CN111603517A - Application of rhizoma Phragmitis in preparing medicine for relieving cough and eliminating phlegm - Google Patents
Application of rhizoma Phragmitis in preparing medicine for relieving cough and eliminating phlegm Download PDFInfo
- Publication number
- CN111603517A CN111603517A CN202010551977.8A CN202010551977A CN111603517A CN 111603517 A CN111603517 A CN 111603517A CN 202010551977 A CN202010551977 A CN 202010551977A CN 111603517 A CN111603517 A CN 111603517A
- Authority
- CN
- China
- Prior art keywords
- cough
- root
- application
- eliminating phlegm
- relieving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an application of a root of a rice ball in preparing a medicine for relieving cough and eliminating phlegm. According to the invention, the root of the plant of the clod is subjected to a mouse experiment, and the result shows that the clod has obvious effects of inhibiting cough, curing cough and eliminating phlegm, and can be used as a cough-relieving and phlegm-eliminating medicine; the invention explores the new medicinal application of the root of the rice ball in the aspect of relieving cough and eliminating phlegm, provides a new choice of medicaments for relieving cough and eliminating phlegm for patients, widens the medicinal value and application of the medicinal material rice ball, develops the new application field of the rice ball, and has wide application prospect and good economic benefit and social benefit.
Description
Technical Field
The invention relates to a new application of a root of a rice ball in preparing a medicine for relieving cough and eliminating phlegm, belonging to the technical field of medicines.
Background
Kadsura coccinea (Lem.) A.C. Smith) ], also called Kadsura coccinea, is a plant of Kadsura of Magnoliaceae, and is perennial woody vine; mainly distributed in Guizhou, Hunan, Yunnan, Sichuan, Guangxi, Guangdong, etc. The traditional Chinese medicine composition is used for treating rheumatic arthralgia, activating blood and dissolving stasis, promoting qi circulation and relieving pain, acute and chronic rheumatic arthritis, rheumatoid arthritis and scapulohumeral periarthritis. From the aspect of the utilized functions, no relevant report is found about the application of the lump prepared from the fringed rice in treating cough relieving and phlegm eliminating.
Disclosure of Invention
The invention aims to provide the application of the root of the rice ball in preparing the medicine for relieving cough and eliminating phlegm, provide a new application approach for the medicinal value of the rice ball and provide a new medicine choice for consumers.
In order to solve the technical problems, the technical scheme of the invention is as follows:
application of radix Tripterygii Wilfordii in preparing medicine for relieving cough and eliminating phlegm is provided.
The application of the root of the kadsura coccinea in preparing the medicine for relieving cough and eliminating phlegm is a preferable scheme, and the medicine is prepared into a clinically common medicinal preparation by taking the root of the kadsura coccinea as an active ingredient and pharmaceutically common auxiliary materials according to a conventional method.
The above-mentioned application of the root of the Boschniakia chinensis in preparing the medicament for relieving cough and eliminating phlegm, specifically, the pharmaceutical preparation can be a dosage form of being administrated through gastrointestinal tract, including tablets, capsules, granules, powder, solutions, emulsions or dropping pills.
The application of the root of kadsura coccinea in preparing the medicine for relieving cough and eliminating phlegm, in particular, the medicine preparation can also be a parenteral administration dosage form, including injection, spray, aerosol, patch, paste, drop or gargle.
The invention has the beneficial effects that: compared with the prior art, the invention explores the new medicinal application of the root of the kadsura coccinea in the aspects of relieving cough and eliminating phlegm, has obvious curative effect and provides a new choice of cough-relieving and phlegm-eliminating medicines for patients. Meanwhile, the invention also widens the medicinal value and application of the medicinal material of the cold rice ball, has important significance for promoting the cold rice ball to prepare the cough-relieving and phlegm-eliminating medicament, develops a new application field of the cold rice ball, and has wide application prospect and good economic benefit and social benefit.
The present invention will be further described with reference to the following embodiments.
Detailed Description
Example 1: preparing the crude drug of the root of the Kadsura coccinea: cleaning root of the plant of the Bombaria smith, air drying, and pulverizing to obtain crude drug of Bombaria smith; collecting 180g of Boschniakia chinensis, adding 1000mL of distilled water, decocting for 2h, filtering to remove residue, concentrating into extract, and storing in refrigerator at 4 deg.C. It is diluted with sodium carboxymethylcellulose to low, medium and high dosage for use.
Firstly, cough relieving effect experiment:
the prepared crude drug of the cooked rice ball is subjected to a mouse experiment, and the specific experimental process comprises the following steps:
(1) after preheating the ultrasonic atomizer, adding 50 mL of ammonia water with 13% mass percentage concentration; the mouse is placed into a 1000mL beaker, the mouth of the beaker is sealed by a preservative film and is provided with two openings, wherein one opening is used for inserting an outlet pipe of the ultrasonic atomizer, and the other opening is a small ventilation hole.
(2) And (3) continuously introducing ammonia gas into the ultrasonic atomizer for 60s at the maximum spraying force (MAX), immediately closing and quickly opening the preservative film to ensure that the ammonia gas in the beaker is naturally diffused. While passing ammonia gas, the number of coughs (cough manifestation: contraction of mouse abdominal muscle with mouth enlarged, cough sound) and cough latency (time to first onset of cough) of the mice within 3min were observed and recorded.
(3) Selecting 60 mice which are qualified in screening (standard: all people with cough latency less than 15s or more than 50s are eliminated, and all people with cough frequency less than 10 times or more than 80 times within 3min are eliminated), randomly dividing the mice into 5 groups, and each group comprises 12 mice; respectively weaving as follows: distilled water group, lung power cough mixture group, low dose group of the rice cooker, medium dose group of the rice cooker and high dose group of the rice cooker, the lung power cough mixture is a Chinese patent medicine produced by Guizhou Jianxing pharmaceutical industry limited company, and the main treatment is as follows: clear heat and remove toxicity, relieve cough and eliminate phlegm. And (3) continuously intragastrically irrigating the mice of each group for 14d by using corresponding medicines respectively, wherein the administration volume is 20mL/kg and 1 time/d, the model is made 1h after the last administration, and the cough frequency and the cough latency time of the mice within 3min are observed and recorded.
Secondly, an effect experiment of eliminating phlegm:
(1) weighing 0.05g of phenol red, dissolving the phenol red by NaOH with the concentration of 1mol/L, adding physiological saline with the pH value of 8.95 to 100mL and the concentration of 500.00ug/mL, then diluting the phenol red by stages to phenol red solutions with the concentrations of 250.00ug/mL, 125.00ug/mL, 62.50ug/mL and 31.25 ug/mL, and measuring the absorbance at 546 nm.
(2) Selecting 60 mice which are qualified in screening (standard: all people with cough latency less than 15s or more than 50s are eliminated, and all people with cough frequency less than 10 times or more than 80 times within 3min are eliminated), randomly dividing the mice into 5 groups, and each group comprises 12 mice; respectively weaving as follows: the mice in each group are continuously irrigated with corresponding medicaments for 14d, the administration volume is 20mL/kg and 1 time/d, after 30min of the last administration, the mice are injected with 20mL/kg of 0.5% phenol red in the abdominal cavity, and the mice are killed by air embolism after 1 h.
(3) The mice were mounted in the supine position on a frog plate and the trachea separated (5 mL numbered tubes prepared beforehand and 5% NaHCO added)3Solution 1.5 mL), 5% NaHCO was aspirated with a 1 mL syringe3Injecting 0.5 mL of the solution into a mouse trachea, repeatedly washing the respiratory tract back and forth for 3 times, finally collecting the washing solution in a test tube with a corresponding number for 1 time, and repeating the steps for 2 times according to the method. The combined washes were centrifuged (at 1000rpm for 5 min), and the supernatant was collected and absorbance measured at 546 nm. The concentration was calculated according to the phenol red standard curve regression equation.
Thirdly, statistics table:
TABLE 1 statistical table of cough incubation period, cough frequency and phenol red excretion of mice
Group of | Dosage per g.kg-1 | Cough latency/s | Cough frequency/time within 3min | Phenol Red excretion (ug/kg) |
Distilled water set | 20 | 35 | 122.5 | 0.234 |
Lung-power cough mixture group | 10 | 47.8 | 97.8 | 0.27 |
Low dose group of root of Kadsura coccinea | 5 | 50.8 | 85.3 | 0.25 |
Middle-dose group of root of Kadsura coccinea | 10 | 55 | 85.8 | 0.257 |
High dose group of root of Kadsura coccinea | 20 | 63.5 | 78 | 0.278 |
As can be seen from Table 1, the root of the Hakka gecko can inhibit the occurrence of cough in mice, the latency period is respectively increased by 45.1-81.4% compared with the distilled water group, and the latency period is respectively increased by 6.3-32.8% compared with the cough-relieving drug, namely the lung-power cough mixture group; the root of the Kadsura coccinea has an influence on the excretion of phenol red of the mouse, compared with a distilled water group, the excretion of phenol red is increased by 6.8-18.8%, and compared with an antitussive lung-strength cough mixture group, a high-dose group is increased by 3.0%, which shows that the root of the Kadsura coccinea has obvious effects on suppressing the occurrence of cough (prolonging the latent period of cough), curing cough (reducing the cough frequency) and eliminating phlegm (increasing the excretion of phenol red in trachea of the mouse), wherein the effect of the high-dose group is far better than that of the antitussive lung-strength cough mixture.
The embodiments of the present invention are not limited to the above-described examples, and various changes made without departing from the spirit of the present invention are within the scope of the present invention. Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred examples, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (4)
1. Application of radix Tripterygii Wilfordii in preparing medicine for relieving cough and eliminating phlegm is provided.
2. Use of a root of a lump of fringed rice according to claim 1 for the preparation of a medicament for the treatment of cough suppressing expectoration, characterized in that: the medicine for relieving cough and eliminating phlegm is a clinically common medicinal preparation prepared by taking the root of the clod-like rice as an active ingredient and pharmaceutically common auxiliary materials according to a conventional method.
3. Use of a root of a lump of fringed rice according to claim 2 for the preparation of a medicament for the treatment of cough suppressing expectoration, characterized in that: the pharmaceutical preparation is a gastrointestinal administration dosage form, and comprises tablets, capsules, granules, powder, solutions, emulsions or dripping pills.
4. Use of a root of a lump of fringed rice according to claim 2 for the preparation of a medicament for the treatment of cough suppressing expectoration, characterized in that: the pharmaceutical preparation is a parenteral administration dosage form, and comprises injection, spray, aerosol, patch, paste, drop or gargle.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010551977.8A CN111603517B (en) | 2020-06-17 | 2020-06-17 | Application of radix Lespedezae Cuneatae in preparing medicine for relieving cough and eliminating phlegm |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010551977.8A CN111603517B (en) | 2020-06-17 | 2020-06-17 | Application of radix Lespedezae Cuneatae in preparing medicine for relieving cough and eliminating phlegm |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111603517A true CN111603517A (en) | 2020-09-01 |
CN111603517B CN111603517B (en) | 2022-11-18 |
Family
ID=72195471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010551977.8A Active CN111603517B (en) | 2020-06-17 | 2020-06-17 | Application of radix Lespedezae Cuneatae in preparing medicine for relieving cough and eliminating phlegm |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111603517B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101099766A (en) * | 2007-07-04 | 2008-01-09 | 曾祥新 | Medical new use of kadsura coccinea root |
CN102764294A (en) * | 2012-08-01 | 2012-11-07 | 江西农业大学 | Cough relieving and sputum eliminating combination and preparation method thereof |
CN105194310A (en) * | 2015-10-13 | 2015-12-30 | 臧海阳 | Chinese herbal composition for treating mammary lumps caused by accumulation of phlegm and blood stasis |
CN106615514A (en) * | 2016-10-12 | 2017-05-10 | 肥西久盛食品有限公司 | Cough-relieving phlegm-reducing plantain candied ginger |
CN108143789A (en) * | 2016-12-06 | 2018-06-12 | 杨俊春 | A kind of Chinese medicine for treating edema face |
-
2020
- 2020-06-17 CN CN202010551977.8A patent/CN111603517B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101099766A (en) * | 2007-07-04 | 2008-01-09 | 曾祥新 | Medical new use of kadsura coccinea root |
CN102764294A (en) * | 2012-08-01 | 2012-11-07 | 江西农业大学 | Cough relieving and sputum eliminating combination and preparation method thereof |
CN105194310A (en) * | 2015-10-13 | 2015-12-30 | 臧海阳 | Chinese herbal composition for treating mammary lumps caused by accumulation of phlegm and blood stasis |
CN106615514A (en) * | 2016-10-12 | 2017-05-10 | 肥西久盛食品有限公司 | Cough-relieving phlegm-reducing plantain candied ginger |
CN108143789A (en) * | 2016-12-06 | 2018-06-12 | 杨俊春 | A kind of Chinese medicine for treating edema face |
Non-Patent Citations (2)
Title |
---|
刘嘉森: "冷饭团中分得4个五味子酯和1个乙酰五味子酯", 《中草药》 * |
刘涛等: "野生水果冷饭团的研究现状及开发利用前景", 《安徽农业科学》 * |
Also Published As
Publication number | Publication date |
---|---|
CN111603517B (en) | 2022-11-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103768308A (en) | Medicament composition for treating upper respiratory infections and preparation method thereof | |
CN104116734A (en) | Pharmaceutical composition and pharmaceutical preparation for treating oral and throat diseases, and applications and preparation method of the pharmaceutical composition and pharmaceutical preparation | |
CN107174638A (en) | A kind of cough-relieving medicinal extract and preparation method thereof | |
CN102641356B (en) | Traditional Chinese medicine composition for treating respiratory tract viral infectious diseases and preparation method thereof | |
CN104257794B (en) | Chinese medicine composition of a kind of spleen reinforcing removing food stagnancy and preparation method thereof | |
CN103933410A (en) | Medicinal use and preparation method of traditional Chinese medicine composition | |
CN102657804B (en) | Traditional Chinese medical composition for treatment of viral influenza and preparation method thereof | |
CN111603517B (en) | Application of radix Lespedezae Cuneatae in preparing medicine for relieving cough and eliminating phlegm | |
CN104257763B (en) | A kind of saline cistanche water extract, preparation method and its usage | |
CN102614269B (en) | Method for preparing traditional Tibetan medicine for treating pharyngitis | |
CN103272113B (en) | Yinhuang granule for clearing away the lung-heat and preparation method thereof | |
CN100475256C (en) | Chinese medicine composition for treating acute and chronic largngopharyngitis and preparing method thereof | |
CN102641335A (en) | Traditional Chinese medicine composition for treating upper respiratory tract viral infection and preparation method thereof | |
CN103285225B (en) | Yinhuang lung-heat-clearing troche and preparation method thereof | |
CN102106999B (en) | A kind of compound Chinese medicinal preparation for the treatment of dysphagia after apoplexy and preparation method thereof | |
CN104138441B (en) | A kind of treat infantile cough, the Chinese prescription of asthma and preparation | |
CN103272114A (en) | Yinhuang medicine for clearing away lung-heat and preparation method thereof | |
CN109106774B (en) | Traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof, and preparation method and application thereof | |
CN103356888B (en) | Traditional Chinese medicinal granules for treating infantile pneumonia | |
CN111588748A (en) | A thyme essential oil soft capsule for treating bronchitis and its treatment method | |
CN108261445A (en) | A kind of Chinese medicine composition with preventing phlegm from forming and stopping coughing, antivirus action | |
CN114470110B (en) | Anti-rhinitis traditional Chinese medicine composition with pain relieving effect | |
CN106389723A (en) | Paediatric nasal cavity medicine for treating upper respiratory tract infection and preparation method thereof | |
CN106728837A (en) | A kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma and preparation method thereof | |
CN106038623A (en) | A preparing method for valeriana officinalis var. latifolia root volatile oil and inflammation-diminishing and pain-easing applications of the volatile oil |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |