CN111615393B - 人参皂苷m1用于制造供治疗口腔癌的药物的用途 - Google Patents

人参皂苷m1用于制造供治疗口腔癌的药物的用途 Download PDF

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CN111615393B
CN111615393B CN201980007031.0A CN201980007031A CN111615393B CN 111615393 B CN111615393 B CN 111615393B CN 201980007031 A CN201980007031 A CN 201980007031A CN 111615393 B CN111615393 B CN 111615393B
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ginsenoside
cells
oral cancer
oral
cancer cells
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CN111615393A (zh
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理筱龙
花国峰
理昱杰
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Liu Wentao
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201980007031.0A 2018-04-17 2019-04-17 人参皂苷m1用于制造供治疗口腔癌的药物的用途 Active CN111615393B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862658732P 2018-04-17 2018-04-17
US62/658,732 2018-04-17
PCT/CN2019/083058 WO2019201280A1 (en) 2018-04-17 2019-04-17 Use of ginsenoside m1 for manufacturing medicament for treating oral cancer

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Publication Number Publication Date
CN111615393A CN111615393A (zh) 2020-09-01
CN111615393B true CN111615393B (zh) 2023-10-10

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Country Status (9)

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US (1) US11524021B2 (https=)
EP (1) EP3668519B1 (https=)
JP (1) JP7307732B2 (https=)
KR (1) KR102709520B1 (https=)
CN (1) CN111615393B (https=)
DK (1) DK3668519T3 (https=)
ES (1) ES2889404T3 (https=)
TW (1) TWI820118B (https=)
WO (1) WO2019201280A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4153072A4 (en) * 2020-05-18 2024-05-22 ChemImage Corporation Systems and methods for detecting oral cancer using molecular chemical imaging
CN115300624A (zh) * 2022-07-08 2022-11-08 中国医学科学院药用植物研究所 人参皂苷联合pd-1阻断剂在制备抗头颈鳞癌药物中的应用
KR20250057225A (ko) 2023-10-19 2025-04-29 단국대학교 천안캠퍼스 산학협력단 차가버섯 추출물을 포함하는 구강암 예방 또는 치료용 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034963A1 (en) * 2003-10-15 2005-04-21 Panagin Pharmaceuticals Inc. USE OF GINSENOSIDES Rh2 & Rg3, AND AGLYCON GINSENOSIDES FOR THE PREVENTION OF CANCER
CN103694297A (zh) * 2013-11-19 2014-04-02 大连杰信生物科技有限公司 提高人参皂苷m1与癸酰氯单酯化选择性的合成方法
CN107635564A (zh) * 2015-03-17 2018-01-26 汇德生物科技股份有限公司 人参皂苷m1用于预防或治疗硅肺病的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59181217A (ja) * 1983-03-30 1984-10-15 Rooto Seiyaku Kk ダンマラン系化合物を含有する抗癌剤組成物
US20030185910A1 (en) * 2002-02-08 2003-10-02 Taik Koo Yun Cancer preventive composition comprising ginsenoside glycosides of red ginseng
EP3137089B1 (en) * 2014-05-02 2018-10-10 Sheau-Long Lee Use of ginsenoside m1 for treating lupus nephritis
KR101722547B1 (ko) * 2015-05-22 2017-04-04 한국과학기술원 파낙사디올류 진세노사이드 화합물을 포함하는 항암보조제
CN106236761A (zh) * 2016-07-27 2016-12-21 陕西巨子生物技术有限公司 一种包含稀有人参皂苷c‑k的稀有人参皂苷组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034963A1 (en) * 2003-10-15 2005-04-21 Panagin Pharmaceuticals Inc. USE OF GINSENOSIDES Rh2 & Rg3, AND AGLYCON GINSENOSIDES FOR THE PREVENTION OF CANCER
CN103694297A (zh) * 2013-11-19 2014-04-02 大连杰信生物科技有限公司 提高人参皂苷m1与癸酰氯单酯化选择性的合成方法
CN107635564A (zh) * 2015-03-17 2018-01-26 汇德生物科技股份有限公司 人参皂苷m1用于预防或治疗硅肺病的用途

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites;Xiao-Jia Chen等;《Evidence-Based Complementary Alternative Medicine》;20160630;第2016卷;文献号5738694，第1-19页 *
人参皂苷CK抗肿瘤活性研究进展;邓晶等;《现代肿瘤医学》;20091125;第17卷(第11期);第2234-2236页，参见全文，尤其是第2235-2236页 *
人参皂苷Rh-2抑制口腔鳞癌细胞增殖、侵袭及转移的研究;宁静;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20120915;E072-558，全文，尤其是摘要 *
人参皂苷Rh2诱导口腔鳞癌耐药细胞凋亡;徐亚娟等;《中国老年学杂志》;20170825;第37卷(第16期);第3956-3958页 *
宁静.人参皂苷Rh-2抑制口腔鳞癌细胞增殖、侵袭及转移的研究.《中国优秀硕士学位论文全文数据库 医药卫生科技辑》.2012,E072-558. *
邓晶等.人参皂苷CK抗肿瘤活性研究进展.《现代肿瘤医学》.2009,第17卷(第11期),第2234-2236页，参见全文，尤其是第2235-2236页. *

Also Published As

Publication number Publication date
KR102709520B1 (ko) 2024-09-25
ES2889404T3 (es) 2022-01-12
US20210023104A1 (en) 2021-01-28
US11524021B2 (en) 2022-12-13
CN111615393A (zh) 2020-09-01
WO2019201280A1 (en) 2019-10-24
JP7307732B2 (ja) 2023-07-12
EP3668519A4 (en) 2020-10-14
TW202002987A (zh) 2020-01-16
TWI820118B (zh) 2023-11-01
KR20200143668A (ko) 2020-12-24
EP3668519B1 (en) 2021-06-16
DK3668519T3 (da) 2021-08-23
JP2021517886A (ja) 2021-07-29
EP3668519A1 (en) 2020-06-24

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