to remove impurities, drying, pulverizing, and sieving with 80-100 mesh sieve to obtain herba Gerberae Piloselloidis coarse powder, herba Rabdosiae Glaucocalycis coarse powder, and herba et Gemma Agrimoniae coarse powder. Mixing the coarse powder and 60% ethanol in a mass-volume ratio of 1: 8 respectively adding 60% ethanol, extracting at 40 deg.C for 3 hr, reflux extracting at 60 deg.C for 2 hr, cooling to room temperature, filtering to obtain filtrate, concentrating under reduced pressure, and spray drying to obtain herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract. Mixing herba Gei Piloselloidis extract 7%, herba Rabdosiae Glaucocalycis extract 1% and herba et Gemma Agrimoniae extract 1%, adding vaseline 70% and lanolin 21%, and concocting to obtain Chinese medicinal paste.
Example 4: preparation of Chinese medicinal ointment for treating hemorrhoid
Selecting traditional Chinese medicine raw materials for removing impurities, cleaning herba Rabdosiae Glaucocalycis (Henan) for removing impurities, drying, pulverizing, and sieving with 80-100 mesh sieve to obtain herba Rabdosiae Glaucocalycis coarse powder. Mixing the coarse powder with 60% ethanol in a mass-volume ratio of 1: 10 adding 60% ethanol, leaching at 40 deg.C for 8 hr, reflux extracting at 60 deg.C for 2 hr, cooling to room temperature, filtering to obtain filtrate, concentrating under reduced pressure, and spray drying to obtain herba Rabdosiae Glaucocalycis extract. Mixing herba Rabdosiae Glaucocalycis extract 9%, vaseline 70% and lanolin 21% to obtain Chinese medicinal paste.
Example 5: preparation of Chinese medicinal ointment for treating hemorrhoid
Selecting traditional Chinese medicine materials, removing impurities, cleaning herba et Gemma Agrimoniae (Shandong), removing impurities, drying, pulverizing, and sieving with 80-100 mesh sieve to obtain herba et Gemma Agrimoniae coarse powder. Mixing the coarse powder with 60% ethanol in a mass-volume ratio of 1: 8 respectively adding 60% ethanol, leaching at 40 deg.C for 3 hr, reflux extracting at 60 deg.C for 2 hr, cooling to room temperature, filtering to obtain filtrate, concentrating under reduced pressure, and spray drying to obtain herba et Gemma Agrimoniae extract. Mixing herba et Gemma Agrimoniae extract 9% with vaseline 70% and lanolin 21% to obtain Chinese medicinal paste.
Example 6:
for 9 cases of internal hemorrhoid patients, the hemorrhoid treatment (ointment) obtained in example 2 was applied by pushing the ointment into the anus, and the ointment was allowed to act directly on the internal hemorrhoid twice a day. Clinical symptoms of hemorrhoids were significantly improved in 9 patients within three days, wherein inflammatory exudation at the anal orifice and pruritus ani around the anus were observed in all of the 9 patients before treatment, and exudation and pruritus were substantially completely eliminated after three days. In 7 cases, the hematochezia is existed, and the hematochezia symptom is also obviously improved after 5 days of treatment by using the ointment. After 1-2 weeks of treatment with the ointment, symptoms such as anal and oral inflammatory exudation, pruritus ani, hemorrhage, pain, swelling, etc. basically disappear completely. The ointment can be used for 1-2 weeks to completely cure the disease. Five patients with internal anal prolapse had no hemorrhoid prolapse after two weeks of treatment.
Example 7:
Wu-Zhi, male 60 years old suffered from mixed hemorrhoids for more than 20 years, and the disease became serious in the early 2018. The anus has obvious inflammatory exudation, the skin around the anus has eczema-like appearance and is itchy, bleeding and the inside of the anus often appears with swelling and prolapse in defecation. The patient firstly takes the oral traditional Chinese medicine preparation containing the alexandrium vulgare active extract for treating the hemorrhoids orally, basically exudation, pruritus and hemorrhage disappear after one week, and the symptom of the prolapse of the tumor appearing in the anus completely disappears. Then, the hemorrhoid traditional Chinese medicine preparation (ointment) obtained in the embodiment 2 is used twice a day, after 2 weeks, the anus protrusion part (external hemorrhoid bulge) is found to be completely retracted and disappeared, and symptoms such as hematochezia, pain, swelling and the like are also completely disappeared, so that the hemorrhoid does not relapse until now (after 2 years).
Example 8:
according to the specific formula, a male with hemorrhoid at the age of 56 years old for more than 10 years is suffered, bleeding, swelling, exudation around the anus, pruritus and pain are difficult to endure each attack, and the hemorrhoid is recurred in 4 months in 2020, and the hemorrhoid is separated from the anus and cannot retract automatically. No obvious effect is seen by adopting various treatment schemes. After the hemorrhoid Chinese medicinal preparation (ointment) obtained in the embodiment 2 is used for treating the hemorrhoid for three days, the symptoms such as bleeding, pain, swelling, perianal exudation and the like are remarkably relieved for one week, and the prolapse of the internal anal tumor is completely disappeared. After about four weeks of treatment, the patient feels completely cured and recurs to the end.
Example 9:
a female, 36 years old, suffers from mixed hemorrhoid during pregnancy, and has been treated with the paste for about 6 years. In the meantime, bleeding and swelling of the anus, exudation around the anus, itching and pain are often observed during defecation. The hemorrhoids with skin covered on the surface can be seen or touched outside the anus, and can not be sent into the anus, and the anus feels foreign body and falls and rises. The disease recurs in 3 months in 2020, and symptoms such as anal bleeding, swelling, perianal exudation and pruritus are caused. When the anus is forcibly defecated, the hemorrhoids with tumors are separated from the anus and can not retract automatically, the wrinkled wall of the skin at the anal margin is protruded like a water bubble, and no obvious effect is seen after the anus is treated by various medicaments. The clinical symptoms of the hemorrhoids are found by taking the blue-cloth positive active part orally for a week: pain, bleeding, swelling, feeling of anal tenesmus, pruritus ani perianal exudation, etc. are all remarkably relieved. After the hemorrhoid traditional Chinese medicine preparation (ointment) obtained in the embodiment 2 is added for treating one week, the internal swelling in anus is completely removed during defecation, and other symptoms such as bleeding, pain, swelling, perianal exudation and the like are basically completely removed. After about six weeks of treatment, the patient feels completely cured, even the external hemorrhoid core covering the skin beside the anus retracts into the anus, and the external hemorrhoid core recurs at present.
Claims (7)
1. A medicine for preventing and treating hemorrhoid is characterized by comprising one or more of herba Gei extract, herba Rabdosiae Glaucocalycis extract and herba et Gemma Agrimoniae extract.
2. The drug for the prevention and treatment of hemorrhoids as claimed in claim 1, wherein said aleppo avens extract, said rabdosia rubescens extract and said agrimony extract are alcohol extracts of the corresponding raw materials.
3. The agent for the prevention and treatment of hemorrhoids as claimed in claim 1, wherein said agent comprises 0.01% to 99.99% by weight of said extract.
4. A medicament for the prevention and treatment of hemorrhoids as claimed in any of claims 1 to 3, further comprising pharmaceutically acceptable carriers and/or adjuvants.
5. Use of herba Gei aleppici extract, herba Rabdosiae Glaucocalycis extract and/or herba et Gemma Agrimoniae extract in preparing medicine for preventing and treating hemorrhoid is provided.
6. The use of claim 5, wherein the Echinacea purpurea extract, the Rabdosia rubescens extract and the Agrimonia pilosa extract are alcohol extracts of the corresponding raw materials.
7. The use according to claim 5, wherein said hemorrhoids include: internal hemorrhoid, mixed hemorrhoid, external hemorrhoid, anal cryptitis, anal fissure, anal carbuncle, anal fistula, rectocele or hemorrhoid complications.
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| CN202010685230.1A CN111643556A (en) | 2020-07-16 | 2020-07-16 | Medicine for preventing and treating hemorrhoids and application thereof |
| PCT/CN2020/125117 WO2022011881A1 (en) | 2020-07-16 | 2020-10-30 | Medication for preventing and treating hemorrhoids and use thereof |
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| WO2022011881A1 (en) * | 2020-07-16 | 2022-01-20 | 杭州科倍安生物制药有限公司 | Medication for preventing and treating hemorrhoids and use thereof |
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Application publication date: 20200911 |