CN111630387A - 用于检测先兆子痫相关生物标志物的方法和装置 - Google Patents

用于检测先兆子痫相关生物标志物的方法和装置 Download PDF

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CN111630387A
CN111630387A CN201880071852.6A CN201880071852A CN111630387A CN 111630387 A CN111630387 A CN 111630387A CN 201880071852 A CN201880071852 A CN 201880071852A CN 111630387 A CN111630387 A CN 111630387A
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biomarker
determining
level
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biomarkers
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卡洛斯·西蒙
苏珊·费希尔
塔玛拉·加里多
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Aquinomi
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/626—Detection means characterised by use of a special device being a flow cytometer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4745—Insulin-like growth factor binding protein
    • G—PHYSICS
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5756—Prolactin
    • G—PHYSICS
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90203—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

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  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201880071852.6A 2017-09-05 2018-09-05 用于检测先兆子痫相关生物标志物的方法和装置 Pending CN111630387A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762554471P 2017-09-05 2017-09-05
US62/554,471 2017-09-05
PCT/IB2018/001117 WO2019048927A2 (en) 2017-09-05 2018-09-05 METHODS AND DEVICES FOR DETECTION OF BIOMARKERS ASSOCIATED WITH PRECLAMPSIA

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CN111630387A true CN111630387A (zh) 2020-09-04

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US (1) US20200271660A1 (enExample)
EP (1) EP3679380A2 (enExample)
JP (1) JP2020532745A (enExample)
CN (1) CN111630387A (enExample)
BR (1) BR112020004390A2 (enExample)
CA (1) CA3074808A1 (enExample)
MA (1) MA50123A (enExample)
WO (1) WO2019048927A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114350805A (zh) * 2022-01-14 2022-04-15 中国人民解放军陆军军医大学第一附属医院 Ablim1作为胶质瘤分子标志物的应用
CN114822682A (zh) * 2022-04-12 2022-07-29 苏州市立医院 一种与早发型重度子痫前期发生相关的靶标基因组合及其应用
CN117192096A (zh) * 2023-09-18 2023-12-08 上海交通大学医学院附属仁济医院 靶向抑制羊膜adamts4的化合物在制备筛选早产防治的药物中的用途
CN118275677A (zh) * 2024-06-03 2024-07-02 山东大学 检测erap2的试剂在制备预测poi预后情况的产品中的应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11401552B2 (en) 2015-08-06 2022-08-02 University Of Utah Research Foundation Methods of identifying male fertility status and embryo quality
CN114599800A (zh) * 2019-08-15 2022-06-07 华盛顿州立大学 不育症诊断方法和试剂盒
CN110794136A (zh) * 2019-11-26 2020-02-14 中国人民武装警察部队特色医学中心 长链脂肪酸辅酶a连接酶1在诊断或预测子痫前期中的应用
KR102302742B1 (ko) * 2019-12-31 2021-09-15 의료법인 성광의료재단 임신중독증 진단용 바이오마커 조성물 및 이의 용도
EP4165416A1 (en) * 2020-06-10 2023-04-19 Board of Regents, The University of Texas System Method for determining risk of pre-term birth
EP4232823A1 (en) * 2020-10-26 2023-08-30 Institut National de la Santé et de la Recherche Médicale Combination of biomarkers of preterm delivery
CN112630436A (zh) * 2021-01-25 2021-04-09 安士(广州)医疗科技有限公司 一种定量检测tex101浓度的荧光试剂条的制备方法及其应用
WO2022171318A1 (en) * 2021-02-12 2022-08-18 Ipremom Pregnancy Healthcare Diagnostics, S.L. In vitro method for determining the risk of suffering from preeclampsia
CN113406326B (zh) * 2021-06-01 2022-08-26 大连医科大学 一种用于预测子痫前期的生物学标志物及其应用
EP4347886A1 (en) 2021-06-03 2024-04-10 Inherent Biosciences, Inc. Dna methylation analysis to identify cell type
WO2022255401A1 (ja) * 2021-06-03 2022-12-08 国立大学法人 東京大学 Ｅｒｋ－ｍａｐｋ経路の異常な活性化に伴い発現する疾患マーカー
CN115044669B (zh) * 2022-06-27 2023-05-16 山东第一医科大学附属省立医院(山东省立医院) 一种血浆lncRNA检测试剂盒及其应用
CN115873943B (zh) * 2023-02-13 2024-03-29 山东大学 骨形态发生蛋白2在子痫前期诊断、预防和治疗中的应用
KR20250079482A (ko) * 2023-11-27 2025-06-04 의료법인 성광의료재단 임신 초기 임신중독증 예측 및 진단을 위한 질환 특이적인 바이오마커 및 그의 용도
KR20250079483A (ko) * 2023-11-27 2025-06-04 의료법인 성광의료재단 임신 중기 임신중독증 예측 및 진단을 위한 질환 특이적인 바이오마커 및 그의 용도

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178605A1 (en) * 2006-02-02 2007-08-02 Yale University Pregnancy biomarker profiles, methods and compositions related thereto
US20100035284A1 (en) * 2005-10-27 2010-02-11 Yale Univeristy Urinary Proteomic Biomarker Patterns in Preeclampsia
US20110171650A1 (en) * 2008-09-16 2011-07-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Gene expression related to preeclampsia
US20150031616A1 (en) * 2013-07-25 2015-01-29 University Of Florida Research Foundation, Inc. Use of relaxin to treat placental syndromes
CN104704364A (zh) * 2012-06-15 2015-06-10 韦恩州立大学 用于先兆子痫和/或hellp综合征的预测或早期检测的生物标记物测试
CN106662589A (zh) * 2014-03-21 2017-05-10 艾基诺米公司 先兆子痫的早期检测

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100035284A1 (en) * 2005-10-27 2010-02-11 Yale Univeristy Urinary Proteomic Biomarker Patterns in Preeclampsia
US20070178605A1 (en) * 2006-02-02 2007-08-02 Yale University Pregnancy biomarker profiles, methods and compositions related thereto
US20110171650A1 (en) * 2008-09-16 2011-07-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Gene expression related to preeclampsia
CN104704364A (zh) * 2012-06-15 2015-06-10 韦恩州立大学 用于先兆子痫和/或hellp综合征的预测或早期检测的生物标记物测试
US20150031616A1 (en) * 2013-07-25 2015-01-29 University Of Florida Research Foundation, Inc. Use of relaxin to treat placental syndromes
CN106662589A (zh) * 2014-03-21 2017-05-10 艾基诺米公司 先兆子痫的早期检测

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114350805A (zh) * 2022-01-14 2022-04-15 中国人民解放军陆军军医大学第一附属医院 Ablim1作为胶质瘤分子标志物的应用
CN114822682A (zh) * 2022-04-12 2022-07-29 苏州市立医院 一种与早发型重度子痫前期发生相关的靶标基因组合及其应用
CN117192096A (zh) * 2023-09-18 2023-12-08 上海交通大学医学院附属仁济医院 靶向抑制羊膜adamts4的化合物在制备筛选早产防治的药物中的用途
CN118275677A (zh) * 2024-06-03 2024-07-02 山东大学 检测erap2的试剂在制备预测poi预后情况的产品中的应用
CN118275677B (zh) * 2024-06-03 2024-08-09 山东大学 检测erap2的试剂在制备预测poi预后情况的产品中的应用

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JP2020532745A (ja) 2020-11-12
CA3074808A1 (en) 2019-03-14
MA50123A (fr) 2020-07-15
WO2019048927A2 (en) 2019-03-14
EP3679380A2 (en) 2020-07-15
BR112020004390A2 (pt) 2020-09-08
WO2019048927A3 (en) 2019-04-18
US20200271660A1 (en) 2020-08-27

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