CN111588748A - A thyme essential oil soft capsule for treating bronchitis and its treatment method - Google Patents
A thyme essential oil soft capsule for treating bronchitis and its treatment method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a thyme essential oil soft capsule for treating bronchitis and a therapy thereof. The thyme essential oil has strong effects of bacteriostasis, antivirus, anti-inflammation, antianaphylaxis, cough relieving, phlegm reducing and the like. According to the invention, thyme essential oil is used as an effective component and is prepared into the soft capsule, the electronic heater is used as an administration tool, the soft capsule is destroyed by utilizing the mechanical structure of the heater, the contained essential oil is slowly released, and the drug molecules in the essential oil are vaporized in an electric heating manner and are inhaled into a respiratory tract through mouth and nose, so that the drug molecules can deeply reach diseased parts such as trachea, bronchus and the like, and the effect of the drug molecules can be rapidly exerted. The therapy is used as a directional administration mode, has obvious quick-acting effect and positioning effect, is used locally, has quick response, small dosage and small toxic and side effect, has obvious curative effects on treating bronchitis, relieving cough and reducing sputum, and can be used as an effective alternative resistance and resistance-reducing treatment means.
Description
Technical Field
The invention belongs to the field of natural medicines, and particularly relates to a thyme essential oil soft capsule for treating bronchitis and a therapy thereof.
Background
Thyme (Thymus mongolicus Ronn) is an ancient plant with a long history of disease treatment, which can be traced back to northern Song in Chinese medical records. The Xinjiang Chinese herbal handbook records the functions of treating cold, expelling wind, strengthening spleen to promote digestion, relieving cough and reducing sputum, warming middle-jiao and dispelling cold; it has spasmolytic, wind-dispelling and strengthening effects, and can be used for treating inflammation, spasmodic cough, pertussis, and sore throat; the thyme decoction can be used for treating pharyngolaryngitis and stomatitis by gargling, and has good effect. Ancient Egyptian preserved with thyme, and ancient Marian preserved with thyme for antibacterial purposes. In the middle century, plague spread throughout europe, which used thyme to treat epidemic and leprosy. In two world war times in the beginning of the 20 th century, hospitals in europe use it as a disinfectant and an antibacterial agent. In recent years, thyme essential oil is used for treating various diseases such as tracheitis, arthritis, influenza, cold, cough and the like in folks, and has better curative effect.
The use of thyme essential oil has been around for thousands of years, with its remarkable efficacy witnessed. The oil content of the thyme essential oil is about 0.5%, and the components with medicinal value mainly comprise thymol, carvacrol, linalool, gamma-terpinene, p-cymene and the like, wherein the content of the thymol is the maximum.
The thyme essential oil has certain anti-inflammatory effect, and researches show that the phagocytic activity of abdominal cavity macrophages of mice can be obviously improved by continuously intragastrically administering the mice for 15 days at a dose of 200 mg/kg; when the rat is continuously perfused with 800mg/kg dose for 10 days, the growth of granulation tissue can be obviously inhibited.
The thyme essential oil has strong bacteriostatic effect and broad spectrum, and has obvious inhibiting effect on escherichia coli, staphylococcus aureus, bacillus subtilis, staphylococcus epidermidis and pseudomonas aeruginosa. In vitro measurement of thyme: (T.magnusNakai) has strong inhibitory effect on pathogenic bacteria such as streptococcus pneumoniae, staphylococcus aureus and salmonella typhimurium, and has synergistic inhibitory effect on staphylococcus aureus, especially drug-resistant strains thereof, thyme essential oil and norfloxacin.
Bronchitis refers to chronic nonspecific inflammation of the trachea, bronchial mucosa, and surrounding tissues. Bronchitis is mainly caused by the chronic nonspecific inflammation of the bronchi resulting from repeated infections with viruses and bacteria. When the temperature is reduced, the respiratory tract small vessel spasm ischemia, defense function is reduced, and the like, the disease is favorably caused; chronic irritation such as smog and dust, and air pollution can also cause diseases; smoking causes bronchospasm, mucosal variation, ciliary movement reduction, mucus secretion increase and infection is benefited; allergic factors are also related. Clinically, it is characterized by long-term cough, expectoration, or accompanied by wheezing and recurrent attacks.
The traditional Chinese medicine and the traditional Chinese medicine are used for treating bronchitis, and the Western medicine mostly uses antibacterial drugs (penicillin, cephalosporins, macrolides, erythromycin and the like), cough-relieving and phlegm-eliminating drugs (ambroxol hydrochloride, bromhexine, carbocysteine and the like) and antiviral drugs, and the drugs are taken by oral administration, intramuscular injection or intravenous drip or are assisted by atomization inhalation for treatment, so that the curative effect is quick, but the long-term use of antibiotics has great damage to the body and is easy to generate drug resistance. The traditional Chinese medicine is mostly decocted and taken by a Chinese herbal medicine formula, can treat both symptoms and root causes, systematically condition body functions, but has long treatment period, slow effect, large dosage and certain toxic and side effects on organisms.
Therefore, in order to fully exert the effects of the thyme essential oil such as relieving cough and reducing sputum, resisting inflammation, resisting bacteria and viruses, treating cold and the like, a novel formulation of the thyme essential oil is developed, the stability of the thyme essential oil is improved, a matched treatment method easy for directional administration is provided, and the thyme essential oil has important significance for treating bronchitis.
Disclosure of Invention
In view of the above problems, the present invention aims to provide a thyme essential oil soft capsule for treating bronchitis and a therapy thereof. The method comprises preparing thyme essential oil into soft capsule, placing into heating cavity of electronic heater, puncturing the soft capsule with needle hole in the heater to release thyme essential oil, heating to vaporize medicinal molecules, inhaling into respiratory tract via mouth and nose, and directly reaching focus parts such as trachea and bronchus to give play to directional administration.
In order to achieve the purpose, the invention adopts the following technical scheme:
a thyme essential oil soft capsule for treating bronchitis and its treatment method, the thyme essential oil is extracted by steam distillation method, and the steps are as follows: weighing a certain amount of dried and crushed thyme flowers or leaves, placing the thyme flowers or leaves in a round-bottom flask according to a material-liquid ratio of 1: adding distilled water 10-20, soaking at room temperature for 12 hr, performing ultrasonic treatment for 30min, and heating and distilling for 5 hr. When no oil drop appears on the condensation tube, the distillation is thorough, the obtained product is put into a separating funnel, and a proper amount of petroleum ether is added to be shaken up for extraction. Standing, collecting the upper layer, absorbing excessive water with anhydrous sodium sulfate, transferring into a distillation flask, vacuum rotary evaporating at 45 deg.C, evaporating petroleum ether completely to obtain thyme essential oil, weighing, and storing at 4 deg.C.
In order to improve the stability of essential oil, reduce the irritation of the essential oil and control the accuracy of the dosage of the medicine, the thyme essential oil is prepared into the soft capsule, and the preparation method of the thyme essential oil soft capsule comprises the following steps:
s1, preparing internal feed liquid: the inner feed liquid comprises: 0.1 to 5 percent of thyme essential oil, 10 to 20 percent of hemp wax, 0.1 to 1 percent of borneol, 0.1 to 1 percent of menthol and the balance of solvent by weight. Heating solvent to 50-60 deg.C, adding hemp wax, dissolving, cooling to room temperature, adding Borneolum Syntheticum and Mentholum, adding thyme essential oil, and stirring to obtain the final product.
S2, preparing capsule shells: medical gelatin, glycerol and purified water are taken as capsule shell materials, and the weight ratio of the gelatin: glycerol: water = 2-4: 1-2: 2-4. Soaking gelatin in 80% purified water for swelling, mixing the rest purified water and glycerol, injecting into a gelatin dissolving tank, heating and stirring to about 75 deg.C, adding gelatin solution, stirring for 30min, cooling, standing, and vacuum defoaming to obtain capsule shell material gelatin solution.
S3, tabletting: putting the capsule shell material glue solution into a glue storage barrel which is pre-insulated at 60 ℃, preserving heat, defoaming and standing the glue solution at 60 ℃ for 4 hours, and pressing the glue solution at 60 ℃; and (4) pressing the prepared qualified film and the content prepared in the step (S1) into soft capsules by an automatic rotary capsule making machine. In the production process of the automatic rotary capsule making machine, the temperature of the pressed pills is controlled to be 25-35 ℃, and the rotating speed of a rolling die is about 3 r/min; controlling the indoor temperature at 20-25 ℃ and the relative air humidity at 40%; the charging amount of each pill is controlled to be 0.4-0.5 g.
S4, pelleting and forming: the soft capsule is shaped by blowing in a net machine at 20 ℃ for 4 hours.
S5, washing and drying pills: washing off an oil layer on the surface of the capsule by using 70-95% ethanol, and drying for 12-24 h at the temperature of 25-40 ℃ and the relative humidity of 25-40% to obtain the thyme essential oil soft capsule.
Further, the hemp wax in step S1 is obtained by extracting industrial hemp leaves with supercritical CO2 to obtain an extract, and performing winterization and dewaxing to obtain dewaxed wax; the solvent is as follows: medical glycerin.
A thyme essential oil soft capsule for treating bronchitis and a therapy thereof are provided, wherein the therapy comprises: the thyme essential oil is used as an effective component, the thyme essential oil is prepared into a soft capsule preparation form, the electronic heater is used as an administration tool, the thyme essential oil soft capsule is placed in a heating cavity of the electronic heater, the soft capsule is damaged by utilizing the mechanical structure of the heater, the thyme essential oil contained in the soft capsule is released, a switch of the electronic heater is turned on, the heating temperature is accurately set, when the temperature exceeds the boiling point of a compound in the thyme essential oil, medicine molecules are vaporized and are inhaled into a breathing passage through mouth and nose and deeply reach the position of a bronchial disease focus, and therefore the effect of directional treatment is exerted.
Further, the heating cavity is set at a temperature of 300-1000 ℃.
Further, the heating cavity also comprises a filler, and the filler is 20-40 meshes of folium artemisiae argyi powder.
Further, the mechanical structure of the soft capsule is a pinhole.
Compared with the prior art, the invention has the advantages and beneficial effects that:
(1) according to the invention, thyme essential oil is used as a medicinal effective component to replace antibiotics and hormones to treat bronchitis, so that the use of the antibiotics and the hormones can be effectively avoided, the dependence of the antibiotics and the hormones and the damage of the antibiotics and the hormones to the body are reduced, and the generation of drug resistance is avoided.
(2) As a directional administration mode, the therapy of the invention vaporizes drug molecules in thyme essential oil by electronic heating, and the thyme essential oil can be directly absorbed through mouth and nose, and can reach the lower respiratory tract, and the drug molecules can directly act on the pathological changes such as bronchus, and the like, and the invention has the advantages of obvious curative effect, small dosage, quick effect, small side effect, convenient use and the like.
(3) The medicinal components of the invention are inhaled into a respiratory system by gas molecules, do not pass through the gastrointestinal tract, can reduce the irritation of the medicament to the gastrointestinal tract, and can avoid the first pass effect of the liver.
(4) The thyme essential oil disclosed by the invention is used in a soft capsule dosage form, and can prevent the essential oil from volatilizing, improve the stability of the essential oil, reduce the irritation of the essential oil and control the accuracy of the dosage of the medicine.
Detailed Description
While the following is a description of the preferred embodiments of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Example 1
1. Extraction of thyme essential oil
A thyme essential oil soft capsule for treating bronchitis and its treatment method, the thyme essential oil is extracted by steam distillation method, and the steps are as follows: weighing 200g dried and pulverized thyme flower, placing in round bottom flask, adding 2000ml distilled water, soaking at room temperature for 12 hr, performing ultrasonic treatment for 30min, and heating and distilling for 5 hr. When no oil drop appears on the condensation tube, the distillation is thorough, the obtained product is put into a separating funnel, and a proper amount of petroleum ether is added to be shaken up for extraction. Standing, collecting the upper layer, absorbing excessive water with anhydrous sodium sulfate, transferring into a distillation flask, vacuum rotary evaporating at 45 deg.C until petroleum ether is completely evaporated to obtain thyme essential oil, weighing, and storing at 4 deg.C with oil yield of 0.25% (w/w).
2. Preparation of thyme essential oil soft capsule
The preparation method comprises the following steps of preparing 100g of soft capsule feed liquid and 100g of gelatin liquid:
s1, preparing internal feed liquid: the formula amount of the internal feed liquid is as follows: 2g of thyme essential oil, 15g of hemp wax, 0.5g of borneol, 0.5g of menthol and 82g of glycerol. Heating glycerol to 50 deg.C, adding hemp wax, dissolving, cooling to room temperature, adding Borneolum Syntheticum and Mentholum, adding thyme essential oil, and stirring to obtain internal liquid containing 2% thyme essential oil.
S2, preparing gelatin solution: 40g of gelatin, 20g of glycerol and 40g of purified water are accurately weighed. Soaking gelatin in 80% purified water for swelling, mixing the rest purified water and glycerol, injecting into a gelatin dissolving tank, heating and stirring to about 75 deg.C, adding gelatin solution, stirring for 30min, cooling, standing, and vacuum defoaming to obtain capsule shell material gelatin solution.
S3, tabletting: putting the gelatin solution into a gelatin storage barrel which is pre-insulated at 60 ℃, preserving heat, defoaming and standing the gelatin solution at 60 ℃ for 4 hours, and pressing the gelatin sheet at 60 ℃; and (4) pressing the prepared qualified film and the content prepared in the step (S1) into soft capsules by an automatic rotary capsule making machine. In the production process of the automatic rotary capsule making machine, the temperature of the pressed pills is controlled at 30 ℃, and the rotating speed of a rolling die is about 3 r/min; controlling the indoor temperature at 22 ℃ and the relative air humidity at 30%; the loading amount of each pill is controlled to be 0.5 g.
S4, pelleting and forming: the soft capsule is shaped by blowing in a net machine at 20 ℃ for 4 hours.
S5, washing and drying pills: washing off oil layer on the surface of the capsule with 75% ethanol, and drying at 30 deg.C and relative humidity of 30% for 20 hr to obtain thyme essential oil soft capsule.
Example 2 in vitro bacteriostatic assay of thyme essential oil
1. Material
Test strains: streptococcus, staphylococcus, escherichia coli, staphylococcus aureus and pseudomonas aeruginosa.
2. Method of producing a composite material
The inhibition effect of thyme essential oil in the soft capsule on the growth of the test bacteria is measured by adopting a cup dish method and a double-layer flat plate method. Pouring the bottom flat plate, sucking 10 mL of prepared bacterial liquid, mixing the bacterial liquid into 90 mL of culture medium cooled to about 45 ℃ to ensure that the final bacterial liquid concentration is 106～107cfu/mL, and preparing an upper layer carrying bacteria plate. After solidification, sterile oxford cups were placed symmetrically on the plate, 100 μ L of the contents taken out of the soft capsules of example 1 was added to the oxford cups, and 3 parallel experiments were performed with sterile water as a blank control. Culturing at 37 ℃ for 24-36 h, measuring the size of the inhibition zone by a cross method, and averaging the results.
3. Measurement results
The antibacterial activity is judged according to the size of the antibacterial zone, and the judgment standard is as follows: diameter >20 mm, extremely sensitive; 15-20 mm, high sensitivity; 10-14 mm, medium sensitivity; 7-9 mm, low sensitivity; diameter <7mm, insensitivity, results are shown in table 1.
The results show (table 1) that the thyme essential oil has broad-spectrum bacteriostatic ability, has strong inhibitory action on test bacteria, has particularly remarkable growth inhibition on streptococcus, staphylococcus aureus, staphylococcus and escherichia coli, achieves extremely sensitive effect, and achieves high sensitive effect on inhibition on pseudomonas aeruginosa. Therefore, the thyme essential oil has better inhibiting effect on bacteria causing bronchial inflammation.
TABLE 1 bacteriostatic effect of thyme essential oil on test bacteria
| Test bacterium | Diameter/mm of bacteriostatic circle | Blank control |
| Streptococcus sp | 25.2±1.4 | 0 |
| Staphylococcus aureus | 23.7±1.0 | 0 |
| Escherichia coli | 20.8±0.5 | 0 |
| Staphylococcus aureus | 31.6±1.8 | 0 |
| Pseudomonas aeruginosa | 16.5±1.2 | 0 |
EXAMPLE 3 anti-inflammatory action of thyme essential oil
1. Experiment grouping
Blank control group: 0.5% Tween-80 normal saline, and perfusing the stomach with 20ml/kg dosage.
Administration group: taking the thyme essential oil soft capsule prepared in the example 1, taking out the content of the soft capsule, and performing intragastric administration according to the low dose of 0.1ml/kg and the high dose of 1 ml/kg.
Positive control group: dexamethasone was administered at 5mg/kg by intragastric administration.
2. Method of producing a composite material
40 mice with the weight of 25.0 +/-1.0 g are respectively provided with 10 mice in each group. On the basis of normal feeding, a blank control group is subjected to intragastric administration of 0.5% Tween-80 normal saline (20 ml/kg), an administration group is subjected to intragastric administration once per day (low dose is 0.1ml/kg, high dose is 1 ml/kg), a positive control group is subjected to intragastric administration of dexamethasone (5 mg/kg), and continuous administration is carried out for 5 days. After the last administration for 1h, each mouse was evenly coated with 30 μ L of xylene-induced inflammation on the inner and outer sides of the same position of the left auricle, and the right auricle was not coated as a control. After 1h of inflammation, the cervical vertebra is whitened and the mice are killed, ear pieces are punched at the same parts of two ears of each mouse by a perforator with the diameter of 8mm, the mouse is accurately weighed by an analytical balance, the ear swelling degree and the inflammation inhibition rate of the mouse are represented by the weight difference of left and right ears, and the swelling degree and the inflammation inhibition rate are calculated according to the following formulas, and the results are shown in table 2.
Swelling = right ear mass-left ear mass.
Inflammation inhibition (%) = (blank control ear swelling degree-administration group ear swelling degree)/blank control ear swelling degree × 100%.
3. Results
As can be seen from Table 2, the thyme essential oil low dose group (0.1 ml/kg) and the thyme essential oil high dose group (1 ml/kg) both significantly inhibited the mouse ear swelling effect caused by xylene, as compared to the blank control group. The inhibition rate of the high-dose group is close to that of the positive control group (dexamethasone), and the inhibition rate reaches 75 percent, which indicates that the thyme essential oil has better anti-inflammatory effect.
TABLE 2 Effect of thyme essential oil on ear swelling of mice by xylene
EXAMPLE 4 Observation of therapeutic Effect
1. Case selection
100 patients with typical bronchitis were randomly selected for observation and treatment, aged 3-60 years, and divided into 2 groups of 50 patients each.
Symptoms are manifested as: upper respiratory infection, thin nasal discharge, nasal obstruction, sore throat, cough, excessive phlegm, and asthma.
2. Method of treatment
Treatment groups: putting the thyme essential oil soft capsule prepared in the example 1 into a heating cavity of an electronic heater, puncturing the soft capsule by using a needle hole in the heater to release thyme essential oil, turning on a switch of the electronic heater, accurately setting the heating temperature to 300 ℃, vaporizing drug molecules in the heated essential oil, and inhaling respiratory tract by a subject through the oral cavity, wherein the soft capsule is taken one time for 3 times/day, and the treatment is continuously carried out for 7 days.
Control group: placebo (the soft capsules without thyme essential oil prepared according to example 1, the preparation method and other auxiliary materials are the same), and the use method, the dosage and the administration period are the same as those of the treatment group.
3. Criteria for efficacy assessment
(1) And (3) healing: within 7 days of treatment, symptoms and signs disappear.
(2) The method has the following advantages: within 7 days of treatment, most symptoms and signs disappear.
(3) And (4) invalidation: within 7 days of treatment, the main symptoms and signs are not improved or aggravated.
4. Results
As can be seen from Table 3, compared with the control group, the treatment of bronchitis by the present invention has significant effect, and the total effective rate is 92%. During the treatment process, the cough frequency of patients in the treatment group is gradually reduced, the secretion of respiratory tract is more likely to be coughed, and the symptom of throat pain is relieved or disappeared. The treatment of the invention has quick effect and no obvious adverse reaction, and is an ideal treatment means for treating respiratory diseases by replacing resistance and reducing resistance.
TABLE 3 therapeutic Effect on bronchitis
| Group of | Treatment group | Control group |
| Recovery (human) | 18 | 0 |
| Effective (human) | 28 | 3 |
| Invalid (human) | 4 | 47 |
| Total effective rate (%) | 92 | 6 |
The foregoing is illustrative of the present invention and is not to be construed as limiting thereof. It will be apparent to those skilled in the art that modifications may be made to the above-described embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, improvement or variation that does not depart from the technical spirit of the present invention is intended to be within the scope of the present invention.
Claims (8)
1. A thyme essential oil soft capsule for treating bronchitis and a therapy thereof are characterized in that the therapy comprises the following steps: the thyme essential oil is used as an effective component, the thyme essential oil is prepared into a soft capsule preparation form, an electronic heater is used as an administration tool, the thyme essential oil soft capsule is placed in a heating cavity of the electronic heater, the soft capsule is damaged by utilizing the mechanical structure of the heater to release the contained essential oil, a switch of the electronic heater is turned on, the heating temperature is accurately set, when the temperature exceeds the boiling point of compounds in the thyme essential oil, medicine molecules are vaporized and are inhaled into a breathing system through mouth and nose to reach the focus parts such as trachea, bronchus and the like, and therefore the effect of directional treatment is achieved.
2. The thyme essential oil soft capsule and the therapy thereof for the treatment of bronchitis according to claim 1, wherein the thyme essential oil is in soft capsule dosage form; the thyme essential oil is prepared by extracting through a steam distillation method.
3. The thyme essential oil soft capsule and the therapy thereof as claimed in claim 1, wherein the temperature range of the heating cavity is 300-1000 ℃.
4. The thyme essential oil soft capsule and the therapy thereof for the treatment of bronchitis according to claim 1, wherein the mechanical structure of the soft capsule is needle holes.
5. The thyme essential oil soft capsule and the therapy thereof for treating bronchitis according to claim 1, wherein the heating cavity further comprises a filler, and the filler is 20-40 mesh folium artemisiae argyi powder.
6. The thyme essential oil soft capsule and the therapy thereof for treating bronchitis according to claims 1 and 2, wherein the thyme essential oil is extracted by steam distillation method, comprising the following steps: weighing a certain amount of dried and crushed thyme flowers or leaves, placing the thyme flowers or leaves in a round-bottom flask according to a material-liquid ratio of 1: 10-20, adding distilled water, soaking at room temperature for 12 h, performing ultrasonic treatment for 30min, and heating and distilling for 5 h; when no oil drop appears on the condensation pipe, the distillation is thorough, the obtained product is put into a separating funnel, and a proper amount of petroleum ether is added for shaking up and extraction; standing, collecting the upper layer, absorbing excessive water with anhydrous sodium sulfate, transferring into a distillation flask, vacuum rotary evaporating at 45 deg.C, evaporating petroleum ether completely to obtain thyme essential oil, weighing, and storing at 4 deg.C.
7. The thyme essential oil soft capsule and the therapy thereof for treating bronchitis according to claims 1 and 2, characterized in that the preparation method of the thyme essential oil soft capsule comprises the following steps:
s1, preparing internal feed liquid: the inner feed liquid comprises: 0.1 to 5 percent of thyme essential oil, 10 to 20 percent of hemp wax, 0.1 to 1 percent of borneol, 0.1 to 1 percent of menthol and the balance of solvent by weight; heating solvent to 50-60 deg.C, adding cannabis wax, dissolving, cooling to room temperature, adding Borneolum Syntheticum and Mentholum, adding thyme essential oil, and stirring to obtain inner liquid;
s2, preparing capsule shells: medical gelatin, glycerol and purified water are taken as capsule shell materials, and the weight ratio of the gelatin: glycerol: water = 2-4: 1-2: 2-4; soaking gelatin in 80% purified water for swelling, mixing the rest purified water and glycerol, injecting into a gelatin dissolving tank, heating and stirring to about 75 deg.C, adding gelatin solution, stirring for 30min, cooling, standing, and vacuum defoaming to obtain capsule shell material gelatin solution;
s3, tabletting: putting the capsule shell material glue solution into a glue storage barrel which is pre-insulated at 60 ℃, preserving heat, defoaming and standing the glue solution at 60 ℃ for 4 hours, and pressing the glue solution at 60 ℃; pressing the qualified film and the content prepared in S1 into soft capsule by an automatic rotary capsule making machine; in the production process of the automatic rotary capsule making machine, the temperature of the pressed pills is controlled to be 25-35 ℃, and the rotating speed of a rolling die is about 3 r/min; controlling the indoor temperature at 20-25 ℃ and the relative air humidity at 40%; controlling the charging amount of each pill to be 0.4-0.5 g;
s4, pelleting and forming: blowing the pressed soft capsule in a net machine at 20 ℃ for shaping for 4 hours;
s5, washing and drying pills: washing off an oil layer on the surface of the capsule by using 70-95% ethanol, and drying for 12-24 h at the temperature of 25-40 ℃ and the relative humidity of 25-40% to obtain the thyme essential oil soft capsule.
8. The thyme essential oil soft capsule and the therapy thereof for treating bronchitis as claimed in claim 7, wherein the hemp wax of step S1 is industrial hemp flower and leaf processed by supercritical CO2Extracting the obtained extract, and performing winterization and dewaxing to obtain dewaxed wax; the solvent is as follows: medical glycerin.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554335A (en) * | 2022-03-29 | 2023-01-03 | 广州果熊生物科技有限公司 | Mother and infant protective essential oil and preparation and use method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554335A (en) * | 2022-03-29 | 2023-01-03 | 广州果熊生物科技有限公司 | Mother and infant protective essential oil and preparation and use method thereof |
| CN115554335B (en) * | 2022-03-29 | 2023-11-21 | 广州果熊生物科技有限公司 | Protective essential oil and preparation method thereof |
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Application publication date: 20200828 |