CN111601798B - 双酰胺肌节活化化合物及其用途 - Google Patents

双酰胺肌节活化化合物及其用途 Download PDF

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Publication number
CN111601798B
CN111601798B CN201880072907.5A CN201880072907A CN111601798B CN 111601798 B CN111601798 B CN 111601798B CN 201880072907 A CN201880072907 A CN 201880072907A CN 111601798 B CN111601798 B CN 111601798B
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trifluoromethyl
prolinamide
carbonyl
methyl
sulfonyl
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CN111601798A (zh
Inventor
L.阿什克拉夫特
A.贝齐奥
J.巴特勒
A.钱德拉
C.闯
S.E.科利比
M.德贝内德托
V.迪马萨
R.格雷斯法
J.马利诺夫斯基
D.梅比乌斯
B.P.摩根
J.佩耶特
A.罗梅罗
D.小圣简
R.瓦加斯
J.耶奥曼
H.张
A.成
F.冈萨雷斯洛佩斯德图里索
M.G.约翰逊
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Amgen Inc
Cytokinetics Inc
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Amgen Inc
Cytokinetics Inc
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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CN201880072907.5A 2017-09-13 2018-09-13 双酰胺肌节活化化合物及其用途 Active CN111601798B (zh)

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