CN106389723A - Paediatric nasal cavity medicine for treating upper respiratory tract infection and preparation method thereof - Google Patents
Paediatric nasal cavity medicine for treating upper respiratory tract infection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses paediatric nasal cavity medicine for treating upper respiratory tract infection. The paediatric nasal cavity medicine is prepared from the following ingredients in parts by weight: 20 to 40 parts of centipeda minima, 20 to 30 parts of XanThium sibiricum, 10 to 20 parts of flos magnoliae, 10 to 20 parts of hyssopus officinalis, 10 to 20 parts of dandelion, 10 to 20 parts of herba houttuyniae, 5 to 15 parts of radix bupleuri, 5 to 10 parts of acorus calamus, 5 to 10 parts of Chinese galls, 5 to 10 parts of herba portulacae, 0.1 to 0.2 part of surface active agents, 0.01 to 0.02 part of preservative and 0.01 to 0.02 part of flavoring agents. In addition, the invention also provides a preparation method of the paediatric nasal cavity medicine for treating upper respiratory tract infection. The paediatric nasal cavity medicine for treating upper respiratory tract infection provided by the invention can reach the goal of treating both symptoms and root causes; a good curative effect is achieved on the upper respiratory tract infection; in addition, the toxic and side effects are small; the use dosage is low; the medicine efficacy is high; wide application prospects are realized.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines and in particular to a kind of pediatric nasal medicine treating the infection of the upper respiratory tract and its
Preparation method.
Background technology
The infection of the upper respiratory tract is infant's common disease, that is, it has often been said that flu, refer to the nose of top respiratory tract,
Pharynx and the respiratory inflammation of throat, the acute tonsillitis of clinical diagnosis, acpuei pharyngitis, acute nasopharyngitis broadly falls into the upper respiratory tract
Infection.90% about the infection of the upper respiratory tract is caused by virus, after bacterium infection Chang Jifa is infected with virus, this disease four
Season, any age all can fall ill, especially children, and due to physiological function imperfection, the incidence of disease is higher.The infection of the upper respiratory tract is general
By containing the virulent spittle, droplet, or the apparatus through pollution is propagated, and local pharynx nasalis easily scorching after children's infection
Disease, shows as schneiderian membrance hyperemia, swelling, take place frequently sneeze, and both sides nostril has a running nose therewith.
Slower for the oral medication onset of nasal cavity local problem, therefore topical intranasal medication is first-selected, and on current children
Respiratory tract infection nasal cavity applied medicine mostly is Western medicine, there is a problem of that toxic and side effect is big, brings potential hazard to medication children, also has one
A little nasal cavity Chinese medicines, but due to being wherein added with menthol, borneol etc., children's nasal cavity is produced to stimulate, and causes infant medication to support
Touch.
Content of the invention
A kind of pediatric nasal medicine treating the infection of the upper respiratory tract that the present invention provides, it is larger to solve Western medicine side effect,
Easily potential hazard is caused to patient, and Chinese medicine contains menthol, borneol etc., easily cause the problem of infant medication conflict.
First purpose of the present invention is to provide a kind of pediatric nasal medicine treating the infection of the upper respiratory tract, by following weight
The component of part is made：Centipeda minima 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part, Hyssopus officinalis 10-20 part, dandelion 10-
20 parts, cordate houttuynia 10-20 part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part, purslane 5-10 part, surfactant
0.1-0.2 part, preservative 0.01-0.02 part, flavouring 0.01-0.02 part.
Preferably, the pediatric nasal medicine of the treatment infection of the upper respiratory tract of the present invention, is made up of the component of following weight portion：
20 parts of Centipeda minima, 30 parts of Siberian cocklebur, 10 parts of the flower bud of lily magnolia, 20 parts of Hyssopus officinalis, 20 parts of dandelion, 10 parts of cordate houttuynia, 5 parts of radix bupleuri, calamus
10 parts, 5 parts of Chinese gall, 7 parts of purslane, 0.1 part of surfactant, 0.01 part of preservative, 0.01 part of flavouring.
Preferably, the pediatric nasal medicine of the treatment infection of the upper respiratory tract of the present invention, is made up of the component of following weight portion：
30 parts of Centipeda minima, 25 parts of Siberian cocklebur, 20 parts of the flower bud of lily magnolia, 10 parts of Hyssopus officinalis, 15 parts of dandelion, 15 parts of cordate houttuynia, 15 parts of radix bupleuri, calamus
8 parts, 10 parts of Chinese gall, 10 parts of purslane, 0.15 part of surfactant, 0.015 part of preservative, 0.015 part of flavouring.
Preferably, the pediatric nasal medicine of the treatment infection of the upper respiratory tract of the present invention, is made up of the component of following weight portion：
40 parts of Centipeda minima, 20 parts of Siberian cocklebur, 15 parts of the flower bud of lily magnolia, 15 parts of Hyssopus officinalis, 10 parts of dandelion, 20 parts of cordate houttuynia, 10 parts of radix bupleuri, calamus
5 parts, 8 parts of Chinese gall, 5 parts of purslane, 0.2 part of surfactant, 0.02 part of preservative, 0.02 part of flavouring.
Preferably, described surfactant is one of tween, sapn or two kinds；Described preservative be Sodium Benzoate,
One of ethyl-para-hydroxybenzoate or two kinds；Described flavouring is one of orange essence, strawberry essence.
Second object of the present invention is to provide a kind of preparation method of the pediatric nasal medicine treating the infection of the upper respiratory tract,
Specifically implement according to following steps：
Step 1, weighs each component by following weight portion：Centipeda minima 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part,
Hyssopus officinalis 10-20 part, dandelion 10-20 part, cordate houttuynia 10-20 part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part,
Purslane 5-10 part, surfactant 0.1-0.2 part, preservative 0.01-0.02 part, flavouring 0.01-0.02 part；
Step 2, is pulverized after the Centipeda minima weighing in step 1, Hyssopus officinalis, cordate houttuynia mixing, crosses 40 mesh sieves, faced with super
Boundary carbon dioxide recycle counter-current extraction 1-3h, extracting pressure is 10-30Mpa, and extraction temperature is 30-70 DEG C, carbon dioxide flow
For 20-50kg/h, extraction finishes and obtains Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are blended in one
Rise, obtain mixture, add, in mixture, the water being equivalent to mixture weight 8-10 times, soak 20-60min, then intense fire
It is fried open, then boils 30-40min by slow fire, filter, obtain first time filtrate and first time filter residue, add quite toward in first time filter residue
In the water of filter residue weight 8-10 times, first intense fire is fried open, then boils 30-40min by slow fire, filters, and obtains second filtrate, merges first
Secondary filtrate and second filtrate, mix, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surface-active weighing in step 1
Agent, preservative and flavouring, obtain medicament concentrate, add and are equivalent to the water of 15-20 times of medicament concentrate and are diluted, mix
Close uniformly, filter, dispense to the pressing spray bottle of 10-20mL specification, obtain final product the paediatrics nose of the described treatment infection of the upper respiratory tract
Chamber medication.
Compared with prior art, the beneficial effects of the present invention is：
1) pediatric nasal medicine of the treatment infection of the upper respiratory tract that the present invention provides is pure Chinese medicinal preparation, and prescription rationally, is marked
Basis is simultaneous to be controlled, determined curative effect, Small side effects.
2) the pediatric nasal medicine direct nasal spray administration of the treatment infection of the upper respiratory tract that the present invention provides, topical application
Fully, materialization is soft not to stimulate, and local action is rapid-action, and acting duration is long, simple and practical for distribution.
Specific embodiment
With reference to specific embodiment, the present invention is described in detail, but should not be construed as the restriction of the present invention.
First, a kind of pediatric nasal medicine component analysis treating the infection of the upper respiratory tract of the present invention
Centipeda minima:There is wind-dispelling, dissipates cold, victory is wet, go the functions such as screen, logical nasal obstruction.Cure mainly flu, cold heavy breathing, larynx numbness, one hundred days
Cough, eruptive disease stomachache, amebic dysentery, malaria, infantile malnutrition due to digestive disturbances or intestinalparasites are rushed down, nasosinusitis, nasal polyp, mesh screen puckery itch, the disease such as ulcer on the shank, mange, bruise.
The achene of Siberian cocklebur：Bitter, sweet, pungent, warm in nature, mild toxicity.Cure mainly anemofrigid headache, nasosinusitis, dentalgia, wind-cold-dampness arthralgia, four limbs contraction pain,
The diseases such as scabies leprosy, itch.
The flower bud of lily magnolia:Pungent, warm.There is the functions such as expelling cold, eliminating, clearing the nasal passage.Cure mainly the diseases such as anemofrigid cold, nasal obstruction, nasosinusitis.
Hyssopus officinalis：Cool in nature, taste is pungent.There is the functions such as heat-clearing heat, preventing phlegm from forming and stopping coughing.Cure mainly pneumonia, asthma out of breath, chronic cough not
More, be diligent to catch a cold, have a toothache, sciatica, pain in the back, liver resistance spleen be swollen, the disease such as oedema, insect-bite.
Dandelion:Sweet, slight bitter, cold.There is the functions such as clearing heat and detoxicating, dispersing swelling and dissipating binds.Cure mainly the infection of the upper respiratory tract, eye conjunctiva
Inflammation, mumps, acute mastitis swell and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary infection, pelvic infecton,
The diseases such as pharyngitis, adenolymphitis, scrofula, cold, fever, acute tonsillitis, acute bronchitis.
Cordate houttuynia：Pungent, tepor, slightly poisonous.There is the clearing heat and detoxicating, function such as removing pus and relieving carbuncle, inducing diuresis for treating strangurtia.Cure mainly phlegm heat panting
Cough, larynx Oh, the disease such as hot dysentery, carbuncle sore tumefacting virus, heat gonorrhea.
Radix bupleuri：Bitter, cold nature.There is soothing liver-gallbladder, dredge the functions such as strongly fragrant, the scattered fire of gas solution.Cure mainly stagnation of QI due to depression of the liver, sternal rib is swollen
Bitterly, prolapse of the anus, uterus come off, the disease such as irregular menstruation.
Calamus：Acrid, bitter, warm.Have resolving sputum, have one's ideas straightened out, invigorating the spleen, the function such as dampness removing.Cure mainly epilepsy, the forgetful, mind of palpitation with fear not
Clearly, the disease such as humidity hysteresis ruffian is swollen, dysentery, rheumatalgia pain, carbuncle swells scabies.
Chinese gall：Taste is sour, puckery, cold in nature.There is the functions such as hidroschesis of astringing the lung, puckery intestines, controlling nocturnal emission with astringent drugs, hemostasis, removing toxic substances.Cure mainly the deficiency syndrome of the lung long
Cough, spontaneous sweating, protracted dysentery chronic diarrhea, prolapse of the anus, various bleeding, the disease such as carbuncle swells boil.
Purslane：Cold in nature, sweet acid.Have that clearing heat and detoxicating, Li Shui dries, dissipate blood detumescence, dust-collection sterilization, anti-inflammatory analgetic,
The functions such as blood-stanching and blood-cooling.Cure mainly dysentery, enteritis, ephritis, postpartum uterine hemorrhage, have blood in stool, the illness such as mastitis.
Based on effect of said components, the invention provides a kind of pediatric nasal medicine treating the infection of the upper respiratory tract, by
The component of following weight portion is made：Centipeda minima 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part, Hyssopus officinalis 10-20 part, Pu
Public English 10-20 part, cordate houttuynia 10-20 part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part, purslane 5-10 part, table
Face activating agent 0.1-0.2 part, preservative 0.01-0.02 part, flavouring 0.01-0.02 part.
Meanwhile, based on same inventive concept, present invention also offers a kind of paediatrics nasal cavity treating the infection of the upper respiratory tract
The preparation method of medication, specifically implements according to following steps：
Step 1, weighs each component by following weight portion：Centipeda minima 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part,
Hyssopus officinalis 10-20 part, dandelion 10-20 part, cordate houttuynia 10-20 part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part,
Purslane 5-10 part, surfactant 0.1-0.2 part, preservative 0.01-0.02 part, flavouring 0.01-0.02 part；
Step 2, is pulverized after the Centipeda minima weighing in step 1, Hyssopus officinalis, cordate houttuynia mixing, crosses 40 mesh sieves, faced with super
Boundary carbon dioxide recycle counter-current extraction 1-3h, extracting pressure is 10-30Mpa, and extraction temperature is 30-70 DEG C, carbon dioxide flow
For 20-50kg/h, extraction finishes and obtains Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are blended in one
Rise, obtain mixture, add, in mixture, the water being equivalent to mixture weight 8-10 times, soak 20-60min, then intense fire
It is fried open, then boils 30-40min by slow fire, filter, obtain first time filtrate and first time filter residue, add quite toward in first time filter residue
In the water of filter residue weight 8-10 times, first intense fire is fried open, then boils 30-40min by slow fire, filters, and obtains second filtrate, merges first
Secondary filtrate and second filtrate, mix, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surface-active weighing in step 1
Agent, preservative and flavouring, obtain medicament concentrate, add and are equivalent to the water of 15-20 times of medicament concentrate and are diluted, mix
Close uniformly, filter, dispense to the pressing spray bottle of 10-20mL specification, obtain final product the paediatrics nose of the described treatment infection of the upper respiratory tract
Chamber medication.
The pediatric nasal medicine of the treatment infection of the upper respiratory tract that the present invention provides has harmonizing Sharyang, dispelling wind and removing heat, righting
Eliminating evil, adjusts the function of immunity, cures mainly：Acute tonsillitis, acpuei pharyngitis, the infection of the upper respiratory tract such as acute nasopharyngitis.Usage
And consumption is as follows：3 times a day, each 10-20 spray, often sprays quantitative 0.12mL, and continuous use can cure patient in the longest 7 days about
The infection of the upper respiratory tract.
Preferably, the pediatric nasal medicine of the treatment infection of the upper respiratory tract that the present invention provides, including following examples：
Embodiment 1
A kind of pediatric nasal medicine treating the infection of the upper respiratory tract, is made up of the component of following weight portion：Centipeda minima 20
Part, 30 parts of Siberian cocklebur, 10 parts of the flower bud of lily magnolia, 20 parts of Hyssopus officinalis, 20 parts of dandelion, 10 parts of cordate houttuynia, 5 parts of radix bupleuri, 10 parts of calamus, Chinese gall
5 parts, 7 parts of purslane, 0.1 part of tween, 0.01 part of Sodium Benzoate, 0.01 part of orange essence, specifically according to following steps implement：
Step 1, weighs each component by following weight portion：20 parts of Centipeda minima, 30 parts of Siberian cocklebur, 10 parts of the flower bud of lily magnolia, Hyssopus officinalis 20
Part, 20 parts of dandelion, 10 parts of cordate houttuynia, 5 parts of radix bupleuri, 10 parts of calamus, 5 parts of Chinese gall, 7 parts of purslane, 0.1 part of tween, benzene first
0.01 part of sour sodium, 0.01 part of orange essence；
Step 2, pulverizes after the Hyssopus officinalis weighing in step 1, Siberian cocklebur, cordate houttuynia mixing, crosses 40 mesh sieves, with overcritical two
Oxidation carbon cycle counter-current extraction 1h, extracting pressure is 30Mpa, and extraction temperature is 70 DEG C, and carbon dioxide flow is 50kg/h, extraction
Finish and obtain Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are blended in one
Rise, obtain mixture, add, in mixture, the water being equivalent to 8 times of mixture weight, soak 20min, then intense fire is fried open, then
Boil 30min by slow fire, filter, obtain first time filtrate and first time filter residue, add toward in first time filter residue and be equivalent to filter residue weight 8
Water again, first intense fire is fried open, then boils 30min by slow fire, filters, and obtains second filtrate, merges first time filtrate and second filter
Liquid, mixes, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surface-active weighing in step 1
Agent, preservative and flavouring, obtain medicament concentrate, add and are equivalent to the water of 15 times of medicament concentrate and are diluted, mixing
Uniformly, filter, dispense to the pressing spray bottle of 10-20mL specification, obtain final product the paediatrics nasal cavity of the described treatment infection of the upper respiratory tract
Medication.
The test of pesticide effectiveness is carried out with this side, there is to children's upper respiratory tract infection good curative effect.
Embodiment 2
A kind of pediatric nasal medicine treating the infection of the upper respiratory tract, is made up of the component of following weight portion：Centipeda minima 30
Part, 25 parts of Siberian cocklebur, 20 parts of the flower bud of lily magnolia, 10 parts of Hyssopus officinalis, 15 parts of dandelion, 15 parts of cordate houttuynia, 15 parts of radix bupleuri, 8 parts of calamus, Chinese gall
10 parts, 10 parts of purslane, 0.15 part of sapn, 0.015 part of Sodium Benzoate, 0.015 part of strawberry essence, specifically real according to following steps
Apply：
Step 1, weighs each component by following weight portion：30 parts of Centipeda minima, 25 parts of Siberian cocklebur, 20 parts of the flower bud of lily magnolia, Hyssopus officinalis 10
Part, 15 parts of dandelion, 15 parts of cordate houttuynia, 15 parts of radix bupleuri, 8 parts of calamus, 10 parts of Chinese gall, 10 parts of purslane, 0.15 part of sapn, benzene
0.015 part of sodium formate, 0.015 part of strawberry essence；
Step 2, pulverizes after the Hyssopus officinalis weighing in step 1, Siberian cocklebur, cordate houttuynia mixing, crosses 40 mesh sieves, with overcritical two
Oxidation carbon cycle counter-current extraction 2h, extracting pressure is 20Mpa, and extraction temperature is 50 DEG C, and carbon dioxide flow is 35kg/h, extraction
Finish and obtain Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are blended in one
Rise, obtain mixture, add, in mixture, the water being equivalent to 9 times of mixture weight, soak 40min, then intense fire is fried open, then
Boil 35min by slow fire, filter, obtain first time filtrate and first time filter residue, add toward in first time filter residue and be equivalent to filter residue weight 9
Water again, first intense fire is fried open, then boils 35min by slow fire, filters, and obtains second filtrate, merges first time filtrate and second filter
Liquid, mixes, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surface-active weighing in step 1
Agent, preservative and flavouring, obtain medicament concentrate, add and are equivalent to the water of 18 times of medicament concentrate and are diluted, mixing
Uniformly, filter, dispense to the pressing spray bottle of 10-20mL specification, obtain final product the paediatrics nasal cavity of the described treatment infection of the upper respiratory tract
Medication.
The test of pesticide effectiveness is carried out with this side, there is to children's upper respiratory tract infection good curative effect.
Embodiment 3
A kind of pediatric nasal medicine treating the infection of the upper respiratory tract, is made up of the component of following weight portion：Centipeda minima 40
Part, 20 parts of Siberian cocklebur, 15 parts of the flower bud of lily magnolia, 15 parts of Hyssopus officinalis, 10 parts of dandelion, 20 parts of cordate houttuynia, 10 parts of radix bupleuri, 5 parts of calamus, Chinese gall
8 parts, 5 parts of purslane, 0.2 part of sapn, 0.02 part of ethyl-para-hydroxybenzoate, 0.02 part of orange essence, specifically according to following step
Rapid enforcement：
Step 1, weighs 40 parts of each component Centipeda minima, 20 parts of Siberian cocklebur, 15 parts of the flower bud of lily magnolia, Hyssopus officinalis 15 by following weight portion
Part, 10 parts of dandelion, 20 parts of cordate houttuynia, 10 parts of radix bupleuri, 5 parts of calamus, 8 parts of Chinese gall, 5 parts of purslane, 0.2 part of sapn, to hydroxyl
0.02 part of yl benzoic acid ethyl ester, 0.02 part of orange essence；
Step 2, pulverizes after the Hyssopus officinalis weighing in step 1, Siberian cocklebur, cordate houttuynia mixing, crosses 40 mesh sieves, with overcritical two
Oxidation carbon cycle counter-current extraction 3h, extracting pressure is 10Mpa, and extraction temperature is 30 DEG C, and carbon dioxide flow is 20kg/h, extraction
Finish and obtain Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are blended in one
Rise, obtain mixture, add, in mixture, the water being equivalent to 10 times of mixture weight, soak 60min, then intense fire is fried open,
Boil 40min again by slow fire, filter, obtain first time filtrate and the first filter residue, add toward in first time filter residue and be equivalent to filter residue weight
10 times of water, first intense fire is fried open, then boils 40min by slow fire, filters, and obtains second filtrate, merges first time filtrate and second
Filtrate, mixes, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surface-active weighing in step 1
Agent, preservative and flavouring, obtain medicament concentrate, add and are equivalent to the water of 20 times of medicament concentrate and are diluted, mixing
Uniformly, filter, dispense to the pressing spray bottle of 10-20mL specification, obtain final product the paediatrics nasal cavity of the described treatment infection of the upper respiratory tract
Medication.
This side carries out the test of pesticide effectiveness, has good curative effect to children's upper respiratory tract infection.
2nd, with reference to specific case, the effect of the present invention is further illustrated.
1st, case selection
Using embodiment 1-3 the treatment infection of the upper respiratory tract pediatric nasal medicine to being diagnosed as the 99 of the infection of the upper respiratory tract
Example pediatric patients carry out clinical observation, wherein boy 47, young girl 52, the age 1-13 year between, average age 6.5 years old,
Average course of disease 1 month.This 100 patients are randomly divided into 3 groups, every group 33, each group is prepared using embodiment 1-3 respectively
The pediatric nasal medicine treatment of the treatment infection of the upper respiratory tract, and the course of disease of each group patient, degrees of symptoms are basically identical, no
Significant difference, has comparativity.
2nd, treatment method
The pediatric nasal medicine of the treatment infection of the upper respiratory tract that treatment 1-3 group is obtained using embodiment of the present invention 1-3 respectively,
3 times a day, each 10-20 spray, often sprays quantitative 0.12mL.
3rd, curative effect determinate standard
(1) cure：Symptom all disappears, and indices recover normal；
(2) effective：Symptom is obviously improved, and indices have taken a turn for the better；
(3) effective：Symptom makes moderate progress, and indices are clearly better；
(4) invalid：After treatment, symptom no mitigates or increases.
4th, treatment results
The nasal cavity applied medicine comparitive study that each embodiment of table 1 is prepared
| Project | Case load | Cure number | Effective number | Significant figure | Invalid number | Cure rate | Total effective rate |
| Embodiment 1 | 33 | 18 | 7 | 8 | 1 | 54.55% | 96.97% |
| Embodiment 2 | 33 | 19 | 5 | 9 | 0 | 57.58% | 100% |
| Embodiment 3 | 33 | 17 | 6 | 10 | 1 | 51.51% | 96.97% |
The nasal cavity applied medicine comparitive study that table 1 is prepared for each embodiment, as shown in Table 1, through the treatment of 3-6 days, each reality
More than 50%, total effective rate, more than 96%, illustrates the paediatrics of the treatment infection of the upper respiratory tract of the present invention to the cure rate applying example
Nasal cavity applied medicine have high cure rate for children's upper respiratory tract infection and efficient it is adaptable to the controlling of children's upper respiratory tract infection
Treat.
5th, model case
Case 1：Shi, man, three years old, paroxysmal cough, no expectoration, wake tears, no chilly, heating, red tongue body, tongue is thin
Huang, superficial and rapid pulse and sliding real, it is diagnosed as children's upper respiratory tract infection, using the treatment infection of the upper respiratory tract of the embodiment of the present invention 1
After pediatric nasal medicine 2 days, symptom is obviously improved, and after taking 3 days, symptom disappears, recovery from illness.
Case 2：River, 5 years old, patient's pharyngalgia, with heating, 39.5 DEG C of body temperature, check and find to burst in pharynx and tonsillotome surface
Ulcer, is diagnosed as children's upper respiratory tract infection, using the pediatric nasal medicine 3 of the treatment infection of the upper respiratory tract of the embodiment of the present invention 2
After it, symptom has taken a turn for the better, and temperature recovery is normal, and after continuing to take 3 days, symptom disappears, recovery from illness.
Case 3：Zhang, female, 12 years old, patient sneezed for continuous 2 days, cough, abundant expectoration, heating, and 38.5 DEG C of body temperature is diagnosed as
The infection of the upper respiratory tract, after 3 days, symptom is for the pediatric nasal medicine of the treatment infection of the upper respiratory tract taking the embodiment of the present invention 3
Take a turn for the better, hypothermia, after continuing to take 3 days, symptom disappears, recovery from illness.
The above results show, the pediatric nasal medicine of the treatment infection of the upper respiratory tract of the present invention has stronger anti-inflammatory and town
Pain acts on, and its anti-inflammatory and analgesic activity are to be realized by the immunologic function adjusting body, and through clinical practice application, card
Obvious results fruit is very good, has harmonizing Sharyang, dispelling wind and removing heat, strengthening vital QI to eliminate pathogenic factors, adjusts effect of immunity, and in the treatment of the present invention
The pediatric nasal medicine of respiratory tract infection is the pure Chinese medicinal preparation that multiple Chinese herbal medicines match, and toxic and side effect is little, is easily connect by patient
It is subject to, it is to avoid the injury to human body for heavy dose of use Chinese medicine, there is the using value of reality, economic and social benefit is notable.
Although preferred embodiments of the present invention have been described, but those skilled in the art once know basic creation
Property concept, then can make other change and modification to these embodiments.So, claims are intended to be construed to including excellent
Select embodiment and fall into being had altered and changing of the scope of the invention.
Obviously, those skilled in the art can carry out the various changes and modification essence without deviating from the present invention to the present invention
God and scope.So, if these modifications of the present invention and modification belong to the scope of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to comprise these changes and modification.
Claims (6)
1. a kind of pediatric nasal medicine treating the infection of the upper respiratory tract is it is characterised in that be made up of the component of following weight portion：Goose
Do not eat careless 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part, Hyssopus officinalis 10-20 part, dandelion 10-20 part, cordate houttuynia 10-20
Part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part, purslane 5-10 part, surfactant 0.1-0.2 part, preservative
0.01-0.02 part, flavouring 0.01-0.02 part.
2. the pediatric nasal medicine of the treatment infection of the upper respiratory tract according to claim 1 is it is characterised in that by following weight
The component of part is made：20 parts of Centipeda minima, 30 parts of Siberian cocklebur, 10 parts of the flower bud of lily magnolia, 20 parts of Hyssopus officinalis, 20 parts of dandelion, 10 parts of cordate houttuynia,
5 parts of radix bupleuri, 10 parts of calamus, 5 parts of Chinese gall, 7 parts of purslane, 0.1 part of surfactant, 0.01 part of preservative, flavouring 0.01
Part.
3. the pediatric nasal medicine of the treatment infection of the upper respiratory tract according to claim 1 is it is characterised in that by following weight
The component of part is made：30 parts of Centipeda minima, 25 parts of Siberian cocklebur, 20 parts of the flower bud of lily magnolia, 10 parts of Hyssopus officinalis, 15 parts of dandelion, 15 parts of cordate houttuynia,
15 parts of radix bupleuri, 8 parts of calamus, 10 parts of Chinese gall, 10 parts of purslane, 0.15 part of surfactant, 0.015 part of preservative, flavouring
0.015 part.
4. the pediatric nasal medicine of the treatment infection of the upper respiratory tract according to claim 1 is it is characterised in that by following weight
The component of part is made：40 parts of Centipeda minima, 20 parts of Siberian cocklebur, 15 parts of the flower bud of lily magnolia, 15 parts of Hyssopus officinalis, 10 parts of dandelion, 20 parts of cordate houttuynia,
10 parts of radix bupleuri, 5 parts of calamus, 8 parts of Chinese gall, 5 parts of purslane, 0.2 part of surfactant, 0.02 part of preservative, flavouring 0.02
Part.
5. the pediatric nasal medicine of the treatment infection of the upper respiratory tract according to claim 1 is it is characterised in that live in described surface
Property agent be one of tween, sapn or two kinds；Described preservative be one of Sodium Benzoate, ethyl-para-hydroxybenzoate or
Two kinds；Described flavouring is one of orange essence, strawberry essence.
6. according to claim 1 treatment the infection of the upper respiratory tract pediatric nasal medicine preparation method it is characterised in that
Specifically implement according to following steps：
Step 1, weighs each component by following weight portion：Centipeda minima 20-40 part, Siberian cocklebur 20-30 part, flower bud of lily magnolia 10-20 part, god are fragrant
Careless 10-20 part, dandelion 10-20 part, cordate houttuynia 10-20 part, radix bupleuri 5-15 part, calamus 5-10 part, Chinese gall 5-10 part, dent
Amaranth 5-10 part, surfactant 0.1-0.2 part, preservative 0.01-0.02 part, flavouring 0.01-0.02 part；
Step 2, pulverizes after the Centipeda minima weighing in step 1, Hyssopus officinalis, cordate houttuynia mixing, crosses 40 mesh sieves, with overcritical two
Oxidation carbon cycle counter-current extraction 1-3h, extracting pressure is 10-30Mpa, and extraction temperature is 30-70 DEG C, and carbon dioxide flow is 20-
50kg/h, extraction finishes and obtains Mixed chaotic sequences；
Step 3, the Siberian cocklebur weighing in step 1, the flower bud of lily magnolia, dandelion, radix bupleuri, calamus, Chinese gall, purslane are mixed,
Obtain mixture, add, in mixture, the water being equivalent to mixture weight 8-10 times, soak 20-60min, then fry by intense fire
Open, then boil 30-40min by slow fire, filter, obtain first time filtrate and first time filter residue, add toward in first time filter residue and be equivalent to
The water of filter residue weight 8-10 times, first intense fire is fried open, then boils 30-40min by slow fire, filters, and obtains second filtrate, merges for the first time
Filtrate and second filtrate, mix, and being evaporated to relative density is 1.05-1.2, obtains mixed concentrated liquid；
Step 4, described Mixed chaotic sequences and the mixing of described mixed concentrated liquid add the surfactant weighing in step 1, prevent
Rotten agent and flavouring, obtain medicament concentrate, add and are equivalent to the water of 15-20 times of medicament concentrate and are diluted, mixing is all
Even, filter, dispense to the pressing spray bottle of 10-20mL specification, the paediatrics nasal cavity obtaining final product the described treatment infection of the upper respiratory tract is used
Medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107184845A (en) * | 2017-06-12 | 2017-09-22 | 肖厥明 | It is a kind of to treat pediatric nasal medicine of the infection of the upper respiratory tract and preparation method thereof |
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| CN1615923A (en) * | 2003-11-12 | 2005-05-18 | 成都三明药物研究所 | Medicinal composition and its preparing method and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1615923A (en) * | 2003-11-12 | 2005-05-18 | 成都三明药物研究所 | Medicinal composition and its preparing method and use |
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| CN107184845A (en) * | 2017-06-12 | 2017-09-22 | 肖厥明 | It is a kind of to treat pediatric nasal medicine of the infection of the upper respiratory tract and preparation method thereof |
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