CN111629741A - 用于痤疮的透明皮肤补充剂和药物组合物 - Google Patents

用于痤疮的透明皮肤补充剂和药物组合物 Download PDF

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CN111629741A
CN111629741A CN201880087140.3A CN201880087140A CN111629741A CN 111629741 A CN111629741 A CN 111629741A CN 201880087140 A CN201880087140 A CN 201880087140A CN 111629741 A CN111629741 A CN 111629741A
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supplement
acne
extractor
mixture
water
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V·谭
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Vt Cm Ltd
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Vt Cm Ltd
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Abstract

本发明公开了一种用于痤疮的透明皮肤补充剂/医药组分，其包括：口服施用的剂量，所述剂量包括约3000至9000mg之间的中药组合物，所述中药组合物按比例包括：各约3.8‑7.6％的桃、红花、白芷、皂荚、紫花地丁、牡丹和栀子；各约5.7‑7.6％的白花蛇舌草和黄芩；约3.8‑5.7％的丹参；约2.5‑5.7％的黄檗；约2.5‑7.6％的龙胆；和各约0‑7.6％的蒲公英，以及忍冬/黄连/苦参的任一种。

Description

用于痤疮的透明皮肤补充剂和药物组合物
相关申请
本发明要求于2017年12月20日提交的、澳大利亚临时专利申请号为2017905083的优先权，其全部内容通过引用合并于此。
技术领域
本发明总体上涉及一种食品补充剂和药物组合物，所述食品补充剂和药物组合物使用天然存在的成分作为口服治疗方法的一部分，用于增强与皮肤病症(例如痤疮和皮肤炎症)相关的皮肤健康，以及制备这种补充剂应用的方法。
背景技术
在西方文明中，诸如痤疮和其他与皮肤相关的病症的治疗主要集中在清洁皮肤和应用药物治疗，例如局部用药膏和凝胶剂，其集中于疏通堵塞的毛孔。这些治疗的失败通常导致这种局部治疗与口服抗生素相结合，所述口服抗生素起着杀死在阻塞的毛孔周围引起炎症的细菌的作用。
通常，这种治疗在治疗轻微的皮肤炎症和与青少年(其可能由于荷尔蒙水平变化和产油量增加而出现皮肤问题)有关的病症上，已取得了一定的成功。但是，此类治疗可能会有副作用，并且这种两步治疗可能并非对所有患者都成功。因此，对于那些患有更严重的痤疮或皮肤炎症的患者，可能会在寻找成功的治疗方法中感到沮丧，所述治疗方法可以采用激光或光治疗来减少炎症并攻击引起痤疮的细菌。这种治疗可能是耗时且昂贵的，同时具有不同程度的成功。
在东方文明中，有一种历史性的方法，通过使用天然存在的产品和补益剂，以解决各种健康状况。包括天然的动物和植物在内的传统中药材料，长期以来一直以补充剂的形式用于解决各种病症，包括皮肤病，并取得了持续的成功。但是，这种原材料的加工和制备以供使用的方式长期以来一直阻止着西方文明对这种治疗方法的接受。因此，需要提供一种传统中国补充剂组合物，其具有简单的配方，以及方便的工艺，用于制备组合物以供使用。
以上对先前提议或产品的引用和描述，并不旨在且不应解释为对本领域公知常识的陈述或承认。特别地，以下现有技术的讨论与本领域技术人员所公知或众所周知的内容无关，而是有助于理解本发明的创造性，其中对相关现有技术提议的识别只是其中一部分。
发明内容
根据第一方面，提供了一种透明皮肤补充剂，供患有皮肤病的个体食用，所述补充剂包括约3000-9000 mg的中药组合物，所述中药组合物按比例包括：各约3.8-7.6％的桃(Prunus persica)、红花(Carthamus tinctorius)、白芷(Angelica dahurica)、皂荚(Gleditsia sinensis)、紫花地丁(Viola yedoensis)、牡丹(Paeonia suffruticosa)和栀子(gardenia jasminoides)；各约5.7-7.6％的白花蛇舌草(Oldenlandia diffusa)和黄芩(Scutellaria baicalensis)；约3.8-5.7％的丹参(Salvia miltiorrhizai)；约2.5-5.7％的黄檗(Phellodendron amurense)；约2.5-7.6％的龙胆(Gentiana scabra)；和各约0-7.6％的蒲公英(Taraxacum mongolicum)，以及忍冬(Lonicera japonica)/黄连(RhizomaCoptidas)/苦参(Sophora flavescens)的任一种。
在第一方面的一个实施方案中，所述补充剂还按比例包括：各在0-3.8％之间的姜(Zingiber officinale)和甘草(Glycyrrhiza uralensis)；和0-5.7％的拐芹(Angelicapolymorpha)。
根据另一方面，提供了一种透明皮肤补充剂，所述补充剂按比例包括：各约3.8-7.6％的桃、红花、白芷、皂荚、紫花地丁、牡丹和栀子；各约5.7-7.6％的白花蛇舌草和黄芩；约3.8-5.7％的丹参；约2.5-5.7％的黄檗；约2.5％-7.6％的龙胆；和各约0-7.6％的蒲公英和忍冬。
根据又一方面，提供了一种治疗皮肤炎症病症的方法，所述方法包括：向患有皮肤炎症的患者口服施用每日剂量的透明皮肤补充剂，其中所述每日剂量以约750mg的补充剂的片剂施用，所述片剂包括：按重量计，各2-3％的桃、红花、丹参、牡丹、龙胆和黄芩；各4-5％的白花蛇舌草、全草(Herba)、白芷、皂荚、棘刺(Spina)、紫花地丁、全草、蒲公英、全草、忍冬；2.3-3.5％的黄檗；和1.5-2.5％的栀子。
在这一方面的一个实施方案中，补充剂组合物还可以包括：按重量计，各0-2％的姜、拐芹和甘草。
根据另一方面，公开了一种补充剂组合物，所述补充剂组合物大约包括：按重量计，各2-3％的桃、红花、丹参、牡丹、龙胆和黄芩；各4-5％的白花蛇舌草、全草、白芷、皂荚、棘刺、紫花地丁、全草、蒲公英、全草、忍冬；2.3-3.5％的黄檗；和1.5-2.5％的栀子。
具体实施方式
下面将参考优选的实施方案，更详细地描述本发明。
在优选的形式中，本发明的透明皮肤补充剂以片剂或胶囊剂形式提供，用于具有皮肤炎病症(例如痤疮)的个体口服摄取。所述片剂可以是未包衣的，但是在某些情况下，可以将例如肠溶衣的包衣施加到该片剂上，以控制其中所含的活性成分的递送和摄取。但是，在可选的实施方案中，本发明可以以粉末或原料形式提供成分，从而可以将它们口服地摄取或局部地施加至正经受炎症的皮肤表面，以解决这种炎症。
本发明的主要成分以及该成分的来源植物部分列于表1中。
上述每种成分均具有不同的中医属性，以应对各种与皮肤相关的病症。例如，桃、红花和丹参已知能增加血液循环和治疗血瘀。白花蛇舌草也已知可用于降低热量和毒性水平以及打破血瘀，例如还有紫花地丁、蒲公英、忍冬、黄檗、牡丹、栀子。白芷和皂荚也已知它们在减少皮肤肿胀和脓肿的用途。
姜、拐芹和甘草都是次要成分，并且已知它们具有与其他成分协同工作以增强它们功效的能力。
表1
对于忍冬，根据可获得性，该成分可以用更容易获得的成分(如黄连或苦参)代替。
在该实施方案中，马铃薯淀粉用作辅料或载体，将以片剂形式的成分结合在一起。
AHN 植物部分
桃 核仁
红花 花
丹参 根
白花蛇舌草，全草 植株
白芷 根
皂荚，棘刺 棘刺
紫花地丁，全草 植株
蒲公英，全草 植株
忍冬 花
黄檗 树皮
牡丹 根皮
栀子 果实
龙胆 根
黄芩 根
姜 根茎
拐芹 根
甘草 根
淀粉马铃薯
表2描述了每750mg片剂中每种成分的比例。
Figure BDA0002592815550000031
Figure BDA0002592815550000041
表2
为了制备片剂，将上述每种原料装入萃取器中，并加入水，水的量多达混合原料重量的十倍。构成原始混合物的原料比例在表3中显示。然后将混合物浸泡一小时，然后将其在100℃下煮沸。所述混合物在该温度下保持约1个小时，然后将液体提取到专用的储罐中，并根据上述体积将提取器重新装满水，并重复提取过程。
Figure BDA0002592815550000042
Figure BDA0002592815550000051
表3
然后将提取的液体送入浓缩器，在浓缩器中将所述液体在40％至60％保持2小时，直到水含量降低至约35-60％，以及该液体具有糊状物的稠度。然后将该浓缩的糊状物冷藏。
所述载体，在该实施方案中，马铃薯淀粉添加到制粒机中，并将浓缩的糊状物喷入制粒机中，制粒机中的温度设定在约55-65℃。出于质量控制的目的，可以对在此过程中生产的颗粒进行分析，然后将颗粒与其他辅料(例如硬脂酸镁)混合，然后制成片剂。然后将所述片剂包装在瓶子中进行分配。
本发明的组合物的成分是基于以下知识确定的：痤疮主要是由皮肤中的热量、血瘀、毒性和炎症引起的。上面提到的主要成分已被选择来解决这些问题中的每一个，以减少炎症和增加血液循环和血液流量，以及保持健康的皮肤温度，避免毒素积聚。
仅在与专家进行初步咨询后，才可以将本发明的片剂推荐给患者。在某些情况下，可能需要增加成分的百分比，以解决咨询过程中发现的特定问题。然而，还可以设想，可以在零售店等中提供所述片剂用于购买，而无需初步咨询。
在整个说明书和权利要求书中，“包括”一词及其派生词旨在具有包容性而非排他性含义，除非明确指出相反或上下文另外要求。就是说，“包括”一词及其派生词将被用来表示不仅包括其直接引用的列出的组成、步骤或特征，而且还包括未明确列出的其他组成、步骤或特征，除非明确地指出相反或上下文另外要求。
本领域技术人员将理解，可以对本文描述的本发明的方法进行许多修改和变型而无需脱离本发明的精神和范围。

Claims (4)

1.一种用于痤疮的透明皮肤补充剂/医药组分，其包括：口服施用的剂量，所述剂量包括约3000至9000mg之间的中药组合物，所述中药组合物按比例包括：各约3.8-7.6％的桃、红花、白芷、皂荚、紫花地丁、牡丹和栀子；各约5.7-7.6％的白花蛇舌草和黄芩；约3.8-5.7％的丹参；约2.5-5.7％的黄檗；约2.5-7.6％的龙胆；和各约0-7.6％的蒲公英，以及忍冬/黄连/苦参的任一种。
2.根据权利要求1所述的补充剂，其中所述中药组合物还按比例包括：各在0-3.8％之间的姜和甘草；和0-5.7％的拐芹。
3.权利要求1或2所述补充剂的施用方法，其中所述补充剂以片剂形式提供，并且所述片剂被使用者摄取。
4.一种用于治疗痤疮的或形成透明皮肤补充剂/医药组分的方法，其包括根据权利要求1和2所述的方法或形成补充剂，其包括：
将原料装入萃取器；
向萃取器中加入水，水的量多达混合原料重量的十倍；
在萃取器内混合原料和水的混合物；
将所述混合物浸泡一段预定的时间；
将所述混合物在约100℃下煮沸，并在约100℃下将混合物保持约1个小时；
将剩余的液体提取到专用的储罐中；
向萃取器中再次注满多达混合原料重量的十倍的水，并重复混合、浸泡、煮沸和提取步骤；
将提取的液体送入浓缩器中，在所述浓缩器中将液体在40-60℃保持约2个小时，直到水含量降低至约35-60％，以及该液体具有糊状物的稠度；
从所述浓缩器中除去糊状物并冷藏糊状物；
将载体加入制粒机中；
在约55-65℃的温度下用浓缩的糊状物喷洒制粒机以形成颗粒；和
将颗粒与其他辅料混合以形成片剂。
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