BR112020004390A2 - métodos e dispositivos para detecção de biomarcadores associados com pré-eclâmpsia - Google Patents

métodos e dispositivos para detecção de biomarcadores associados com pré-eclâmpsia Download PDF

Info

Publication number
BR112020004390A2
BR112020004390A2 BR112020004390-7A BR112020004390A BR112020004390A2 BR 112020004390 A2 BR112020004390 A2 BR 112020004390A2 BR 112020004390 A BR112020004390 A BR 112020004390A BR 112020004390 A2 BR112020004390 A2 BR 112020004390A2
Authority
BR
Brazil
Prior art keywords
level
fact
biomarker
determining
group
Prior art date
Application number
BR112020004390-7A
Other languages
English (en)
Portuguese (pt)
Inventor
Carlos Simon
Susan Fisher
Tamara Garrido
Original Assignee
Igenomix S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igenomix S.L. filed Critical Igenomix S.L.
Publication of BR112020004390A2 publication Critical patent/BR112020004390A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/113—Real time assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/626—Detection means characterised by use of a special device being a flow cytometer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4745—Insulin-like growth factor binding protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5756—Prolactin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90203—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BR112020004390-7A 2017-09-05 2018-09-05 métodos e dispositivos para detecção de biomarcadores associados com pré-eclâmpsia BR112020004390A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762554471P 2017-09-05 2017-09-05
US62/554,471 2017-09-05
PCT/IB2018/001117 WO2019048927A2 (en) 2017-09-05 2018-09-05 METHODS AND DEVICES FOR DETECTION OF BIOMARKERS ASSOCIATED WITH PRECLAMPSIA

Publications (1)

Publication Number Publication Date
BR112020004390A2 true BR112020004390A2 (pt) 2020-09-08

Family

ID=64184119

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020004390-7A BR112020004390A2 (pt) 2017-09-05 2018-09-05 métodos e dispositivos para detecção de biomarcadores associados com pré-eclâmpsia

Country Status (8)

Country Link
US (1) US20200271660A1 (enExample)
EP (1) EP3679380A2 (enExample)
JP (1) JP2020532745A (enExample)
CN (1) CN111630387A (enExample)
BR (1) BR112020004390A2 (enExample)
CA (1) CA3074808A1 (enExample)
MA (1) MA50123A (enExample)
WO (1) WO2019048927A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11401552B2 (en) 2015-08-06 2022-08-02 University Of Utah Research Foundation Methods of identifying male fertility status and embryo quality
CN114599800A (zh) * 2019-08-15 2022-06-07 华盛顿州立大学 不育症诊断方法和试剂盒
CN110794136A (zh) * 2019-11-26 2020-02-14 中国人民武装警察部队特色医学中心 长链脂肪酸辅酶a连接酶1在诊断或预测子痫前期中的应用
KR102302742B1 (ko) * 2019-12-31 2021-09-15 의료법인 성광의료재단 임신중독증 진단용 바이오마커 조성물 및 이의 용도
EP4165416A1 (en) * 2020-06-10 2023-04-19 Board of Regents, The University of Texas System Method for determining risk of pre-term birth
EP4232823A1 (en) * 2020-10-26 2023-08-30 Institut National de la Santé et de la Recherche Médicale Combination of biomarkers of preterm delivery
CN112630436A (zh) * 2021-01-25 2021-04-09 安士(广州)医疗科技有限公司 一种定量检测tex101浓度的荧光试剂条的制备方法及其应用
WO2022171318A1 (en) * 2021-02-12 2022-08-18 Ipremom Pregnancy Healthcare Diagnostics, S.L. In vitro method for determining the risk of suffering from preeclampsia
CN113406326B (zh) * 2021-06-01 2022-08-26 大连医科大学 一种用于预测子痫前期的生物学标志物及其应用
EP4347886A1 (en) 2021-06-03 2024-04-10 Inherent Biosciences, Inc. Dna methylation analysis to identify cell type
WO2022255401A1 (ja) * 2021-06-03 2022-12-08 国立大学法人 東京大学 Ｅｒｋ－ｍａｐｋ経路の異常な活性化に伴い発現する疾患マーカー
CN114350805A (zh) * 2022-01-14 2022-04-15 中国人民解放军陆军军医大学第一附属医院 Ablim1作为胶质瘤分子标志物的应用
CN114822682B (zh) * 2022-04-12 2023-07-21 苏州市立医院 与早发型重度子痫前期发生相关的基因组合及其应用
CN115044669B (zh) * 2022-06-27 2023-05-16 山东第一医科大学附属省立医院(山东省立医院) 一种血浆lncRNA检测试剂盒及其应用
CN115873943B (zh) * 2023-02-13 2024-03-29 山东大学 骨形态发生蛋白2在子痫前期诊断、预防和治疗中的应用
CN117192096A (zh) * 2023-09-18 2023-12-08 上海交通大学医学院附属仁济医院 靶向抑制羊膜adamts4的化合物在制备筛选早产防治的药物中的用途
KR20250079482A (ko) * 2023-11-27 2025-06-04 의료법인 성광의료재단 임신 초기 임신중독증 예측 및 진단을 위한 질환 특이적인 바이오마커 및 그의 용도
KR20250079483A (ko) * 2023-11-27 2025-06-04 의료법인 성광의료재단 임신 중기 임신중독증 예측 및 진단을 위한 질환 특이적인 바이오마커 및 그의 용도
CN118275677B (zh) * 2024-06-03 2024-08-09 山东大学 检测erap2的试剂在制备预测poi预后情况的产品中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1946121A2 (en) * 2005-10-27 2008-07-23 Yale University, Inc. Urinary proteomic biomarker patterns in preeclampsia
US7790463B2 (en) * 2006-02-02 2010-09-07 Yale University Methods of determining whether a pregnant woman is at risk of developing preeclampsia
US20110171650A1 (en) * 2008-09-16 2011-07-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Gene expression related to preeclampsia
CN104704364B (zh) * 2012-06-15 2018-12-04 韦恩州立大学 用于先兆子痫和/或hellp综合征的预测或早期检测的生物标记物测试
US9907833B2 (en) * 2013-07-25 2018-03-06 University Of Florida Research Foundation, Incorporated Use of relaxin to treat placental syndromes
US20170097358A1 (en) * 2014-03-21 2017-04-06 Igenomix S.L. Early detection of preeclampsia

Also Published As

Publication number Publication date
JP2020532745A (ja) 2020-11-12
CA3074808A1 (en) 2019-03-14
MA50123A (fr) 2020-07-15
WO2019048927A2 (en) 2019-03-14
EP3679380A2 (en) 2020-07-15
CN111630387A (zh) 2020-09-04
WO2019048927A3 (en) 2019-04-18
US20200271660A1 (en) 2020-08-27

Similar Documents

Publication Publication Date Title
BR112020004390A2 (pt) métodos e dispositivos para detecção de biomarcadores associados com pré-eclâmpsia
CN105886659A (zh) Dstn基因及其表达产物作为子宫内膜癌的诊治靶标
CN105368975B (zh) 颅内动脉瘤标志物odam及其应用
CN109952511B (zh) 用于确定先兆子痫的风险的测定方法
CN106191283B (zh) 多发性骨髓瘤生物标志物的诊治产品
Chen et al. Upregulated CXCL8 in placenta accreta spectruma regulates the migration and invasion of HTR-8/SVneo cells
CN106222259B (zh) 一种诊治多发性骨髓瘤的分子标志物
CN105886660A (zh) Uhrf1作为子宫内膜癌诊治标志物的用途
CN106011260B (zh) 一种诊治子宫内膜癌的分子标志物
CN106011288B (zh) 多发性骨髓瘤诊治标志物及其应用
CN106244705B (zh) Erc1在制备诊断或治疗下咽癌工具中的应用
US20220268780A1 (en) Methods of predicting endometrial receptivity
CN106011291B (zh) 一种诊治下咽癌的分子标志物
CN106119358B (zh) 子宫内膜癌生物标志物的诊治产品
US20140113288A1 (en) Methods of identifying risk of preeclampsia and pregnancy-related disorders
CN106119399B (zh) Znf385c作为下咽癌诊治标志物的用途
CN106381329B (zh) C18orf8基因及其表达产物作为下咽癌的诊治靶标
CN106148531A (zh) 下咽癌生物标志物
CN106119400B (zh) C2cd4c在制备诊治下咽癌产品中的应用
Bausyte et al. A bridge between infertility and anxiety: a novel role for genes
CN106048031B (zh) Synm在制备诊断或治疗子宫内膜癌工具中的应用
CN106011286B (zh) 下咽癌诊治标志物及其应用
CN106011290A (zh) Rpl8在制备诊断或治疗多发性骨髓瘤工具中的应用

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2738 DE 27-06-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.