CN111568974A - Spray for treating toothache and preparation method thereof - Google Patents
Spray for treating toothache and preparation method thereof Download PDFInfo
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- CN111568974A CN111568974A CN202010662993.4A CN202010662993A CN111568974A CN 111568974 A CN111568974 A CN 111568974A CN 202010662993 A CN202010662993 A CN 202010662993A CN 111568974 A CN111568974 A CN 111568974A
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- 239000007921 spray Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 208000004371 toothache Diseases 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 51
- 239000000341 volatile oil Substances 0.000 claims abstract description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 124
- 239000007788 liquid Substances 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 47
- 238000002156 mixing Methods 0.000 claims description 38
- 235000013399 edible fruits Nutrition 0.000 claims description 37
- 239000000463 material Substances 0.000 claims description 36
- 238000005303 weighing Methods 0.000 claims description 34
- 238000000605 extraction Methods 0.000 claims description 29
- 244000241872 Lycium chinense Species 0.000 claims description 27
- 235000015468 Lycium chinense Nutrition 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000012452 mother liquor Substances 0.000 claims description 21
- 239000003921 oil Substances 0.000 claims description 18
- 241000722824 Ardisia crenata Species 0.000 claims description 17
- 241000758794 Asarum Species 0.000 claims description 17
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 17
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 17
- 244000182216 Mimusops elengi Species 0.000 claims description 17
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 17
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 17
- 241001506766 Xanthium Species 0.000 claims description 17
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 15
- 229920000053 polysorbate 80 Polymers 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 14
- 238000001256 steam distillation Methods 0.000 claims description 14
- 238000010992 reflux Methods 0.000 claims description 12
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 11
- 238000002372 labelling Methods 0.000 claims description 9
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 claims description 8
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- 238000002481 ethanol extraction Methods 0.000 claims description 8
- 238000001556 precipitation Methods 0.000 claims description 6
- 230000003381 solubilizing effect Effects 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 238000003809 water extraction Methods 0.000 claims description 6
- 238000007865 diluting Methods 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 4
- 229960000278 theophylline Drugs 0.000 claims description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 4
- 244000273928 Zingiber officinale Species 0.000 claims description 3
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 3
- 235000008397 ginger Nutrition 0.000 claims description 3
- 235000015203 fruit juice Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 208000002193 Pain Diseases 0.000 abstract description 5
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 102000004190 Enzymes Human genes 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 2
- 238000000222 aromatherapy Methods 0.000 abstract description 2
- 239000003205 fragrance Substances 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 230000014759 maintenance of location Effects 0.000 abstract description 2
- 230000036651 mood Effects 0.000 abstract description 2
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 2
- 235000019462 natural additive Nutrition 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 description 3
- 229940126673 western medicines Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010004542 Bezoar Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 208000004480 periapical periodontitis Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a spray for treating toothache and a preparation method thereof, belonging to the field of dental pain-relieving sprays, and the spray does not contain any non-natural additive, reduces oral cavity stimulation and protects oral mucosa, prolongs the retention time of a medicament in the oral cavity, inhibits enzyme and improves the bioavailability of the medicament, and contributes to pharmaceutics; but also actively utilizes the natural fragrance of the plant essential oil with aromatherapy effect to stimulate oral cells to achieve the purposes of adjusting mood, balancing immunity and assisting medicaments for overall treatment. In addition, the invention also achieves the purpose of improving the chemical and biological stability of the medicament in the storage period by using the form of a spray.
Description
Technical Field
The invention relates to the field of dental pain relieving sprays, in particular to a spray for treating toothache and a preparation method thereof.
Background
Toothache is one of the most common symptoms of oral cavity diseases, and seriously troubles the daily life of most people. Toothache is caused by a number of factors, such as dental caries, pulpitis, periapical periodontitis, dentinal hypersensitivity, dental caries or broken teeth resulting in pulpal (nerve) infection. The existing medicines for treating toothache mainly have the effects of relieving fever, resisting bacteria, relieving pain and the like. The oral medicine is commonly compound toothache tincture, periodontal medicine, Wantong yankang tablets or bezoar antidotal pills and the like, although the medicine has a certain treatment effect, the problem cannot be solved quickly, the short time is several hours, and the long time is tens of hours, so that the medicine has a gradual effect, the pain is suffered in the process, the inflammation is possibly increased, and the disease period is prolonged. Many people use metronidazole, fenbide and other western medicines to relieve pain, but the western medicines treat symptoms and do not treat the root causes, have side effects after long-term use, and possibly damage periodontal nerves; compared with the analgesic western medicines, the traditional Chinese medicine has small side effect and can achieve the effect of treating both symptoms and root causes.
Disclosure of Invention
The invention provides a spray for treating toothache and a preparation method thereof in order to solve the problems.
In order to achieve the purpose, the invention adopts the following technical scheme:
a spray for treating toothache and a preparation method thereof, comprising the following steps:
s1, weighing the following medicinal materials according to the prescription: chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii;
s2, juicing or not juicing the medlar in the S1;
s3, carrying out complete formula oil extraction treatment or complete formula oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juice extraction treatment in the step S2; carrying out medlar non-oil extraction treatment or whole formula oil extraction treatment on the medlar and other medicinal materials which are subjected to juicing treatment in the step S2;
s4, carrying out oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juice extraction treatment in the S3, and then carrying out 30% ethanol extraction or 60% ethanol extraction, and marking as a process 1 and a process 2; carrying out full formula oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juicing treatment in the step S3, and then carrying out water extraction and alcohol precipitation extraction or 60% ethanol extraction, and marking as a process 3 and a process 4; carrying out medlar non-oil extraction treatment on the medlar and other medicinal materials after the juicing treatment in the S3, carrying out water extraction and alcohol precipitation extraction on the other medicinal materials after oil extraction treatment, and marking as a process 5; carrying out complete oil extraction treatment on the wolfberry fruits and other medicinal materials subjected to the juicing treatment in the step S3, and then carrying out water extraction and alcohol precipitation extraction or 60% ethanol extraction; denoted as process 6 and process 7.
Preferably, the process 1 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: adding 8 times of 30% ethanol into the flying Chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, refluxing for 1h, pouring out the medicinal liquid, adding 6 times of 30% ethanol, refluxing for 1h, mixing the medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid, and labeling as Process 1.
Preferably, the process 2 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: adding 8 times of 60% ethanol into the flying Chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, refluxing for 1h, pouring out the medicinal liquid, adding 6 times of 60% ethanol, refluxing for 1h, mixing the medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid, and labeling as process 2.
Preferably, the process 3 in S4 includes the following steps: weighing the following medicinal materials according to the prescription: 10 times of water is added into flying Chi , ardisia crenata, asarum, cocklebur fruit and medlar, volatile oil is extracted for 7 hours by steam distillation, mother liquor is filtered, 6 times of water is added into medicine residue, the decoction is decocted for 1 hour, the filtration is carried out, medicine liquid is combined and centrifuged, supernate is decompressed and concentrated to the density of 1.05g/mL, 95% ethanol is added to ensure that the ethanol content in the medicine liquid reaches 60, the medicine liquid is kept stand for 12 hours, the filtration is carried out, the ethanol is recovered, the tween-80 is used for solubilizing the volatile oil and then is uniformly mixed with the medicine liquid, the volume is determined, and the mark.
Preferably, the process 4 in S4 includes the following steps: weighing the following medicinal materials according to the prescription: chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, adding 12 times of water, extracting volatile oil by steam distillation, filtering mother liquor after 7 hr, pouring out, extracting with 6 times of 60% ethanol for 2 times, each time for 1 hr, mixing the ethanol extractive solutions, recovering ethanol under reduced pressure, mixing with the mother liquor, and concentrating to appropriate amount. Tween-80 is added to solubilize volatile oil, and then mixed with the liquid medicine uniformly, and the volume is determined, and the label is process 4.
Preferably, the process 5 in S4 includes the steps of: weighing medlar juice according to the prescription amount, weighing flying Chi , ardisia crenata, asarum and cocklebur fruit according to the prescription amount, adding 12 times of water, extracting volatile oil by steam distillation, pouring out mother liquor after 7h, mixing medicine residues and ginger medicine residues, adding 6 times of water, and decocting for 1 h; mixing the medicinal liquids, centrifuging, concentrating the supernatant to density of 1.05g/mL, slowly adding 95% ethanol to make ethanol concentration in the medicinal liquid reach 60%, standing overnight, vacuum filtering, recovering ethanol under reduced pressure, adding tween-80 to solubilize volatile oil, mixing with the medicinal liquid, and diluting to desired volume, and labeling as process 5.
Preferably, the process 6 in S4 includes the steps of: weighing formula amount of Chinese wolfberry fruit, juicing for later use, weighing formula amount of flying Chi , ardisia crenata, asarum, xanthium and Chinese wolfberry fruit dregs, mixing, adding 12 times of water, extracting volatile oil by steam distillation, filtering and pouring out mother liquor after 7h, adding 6 times of water, decocting for 1h, mixing liquid medicine and mother liquor, centrifuging, concentrating supernatant to density of 1.05g/mL, slowly adding 95% ethanol to enable ethanol concentration in liquid medicine to reach 60%, standing for 12h, carrying out suction filtration, and recovering ethanol under reduced pressure. Mixing the medicinal liquid with fructus Lycii juice, adding Tween-80 to solubilize volatile oil, mixing with the medicinal liquid, and making into desired volume by process 6.
Preferably, the process 7 in S4 includes the steps of: weighing formula amount of Chinese wolfberry fruit, juicing for later use, weighing formula amount of flying Chi , ardisia crenata, asarum, xanthium and Chinese wolfberry fruit dregs, mixing, adding 12 times of water, extracting volatile oil by steam distillation, mixing, pouring out mother liquor after 7h, adding 6 times of 60% ethanol, extracting for 2 times, 1h each time, recovering ethanol under reduced pressure, mixing the liquid medicine with Chinese wolfberry fruit juice, solubilizing the volatile oil by tween-80, mixing with the liquid medicine uniformly, fixing the volume, and marking as process 7.
Compared with the prior art, the invention provides a spray for treating toothache and a preparation method thereof, and the spray has the following beneficial effects:
1. the invention has the beneficial effects that: the oral liquid does not contain any non-natural additive, reduces oral cavity stimulation and protects oral mucosa, prolongs the retention time of the medicine in the oral cavity, inhibits enzyme and improves the bioavailability of the medicine, and contributes to pharmaceutics; but also actively utilizes the natural fragrance of the plant essential oil with aromatherapy effect to stimulate oral cells to achieve the purposes of adjusting mood, balancing immunity and assisting medicaments for overall treatment. In addition, the invention also achieves the purpose of improving the chemical and biological stability of the medicament in the storage period by using the form of a spray.
Drawings
Fig. 1 is a plurality of process flow charts of the spray for treating toothache and the preparation method thereof.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Example 1:
refer to fig. 1; the preparation of the spray is carried out according to the process 1: weighing the following medicinal materials: chi 3 flying to sky, 5 portions of ardisia crenata, 8 portions of asarum, 12 portions of cocklebur fruit and 8 portions of medlar are added with 8 times of 30 percent ethanol for refluxing for 1h, the liquid medicine is poured out, then 6 times of 30 percent ethanol is added for refluxing for 1h, the liquid medicine is merged, the ethanol is recovered under reduced pressure, the liquid medicine is continuously concentrated and marked as process 1;
example 2:
refer to fig. 1; the preparation of the spray is carried out according to the process 2: weighing the following medicinal materials: chi 3 Feitian, 5 portions of ardisia crenata, 8 portions of asarum, 12 portions of cocklebur fruit and 8 portions of medlar are added with 8 times of 60 percent ethanol for refluxing for 1h, the liquid medicine is poured out, then 6 times of 60 percent ethanol is added for refluxing for 1h, the liquid medicine is merged, the ethanol is recovered under reduced pressure, the liquid medicine is continuously concentrated and marked as a process 2;
example 3:
refer to fig. 1; the preparation of the spray is carried out according to the process 3: weighing the following medicinal materials: weighing the following medicinal materials: philadelphia Chinensis 3, ardisia crenata 5, asarum herb 8, cocklebur fruit 12 and wolfberry fruit 8, adding 10 times of water, distilling by steam to extract volatile oil for 7h, filtering mother liquor, adding 6 times of water into dregs, decocting for 1h, filtering, merging liquid medicine, centrifuging, concentrating supernate under reduced pressure until the density is 1.05g/mL, adding 95% ethanol to ensure that the ethanol content in the liquid medicine reaches 60, standing for 12h, carrying out suction filtration, recovering ethanol, solubilizing the tween-80, uniformly mixing the volatile oil with the liquid medicine, fixing the volume to 150mL, and marking as a process 3;
example 4:
refer to fig. 1; the preparation of the spray is carried out according to the process 4: weighing the following medicinal materials: weighing the following medicinal materials: chi 3 parts, 5 parts of ardisia crenata, 8 parts of asarum, 12 parts of cocklebur fruit and 8 parts of medlar are added with 12 times of water, volatile oil is extracted by steam distillation, the mother liquor is filtered and poured out after 7 hours, 6 times of 60 percent ethanol is extracted for 2 times, 1 hour is carried out each time, the ethanol extract is merged, the ethanol is recovered under reduced pressure, and the merged mother liquor is merged and continuously concentrated to a proper amount. Mixing Tween-80 with the medicinal liquid after solubilizing volatile oil, diluting to 150mL, and labeling as Process 4;
example 5:
refer to fig. 1; the preparation of the spray is carried out according to the process 5: weighing the following medicinal materials: weighing the following medicinal materials: chi 3 parts, 5 parts of ardisia crenata, 8 parts of asarum, 12 parts of cocklebur fruit and 8 parts of wolfberry fruit are added with 12 times of water, volatile oil is extracted by steam distillation, the mother liquor is poured out after 7 hours, the medicine residue and the ginger medicine residue are combined, 6 times of water is added, and the decoction is carried out for 1 hour; mixing the medicinal liquids, centrifuging, concentrating the supernatant to density of 1.05g/mL, slowly adding 95% ethanol to make ethanol concentration in the medicinal liquid reach 60%, standing overnight, vacuum filtering, recovering ethanol under reduced pressure, adding tween-80 to solubilize volatile oil, mixing with the medicinal liquid, diluting to 150mL, and labeling to 5
Example 6:
refer to fig. 1; the preparation of the spray is carried out according to the process 6: weighing the following medicinal materials: weighing the following medicinal materials: 893 parts of flying Chi 3 parts, 5 parts of ardisia crenata, 8 parts of asarum, 12 parts of cocklebur fruit and 8 parts of wolfberry fruit, and juicing the wolfberry fruit for later use, then mixing the flying Chi , the ardisia crenata, the asarum, the cocklebur fruit and the wolfberry fruit dregs, adding 12 times of water, extracting volatile oil by steam distillation, filtering the mother liquor after 7h, pouring out, adding 6 times of water, decocting for 1h, mixing the liquor and the mother liquor, centrifuging, concentrating the supernatant to the density of 1.05g/mL, slowly adding 95% ethanol to ensure that the ethanol concentration in the liquor reaches 60%, standing for 12h, carrying out suction filtration, and recovering the ethanol under reduced pressure. Mixing the medicinal liquid with fructus Lycii juice, adding Tween-80 to solubilize volatile oil, mixing with the medicinal liquid, diluting to 150mL, and labeling as process 6;
example 7:
refer to fig. 1; the preparation of the spray is carried out according to the process 7: weighing the following medicinal materials: weighing the following medicinal materials: philippine Chinese 3 parts, ardisia crenata, asarum herb 8 parts, cocklebur fruit 12 parts and wolfberry fruit 8 parts, and wolfberry fruit are squeezed to obtain juice for later use, Philippine Chinese , ardisia crenata, asarum herb, cocklebur fruit and wolfberry fruit dregs are combined, 12 times of water is added, volatile oil is extracted and combined through steam distillation, mother liquor is poured out after 7 hours, 60% ethanol in 6 times of amount is added, extraction is carried out for 2 times, 1 hour each time, ethanol is recovered under reduced pressure, liquid medicine is combined with wolfberry juice, Tween-80 is solubilized and then is uniformly mixed with the liquid medicine, the volume is fixed to 150mL, and the process.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A spray for treating toothache and a preparation method thereof are characterized by comprising the following steps:
s1, weighing the following medicinal materials according to the prescription: chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii;
s2, juicing or not juicing the medlar in the S1;
s3, carrying out complete formula oil extraction treatment or complete formula oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juice extraction treatment in the step S2; carrying out medlar non-oil extraction treatment or whole formula oil extraction treatment on the medlar and other medicinal materials which are subjected to juicing treatment in the step S2;
s4, carrying out oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juice extraction treatment in the S3, and then carrying out 30% ethanol extraction or 60% ethanol extraction, and marking as a process 1 and a process 2; carrying out full formula oil extraction treatment on the wolfberry fruits and other medicinal materials which are not subjected to juicing treatment in the step S3, and then carrying out water extraction and alcohol precipitation extraction or 60% ethanol extraction, and marking as a process 3 and a process 4; carrying out medlar non-oil extraction treatment on the medlar and other medicinal materials after the juicing treatment in the S3, carrying out water extraction and alcohol precipitation extraction on the other medicinal materials after oil extraction treatment, and marking as a process 5; carrying out complete oil extraction treatment on the wolfberry fruits and other medicinal materials subjected to the juicing treatment in the step S3, and then carrying out water extraction and alcohol precipitation extraction or 60% ethanol extraction; denoted as process 6 and process 7.
2. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 1 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: adding 8 times of 30% ethanol into the flying Chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, refluxing for 1h, pouring out the medicinal liquid, adding 6 times of 30% ethanol, refluxing for 1h, mixing the medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid, and labeling as Process 1.
3. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 2 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: adding 8 times of 60% ethanol into the flying Chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, refluxing for 1h, pouring out the medicinal liquid, adding 6 times of 60% ethanol, refluxing for 1h, mixing the medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid, and labeling as process 2.
4. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 3 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: 10 times of water is added into flying Chi , ardisia crenata, asarum, cocklebur fruit and medlar, volatile oil is extracted for 7 hours by steam distillation, mother liquor is filtered, 6 times of water is added into medicine residue, the decoction is decocted for 1 hour, the filtration is carried out, medicine liquid is combined and centrifuged, supernate is decompressed and concentrated to the density of 1.05g/mL, 95% ethanol is added to ensure that the ethanol content in the medicine liquid reaches 60, the medicine liquid is kept stand for 12 hours, the filtration is carried out, the ethanol is recovered, the tween-80 is used for solubilizing the volatile oil and then is uniformly mixed with the medicine liquid, the volume is determined, and the mark.
5. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 4 in S4 includes the steps of: weighing the following medicinal materials according to the prescription: chi , radix Ardisiae Crenatae, herba asari, fructus Xanthii and fructus Lycii, adding 12 times of water, extracting volatile oil by steam distillation, filtering mother liquor after 7 hr, pouring out, extracting with 6 times of 60% ethanol for 2 times, each time for 1 hr, mixing the ethanol extractive solutions, recovering ethanol under reduced pressure, mixing with the mother liquor, and concentrating to appropriate amount. Tween-80 is added to solubilize volatile oil, and then mixed with the liquid medicine uniformly, and the volume is determined, and the label is process 4.
6. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 5 in S4 includes the steps of: weighing medlar juice according to the prescription amount, weighing flying Chi , ardisia crenata, asarum and cocklebur fruit according to the prescription amount, adding 12 times of water, extracting volatile oil by steam distillation, pouring out mother liquor after 7h, mixing medicine residues and ginger medicine residues, adding 6 times of water, and decocting for 1 h; mixing the medicinal liquids, centrifuging, concentrating the supernatant to density of 1.05g/mL, slowly adding 95% ethanol to make ethanol concentration in the medicinal liquid reach 60%, standing overnight, vacuum filtering, recovering ethanol under reduced pressure, adding tween-80 to solubilize volatile oil, mixing with the medicinal liquid, and diluting to desired volume, and labeling as process 5.
7. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 6 in S4 includes the steps of: weighing formula amount of Chinese wolfberry fruit, juicing for later use, weighing formula amount of flying Chi , ardisia crenata, asarum, xanthium and Chinese wolfberry fruit dregs, mixing, adding 12 times of water, extracting volatile oil by steam distillation, filtering and pouring out mother liquor after 7h, adding 6 times of water, decocting for 1h, mixing liquid medicine and mother liquor, centrifuging, concentrating supernatant to density of 1.05g/mL, slowly adding 95% ethanol to enable ethanol concentration in liquid medicine to reach 60%, standing for 12h, carrying out suction filtration, and recovering ethanol under reduced pressure. Mixing the medicinal liquid with fructus Lycii juice, adding Tween-80 to solubilize volatile oil, mixing with the medicinal liquid, and making into desired volume by process 6.
8. The spray for treating toothache and the preparation method thereof according to claim 1, wherein: the process 7 in S4 includes the steps of: weighing formula amount of Chinese wolfberry fruit, juicing for later use, weighing formula amount of flying Chi , ardisia crenata, asarum, xanthium and Chinese wolfberry fruit dregs, mixing, adding 12 times of water, extracting volatile oil by steam distillation, mixing, pouring out mother liquor after 7h, adding 6 times of 60% ethanol, extracting for 2 times, 1h each time, recovering ethanol under reduced pressure, mixing the liquid medicine with Chinese wolfberry fruit juice, solubilizing the volatile oil by tween-80, mixing with the liquid medicine uniformly, fixing the volume, and marking as process 7.
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| CN1840062A (en) * | 2006-01-24 | 2006-10-04 | 张航 | Toothache-treating medicine |
| KR20110080678A (en) * | 2010-01-06 | 2011-07-13 | 원광대학교산학협력단 | A veterinary composition comprising apigenin isolated from the extract of daphne genkwa showing anti-inflammatory effects on periodontal ligament cells |
| CN104815304A (en) * | 2015-04-15 | 2015-08-05 | 苏州市天灵中药饮片有限公司 | Swollen sore throat tablet and preparing method thereof |
| CN107224513A (en) * | 2016-03-23 | 2017-10-03 | 胡厚兴 | A kind of Chinese medicine composition for being used to treat senile toothache |
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2020
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| CN1840062A (en) * | 2006-01-24 | 2006-10-04 | 张航 | Toothache-treating medicine |
| KR20110080678A (en) * | 2010-01-06 | 2011-07-13 | 원광대학교산학협력단 | A veterinary composition comprising apigenin isolated from the extract of daphne genkwa showing anti-inflammatory effects on periodontal ligament cells |
| CN104815304A (en) * | 2015-04-15 | 2015-08-05 | 苏州市天灵中药饮片有限公司 | Swollen sore throat tablet and preparing method thereof |
| CN107224513A (en) * | 2016-03-23 | 2017-10-03 | 胡厚兴 | A kind of Chinese medicine composition for being used to treat senile toothache |
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Application publication date: 20200825 |